The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function

Circulation Research

Volumn 108, Issue 2, 2011, Pages 184-193

  Vanderlaan, Rachel D ^a,b,c   Hardy, W Rod ^a,b,e   Kabir, M Golam ^c   Pasculescu, Adrian ^a   Jones, Nina ^a,f   Detombe, Pieter P ^d,g   Backx, Peter H ^b,c,h   Pawson, Tony ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HEART AND STROKE FOUNDATION OF CANADA   (Canada)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF GUELPH   (Canada)

^g LOYOLA UNIVERSITY CHICAGO   (United States)

^h NONE   (Canada)

Author keywords

adaptor protein; cardiomyopathy; signal transduction; tyrosine kinase

Indexed keywords

COLLAGEN; DOCKING PROTEIN; PHOSPHOTYROSINE; PROTEIN SHC A; PROTEIN TYROSINE KINASE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CELL DISRUPTION; CELL FUNCTION; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DATA ANALYSIS; DISSECTION; DOWNSTREAM PROCESSING; EXCITATION CONTRACTION COUPLING; EXTRACELLULAR MATRIX; HEART FUNCTION; HEART HEMODYNAMICS; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE OVERLOAD; HEART VENTRICLE REMODELING; HEAT INJURY; IN VIVO STUDY; MEDICAL RECORD; MOUSE; MUSCLE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN;

ANIMALS; BIOMECHANICS; CARDIOMYOPATHY, DILATED; COLLAGEN; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX PROTEINS; HEART; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHOSPHOTYROSINE; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 79251616305     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.233924     Document Type: Article

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