Is interleukin-6 a gender-specific risk factor for liver cancer?

Hepatology

Volumn 46, Issue 4, 2007, Pages 1304-1305

  Sander, Leif E ^a   Trautwein, Christian ^a   Liedtke, Christian ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CARCINOGEN; DIETHYLNITROSAMINE; ESTROGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; SEX HORMONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CANCER GROWTH; CANCER RISK; CANCER SUSCEPTIBILITY; CELL PROLIFERATION; CELL SURVIVAL; CIRCULATION; CONTROLLED STUDY; DRUG INHIBITION; FEMALE; GENE MUTATION; GENETIC TRANSCRIPTION; HEPATITIS; KUPFFER CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER NECROSIS; MALE; MOUSE; NONHUMAN; NOTE; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENCE;

EID: 36349018388     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21982     Document Type: Note

References (9)

1. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132:2557-2576.
2. Giannitrapani L, Soresi M, La Spada E, Cervello M, D'Alessandro N, Montalto G. Sex hormones and risk of liver tumor. Ann N Y Acad Sci 2006;1089:228-236.
3. Kemp CJ, Leary CN, Drinkwater NR. Promotion of murine hepatocarcinogenesis by testosterone is androgen receptor-dependent but not cell autonomous. Proc Natl Acad Sci U S A 1989;86:7505-7509.
4. Nakatani T, Roy G, Fujimoto N, Asahara T, Ito A. Sex hormone dependency of diethylnitrosamine-induced liver tumors in mice and chemoprevention by leuprorelin. Jpn J Cancer Res 2001;92:249-256.
5. Lee JS, Chu IS, Mikaelyan A, Calvisi DF, Heo J, Reddy JK, et al. Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet 2004;36:1306-1311.
6. Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007;317:121-124.
7. Streetz KL, Tacke F, Leifeld L, Wustefeld T, Graw A, Klein C, et al. Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases. HEPATOLOGY 2003;38:218-229.
8. Wuestefeld T, Klein C, Streetz KL, Betz U, Lauber J, Buer J, et al. Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. J Biol Chem 2003;278:11281-11288.
9. Stein B, Yang MX. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol Cell Biol 1995;15:4971-4979.