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Volumn 34, Issue 2, 2011, Pages 229-236

Identification and evaluation of neutral sphingomyelinase 2 inhibitors

Author keywords

Inhibitors; Signal transduction; Sphingolipids; Sphingomyelinase

Indexed keywords

D ARABINO PHYTOSPHINGOSINE; D LYXOLYXOPHYTOSPHINGOSINE; ENZYME INHIBITOR; GW 4869; MAGNESIUM ION; NEUTRAL SPHINGOMYELINASE 2; PHOSPHODIESTERASE; PHYTOSPHINGOSINE; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; TRITON X 100; UNCLASSIFIED DRUG;

EID: 79953329227     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0208-y     Document Type: Article
Times cited : (13)

References (42)
  • 1
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • Bose, R., Verheij, M., Haimovitz-Friedman, A., Scotto, K., Fuks, Z., and Kolesnick, R., Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell, 82, 405-414 (1995).
    • (1995) Cell , vol.82 , pp. 405-414
    • Bose, R.1    Verheij, M.2    Haimovitz-Friedman, A.3    Scotto, K.4    Fuks, Z.5    Kolesnick, R.6
  • 2
    • 0024596564 scopus 로고
    • Purified rat brain microvessels exhibit both acid and neutral sphingomyelinase activities
    • Carre, J. B., Morand, O., Homayoun, P., Roux, F., Bourre, J. M., and Baumann, N., Purified rat brain microvessels exhibit both acid and neutral sphingomyelinase activities. J. Neurochem., 52, 1294-1299 (1989).
    • (1989) J. Neurochem. , vol.52 , pp. 1294-1299
    • Carre, J.B.1    Morand, O.2    Homayoun, P.3    Roux, F.4    Bourre, J.M.5    Baumann, N.6
  • 3
    • 0030019790 scopus 로고    scopus 로고
    • Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death
    • Casaccia-Bonnefil, P., Aibel, L., and Chao, M. V., Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death. J. Neurosci. Res., 43, 382-389 (1996).
    • (1996) J. Neurosci. Res. , vol.43 , pp. 382-389
    • Casaccia-Bonnefil, P.1    Aibel, L.2    Chao, M.V.3
  • 4
    • 0030694454 scopus 로고    scopus 로고
    • Myelin contains neutral sphingomyelinase activity that is stimulated by tumor necrosis factor-alpha
    • Chakraborty, G., Ziemba, S., Drivas, A., and Ledeen, R. W., Myelin contains neutral sphingomyelinase activity that is stimulated by tumor necrosis factor-alpha. J. Neurosci. Res., 50, 466-476 (1997).
    • (1997) J. Neurosci. Res. , vol.50 , pp. 466-476
    • Chakraborty, G.1    Ziemba, S.2    Drivas, A.3    Ledeen, R.W.4
  • 5
    • 0024412128 scopus 로고
    • Neutral sphingomyelinase from human urine. Purification and preparation of mono-specific antibodies
    • Chatterjee, S. and Ghosh, N., Neutral sphingomyelinase from human urine. Purification and preparation of mono-specific antibodies. J. Biol. Chem., 264, 12554-12561 (1989).
    • (1989) J. Biol. Chem. , vol.264 , pp. 12554-12561
    • Chatterjee, S.1    Ghosh, N.2
  • 6
    • 0029090337 scopus 로고
    • Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors
    • Dobrowsky, R. T., Jenkins, G. M., and Hannun, Y. A., Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. J. Biol. Chem., 270, 22135-22142 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 22135-22142
    • Dobrowsky, R.T.1    Jenkins, G.M.2    Hannun, Y.A.3
  • 7
    • 0029562926 scopus 로고
    • Stimulation of the sphingomyelin pathway induces interleukin-6 gene expression in human astrocytoma cells
    • Fiebich, B. L., Lieb, K., Berger, M., and Bauer, J., Stimulation of the sphingomyelin pathway induces interleukin-6 gene expression in human astrocytoma cells. J. Neuroimmunol., 63, 207-211 (1995).
    • (1995) J. Neuroimmunol. , vol.63 , pp. 207-211
    • Fiebich, B.L.1    Lieb, K.2    Berger, M.3    Bauer, J.4
  • 8
    • 0034730746 scopus 로고    scopus 로고
