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Volumn 28, Issue SUPPL 1, 2013, Pages 43-48

Tumor microenviroment and hepatocellular carcinoma metastasis

Author keywords

Hepatocellular carcinoma; Tumor metastasis; Tumor microenviroment

Indexed keywords

COLONY STIMULATING FACTOR 1; CYCLIN A; CYCLIN D1; CYCLINE; CYCLOOXYGENASE 2; GELATINASE A; GELATINASE B; INTERLEUKIN 6; VASCULOTROPIN;

EID: 84880411633     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12091     Document Type: Review
Times cited : (92)

References (82)
  • 1
    • 79952038728 scopus 로고    scopus 로고
    • The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets
    • Yang JD, Nakamura I, Roberts LR. The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets. Semin. Cancer Biol. 2011; 21: 35-43.
    • (2011) Semin. Cancer Biol. , vol.21 , pp. 35-43
    • Yang, J.D.1    Nakamura, I.2    Roberts, L.R.3
  • 2
    • 84861782272 scopus 로고    scopus 로고
    • The tumor microenvironment in hepatocellular carcinoma (review)
    • Leonardi GC, Candido S, Cervello M etal. The tumor microenvironment in hepatocellular carcinoma (review). Int. J. Oncol. 2012; 40: 1733-1747.
    • (2012) Int. J. Oncol. , vol.40 , pp. 1733-1747
    • Leonardi, G.C.1    Candido, S.2    Cervello, M.3
  • 3
    • 58649083678 scopus 로고    scopus 로고
    • The prometastatic microenvironment of the liver
    • Vidal-Vanaclocha F. The prometastatic microenvironment of the liver. Cancer Microenviron. 2008; 1: 113-129.
    • (2008) Cancer Microenviron. , vol.1 , pp. 113-129
    • Vidal-Vanaclocha, F.1
  • 5
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 2000; 275: 2247-2250.
    • (2000) J. Biol. Chem. , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 6
    • 0035064480 scopus 로고    scopus 로고
    • Expression and cellular localization of fibrillin-1 in normal and pathological human liver
    • Dubuisson L, Lepreux S, Bioulac-Sage P etal. Expression and cellular localization of fibrillin-1 in normal and pathological human liver. J. Hepatol. 2001; 34: 514-522.
    • (2001) J. Hepatol. , vol.34 , pp. 514-522
    • Dubuisson, L.1    Lepreux, S.2    Bioulac-Sage, P.3
  • 7
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver
    • Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol. Rev. 2008; 88: 125-172.
    • (2008) Physiol. Rev. , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 8
    • 84861147161 scopus 로고    scopus 로고
    • Hepatocyte-stellate cell crosstalk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma
    • Coulouarn C, Corlu A, Glaise D etal. Hepatocyte-stellate cell crosstalk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma. Cancer Res. 2012; 72: 2533-2542.
    • (2012) Cancer Res. , vol.72 , pp. 2533-2542
    • Coulouarn, C.1    Corlu, A.2    Glaise, D.3
  • 9
    • 80055063430 scopus 로고    scopus 로고
    • Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal-regulated kinase/matrix metalloproteinase-9 axis
    • Jia YL, Shi L, Zhou JN etal. Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal-regulated kinase/matrix metalloproteinase-9 axis. Hepatology 2011; 54: 1808-1818.
    • (2011) Hepatology , vol.54 , pp. 1808-1818
    • Jia, Y.L.1    Shi, L.2    Zhou, J.N.3
  • 10
    • 82355182092 scopus 로고    scopus 로고
    • Inhibition of T-cell responses by intratumoral hepatic stellate cells contribute to migration and invasion of hepatocellular carcinoma
    • Xia Y, Chen R, Ye SL, Sun R, Chen J, Zhao Y. Inhibition of T-cell responses by intratumoral hepatic stellate cells contribute to migration and invasion of hepatocellular carcinoma. Clin. Exp. Metastasis 2011; 28: 661-674.
