메뉴 건너뛰기




Volumn 215, Issue , 2013, Pages 187-196

Novel drugs targeting sphingolipid metabolism

Author keywords

Drugs; Enzyme assays; Enzyme inhibitors; Natural products; Small molecules

Indexed keywords

3,3' (1,4 PHENYLENE)BIS[N [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ACRYLAMIDE]; AMITRIPTYLINE; B 13; C 11AG; CERAMIDASE; CERAMIDE; DESIPRAMINE; DEXAMETHASONE; DIHYDROCERAMIDE DESATURASE; ENZYME; ENZYME INHIBITOR; FINGOLIMOD; FUMONISIN B1; GALBONOLIDE A; GT 11; IMIPRAMINE; ISOFAGOMINE; KHAFREFUNGIN; MANUMYCIN A; MIGLUSTAT; SCYPHOSTATIN; SERINE PALMITOYLTRANSFERASE; SPHINGOLACTONE 24; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE; SPIROEPOXIDE; THERMOZYMOCIDIN; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84880417882     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-7091-1368-4_10     Document Type: Article
Times cited : (6)

References (46)
  • 1
    • 84862906027 scopus 로고    scopus 로고
    • Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: A mini-review of literature
    • doi:10.1007/s11064- 011-0659-z
    • Adibhatla RM, Hatcher JF, Gusain A (2011) Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature. Neurochem Res. doi:10.1007/s11064- 011-0659-z
    • (2011) Neurochem Res
    • Adibhatla, R.M.1    Hatcher, J.F.2    Gusain, A.3
  • 2
    • 0019723109 scopus 로고
    • Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures
    • Albouz S, Hauw JJ, Berwald-Netter Y, Boutry JM, Bourdon R, Baumann N (1981) Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures. Biomedicine 35:218-220
    • (1981) Biomedicine , vol.35 , pp. 218-220
    • Albouz, S.1    Hauw, J.J.2    Berwald-Netter, Y.3    Boutry, J.M.4    Bourdon, R.5    Baumann, N.6
  • 3
    • 0030480576 scopus 로고    scopus 로고
    • The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C
    • Amtmann E (1996) The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp Clin Res 22:287-294
    • (1996) Drugs Exp Clin Res , vol.22 , pp. 287-294
    • Amtmann, E.1
  • 4
    • 15744376272 scopus 로고    scopus 로고
    • Stimulation of CD95-induced apoptosis in T-cells by a subtype specific neutral sphingomyelinase inhibitor
    • Amtmann E, Zoller M (2005) Stimulation of CD95-induced apoptosis in T-cells by a subtype specific neutral sphingomyelinase inhibitor. Biochem Pharmacol 69:1141-1148
    • (2005) Biochem Pharmacol , vol.69 , pp. 1141-1148
    • Amtmann, E.1    Zoller, M.2
  • 5
    • 0342368723 scopus 로고    scopus 로고
    • Neutral sphingomyelinase-inhibiting guanidines prevent herpes simplex virus-1 replication
    • Amtmann E, Zoller M, Schilling G (2000) Neutral sphingomyelinase- inhibiting guanidines prevent herpes simplex virus-1 replication. Drugs Exp Clin Res 26:57-65
    • (2000) Drugs Exp Clin Res , vol.26 , pp. 57-65
    • Amtmann, E.1    Zoller, M.2    Schilling, G.3
  • 6
    • 0038383462 scopus 로고    scopus 로고
    • Neutral sphingomyelinase inhibitor C11AG prevents lipopolysaccharide- induced macrophage activation
    • Amtmann E, Baader W, Zoller M (2003) Neutral sphingomyelinase inhibitor C11AG prevents lipopolysaccharide-induced macrophage activation. Drugs Exp Clin Res 29:5- 13
    • (2003) Drugs Exp Clin Res , vol.29 , pp. 5-13
    • Amtmann, E.1    Baader, W.2    Zoller, M.3
  • 7
    • 77952943373 scopus 로고    scopus 로고
    • Small molecule inhibitors of acid sphingomyelinase
    • Arenz C (2010) Small molecule inhibitors of acid sphingomyelinase. Cell Physiol Biochem 26:01-08
    • (2010) Cell Physiol Biochem , vol.26 , pp. 01-08
    • Arenz, C.1
  • 8
    • 0034678911 scopus 로고    scopus 로고