    • Reconstitution of ATP- and cytosol-dependent transport of de novo synthesized ceramide to the site of sphingomyelin synthesis in semi-intact cells
    • Funakoshi, T., Yasuda, S., Fukasawa, M., Nishijima, M., and Hanada, K., Reconstitution of ATP- and cytosol-dependent transport of de novo synthesized ceramide to the site of sphingomyelin synthesis in semi-intact cells. J. Biol. Chem., 275, 29938-29945 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 29938-29945
    • Funakoshi, T.1    Yasuda, S.2    Fukasawa, M.3    Nishijima, M.4    Hanada, K.5
  • 9
    • 0027994349 scopus 로고
    • The sphingomyelin cycle and the second messenger function of ceramide
    • Hannun, Y. A., The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem., 269, 3125-3128 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 3125-3128
    • Hannun, Y.A.1
  • 10
    • 0034705097 scopus 로고    scopus 로고
    • Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase
    • Hofmann, K., Tomiuk, S., Wolff, G., and Stoffel, W., Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase. Proc. Natl. Acad. Sci. U. S. A., 97, 5895-5900 (2000).
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 5895-5900
    • Hofmann, K.1    Tomiuk, S.2    Wolff, G.3    Stoffel, W.4
  • 14
    • 0026534541 scopus 로고
    • Elevated ceramide levels in GH4C1 cells treated with retinoic acid
    • Kalen, A., Borchardt, R. A., and Bell, R. M., Elevated ceramide levels in GH4C1 cells treated with retinoic acid. Biochim. Biophys. Acta, 1125, 90-96 (1992).
    • (1992) Biochim. Biophys. Acta , vol.1125 , pp. 90-96
    • Kalen, A.1    Borchardt, R.A.2    Bell, R.M.3
  • 15
    • 75149116783 scopus 로고    scopus 로고
    • Purification of neutral sphingomyelinase 2 from bovine brain and its calcium-dependent activation
    • Kim, S. K., Ahn, K. H., Jeon, H. J., Lee, D. H., Jung, S. Y., Jung, K. M., and Kim, D. K., Purification of neutral sphingomyelinase 2 from bovine brain and its calcium-dependent activation. J. Neurochem., 112, 1088-1097 (2010).
    • (2010) J. Neurochem. , vol.112 , pp. 1088-1097
    • Kim, S.K.1    Ahn, K.H.2    Jeon, H.J.3    Lee, D.H.4    Jung, S.Y.5    Jung, K.M.6    Kim, D.K.7
  • 16
    • 0035957921 scopus 로고    scopus 로고
    • Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria
    • Kroesen, B. J., Pettus, B., Luberto, C., Busman, M., Sietsma, H., De Leij, L., and Hannun, Y. A., Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J. Biol. Chem., 276, 13606-13614 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 13606-13614
    • Kroesen, B.J.1    Pettus, B.2    Luberto, C.3    Busman, M.4    Sietsma, H.5    De Leij, L.6    Hannun, Y.A.7
  • 17
    • 33744953581 scopus 로고    scopus 로고
    • Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein
    • Krut, O., Wiegmann, K., Kashkar, H., Yazdanpanah, B., and Kronke, M., Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein. J. Biol. Chem., 281, 13784-13793 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 13784-13793
    • Krut, O.1    Wiegmann, K.2    Kashkar, H.3    Yazdanpanah, B.4    Kronke, M.5
  • 18
    • 0024405793 scopus 로고
    • Accumulation of ceramide in ischemic human brain of an acute case of cerebral occlusion
    • Kubota, M., Kitahara, S., Shimasaki, H., and Ueta, N., Accumulation of ceramide in ischemic human brain of an acute case of cerebral occlusion. Jpn. J. Exp. Med., 59, 59-64 (1989).
    • (1989) Jpn. J. Exp. Med. , vol.59 , pp. 59-64
    • Kubota, M.1    Kitahara, S.2    Shimasaki, H.3    Ueta, N.4
  • 19
    • 0035875776 scopus 로고    scopus 로고
    • Phytosphingosine and C2-phytoceramide induce cell death and inhibit carbachol-stimulated phospholipase D activation in Chinese hamster ovary cells expressing the Caenorhabditis elegans muscarinic acetylcholine receptor