    • (2011) Clin. Exp. Metastasis , vol.28 , pp. 661-674
    • Xia, Y.1    Chen, R.2    Ye, S.L.3    Sun, R.4    Chen, J.5    Zhao, Y.6
  • 11
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006; 124: 263-266.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 12
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005; 7: 211-217.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 13
    • 45749137283 scopus 로고    scopus 로고
    • High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma
    • Zhu XD, Zhang JB, Zhuang PY etal. High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J. Clin. Oncol. 2008; 26: 2707-2716.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2707-2716
    • Zhu, X.D.1    Zhang, J.B.2    Zhuang, P.Y.3
  • 14
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • Budhu A, Forgues M, Ye QH etal. Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 2006; 10: 99-111.
    • (2006) Cancer Cell , vol.10 , pp. 99-111
    • Budhu, A.1    Forgues, M.2    Ye, Q.H.3
  • 15
    • 77954229219 scopus 로고    scopus 로고
    • Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and anti-angiogenic effects
    • Zhang W, Zhu XD, Sun HC etal. Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and anti-angiogenic effects. Clin. Cancer Res. 2010; 16: 3420-3430.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3420-3430
    • Zhang, W.1    Zhu, X.D.2    Sun, H.C.3
  • 16
    • 36349018388 scopus 로고    scopus 로고
    • Is interleukin-6 a gender-specific risk factor for liver cancer?
    • Sander LE, Trautwein C, Liedtke C. Is interleukin-6 a gender-specific risk factor for liver cancer? Hepatology 2007; 46: 1304-1305.
    • (2007) Hepatology , vol.46 , pp. 1304-1305
    • Sander, L.E.1    Trautwein, C.2    Liedtke, C.3
  • 17
    • 72849131596 scopus 로고    scopus 로고
    • Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression
    • Lai JJ, Lai KP, Chuang KH etal. Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression. J. Clin. Invest. 2009; 119: 3739-3751.
    • (2009) J. Clin. Invest. , vol.119 , pp. 3739-3751
    • Lai, J.J.1    Lai, K.P.2    Chuang, K.H.3
  • 18
    • 33750997279 scopus 로고    scopus 로고
    • Intracellular survival pathways in the liver
    • Luedde T, Trautwein C. Intracellular survival pathways in the liver. Liver Int. 2006; 26: 1163-1174.
    • (2006) Liver Int. , vol.26 , pp. 1163-1174
    • Luedde, T.1    Trautwein, C.2
  • 19
    • 0037391756 scopus 로고    scopus 로고
    • Predicting hepatitis B virus-positive meta-static hepatocellular carcinomas using gene expression profiling and supervised machine learning
    • Ye QH, Qin LX, Forgues M etal. Predicting hepatitis B virus-positive meta-static hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat. Med. 2003; 9: 416-423.
    • (2003) Nat. Med. , vol.9 , pp. 416-423
    • Ye, Q.H.1    Qin, L.X.2    Forgues, M.3
  • 20
    • 70350234729 scopus 로고    scopus 로고
    • Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions
    • Wu K, Kryczek I, Chen L, Zou W, Welling TH. Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions. Cancer Res. 2009; 69: 8067-8075.
    • (2009) Cancer Res. , vol.69 , pp. 8067-8075
    • Wu, K.1    Kryczek, I.2    Chen, L.3    Zou, W.4    Welling, T.H.5
  • 21
    • 58149374671 scopus 로고    scopus 로고
    • Lentiviral-mediated silencing of Osteopontin through RNA interference suppresses invasiveness and tumorigenicity of liver cancer cells
    • Sun BS, Ye QH, Ren N etal. Lentiviral-mediated silencing of Osteopontin through RNA interference suppresses invasiveness and tumorigenicity of liver cancer cells. Hepatology 2008; 48: 1834-1842.
    • (2008) Hepatology , vol.48 , pp. 1834-1842
    • Sun, B.S.1    Ye, Q.H.2    Ren, N.3
  • 22
    • 78649532564 scopus 로고    scopus 로고
    • Thrombin is a therapeutic target for metastatic osteopontin-positive hepatocellular carcinoma
    • Xue YH, Zhang XF, Dong QZ etal. Thrombin is a therapeutic target for metastatic osteopontin-positive hepatocellular carcinoma. Hepatology 2010; 52: 2012-2022.
    • (2010) Hepatology , vol.52 , pp. 2012-2022
    • Xue, Y.H.1    Zhang, X.F.2    Dong, Q.Z.3
  • 23
    • 42149085600 scopus 로고    scopus 로고
    • Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer
    • Ramaiah SK, Rittling S. Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer. Toxicol. Sci. 2008; 103: 4-13.
