Chemokine receptors as fusion cofactors fat human immunodeficiency virus type 1 (HIV-1)

Immunologic Research

Volumn 16, Issue 1, 1997, Pages 15-28

  Doranz, Benjamin J ^a   Berson, Joanne F ^a   Rucker, Joseph ^a   Doms, Robert W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

CCR 5; Chemokine receptor; Cofactor; CXCR 4; Entry; Fusion; HIV

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; VIRUS PATHOGENESIS; VIRUS TRANSMISSION;

EID: 0030932188     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786321     Document Type: Article

References (79)

1. Sattentau QJ, Moore JP: Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding. J Exp Med 1991; 174:407-415.
2. Sattentau QJ, Moore JP, Vignaux F, Traincard F, Poignard P: Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding. J Virol 1993;67:7383-7393.
3. Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R: The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 1986;47:333-348.
4. Clapham PR, Blanc D, Weiss RA: Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by simian immunodeficiency virus. Virology 1991;181:703-715.
5. Ashorn PA, Berger EA, Moss B: Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells. J Virol 1990;64: 2149-2156.
6. Dragic T, Picard L, Alizon M: Proteinase-resistant factors in human erythrocyte membranes mediate CD4-dependent fusion with cells expressing human immunodeficiency virus type 1 envelope glycoproteins. J Virol 1995;69:1013-1018.
7. Dragic T, Charneau P, Clavel F, Alizon M: Complementation of murine cells for human immunodeficiency virus envelope/CD4-mediated fusion in human/murine heterokaryons. J Virol 1992;66: 4794-4802.
8. Broder CC, Dimitrov DS, Blumenthal R, Berger EA: The block to HIV-1 envelope glycoprotein-mediated membrane fusion in animal cells expresing human CD4 can be overcome by a human cell component(s). Virology 1993;193: 483-491.
9. Veenstra J, Schuurman R, Cornelissen M, van't Wout AB, Boucher CAB, Schuitemaker H, Goudsmit J, Coutinho RA: Transmission of zidovudine-resistant human immunodeficiency virus type 1 variants following deliberate injection of blood from a patient with AIDS: characteristics and natural history of the virus. Clin Infect Dis 1995; 21:556-560.
10. Connor RI, Ho DD: Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression. J Virol 1994;68:4400-4408.
11. van't Wout AB, Kootstra NA, Mulder-Kampinga GA, Albrecht van Lent N, Scherpbier HJ, Veenstra J, Boer K, Coutinho RA, Miedema F, Schuitemaker H: Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission. J Clin Invest 1994;94:2060-2067.
12. Zhu T, Mo H, Wang N, Nam DS, Cao Y, Koup RA, Ho DD: Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 1993; 261:1179-1181.
13. + cell depletion and progression to AIDS. Ann Intern Med 1993;118:681-688.
14. Hildreth JE, Orentas RJ: Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation. Science 1989; 244:1075-1078.
15. Avril LE, DiMartino-Ferrer M, Barin F, Gauthier F: Interaction between a membrane-associated serine proteinase of U-937 monocyles and peptides from the V3 loop of the human immunodeficiency virus type 1 (HIV-1) gp120 envelope glycoprotein. FEBS Lett 1993;317:167-172.
16. + cells. Science 1993;262:2045-2050.
17. Sato AI, Balamuth FB, Ugen KE, Williams WV, Weiner DB: Identification of CD7 glycoprotein as an accessory molecule in HIV-1-mediated syncytium formation and cell-free infection. J Immunol 1994;152:5142-5152.
18. Dukes CS, Yu Y, Rivadeneira ED, Sauls DL, Liao HX, Haynes BF, Weinberg JB: Cellular CD44S as a determinant of human immunodeficiency virus type 1 infection and cellular tropism. J Virol 1995;69:4000-4005.
19. Harouse JM, Bhat S, Spitalnik SL, Laughlin M, Stefano K, Silberberg DH, Gonzalez-Scarano F: Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide. Science 1991;253:320-323.
20. Horuk R: Molecular properties of the chemokine receptor family. Trends Pharm Sci 1994;15:159-165.
21. Schall TJ, Bacon KB: Chemokines, leukocyte trafficking, and inflammation. Curr Opin Immunol 1994;6:865-873.
22. Kelvin DJ, Michiel DF, Johnston JA, Lloyd AR, Sprenger H, Oppenheim JJ, Wang J-M: Chemokines and sepentines: the molecular biology of chemokine receptors. J Leukocyte Biol 1993;54:604-612.
23. + T cells. Science 1995;270:1811-1815.
24. Feng Y, Broder CC, Kennedy PE, Berger EA: HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996; 272:872-877.
25. Berson JF, Long D, Doranz BJ, Rucker J, Jirik FR, Doms RW: A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains. J Virol 1996;70:6288-6295.
26. Herzog H, Hort YJ, Shine J, Selbie LA: Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation. DNA Cell Biol 1993;12:465-471.
27. Jazin EE, Yoo H, Blomqvist AG, Yee F, Weng G, Walker MW, Salon J, Larhammar D, Wahlestedt C: A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells. Regul Pept 1993;47: 247-258.
