Targeting of AID to immunoglobulin genes

Advances in Experimental Medicine and Biology

Volumn 596, Issue , 2007, Pages 83-91

  Storb, Ursula ^a   Shen, Hong Ming ^a   Longerich, Simonne ^a   Ratnam, Sarayu ^a   Tanaka, Atsushi ^a   Bozek, Grazyna ^a   Pylawka, Serhiy ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; BISULFITE; DOUBLE STRANDED DNA;

CONFERENCE PAPER; GENE MUTATION; IMMUNOGLOBULIN GENE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SOMATIC HYPERMUTATION;

EID: 84934444740     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/0-387-46530-8_8     Document Type: Conference Paper

References (20)

1. Longerich, S., Basu, U., Alt, F. & Storb, U. AID in somatic hypermutation and class switch recombination. Curr Opin Immunol 18, 164-74 (2006).
2. Rogerson, B. Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes. Mol. Immunol. 31, 83-98 (1994).
3. Wu, P. & Claflin, L. Promoter-associated displacement of hypermutations. Internatl. Immunol. 10, 1131-1138 (1998).
4. Motoyama, N., Miwa, T., Suzuki, Y., Okada, H. & Azuma, T. Comparison of somatic mutation frequency among immunoglobulin genes. J. Exp. Med. 179, 395-403 (1994).
5. Lebecque, S. & Gearhart, P. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is ∼1kb from V(D)J gene. J. Exp. Med. 172, 1717-1727 (1990).
6. Rada, C., Gonzalez-Fernandez, A., Jarvis, J. M. & Milstein, C. The 5′ boundary of somatic hypermutation in a Vk gene is in the leader intron. Eur. J. immunol. 24, 1453-1457 (1994).
7. Longerich, S., Tanaka, A., Bozek, G. & Storb, U. The very 5′ end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions. J. Exp. Med. 202, 1443-1454 (2005).
8. Chaudhuri, J., Khuong, C. & Alt, F. W. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature 430, 992-998 (2004).
9. Peters, A. & Storb, U. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4, 57-65 (1996).
10. Rada, C. & Milstein, C. The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially. EMBO J. 20, 4570-4576 (2001).
11. Motoyama, N., Okada, H. & Azuma, T. Somatic mutation in constant region of mouse 1 light chains. Proc. Natl. Acad. Sci. USA 88, 7933-7937 (1991).
12. Storb, U. et al. Physical linkage of mouse λ genes by pulsed -field gel electrophoresis suggests that the rearrangement process favors proximate target sequences. Mol.Cell.Biol. 9, 711-718 (1989).
13. Bransteitter, R., Pham, P., Scharff, M. & Goodman, M. Activation-induced cytidine deminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. USA 100, 4102-4107 (2003).
14. Dickerson, S., Market, E., Besmer, E. & Papavasiliou, F. N. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 197, 1291-1296 (2003).
15. Pham, P., Bransteitter, R., Petruska, J. & Goodman, M. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 424, 103-107 (2003).
16. Bransteitter, R., Pham, P., Calabrese, P. & Goodman, M. F. Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase. J. Biol. Chem. 279, 51612-51621 (2004).
17. Chaudhuri, J. et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature 421, 726-730 (2003).
18. Sohail, A., Klapacz, J., Samaranayake, M., Ullah, A. & Bhagwat, A. Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations. Nuc. Acids Res. 31, 2990-2994 (2003).
19. Shen, H. & Storb, U. Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. Proc. Natl. Acad. Sci. 101, 12997-13002 (2004).
20. Shen, H., S., R. & U., S. Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA. Mol. Cell. Biol. 25, 10815-10821(2005).