    • Lee, J. S., Min, D. S., Park, C., Park, C. S., and Cho, N. J., Phytosphingosine and C2-phytoceramide induce cell death and inhibit carbachol-stimulated phospholipase D activation in Chinese hamster ovary cells expressing the Caenorhabditis elegans muscarinic acetylcholine receptor. FEBS Lett., 499, 82-86 (2001).
    • (2001) FEBS Lett. , vol.499 , pp. 82-86
    • Lee, J.S.1    Min, D.S.2    Park, C.3    Park, C.S.4    Cho, N.J.5
  • 20
    • 0347122965 scopus 로고    scopus 로고
    • Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway
    • Lee, J. T., Xu, J., Lee, J. M., Ku, G., Han, X., Yang, D. I., Chen, S., and Hsu, C. Y., Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway. J. Cell Biol., 164, 123-131 (2004).
    • (2004) J. Cell Biol. , vol.164 , pp. 123-131
    • Lee, J.T.1    Xu, J.2    Lee, J.M.3    Ku, G.4    Han, X.5    Yang, D.I.6    Chen, S.7    Hsu, C.Y.8
  • 21
    • 0032545461 scopus 로고    scopus 로고
    • Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain
    • Liu, B., Hassler, D. F., Smith, G. K., Weaver, K., and Hannun, Y. A., Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain. J. Biol. Chem., 273, 34472-34479 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 34472-34479
    • Liu, B.1    Hassler, D.F.2    Smith, G.K.3    Weaver, K.4    Hannun, Y.A.5
  • 23
    • 0030752208 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor binding to the p75 neurotrophin receptor reduces TrkA signaling while increasing serine phosphorylation in the TrkA intracellular domain
    • Macphee, I. J. and Barker, P. A., Brain-derived neurotrophic factor binding to the p75 neurotrophin receptor reduces TrkA signaling while increasing serine phosphorylation in the TrkA intracellular domain. J. Biol. Chem., 272, 23547-23551 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 23547-23551
    • Macphee, I.J.1    Barker, P.A.2
  • 25
    • 77951889353 scopus 로고    scopus 로고
    • Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids
    • Milhas, D., Clarke, C. J., and Hannun, Y. A., Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids. FEBS Lett., 584, 1887-1894 (2010).
    • (2010) FEBS Lett. , vol.584 , pp. 1887-1894
    • Milhas, D.1    Clarke, C.J.2    Hannun, Y.A.3
  • 27
  • 28
    • 0024795059 scopus 로고
    • Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation
    • Okazaki, T., Bell, R. M., and Hannun, Y. A., Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J. Biol. Chem., 264, 19076-19080 (1989).
    • (1989) J. Biol. Chem. , vol.264 , pp. 19076-19080
    • Okazaki, T.1    Bell, R.M.2    Hannun, Y.A.3
  • 29
    • 0025003424 scopus 로고
    • Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation
    • Okazaki, T., Bielawska, A., Bell, R. M., and Hannun, Y. A., Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J. Biol. Chem., 265, 15823-15831 (1990).
    • (1990) J. Biol. Chem. , vol.265 , pp. 15823-15831
    • Okazaki, T.1    Bielawska, A.2    Bell, R.M.3    Hannun, Y.A.4
  • 30
    • 0034708594 scopus 로고    scopus 로고
    • Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
    • Perry, D. K., Carton, J., Shah, A. K., Meredith, F., Uhlinger, D. J., and Hannun, Y. A., Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J. Biol. Chem., 275, 9078-9084 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 9078-9084
    • Perry, D.K.1    Carton, J.2    Shah, A.K.3    Meredith, F.4    Uhlinger, D.J.5    Hannun, Y.A.6
  • 32
    • 0033621471 scopus 로고    scopus 로고
    • Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C
    • Sawai, H., Domae, N., Nagan, N., and Hannun, Y. A., Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. J. Biol. Chem., 274, 38131-38139 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 38131-38139
