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Volumn 39, Issue 8, 2000, Pages 1440-1442

Synthesis of the first selective irreversible inhibitor of neutral sphingomyelinase

Author keywords

Bioorganic chemistry; Ceramide; Enzyme inhibitors; Sphingolipids

Indexed keywords

PHOSPHODIESTERASE INHIBITOR; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 0034678911     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(20000417)39:8<1440::AID-ANIE1440>3.0.CO;2-R     Document Type: Article
Times cited : (53)

References (29)
  • 1
    • 0000591717 scopus 로고    scopus 로고
    • T. Kolter, K. Sandhoff, Angew. Chem. 1999, 111, 1632-1670; Angew. Chem. Int. Ed. 1999, 38, 1532-1568.
    • (1999) Angew. Chem. , vol.111 , pp. 1632-1670
    • Kolter, T.1    Sandhoff, K.2
  • 2
    • 0033152727 scopus 로고    scopus 로고
    • T. Kolter, K. Sandhoff, Angew. Chem. 1999, 111, 1632-1670; Angew. Chem. Int. Ed. 1999, 38, 1532-1568.
    • (1999) Angew. Chem. Int. Ed. , vol.38 , pp. 1532-1568
  • 7
    • 0030448021 scopus 로고    scopus 로고
    • Y. A. Hannun, Science 1996, 274, 1855-1859.
    • (1996) Science , vol.274 , pp. 1855-1859
    • Hannun, Y.A.1
  • 19
    • 0001673523 scopus 로고
    • Regarding the synthesis and reactivity of similar spiroepoxides, see: a) H. D. Becker, T. Bremholt, E. Adler, Tetrahedron Lett. 1972, 41, 4205-4208; b) S. Danishefsky, M. D. Shair, J. Org. Chem. 1996, 61, 16-44; c) E. J. Corey, J. P. Dittami, J. Am. Chem. Soc. 1985, 107, 256- 257; d) H. Waldmann, K. Hinterding, P. Herrlich, H. J. Rahmsdorf, A. Knebel, Angew. Chem. 1997, 109, 1553-1555; Angew. Chem.Int. Ed. Engl. 1997, 36, 1541-1542; e) K. Hinterding, A. Knebel, P. Herrlich, H. Waldmann, Bioorg. Med. Chem. 1998, 6, 1153-1162.
    • (1972) Tetrahedron Lett. , vol.41 , pp. 4205-4208
    • Becker, H.D.1    Bremholt, T.2    Adler, E.3
  • 20
    • 0030069884 scopus 로고    scopus 로고
    • Regarding the synthesis and reactivity of similar spiroepoxides, see: a) H. D. Becker, T. Bremholt, E. Adler, Tetrahedron Lett. 1972, 41, 4205-4208; b) S. Danishefsky, M. D. Shair, J. Org. Chem. 1996, 61, 16-44; c) E. J. Corey, J. P. Dittami, J. Am. Chem. Soc. 1985, 107, 256- 257; d) H. Waldmann, K. Hinterding, P. Herrlich, H. J. Rahmsdorf, A. Knebel, Angew. Chem. 1997, 109, 1553-1555; Angew. Chem.Int. Ed. Engl. 1997, 36, 1541-1542; e) K. Hinterding, A. Knebel, P. Herrlich, H. Waldmann, Bioorg. Med. Chem. 1998, 6, 1153-1162.
    • (1996) J. Org. Chem. , vol.61 , pp. 16-44
    • Danishefsky, S.1    Shair, M.D.2
  • 21
    • 33845378330 scopus 로고
    • Regarding the synthesis and reactivity of similar spiroepoxides, see: a) H. D. Becker, T. Bremholt, E. Adler, Tetrahedron Lett. 1972, 41, 4205-4208; b) S. Danishefsky, M. D. Shair, J. Org. Chem. 1996, 61, 16-44; c) E. J. Corey, J. P. Dittami, J. Am. Chem. Soc. 1985, 107, 256-257; d) H. Waldmann, K. Hinterding, P. Herrlich, H. J. Rahmsdorf, A. Knebel, Angew. Chem. 1997, 109, 1553-1555; Angew. Chem.Int. Ed. Engl. 1997, 36, 1541-1542; e) K. Hinterding, A. Knebel, P. Herrlich, H. Waldmann, Bioorg. Med. Chem. 1998, 6, 1153-1162.
