Rnai-mediated mmp-9 silencing inhibits mouse melanoma cell invasion and migration in vitro and in vivo

Cell Biology International

Volumn 37, Issue 8, 2013, Pages 849-854

  Tang, Zhao Yong ^a,b   Liu, Yang ^a   Liu, Long Xing ^a   Ding, Xiao Yan ^b   Zhang, Hong ^b   Fang, Liao Qiong ^a,b  

^a SOUTHWEST UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Anti cancer therapy; Invasion; Melanoma; Metastasis; MMP 9; Sirna; Tumour growth

Indexed keywords

COMPLEMENTARY RNA; GELATINASE B; GREEN FLUORESCENT PROTEIN; PLASMID DNA; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE SILENCING; GENE SYNTHESIS; GENE TARGETING; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; LUNG METASTASIS; MELANOMA B16; MELANOMA CELL; METASTASIS INHIBITION; MOUSE; NEOPLASM; NONHUMAN; RNA INTERFERENCE; TUMOR MODEL;

EID: 84880686199     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10107     Document Type: Article

References (23)

1. Alvarez-Erviti L, Seow Y, YinH, Betts C, Lakhal S,Wood MJ (2011) Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotech 29: 341-5.
2. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D (2000) Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogensis. Nat Cell Biol 2: 737-44.
3. Chieh C, Zena W (2001) The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol 11: 537-43.
4. Elbashir SM, Harborth J, Weber K, Tuschl T (2002) Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26: 199-213.
5. Gencer S, Cebeci A, Irmak-Yazicioglu MB (2011) Silencing of the MMP-3 gene by siRNA transfection in gastric cancer AGs cells. J Gastrointestin Liver Dis 20: 19-26.
6. Gondi CS, Dinh DH, Gujrati M, Rao JS (2009) RNAi-mediated downregulation of MMP-2 activates the extrinsic apoptotic pathway in human glioma xenograft cells. Int J Oncol 35: 851-9.
7. Gondi CS, Lakka SS, Dinh D, OliveroW, Gujrati M, Rao JS (2004) Downregulation of uPA, uPAR and MMP-9 using small interfering hairpin RNA (siRNA) inhibits glioma cell invasion, angiogenesis and tumor growth. Neuron Glia Biol 1: 165-76.
8. Hammond SM, Boettcher S, Caudy AA, Kobayashi R, Hannon GJ (2001) Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293: 1146-50.
9. Hannon GJ (2002) RNA interference. Nature 418: 244-51.
10. Hawinkels LJ, Zuidwijk K, Verspaget HW, de Jonge-Muller ES, van Duijn W, Ferreira V, Fontijn RD, David G, Hommes DW, Lamers CB, Sier CF (2008) VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis. Eur J Cancer 44: 1904-13.
11. Lakka SS, Gondi CS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M, et al. (2004) Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene 23: 4681-9.
12. Linos E, Swetter SM, Cockburn MG, Colditz GA, Clarke CA (2009) Increasing burden of melanoma in the United States. J Invest Dermatol 129: 1666-74.
13. Nikkola J, Vihinen P, Vuoristo MS, Kellokumpu-Lehtinen P, Kahari VM, Pyrhonen S (2005) High serum levels of matrix metalloproteinase-9 and matrix metalloproteinase-1 are associated with rapid progression in patients with metastatic melanoma. Clin Cancer Res 11: 5158-66.
14. Qian F, Li YP, Sheng X, Zhang ZC, Song R, Dong W, Cao SX, Hua ZC, Xu Q (2007) PRL-3 siRNA inhibits the metastasis of B16- BL6 mouse melanoma cells in vitro and in vivo. Mol Med 13: 151-9.
15. Qiu Z, Huang C, Sun J, Qiu W, Zhang J, Li H, Jiang T, Huang K, Cao J (2007) RNA interference mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells. Cancer Sci 98: 1099-106.
16. Rao JS, Bhoopathi P, Chetty C, Gujrati M, Lakka SS (2007)MMP-9 siRNA induced senescence resulting in inhibition of medulloblastoma growth via p16INK4A and MAPK pathway. Cancer Res 67: 4956-64.
17. Redondo P, Lloret P, Idoate M, Inoges S (2005) Expression and serum levels of MMP-2 and MMP-9 during human melanoma progression. Clin Exp Dermatol 30: 541-5.
18. Rosenberg SA, Aebersold P, Cornetta K, Kasid A, Morgan RA, Moen R, Karson EM, Lotze MT, Yang JC, Topalian SL, Merino MJ, Culver K, Miller AD, Blaese RM, Anderson WF (1990) Gene transfer into humans immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med 323: 570-8.
19. Snoek-van Beurden PA, Von den Hoff JW (2005) Zymographic techniques for the analysis of matrix metalloproteinases and their inhibitors. Biotechniques 38: 73-83.
20. Suzuki R, Namai E, Oda Y, Nishiie N, Otake S, Koshima R, Hirata K, Taira Y, Utoguchi N, Negishi Y, Nakagawa S, Maruyama K (2010) Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure. J Controlled Release 142: 245-50.
21. Suzuki R, Oda Y, Utoguchi N, Maruyama K (2011) Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles. J Controlled Release 149: 36-41.
22. Visse R, Nagase H (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 92: 827-39.
23. Yuan J, Dutton CM, Scully SP (2005) RNAi mediated MMP-1 silencing inhibits human chondrosarcoma invasion. J Orthop Res 23: 1467-74.