    • (2008) Toxicol. Sci. , vol.103 , pp. 4-13
    • Ramaiah, S.K.1    Rittling, S.2
  • 24
    • 67651160649 scopus 로고    scopus 로고
    • CD4 (+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • DeNardo DG, Barreto JB, Andreu P etal. CD4 (+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009; 16: 91-102.
    • (2009) Cancer Cell , vol.16 , pp. 91-102
    • DeNardo, D.G.1    Barreto, J.B.2    Andreu, P.3
  • 25
    • 34247464330 scopus 로고    scopus 로고
    • Swords into plowshares: IL-23 repurposes tumor immune surveillance
    • Langowski JL, Kastelein RA, Oft M. Swords into plowshares: IL-23 repurposes tumor immune surveillance. Trends Immunol. 2007; 28: 207-212.
    • (2007) Trends Immunol. , vol.28 , pp. 207-212
    • Langowski, J.L.1    Kastelein, R.A.2    Oft, M.3
  • 26
    • 33646755569 scopus 로고    scopus 로고
    • Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity
    • Smyth MJ, Dunn GP, Schreiber RD. Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity. Adv. Immunol. 2006; 90: 1-50.
    • (2006) Adv. Immunol. , vol.90 , pp. 1-50
    • Smyth, M.J.1    Dunn, G.P.2    Schreiber, R.D.3
  • 27
    • 42249087302 scopus 로고    scopus 로고
    • Gene expression-based recurrence prediction of hepatitis B virus -related human hepatocellular carcinoma
    • Woo HG, Park ES, Cheon JH etal. Gene expression-based recurrence prediction of hepatitis B virus -related human hepatocellular carcinoma. Clin. Cancer Res. 2008; 14: 2056-2064.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 2056-2064
    • Woo, H.G.1    Park, E.S.2    Cheon, J.H.3
  • 28
    • 34447256838 scopus 로고    scopus 로고
    • Regulatory T lymphocytes: pivotal components of the host antitumor response
    • Yakirevich E, Resnick MB. Regulatory T lymphocytes: pivotal components of the host antitumor response. J. Clin. Oncol. 2007; 25: 2506-2508.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 2506-2508
    • Yakirevich, E.1    Resnick, M.B.2
  • 29
    • 53549091864 scopus 로고    scopus 로고
    • Positive and negative influences of regulatory T cells on tumour immunity
    • Gallimore AM, Simon AK. Positive and negative influences of regulatory T cells on tumour immunity. Oncogene 2008; 27: 5886-5893.
    • (2008) Oncogene , vol.27 , pp. 5886-5893
    • Gallimore, A.M.1    Simon, A.K.2
  • 30
    • 34250005419 scopus 로고    scopus 로고
    • Increased regulatory T cells correlate with CD8 T cell impairment and poor survival in hepatocellular carcinoma patients
    • Fu J, Xu D, Liu Z etal. Increased regulatory T cells correlate with CD8 T cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology 2007; 132: 2328-2339.
    • (2007) Gastroenterology , vol.132 , pp. 2328-2339
    • Fu, J.1    Xu, D.2    Liu, Z.3
  • 31
    • 80052827580 scopus 로고    scopus 로고
    • Selective recruitment of regulatory T cell through CCR6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis
    • Chen KJ, Lin SZ, Zhou L etal. Selective recruitment of regulatory T cell through CCR6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis. PLoS ONE 2011; 6: e24671.
    • (2011) PLoS ONE , vol.6
    • Chen, K.J.1    Lin, S.Z.2    Zhou, L.3
  • 32
    • 34447277894 scopus 로고    scopus 로고
    • Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    • Gao Q, Qiu S-J, Fan J etal. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J. Clin. Oncol. 2007; 25: 2586-2593.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 2586-2593
    • Gao, Q.1    Qiu, S.-J.2    Fan, J.3
  • 33
    • 84856673287 scopus 로고    scopus 로고
    • Infiltrating memory/senescent T cell ratio predicts extrahepatic metastasis of hepatocellular carcinoma
    • Gao Q, Zhou J, Wang XY etal. Infiltrating memory/senescent T cell ratio predicts extrahepatic metastasis of hepatocellular carcinoma. Ann. Surg. Oncol. 2012; 19: 455-466.
