Upregulation of the Rab27a-Dependent Trafficking and Secretory Mechanisms Improves Lysosomal Transport, Alleviates Endoplasmic Reticulum Stress, and Reduces Lysosome Overload in Cystinosis

Molecular and Cellular Biology

Volumn 33, Issue 15, 2013, Pages 2950-2962

  Johnson, Jennifer L ^a   Napolitano, Gennaro ^a   Monfregola, Jlenia ^a   Rocca, Celine J ^b   Cherqui, Stephanie ^b   Catz, Sergio D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTINE; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; RAB27A PROTEIN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; CYSTINOSIS; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; KIDNEY TUBULE CELL; LYSOSOME; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SECRETORY PATHWAY; UPREGULATION;

AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CELL LINE; CELLS, CULTURED; CYSTINE; CYSTINOSIS; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; EXOCYTOSIS; HUMANS; LYSOSOMES; MICE; MICE, INBRED C57BL; RAB GTP-BINDING PROTEINS; UP-REGULATION;

EID: 84880678314     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00417-13     Document Type: Article

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