Rab27b is expressed in a wide range of exocytic cells and involved in the delivery of secretory granules near the plasma membrane

Molecular Biology of the Cell

Volumn 18, Issue 11, 2007, Pages 4377-4386

  Gomi, Hiroshi ^a   Mori, Kenichi ^a   Itohara, Shigeyoshi ^b   Izumi, Tetsuro ^a  

^a GUNMA UNIVERSITY   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CELL PROTEIN; CORTICOTROPIN; GRANUPHILIN; PROTEIN RAB27B; RAB27A PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CORTICOTROPIN RELEASE; EXOCYTOSIS; GENE DISRUPTION; GENE INSERTION; HYPOPHYSIS; KNOCKOUT MOUSE; MEMBRANE TRANSPORT; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; REPORTER GENE; SECRETORY GRANULE; START CODON;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CELL MEMBRANE; EXOCYTOSIS; GENE EXPRESSION REGULATION; GENES, REPORTER; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, SCANNING TRANSMISSION; MUTATION; ORGAN SPECIFICITY; PITUITARY GLAND; PROTEIN ISOFORMS; RAB GTP-BINDING PROTEINS; SECRETORY VESICLES;

MUS;

EID: 35848959050     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E07-05-0409     Document Type: Article

References (25)

1. Bahadoran, P., Aberdam, E., Mantoux, F., Buscà, R., Bille, K., Yalman, N., de Saint-Basile, G., Casaroli-Marano, R., Ortonne, J.-P., and Ballotti, R. (2001). Rab27a: a key to melanosome transport in human melanocytes. J. Cell Biol. 152, 843-849.
2. Barral, D. C., Ramalho, J. S., Anders, R., Hume, A. N., Knapton, H. J., Tolmachova, T., Collinson, L. M., Goulding, D. Authi, K. S., and Seabra, M. C. (2002). Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J. Clin. Invest. 110, 247-257.
3. Chen, X., Li, C., Izumi, T., Ernst, S. A., Andrews, P. C., and Williams, J. A. (2004). Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Biochem. Biophys. Res. Commun. 323, 1157-1162.
4. Chen, Y., Guo, X., Deng, F.-M., Liang, F.-X., Sun, W., Ren, M., Izumi, T., Sabatini, D. D., Sun, T.-T., and Kreibich, G. (2003). Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes. Proc. Natl. Acad. Sci. USA 100, 14012-14017.
5. Fukuda, M. (2005). Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families. J. Biochem. 137, 9-16.
6. Gomi, H., Mizutani, S., Kasai, K., Itohara, S., and Izumi, T. (2005). Granuphilin molecularly docks insulin granules to the fusion machinery. J. Cell Biol. 171, 99-109.
7. Gomi, H., Yokoyama, T., Fujimoto, K., Ikeda, T., Katoh, A., Itoh, T., and Itohara, S. (1995). Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions. Neuron 14, 29-41.
8. Grosshans, B. L., Ortiz, D., and Novick, P. (2006). Rabs and their effectors: achieving specificity in membrane traffic. Proc. Natl. Acad. Sci. USA 103, 11821-11827.
9. Haddad, E. K., Wu, X., Hammer, J. A., 3rd, and Henkart, P. A. (2001). Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice. J. Cell Biol. 152, 835-841.
10. Hume, A. N., Collinson, L. M., Repak, A., Gomes, A. Q., Hopkins, C. R., and Seabra, M. C. (2001). Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J. Cell Biol. 152, 795-808.
11. Imai, A., Yoshie, S., Nashida, T., Shimomura, H., and Fukuda, M. (2004). The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. J. Cell Sci. 117, 1945-1953.
12. Izumi, T., Gomi, H., Kasai, K., Mizutani, S., and Torii, S. (2003). The roles of Rab27 and its effectors in the regulated secretory pathways. Cell Struct. Funct. 28, 465-474.
13. Kasai, K., Ohara-Imaizumi, M., Takahashi, N., Mizutani, S., Zhao, S., Kikuta, T., Kasai, H., Nagamatsu, S., Gomi, H., and Izumi, T. (2005). Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J. Clin. Invest. 115, 388-396.
14. Ménasché, G. et al. (2000). Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome. Nat. Genet. 25, 173-176.
15. Ramalho, J. S., Tolmachova, T., Hume, A. N., McGuigan, A., Gregory-Evans, C. Y., Huxley, C., and Seabra, M. C. (2001). Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. BMC Genet. 2, 2.
16. Siperstein, E. R., and Miller, K. J. (1970). Further cytophysiologic evidence for the dentity of the cells that produce adrenocorticotrophic hormone. Endocrinology 86, 451-486.
17. Stinchcombe, J. C., Barral, D. C., Mules, E. H., Booth, S., Hume, A. N., Machesky, L. M., Seabra, M. C., and Griffiths, G. M. (2001). Rab27A is required for regulated secretion in cytotoxic T lymphocytes. J. Cell Biol. 152, 825-833.
18. Tiwari, S., Italiano, J. E., Jr., Barral, D. C., Mules, E. H., Novak, E. K., Swank, R. T., Seabra, M. C., and Shivdasani, R. A. (2003). A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood 102, 3970-3979.
19. Tolmachova, T., Åbrink, M., Futter, C. E., Authi, K. S., and Seabra, M. C. (2007). Rab27b regulates number and secretion of platelet dense granules. Proc. Natl. Acad. Sci. USA 104, 5872-5877.
20. Tolmachova, T., Anders, R., Stinchcombe, J., Bossi, G., Griffiths, G. M., Huxley, C., and Seabra, M. C. (2004). A general role for Rab27a in secretory cells. Mol. Biol. Cell 15, 332-344.
21. Wilson, S. M., Yip, R., Swing, D. A., O'Sullivan, T. N., Zhang, Y., Novak, E. K., Swank, R. T., Russell, L. B., Copeland, N. G., and Jenkins, N. A. (2000). A mutation in Rab27A causes the vesicle transport defects observed in ashen mice. Proc. Natl. Acad. Sci. USA 97, 7933-7938.
22. Yanagawa, Y., Kobayashi, T., Ohnishi, M., Kobayashi, T., Tamura, S., Tsuzuki, T., Sanbo, M., Yagi, T., Tashiro, F., and Miyazaki, J. (1999). Enrichment and efficient screening of ES cells containing a targeted mutation: the use of DT-A gene with the polyadenylation signal as a negative selection marker. Transgenic Res. 8, 215-221.
23. Yi, Z., Yokota, H., Torii, S., Aoki, T., Hosaka, M., Zhao, S., Takata, K., Takeuchi, T., and Izumi, T. (2002). The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol. Cell. Biol. 22, 1858-1867.
24. 2+-inhibitory phospholipid-binding activity of the C2A domain. Mol. Biol. Cell 18, 688-696.
25. Zhao, S., Torii, S., Yokota-Hashimoto, H., Takeuchi, T., and Izumi, T. (2002). Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology 143, 1817-1824.