    • (2012) Ann. Surg. Oncol. , vol.19 , pp. 455-466
    • Gao, Q.1    Zhou, J.2    Wang, X.Y.3
  • 34
    • 55249097842 scopus 로고    scopus 로고
    • Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients
    • Cai L, Zhang Z, Zhou L etal. Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients. Clin. Immunol. 2008; 129: 428-437.
    • (2008) Clin. Immunol. , vol.129 , pp. 428-437
    • Cai, L.1    Zhang, Z.2    Zhou, L.3
  • 35
    • 33750691006 scopus 로고    scopus 로고
    • The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression
    • Ghiringhelli F, Ménard C, Martin F, Zitvogel L. The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression. Immunol. Rev. 2006; 214: 229-238.
    • (2006) Immunol. Rev. , vol.214 , pp. 229-238
    • Ghiringhelli, F.1    Ménard, C.2    Martin, F.3    Zitvogel, L.4
  • 36
    • 82255164203 scopus 로고    scopus 로고
    • Human tumor-induced and naturally occurring Treg cells differentially affect NK cells activated by either IL-2 or target cells
    • Bergmann C, Wild CA, Narwan M, Lotfi R, Lang S, Brandau S. Human tumor-induced and naturally occurring Treg cells differentially affect NK cells activated by either IL-2 or target cells. Eur. J. Immunol. 2011; 41: 3564-3573.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 3564-3573
    • Bergmann, C.1    Wild, C.A.2    Narwan, M.3    Lotfi, R.4    Lang, S.5    Brandau, S.6
  • 37
    • 0025060392 scopus 로고
    • Natural killer cell activity in patients with hepatocellular carcinoma relative to early development and tumor invasion
    • Chuang WL, Liu HW, Chang WY. Natural killer cell activity in patients with hepatocellular carcinoma relative to early development and tumor invasion. Cancer 1990; 65: 926-930.
    • (1990) Cancer , vol.65 , pp. 926-930
    • Chuang, W.L.1    Liu, H.W.2    Chang, W.Y.3
  • 38
    • 33846413504 scopus 로고    scopus 로고
    • Intrahepatic delivery of -galactosylceramide-pulsed dendritic cells suppresses liver tumor
    • Tatsumi T, Takehara T, Yamaguchi S etal. Intrahepatic delivery of -galactosylceramide-pulsed dendritic cells suppresses liver tumor. Hepatology 2007; 45: 22-30.
    • (2007) Hepatology , vol.45 , pp. 22-30
    • Tatsumi, T.1    Takehara, T.2    Yamaguchi, S.3
  • 39
    • 7044274703 scopus 로고    scopus 로고
    • Concanavalin A injection activates intrahepatic innate immune cells to provoke an antitumor effect in murine liver
    • Miyagi T, Takehara T, Tatsumi T etal. Concanavalin A injection activates intrahepatic innate immune cells to provoke an antitumor effect in murine liver. Hepatology 2004; 40: 1190-1196.
    • (2004) Hepatology , vol.40 , pp. 1190-1196
    • Miyagi, T.1    Takehara, T.2    Tatsumi, T.3
  • 40
    • 60449097353 scopus 로고    scopus 로고
    • Invariant natural killer T cells suppresses the neutrophil inflammatory response in a mouse model of cholestatic liver damage
    • Wintermeyer P, Cheng C, Gehring S etal. Invariant natural killer T cells suppresses the neutrophil inflammatory response in a mouse model of cholestatic liver damage. Gastroenterology 2009; 136: 1048-1059.
    • (2009) Gastroenterology , vol.136 , pp. 1048-1059
    • Wintermeyer, P.1    Cheng, C.2    Gehring, S.3
  • 41
    • 0030991267 scopus 로고    scopus 로고
    • Decreased natural killer cytotoxic activity in chronic alcoholism is associated with alcohol liver dis-ease but not active ethanol consumption
    • Laso FJ, Madruga JI, Giron JA etal. Decreased natural killer cytotoxic activity in chronic alcoholism is associated with alcohol liver dis-ease but not active ethanol consumption. Hepatology 1997; 25: 1096-1100.
    • (1997) Hepatology , vol.25 , pp. 1096-1100
    • Laso, F.J.1    Madruga, J.I.2    Giron, J.A.3
  • 42
    • 0027194656 scopus 로고
    • Depressed immune function in patients with cirrhosis before emergence of hepatocellular carcinoma
    • Saibara T, Maeda T, Miyazaki M, Onishi S, Yamamoto Y. Depressed immune function in patients with cirrhosis before emergence of hepatocellular carcinoma. Hepatology 1993; 18: 315-319.