    • Sawai, H.1    Domae, N.2    Nagan, N.3    Hannun, Y.A.4
  • 33
    • 0029862561 scopus 로고    scopus 로고
    • Sphingolipid metabolism and cell growth regulation
    • Spiegel, S. and Merrill, A. H., Jr., Sphingolipid metabolism and cell growth regulation. FASEB J., 10, 1388-1397 (1996).
    • (1996) FASEB J. , vol.10 , pp. 1388-1397
    • Spiegel, S.1    Merrill Jr., A.H.2
  • 34
    • 13944250986 scopus 로고    scopus 로고
    • Actvation of NF-kappaB by the API2/MALT1 fusions inhibits p53 dependant but not FAS induced apoptosis: A directional link between NF-kappaB and p53
    • Stoffel, A. and Levine, A. J., Actvation of NF-kappaB by the API2/MALT1 fusions inhibits p53 dependant but not FAS induced apoptosis: a directional link between NF-kappaB and p53. Cell Cycle, 3, 1017-1020 (2004).
    • (2004) Cell Cycle , vol.3 , pp. 1017-1020
    • Stoffel, A.1    Levine, A.J.2
  • 35
    • 34547653109 scopus 로고    scopus 로고
    • Neutral sphingomyelinase (SMPD3) deficiency causes a novel form of chondrodysplasia and dwarfism that is rescued by Col2A1-driven smpd3 transgene expression
    • Stoffel, W., Jenke, B., Holz, B., Binczek, E., Gunter, R. H., Knifka, J., Koebke, J., and Niehoff, A., Neutral sphingomyelinase (SMPD3) deficiency causes a novel form of chondrodysplasia and dwarfism that is rescued by Col2A1-driven smpd3 transgene expression. Am. J. Pathol., 171, 153-161 (2007).
    • (2007) Am. J. Pathol. , vol.171 , pp. 153-161
    • Stoffel, W.1    Jenke, B.2    Holz, B.3    Binczek, E.4    Gunter, R.H.5    Knifka, J.6    Koebke, J.7    Niehoff, A.8
  • 37
    • 0034102425 scopus 로고    scopus 로고
    • Characterization and subcellular localization of murine and human magnesium-dependent neutral sphingomyelinase
    • Tomiuk, S., Zumbansen, M., and Stoffel, W., Characterization and subcellular localization of murine and human magnesium-dependent neutral sphingomyelinase. J. Biol. Chem., 275, 5710-5717 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 5710-5717
    • Tomiuk, S.1    Zumbansen, M.2    Stoffel, W.3
  • 40
    • 0017381606 scopus 로고
    • Purification and characterization of sphingomyelinase from human brain
    • Yamaguchi, S. and Suzuki, K., Purification and characterization of sphingomyelinase from human brain. J. Biol. Chem., 252, 3805-3813 (1977).
    • (1977) J. Biol. Chem. , vol.252 , pp. 3805-3813
    • Yamaguchi, S.1    Suzuki, K.2
  • 41
    • 33751018567 scopus 로고    scopus 로고
    • Liquid chromatography-tandem mass spectrometric determination of ceramides and related lipid species in cellular extracts
    • Yoo, H. H., Son, J., and Kim, D. H., Liquid chromatography-tandem mass spectrometric determination of ceramides and related lipid species in cellular extracts. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 843, 327-333 (2006).
    • (2006) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.843 , pp. 327-333
    • Yoo, H.H.1    Son, J.2    Kim, D.H.3
  • 42
    • 15144359445 scopus 로고    scopus 로고
    • Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation
    • Yoshimura, S., Banno, Y., Nakashima, S., Takenaka, K., Sakai, H., Nishimura, Y., Sakai, N., Shimizu, S., Eguchi, Y., Tsujimoto, Y., and Nozawa, Y., Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation. J. Biol. Chem., 273, 6921-6927 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 6921-6927
    • Yoshimura, S.1    Banno, Y.2    Nakashima, S.3    Takenaka, K.4    Sakai, H.5    Nishimura, Y.6    Sakai, N.7    Shimizu, S.8    Eguchi, Y.9    Tsujimoto, Y.10    Nozawa, Y.11


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