    • Synthesis of the first selective irreversible inhibitor of neutral sphingomyelinase
    • Arenz C, Giannis A (2000) Synthesis of the first selective irreversible inhibitor of neutral sphingomyelinase. Angew Chem Int Ed 39:1440-1442
    • (2000) Angew Chem Int Ed , vol.39 , pp. 1440-1442
    • Arenz, C.1    Giannis, A.2
  • 10
    • 2442698935 scopus 로고    scopus 로고
    • Prodrug modification increases potassium tricyclo[5.2.1.0(26)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells
    • Bai A, Meier GP, Wang Y, Luberto C, Hannun YA, Zhou D (2004) Prodrug modification increases potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells. J Pharmacol Exp Ther 309:1051- 1059
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 1051-1059
    • Bai, A.1    Meier, G.P.2    Wang, Y.3    Luberto, C.4    Hannun, Y.A.5    Zhou, D.6
  • 12
    • 34250311282 scopus 로고    scopus 로고
    • Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases
    • Bedia C, Casas J, Garcia V, Levade T, Fabriàs G (2007) Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases. Chembiochem 8:642-648
    • (2007) Chembiochem , vol.8 , pp. 642-648
    • Bedia, C.1    Casas, J.2    Garcia, V.3    Levade, T.4    Fabriàs, G.5
  • 15
    • 79958052481 scopus 로고    scopus 로고
    • Drug targeting of sphingolipid metabolism: Sphingomyelinases and ceramidases
    • Canals D, Perry DM, Jenkins RW, Hannun YA (2011) Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. Br J Pharmacol 163:694-712
    • (2011) Br J Pharmacol , vol.163 , pp. 694-712
    • Canals, D.1    Perry, D.M.2    Jenkins, R.W.3    Hannun, Y.A.4
  • 19
    • 0043235841 scopus 로고    scopus 로고
    • A contradictory treatment for lysosomal storage disorders: Inhibitors enhance mutant enzyme activity
    • Fan JQ (2003) A contradictory treatment for lysosomal storage disorders: inhibitors enhance mutant enzyme activity. Trends Pharmacol Sci 24:355-360
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 355-360
    • Fan, J.Q.1
  • 21
    • 82955233827 scopus 로고    scopus 로고
    • Emerging therapies for neurodegenerative lysosomal storage disorders - From concept to reality
    • Hemsley KM, Hopwood JJ (2011) Emerging therapies for neurodegenerative lysosomal storage disorders - from concept to reality. J Inherit Metab Dis 34:1003-1012
    • (2011) J Inherit Metab Dis , vol.34 , pp. 1003-1012
    • Hemsley, K.M.1    Hopwood, J.J.2
  • 22
    • 0033152727 scopus 로고    scopus 로고
    • Sphingolipids-their metabolic pathways and the pathobiochemistry of neurodegenerative diseases
    • Kolter T, Sandhoff K (1999) Sphingolipids-their metabolic pathways and the pathobiochemistry of neurodegenerative diseases. Angew Chem Int Ed 11:1532-1568
    • (1999) Angew Chem Int Ed , vol.11 , pp. 1532-1568
    • Kolter, T.1    Sandhoff, K.2
  • 23
    • 0037135608 scopus 로고    scopus 로고
    • Combinatorial ganglioside biosynthesis
    • Kolter T, Proia RL, Sandhoff K (2002) Combinatorial ganglioside biosynthesis. J Biol Chem 277:25859-25862
    • (2002) J Biol Chem , vol.277 , pp. 25859-25862
    • Kolter, T.1    Proia, R.L.2    Sandhoff, K.3
  • 24
    • 17544390315 scopus 로고    scopus 로고
    • Phosphatidylinositol-3,5-bisphosphate is a potent and selective inhibitor of acid sphingomyelinase
    • Kölzer M, Arenz C, Ferlinz K, Werth N, Schulze H, Klingenstein R, Sandhoff K (2003) Phosphatidylinositol-3,5-bisphosphate is a potent and selective inhibitor of acid sphingomyelinase. Biol Chem 384:1293-1298
    • (2003) Biol Chem , vol.384 , pp. 1293-1298