28. Federsppiel B, Melhado IG, Duncan AMV, Delaney A, Schappert K, dark-Lewis I, Jirik FR: Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen. Genomics 1993;16:707-712.
29. Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ: Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor, Cell 1993;72: 415-425.
30. Nomura H, Nielsen BW, Matsushima K: Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. Int Immunol 1993;5:1239-1249.
31. Loetscher M, Geiser T, O'Reilly T, Zwahlen R, Baggiolini M, Moser B: Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J Biol Chem 1994;269:232-237.
32. Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, Springer TA: The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996;382:829-833.
33. Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, Loetscher M, Baggiolini M, Moser B: The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 1996;382: 833-835.
34. Nagasaw T, Hirota S, Tachibana K, Takakura N, NishikawaS, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T: Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996;382:635-638.
35. Probst WC, Snyder LA, Schuster DI, Brosius J, Sealfon SC: Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol 1992;11:1-20.
36. Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M: Molecular cloning and functional expression of anew human CC-chemokine receptor gene. Biochemistry 1996; 35:3362-3367.
37. Rucker J, Samson M, Doranz BJ, Libert F, Berson JF, Yi Y, Smyth RJ, Collman RG, Broder CC, Vassart G, Doms RW, Parmentier M: Regions in β-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity. Cell 1996;87:437-446.
38. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA: CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996; 272:1955-1958.
39. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, DiMarzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR: Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996;381:661-666.
40. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996;381:667-673.
41. Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW: A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-26 as fusion cofactors. Cell 1996;85:1149-1158.
42. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J: The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996;85:1135-1148.
43. Horuk R, Chitnis CE, Darbonne WC, Colby TJ, Rybicki A, Hadley TJ, Miller LH: A receptor for the malarial parasite Plasmodium vivax: the erythrocyte chemokine receptor. Science 1993;261:1182-1184.
44. Zhao-hai L, Zi-xuan W, Horuk R, Hesselgesser J, Yan-chun L, Hadley TJ, Peiper SC: The promiscuous chemokine binding profile of the Duffy antigen/receptor for chemokines is primarily localized to sequences in the amino-terminal domain. J Biol Chem 1995;270: 26,239-26,245.
45. Hwang SS, Boyle TJ, Lyerly HK, Cullen BR: Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science 1991;253:71-74.
46. Kim FM, Kolson DL, Balliet JW, Srinivasan A, Collman RG: V3-independent determinants of macrophage tropism in a primary human immunodeficiency virus type 1 isolate. J Virol 1995;69:1755-1761.
47. Weller PF, Marshall WL, Lucey DR, Rand TH, Dvorak AM, Finberg RW: Infection, apoptosis, and killing of mature human eosinophils by human immunodeficiency virus-1. Am J Respir Cell Mol Biol 1995;13:610-620.
48. Freedman AR, Gibson FM, Fleming SC, Spry CJ, Griffin GE: Human immunodeficiency virus infection of eosinophils in human bone marrow cultures. J Exp Med 1991;174:1661-1664.
49. Loetscher P, Seitz M, Baggiolini M, Moser B: Inlerleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J Exp Med 1996;184:569-577.
50. Paxton WA, Martin SR, Tse D, O'Brien TR, Skurnick J, VanDevanter NL, Padian N, Braun JF, Kotler DP, Wolinsky SM, Koup RA: Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nature Med 1996;2:412-417.
51. Donegan E, Stuart M, Niland JC, Sacks HS, Azen SP, Dietrich SL, Faucett C, Fletcher MA, Kleinman SH, Operskalski EA, Perkins HA, Pindyck J, Schiff ER, Stites DP, Tomasulo PA, Mosley JW, Transfusion Safety Group: Infection with human immunodeficiency virus type 1 (HIV-1) among recipients of antibody-positive blood donations. Ann Intern Med 1990; 113: 733-739.
52. Detels R, Liu Z, Hennessey K, Kan J, Visscher BR, Taylor JMG, Hoover DR, Rinaldo CR, Phair JP, Saah AJ, Giorgi JV: Resistance to HIV-1 infection. J Acquired Immune Defic Syndrome 1994;7:1263-1269.
53. Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R, MacDonald ME, Stuhlmann H, Koup RA, Landau NR: Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996;86: 367-377.
54. Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapouméroulie C, Cognaux J, Forceille C, Muyldermans G, Verhofstede C, Burtonboy G, Georges M, Imai T, Rana S, Yi Y, Smyth RJ, Collman RG, Doms RW, Vassart G, Parmentier M: Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996; 382:722-725.
55. Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, Goedert JJ, Buchbinder SP, Vittinghoff E, Gomperts E, Donfield S, Vlahov D, Kaslow R, Saah A, Rinaldo C, Detels R, Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study, O'Brien SJ: Genetic resistance of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 1996;273:1856-1862.
56. Chaudhuri A, Polyakova J, Zbrzezna V, Williams K, Gulati S, Pogo AO: Cloning of glycoprotein DcDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. Proc Natl Acad Sci USA 1993;90:10,793-10,797.
57. Mallison G, Soo KS, Schall TJ, Pisacka M, Anstee DJ: Mutations in the erythrocyte chemokine receptor (Duffy) gene: the molecular basis of the Fya/Fyb antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(a-b-) phenotype. Br J Haematol 1995;90: 823-829.
58. Kirchhoff F, Greenough TC, Brettler DB, Sullivan JL, Desrosiers RC: Absence of intact nef sequences in a long-term survivor with non-progressive HIV-1 infection. N Engl J Med 1995;332:228-232.
59. Learmont J, Tindall B, Evans L, Cunningham A, Cunningham P, Wells J, Penny R, Kaldor J, Cooper DA: Long-term symptomless HIV-1 infection in recipients of blood products from a single donor. Lancet 1992;340:863-867.
60. Travers K, Mboup S, Marlink R, Gueye-Nidaye A, Siby T, Thior I, Traore I, Dieng-Sarr A, Sankale JL, Mullins C: Natural protection against HIV-1 infection provided by HIV-2. Science 1995;5217: 1612-1615.
61. Cao Y, Qin L, Zhang L, Safrit J, Ho DD: Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med 1995;332:201-208.
62. Chung CW, Cooke RM, Proudfoot AE, Wells TN: The three-dimensional solution structure of RANTES. Biochemistry 1995;34:9307-9314.
63. Lodi PJ, Garrett DS, Kuszewski J, Tsang ML, Weatherbee JA, Leonard WJ, Gronenborn AM, Clore GM: High-resolution solution structure of the β chemokine hMILP-1β by multidimensional NMR. Science 1994;263:1762-1767.
64. Clubb RT, Omichinski JG, Clore GM, Gronenborn AM: Mapping the binding surface of interleukin-8 complexed with an N-terminal fragment of the type 1 human interleukin-8 receptor. FEBS Lett 1994; 338:93-97.
65. Ahuja SK, Lee JC, Murphy PM: CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B. J Biol Chem 1996;271:225-232.
66. Gayle RB, Sleuth PR, Srinivason S, Birks CW, Weerawarna KS, Cerretti DP, Kozlosky CJ, Nelson N, Bos TV, Beckmann MP: Importance of the amino terminus of the interleukin-8 receptor in ligand interactions. J Biol Chem 1993; 268:7283-7289.
67. Hebert CA, Chuntharapai A, Smith M, Colby T, Kim J, Horuk R: Partial functional mapping of the human interleukin-8 type A receptor. J Biol Chem 1993;268: 18,549-18,553.
68. Monteclaro FS, Charo IF: The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1α receptor, confers chemokine selectivity. J Biol Chem 1996;271:19,084-19,092.
69. Siciliano SJ, Rollins TE, DeMartino J, Konteatis Z, Malkowitz L, VanRiper G, Bondy S, Rosen H, Springer MS: Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors. Proc Natl Acad Sci USA 1994;91: 1214-1218.
70. DeMartino JA, Riper GV, Siciliano SJ, Molineaux CJ, Konteatis ZD, Rosen H, Springer MS: The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs. J Biol Chem 1994;269: 14,446-14,450.
71. Golding H, Dimitrov DS, Manischewitz J, Broder CC, Robinson J, Fabian S, Littman DR, Lapham CK: Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules. J Virol 1995; 69:6140-6148.
72. Golding H, Manischewitz J, Vujcic L, Blumenthal R, Dimitrov DS: The phorbol ester phorbol myristate acetate inhibits human immunodeficiency virus type 1 envelope-mediated fusion by modulating an accessory component(s) in CD4-expressing cells. J Virol 1994;68:1962-1969.
73. Wahl SM, Allen JB, Gartner S, Orenstein JM, Popovic M, Chenoweth DE, Arthur LO, Farrar WL, Wahl LM: HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes. J Immunol 1989; 142:3553-3559.
74. Schmidtmayerova H, Nottet HSLM, Nuovo G, Raabe T, Flanagan CR, Dubrovsky L, Gendelman HE, Cerami A, Bukrinsky M, Sherry B: Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci USA 1996;93:700-704.
75. Canque B, Rosenzwajg M, Gey A, Tartour E, Fridman WH, Gluckman JC: Macrophage inflammatory protein-1-alpha is induced by human-immunodeficiency-virus infection of monocyte-derived macrophages. Blood 1996;87: 2011-2019.
76. Borghi P, Fantuzzi L, Varano B, Gessani S, Puddu P, Conti L, Capobianchi MR, Ameglio F, Belardelli F: Induction of interleukin-10 by human immunodeficiency virus type 1 and its gp120 protein in human monocytes/ macrophages. J Virol 1995;69: 1284-1287.
77. Seitz M, Loetscher P, Dewald B, Towbin H, Gallati H, Baggiolini M: Interleukin-10 differentially regulates cytokine inhibitor and chemokine release from blood mononuclear cells and fibroblasts. Eur J Immunol 1995;25:1129-1132.
78. Schols D, DeClerco E: Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production. J Virol 1996;70:4953-4960.
79. Schmidtmayerova H, Sherry B, Bukrinsky M: Chemokines and HIV replication. Nature 1996; 382:767.