    • (1993) Hepatology , vol.18 , pp. 315-319
    • Saibara, T.1    Maeda, T.2    Miyazaki, M.3    Onishi, S.4    Yamamoto, Y.5
  • 43
    • 33845332083 scopus 로고    scopus 로고
    • Enhanced antitumor response by divergent modulation of natural killer and natural killer T cells in the liver
    • Subleski JJ, Hall VL, Back TC, Ortaldo JR, Wiltrout RH. Enhanced antitumor response by divergent modulation of natural killer and natural killer T cells in the liver. Cancer Res. 2006; 66: 11005-11012.
    • (2006) Cancer Res. , vol.66 , pp. 11005-11012
    • Subleski, J.J.1    Hall, V.L.2    Back, T.C.3    Ortaldo, J.R.4    Wiltrout, R.H.5
  • 44
    • 21344457276 scopus 로고    scopus 로고
    • The role of natural killer cells in tumor control-effectors and regulators of adaptive immunity
    • Wallace ME, Smyth MJ. The role of natural killer cells in tumor control-effectors and regulators of adaptive immunity. Springer Semin. Immunopathol. 2005; 27: 49-64.
    • (2005) Springer Semin. Immunopathol. , vol.27 , pp. 49-64
    • Wallace, M.E.1    Smyth, M.J.2
  • 45
    • 27744562232 scopus 로고    scopus 로고
    • Differential antitumor immunity mediated by NKT cell subsets in vivo
    • Crowe NY, Coquet JM, Berzins SP etal. Differential antitumor immunity mediated by NKT cell subsets in vivo. J. Exp. Med. 2005; 202: 1279-1288.
    • (2005) J. Exp. Med. , vol.202 , pp. 1279-1288
    • Crowe, N.Y.1    Coquet, J.M.2    Berzins, S.P.3
  • 46
    • 65249176389 scopus 로고    scopus 로고
    • Enrichment of human CD4+ V(alpha)24/Vbeta11 invariant NKT cells in intrahepatic malignant tumors
    • Bricard G, Cesson V, Devevre E etal. Enrichment of human CD4+ V(alpha)24/Vbeta11 invariant NKT cells in intrahepatic malignant tumors. J. Immunol. 2009; 182: 5140-5151.
    • (2009) J. Immunol. , vol.182 , pp. 5140-5151
    • Bricard, G.1    Cesson, V.2    Devevre, E.3
  • 47
    • 78449302417 scopus 로고    scopus 로고
    • Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97-H cell line
    • Li GC, Ye QH, Xue YH etal. Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97-H cell line. Cancer Sci. 2010; 101: 2546-2553.
    • (2010) Cancer Sci. , vol.101 , pp. 2546-2553
    • Li, G.C.1    Ye, Q.H.2    Xue, Y.H.3
  • 48
    • 84865527612 scopus 로고    scopus 로고
    • Mesenchymal stem cells in inflammation microenvironment accelerates hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition
    • Jing Y, Han Z, Liu Y etal. Mesenchymal stem cells in inflammation microenvironment accelerates hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition. PLoS ONE 2012; 7: e43272.
    • (2012) PLoS ONE , vol.7
    • Jing, Y.1    Han, Z.2    Liu, Y.3
  • 49
    • 84862798754 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 overexpression is closely related to invasiveness of hepatocellular carcinoma
    • Lee D, Chung YH, Kim JA etal. Transforming growth factor beta 1 overexpression is closely related to invasiveness of hepatocellular carcinoma. Oncology 2012; 82: 11-18.
    • (2012) Oncology , vol.82 , pp. 11-18
    • Lee, D.1    Chung, Y.H.2    Kim, J.A.3
  • 50
    • 84863603551 scopus 로고    scopus 로고
    • CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma
    • Mima K, Okabe H, Ishimoto T etal. CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma. Cancer Res. 2012; 72: 3414-3423.
    • (2012) Cancer Res. , vol.72 , pp. 3414-3423
    • Mima, K.1    Okabe, H.2    Ishimoto, T.3
  • 51
    • 84863111015 scopus 로고    scopus 로고
    • Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF
    • Bi Q, Tang S, Xia L etal. Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF. PLoS ONE 2012; 7: e40169.