    • Kölzer, M.1    Arenz, C.2    Ferlinz, K.3    Werth, N.4    Schulze, H.5    Klingenstein, R.6    Sandhoff, K.7
  • 28
    • 0032486257 scopus 로고    scopus 로고
    • Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?
    • Luberto C, Hannun YA (1998) Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J Biol Chem 273:14550-14559
    • (1998) J Biol Chem , vol.273 , pp. 14550-14559
    • Luberto, C.1    Hannun, Y.A.2
  • 33
    • 0028176432 scopus 로고
    • N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis
    • Platt FM, Neises GR, Dwek RA, Butter TD (1994) N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J Biol Chem 269:8362-8365
    • (1994) J Biol Chem , vol.269 , pp. 8362-8365
    • Platt, F.M.1    Neises, G.R.2    Dwek, R.A.3    Butter, T.D.4
  • 36
    • 70350536352 scopus 로고    scopus 로고
    • Potent inhibition of acid sphingomyelinase by phosphoinositide analogues
    • Roth AG, Redmer S, Arenz C (2009a) Potent inhibition of acid sphingomyelinase by phosphoinositide analogues. Chembiochem 10:2367-2374
    • (2009) Chembiochem , vol.10 , pp. 2367-2374
    • Roth, A.G.1    Redmer, S.2    Arenz, C.3
  • 37
  • 38
    • 76449107820 scopus 로고    scopus 로고
    • Development of carbohydrate-derived inhibitors of acid sphingomyelinase
    • Roth AG, Redmer S, Arenz C (2010) Development of carbohydrate-derived inhibitors of acid sphingomyelinase. Bioorg Med Chem 18:939-944
    • (2010) Bioorg Med Chem , vol.18 , pp. 939-944
    • Roth, A.G.1    Redmer, S.2    Arenz, C.3
  • 43
    • 0035906870 scopus 로고    scopus 로고
    • Synthesis of a cyclopropene analogue of ceramide, a potent inhibitor of dihydroceramide desaturase
    • Triola G, Fabrias G, Llebaria A (2001) Synthesis of a cyclopropene analogue of ceramide, a potent inhibitor of dihydroceramide desaturase. Angew Chem Int Ed Engl 40:1960-1962
    • (2001) Angew Chem Int Ed Engl , vol.40 , pp. 1960-1962
    • Triola, G.1    Fabrias, G.2    Llebaria, A.3
  • 44
    • 9444251152 scopus 로고    scopus 로고
    • Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1- hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]o ctanamide (GT11) in primary ultured cerebellar neurons
    • Triola G, Fabrias G, Dragusin M, Niederhausen L, Broere R, Llebaria A, van Echten- eckert G(2004) Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1- hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl) ethyl]o ctanamide (GT11) in primary ultured cerebellar neurons. Mol Pharmacol 66:1671-1678
    • (2004) Mol Pharmacol , vol.66 , pp. 1671-1678
    • Triola, G.1    Fabrias, G.2    Dragusin, M.3    Niederhausen, L.4    Broere, R.5    Llebaria, A.6    Van Echten- Eckert, G.7
  • 45
    • 0035929564 scopus 로고    scopus 로고
    • Purification and characterization of an acid midase selective for N-palmitoylethanolamine a putative endogenous anti- inflammatory substance
    • Ueda N, Yamanaka K, Yamamoto S (2001) Purification and characterization of an acid midase selective for N-palmitoylethanolamine, a putative endogenous anti- inflammatory substance.J Biol Chem 276:35552-35557
    • (2001) J Biol Chem , vol.276 , pp. 35552-35557
    • Ueda, N.1    Yamanaka, K.2    Yamamoto, S.3
  • 46
    • 31444453971 scopus 로고    scopus 로고
    • Sphingolactones: Selective and irreversible inhibitors of neutral sphingomyelinase
    • Wascholowski V, Giannis A (2006) Sphingolactones: selective and irreversible inhibitors of neutral sphingomyelinase. Angew Chem Int Ed 45:827-830
    • (2006) Angew Chem Int Ed , vol.45 , pp. 827-830
    • Wascholowski, V.1    Giannis, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.