    • (1985) J. Am. Chem. Soc. , vol.107 , pp. 256-257
    • Corey, E.J.1    Dittami, J.P.2
  • 22
    • 0001352727 scopus 로고    scopus 로고
    • Regarding the synthesis and reactivity of similar spiroepoxides, see: a) H. D. Becker, T. Bremholt, E. Adler, Tetrahedron Lett. 1972, 41, 4205-4208; b) S. Danishefsky, M. D. Shair, J. Org. Chem. 1996, 61, 16-44; c) E. J. Corey, J. P. Dittami, J. Am. Chem. Soc. 1985, 107, 256- 257; d) H. Waldmann, K. Hinterding, P. Herrlich, H. J. Rahmsdorf, A. Knebel, Angew. Chem. 1997, 109, 1553-1555; Angew. Chem.Int. Ed. Engl. 1997, 36, 1541-1542; e) K. Hinterding, A. Knebel, P. Herrlich, H. Waldmann, Bioorg. Med. Chem. 1998, 6, 1153-1162.
    • (1997) Angew. Chem. , vol.109 , pp. 1553-1555
    • Waldmann, H.1    Hinterding, K.2    Herrlich, P.3    Rahmsdorf, H.J.4    Knebel, A.5
  • 23
    • 0030767596 scopus 로고    scopus 로고
    • Regarding the synthesis and reactivity of similar spiroepoxides, see: a) H. D. Becker, T. Bremholt, E. Adler, Tetrahedron Lett. 1972, 41, 4205-4208; b) S. Danishefsky, M. D. Shair, J. Org. Chem. 1996, 61, 16-44; c) E. J. Corey, J. P. Dittami, J. Am. Chem. Soc. 1985, 107, 256- 257; d) H. Waldmann, K. Hinterding, P. Herrlich, H. J. Rahmsdorf, A. Knebel, Angew. Chem. 1997, 109, 1553-1555; Angew. Chem.Int. Ed. Engl. 1997, 36, 1541-1542; e) K. Hinterding, A. Knebel, P. Herrlich, H. Waldmann, Bioorg. Med. Chem. 1998, 6, 1153-1162.
    • (1997) Angew. Chem.Int. Ed. Engl. , vol.36 , pp. 1541-1542
  • 24
    • 0031690667 scopus 로고    scopus 로고
    • Regarding the synthesis and reactivity of similar spiroepoxides, see: a) H. D. Becker, T. Bremholt, E. Adler, Tetrahedron Lett. 1972, 41, 4205-4208; b) S. Danishefsky, M. D. Shair, J. Org. Chem. 1996, 61, 16-44; c) E. J. Corey, J. P. Dittami, J. Am. Chem. Soc. 1985, 107, 256- 257; d) H. Waldmann, K. Hinterding, P. Herrlich, H. J. Rahmsdorf, A. Knebel, Angew. Chem. 1997, 109, 1553-1555; Angew. Chem.Int. Ed. Engl. 1997, 36, 1541-1542; e) K. Hinterding, A. Knebel, P. Herrlich, H. Waldmann, Bioorg. Med. Chem. 1998, 6, 1153-1162.
    • (1998) Bioorg. Med. Chem. , vol.6 , pp. 1153-1162
    • Hinterding, K.1    Knebel, A.2    Herrlich, P.3    Waldmann, H.4
  • 25
    • 0343147859 scopus 로고    scopus 로고
    • note
    • r 0.49 (dichloromethane/methanol, 10/1).
  • 26
    • 0342713324 scopus 로고    scopus 로고
    • Ref. [10] and b US-96-774104-961224, 1998; S. Chatterjee, CAN-129:91437, 1998
    • 2+-dependent neutral sphingomyelinases have been cloned so far: a) Ref. [10] and b) S. Chatterjee, US-96-774104-961224, 1998; S. Chatterjee, CAN-129:91437, 1998.
    • Chatterjee, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.