    • (2012) PLoS ONE , vol.7
    • Bi, Q.1    Tang, S.2    Xia, L.3
  • 52
    • 42549110530 scopus 로고    scopus 로고
    • VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma
    • Thelen A, Scholz A, Benckert C etal. VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma. Int. J. Cancer 2008; 122: 2471-2481.
    • (2008) Int. J. Cancer , vol.122 , pp. 2471-2481
    • Thelen, A.1    Scholz, A.2    Benckert, C.3
  • 53
    • 73149115105 scopus 로고    scopus 로고
    • Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma
    • Wu F, Yang LY, Li YF, Ou DP, Chen DP, Fan C. Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma. Hepatology 2009; 50: 1839-1850.
    • (2009) Hepatology , vol.50 , pp. 1839-1850
    • Wu, F.1    Yang, L.Y.2    Li, Y.F.3    Ou, D.P.4    Chen, D.P.5    Fan, C.6
  • 54
    • 80053378588 scopus 로고    scopus 로고
    • Overexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinoma
    • Ng KT, Qi X, Kong KL etal. Overexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinoma. Eur. J. Cancer 2011; 47: 2299-2305.
    • (2011) Eur. J. Cancer , vol.47 , pp. 2299-2305
    • Ng, K.T.1    Qi, X.2    Kong, K.L.3
  • 55
    • 84880431266 scopus 로고    scopus 로고
    • Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer
    • Epub ahead of print].
    • Chen JS, Huang XH, Wang Q etal. Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer. Carcinogenesis 2012 [Epub ahead of print].
    • (2012) Carcinogenesis
    • Chen, J.S.1    Huang, X.H.2    Wang, Q.3
  • 56
    • 0030683506 scopus 로고    scopus 로고
    • Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: evidence for a role of hepatocyte growth factor
    • Neaud V, Faouzi S, Guirouilh J etal. Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: evidence for a role of hepatocyte growth factor. Hepatology 1997; 26: 1458-1466.
    • (1997) Hepatology , vol.26 , pp. 1458-1466
    • Neaud, V.1    Faouzi, S.2    Guirouilh, J.3
  • 57
    • 84866509682 scopus 로고    scopus 로고
    • Hepatocyte growth factor enhances alternative splicing of the Kruppel-like factor 6 (KLF6) tumor suppressor to promote growth through SRSF1
    • Muñoz U, Puche JE, Hannivoort R, Lang UE, Cohen-Naftaly M, Friedman SL. Hepatocyte growth factor enhances alternative splicing of the Kruppel-like factor 6 (KLF6) tumor suppressor to promote growth through SRSF1. Mol. Cancer Res. 2012; 10: 1216-1227.
    • (2012) Mol. Cancer Res. , vol.10 , pp. 1216-1227
    • Muñoz, U.1    Puche, J.E.2    Hannivoort, R.3    Lang, U.E.4    Cohen-Naftaly, M.5    Friedman, S.L.6
  • 58
    • 82355185942 scopus 로고    scopus 로고
    • Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways
    • Ogunwobi OO, Liu C. Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways. Clin. Exp. Metastasis 2011; 28: 721-731.
    • (2011) Clin. Exp. Metastasis , vol.28 , pp. 721-731
    • Ogunwobi, O.O.1    Liu, C.2
  • 59
    • 79960374570 scopus 로고    scopus 로고
    • miR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway
    • Tan S, Li R, Ding K, Lobie PE, Zhu T. miR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway. FEBS Lett. 2011; 585: 2229-2234.
    • (2011) FEBS Lett. , vol.585 , pp. 2229-2234
    • Tan, S.1    Li, R.2    Ding, K.3    Lobie, P.E.4    Zhu, T.5
  • 60
    • 84859429709 scopus 로고    scopus 로고
    • Estrogen suppresses metastasis in rat hepatocellular carcinoma through decreasing interleukin-6 and hepatocyte growth factor expression
    • Wang YC, Xu GL, Jia WD etal. Estrogen suppresses metastasis in rat hepatocellular carcinoma through decreasing interleukin-6 and hepatocyte growth factor expression. Inflammation 2012; 35: 143-149.
    • (2012) Inflammation , vol.35 , pp. 143-149
    • Wang, Y.C.1    Xu, G.L.2    Jia, W.D.3
  • 63
    • 0028899009 scopus 로고
    • Androgen and oestrogen receptors in hepatocellular carcinoma and surrounding liver parenchyma: impact on intrahepatic recurrence after hepatic resection
    • Nagasue N, Yu L, Yukaya H. Androgen and oestrogen receptors in hepatocellular carcinoma and surrounding liver parenchyma: impact on intrahepatic recurrence after hepatic resection. Br. J. Surg. 1995; 82: 542-547.
    • (1995) Br. J. Surg. , vol.82 , pp. 542-547
    • Nagasue, N.1    Yu, L.2    Yukaya, H.3
  • 64
    • 84866234502 scopus 로고    scopus 로고
    • Oestrogen attenuates tumour progression in hepatocellular carcinoma
    • Xu H, Wei Y, Zhang Y etal. Oestrogen attenuates tumour progression in hepatocellular carcinoma. J. Pathol. 2012; 228: 216-229.
    • (2012) J. Pathol. , vol.228 , pp. 216-229
    • Xu, H.1    Wei, Y.2    Zhang, Y.3
  • 65
    • 84863510908 scopus 로고    scopus 로고
    • Hepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikis
    • Ma WL, Hsu CL, Yeh CC etal. Hepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikis. Hepatology 2012; 56: 176-185.
    • (2012) Hepatology , vol.56 , pp. 176-185
    • Ma, W.L.1    Hsu, C.L.2    Yeh, C.C.3
  • 66
    • 84870974529 scopus 로고    scopus 로고
    • Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL
    • Chi HC, Chen SL, Liao CJ etal. Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL. Cell Death Differ. 2012; 19: 1802-1814.
    • (2012) Cell Death Differ. , vol.19 , pp. 1802-1814
    • Chi, H.C.1    Chen, S.L.2    Liao, C.J.3
  • 67
    • 84862828628 scopus 로고    scopus 로고
    • Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells
    • Liao CH, Yeh CT, Huang YH etal. Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells. Hepatology 2012; 55: 910-920.
    • (2012) Hepatology , vol.55 , pp. 910-920
    • Liao, C.H.1    Yeh, C.T.2    Huang, Y.H.3
  • 68
    • 68549135400 scopus 로고    scopus 로고
    • A somatostatin analogue, octreotide, inhibits the occurrence of second primary tumors and lung metastasis after resection of hepatocellular carcinoma in mice
    • Jia WD, Xu GL, Wang W etal. A somatostatin analogue, octreotide, inhibits the occurrence of second primary tumors and lung metastasis after resection of hepatocellular carcinoma in mice. Tohoku J. Exp. Med. 2009; 218: 155-160.
    • (2009) Tohoku J. Exp. Med. , vol.218 , pp. 155-160
    • Jia, W.D.1    Xu, G.L.2    Wang, W.3
  • 70
    • 8644274040 scopus 로고    scopus 로고
    • The enigmatic X gene of hepatitis B virus
    • Bouchard MJ, Schneider RJ. The enigmatic X gene of hepatitis B virus. J. Virol. 2004; 78: 12725-12734.
    • (2004) J. Virol. , vol.78 , pp. 12725-12734
    • Bouchard, M.J.1    Schneider, R.J.2
  • 71
    • 68349120124 scopus 로고    scopus 로고
    • Transformation of human liver LO2 cells mediated by stable HBx transfection
    • Zhang WY, Cai N, Ye LH, Zhang XD. Transformation of human liver LO2 cells mediated by stable HBx transfection. Acta Pharmacol. Sin. 2009; 30: 1153-1161.
    • (2009) Acta Pharmacol. Sin. , vol.30 , pp. 1153-1161
    • Zhang, W.Y.1    Cai, N.2    Ye, L.H.3    Zhang, X.D.4
  • 72
    • 0035072365 scopus 로고    scopus 로고
    • Effect of the hepatitis B virus HBx protein on integrin-mediated adhesion to and migration on extracellular matrix
    • Lara-Pezzi E, Majano PL, Yanez-Mo M etal. Effect of the hepatitis B virus HBx protein on integrin-mediated adhesion to and migration on extracellular matrix. J. Hepatol. 2001; 34: 409-415.
    • (2001) J. Hepatol. , vol.34 , pp. 409-415
    • Lara-Pezzi, E.1    Majano, P.L.2    Yanez-Mo, M.3
  • 73
    • 60649090597 scopus 로고    scopus 로고
    • HBx protein induces expression of MIG and increases migration of leukocytes through activation of NF-kappaB
    • Xia LM, Huang WJ, Wu JG etal. HBx protein induces expression of MIG and increases migration of leukocytes through activation of NF-kappaB. Virology 2009; 385: 335-342.
    • (2009) Virology , vol.385 , pp. 335-342
    • Xia, L.M.1    Huang, W.J.2    Wu, J.G.3
  • 74
    • 7744229935 scopus 로고    scopus 로고
    • Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential
    • Chung TW, Lee YC, Kim CH. Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J. 2004; 18: 1123-1125.
    • (2004) FASEB J. , vol.18 , pp. 1123-1125
    • Chung, T.W.1    Lee, Y.C.2    Kim, C.H.3
  • 75
    • 77953525398 scopus 로고    scopus 로고
    • Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells
    • Zhang F, Wang Q, Ye L, Feng Y, Zhang X. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. J. Med. Virol. 2010; 82: 920-928.
    • (2010) J. Med. Virol. , vol.82 , pp. 920-928
    • Zhang, F.1    Wang, Q.2    Ye, L.3    Feng, Y.4    Zhang, X.5
  • 76
    • 44449114668 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells
    • Yoo Y-G, Na T-Y, Seo H-W etal. Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells. Oncogene 2008; 27: 3405-3413.
    • (2008) Oncogene , vol.27 , pp. 3405-3413
    • Yoo, Y.-G.1    Na, T.-Y.2    Seo, H.-W.3
  • 77
    • 79955870017 scopus 로고    scopus 로고
    • Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model
    • Kong G, Zhang J, Zhang S, Shan C, Ye L, Zhang X. Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model. PLoS ONE 2011; 6: e19518.
    • (2011) PLoS ONE , vol.6
    • Kong, G.1    Zhang, J.2    Zhang, S.3    Shan, C.4    Ye, L.5    Zhang, X.6
  • 78
    • 79960061468 scopus 로고    scopus 로고
    • Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression
    • Li J, Lau GK, Chen L etal. Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression. PLoS ONE 2011; 6: e21816.
    • (2011) PLoS ONE , vol.6
    • Li, J.1    Lau, G.K.2    Chen, L.3
  • 79
    • 80052291995 scopus 로고    scopus 로고
    • Dual effects of interleukin-18: inhibiting hepatitis B virus replication in HepG2.2.15 cells and promoting hepatoma cells metastasis
    • Zhang Y, Li Y, Ma Y etal. Dual effects of interleukin-18: inhibiting hepatitis B virus replication in HepG2.2.15 cells and promoting hepatoma cells metastasis. Am. J. Physiol. Gastrointest. Liver Physiol. 2011; 301: G565-573.
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.301
    • Zhang, Y.1    Li, Y.2    Ma, Y.3
  • 80
    • 80052023399 scopus 로고    scopus 로고
    • Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3
    • Jiang R, Tan Z, Deng L etal. Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3. Hepatology 2011; 54: 900-909.
    • (2011) Hepatology , vol.54 , pp. 900-909
    • Jiang, R.1    Tan, Z.2    Deng, L.3
  • 81
    • 25144507526 scopus 로고    scopus 로고
    • Interleukin 8 in human hepatocellular carcinoma correlates with cancer cell invasion of vessels but not with tumor angiogenesis
    • Kubo F, Ueno S, Hiwatashi K etal. Interleukin 8 in human hepatocellular carcinoma correlates with cancer cell invasion of vessels but not with tumor angiogenesis. Ann. Surg. Oncol. 2005; 12: 800-807.
    • (2005) Ann. Surg. Oncol. , vol.12 , pp. 800-807
    • Kubo, F.1    Ueno, S.2    Hiwatashi, K.3
  • 82
    • 84865138796 scopus 로고    scopus 로고
    • OV6(+) tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma
    • Yang W, Wang C, Lin Y etal. OV6(+) tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma. J. Hepatol. 2012; 57: 613-620.
    • (2012) J. Hepatol. , vol.57 , pp. 613-620
    • Yang, W.1    Wang, C.2    Lin, Y.3


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