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Volumn 9, Issue 8, 2013, Pages 955-968

Drug-induced hypo- and hyperprolactinemia: Mechanisms, clinical and therapeutic consequences

Author keywords

Anterior hypophysis; Antidepressants; Antipsychotics; Blood brain barrier; Dopamine D2 receptors; Hyperprolactinemia; LogBB; Therapeutic switching

Indexed keywords

AMISULPRIDE; ANTIDEPRESSANT AGENT; ANTIHYPERTENSIVE AGENT; ARIPIPRAZOLE; ATROPINE; BROMOCRIPTINE; CABERGOLINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; HALOPERIDOL; HISTAMINE H2 RECEPTOR ANTAGONIST; NALOXONE; NEUROLEPTIC AGENT; OLANZAPINE; OPIATE; PALIPERIDONE; PERGOLIDE; PHENOTHIAZINE; PROKINETIC AGENT; PROLACTIN; PROLACTIN RECEPTOR; RISPERIDONE; SEROTONIN ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; THIOXANTHENE DERIVATIVE; UNINDEXED DRUG; VERAPAMIL; XENOBIOTIC AGENT;

EID: 84880383383     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2013.791283     Document Type: Review
Times cited : (41)

References (108)
  • 1
    • 51149087719 scopus 로고    scopus 로고
    • Medical causes and consequences of hyperprolactinaemia. A context for psychiatrists
    • Holt RI. Medical causes and consequences of hyperprolactinaemia. A context for psychiatrists. J Psychopharmacol 2008;22:28-37
    • (2008) J Psychopharmacol , vol.22 , pp. 28-37
    • Holt, R.I.1
  • 2
    • 0036196827 scopus 로고    scopus 로고
    • Prolactin: The new biology of an old hormone
    • Goffin V, Binart N, Touraine P, et al. Prolactin: The new biology of an old hormone. Annu Rev Physiol 2002;64:47-67
    • (2002) Annu Rev Physiol , vol.64 , pp. 47-67
    • Goffin, V.1    Binart, N.2    Touraine, P.3
  • 3
    • 0029035666 scopus 로고
    • Structural variants of prolactin: Occurrence and physiological significance
    • Sinha YN. Structural variants of prolactin: Occurrence and physiological significance. Endocr Rev 1995;16(3):354-69
    • (1995) Endocr Rev , vol.16 , Issue.3 , pp. 354-369
    • Sinha, Y.N.1
  • 5
    • 0033771336 scopus 로고    scopus 로고
    • Prolactin: Structure, function, and regulation of secretion
    • Freeman ME, Kanyicska B, Lerant A, et al. Prolactin: Structure, function, and regulation of secretion. Physiol Rev 2000;80:1523-631
    • (2000) Physiol Rev , vol.80 , pp. 1523-1631
    • Freeman, M.E.1    Kanyicska, B.2    Lerant, A.3
  • 6
    • 0035721572 scopus 로고    scopus 로고
    • Dopamine as a prolactin (PRL) inhibitor
    • Ben-Jonathan N, Hnasko R. Dopamine as a prolactin (PRL) inhibitor. Endocr Rev 2001;22:724-63
    • (2001) Endocr Rev , vol.22 , pp. 724-763
    • Ben-Jonathan, N.1    Hnasko, R.2
  • 7
    • 84882923442 scopus 로고    scopus 로고
    • Prolactin and its neuroendocrine control
    • . In: Larry RS Editors. Academic Press, Oxford
    • Ben-Jonathan N, LaPensee CR. Prolactin and its neuroendocrine control. In: Larry RS, editors. Encyclopedia of Neuroscience. Academic Press, Oxford; 2009. 1125-31
    • (2009) Encyclopedia Of Neuroscience. , pp. 1125-1131
    • Ben-Jonathan, N.1    LaPensee, C.R.2
  • 8
    • 0020693317 scopus 로고
    • Hypoprolactinemic action of calcitonin and the tuberoinfundibular dopaminergic system
    • Clementi G, Nicoletti F, Patacchioli F, et al. Hypoprolactinemic action of calcitonin and the tuberoinfundibular dopaminergic system. J Neurochem 1983;40:885-6
    • (1983) J Neurochem , vol.40 , pp. 885-886
    • Clementi, G.1    Nicoletti, F.2    Patacchioli, F.3
  • 9
    • 0031756646 scopus 로고    scopus 로고
    • Endothelin is an autocrine regulator of prolactin secretion
    • Kanyicska B, Lerant A, Freeman ME. Endothelin is an autocrine regulator of prolactin secretion. Endocrinology 1998;139:5164-73
    • (1998) Endocrinology , vol.139 , pp. 5164-5173
    • Kanyicska, B.1    Lerant, A.2    Freeman, M.E.3
  • 10
    • 0024591346 scopus 로고
    • Biochemical and functional aspects on the control of prolactin release by the hypothalamo-pituitary GABAergic system
    • Apud JA, Cocchi D, Locatelli V, et al. Biochemical and functional aspects on the control of prolactin release by the hypothalamo-pituitary GABAergic system. Psychoneuroendocrinology 1989;14:3-17
    • (1989) Psychoneuroendocrinology , vol.14 , pp. 3-17
    • Apud, J.A.1    Cocchi, D.2    Locatelli, V.3
  • 11
    • 0019127678 scopus 로고
    • Characterization of muscarinic cholinergic receptors on intact rat anterior pituitary cells
    • Mukherjee A, Snyder G, McCann SM. Characterization of muscarinic cholinergic receptors on intact rat anterior pituitary cells. Life Sci 1980;27:475-82
    • (1980) Life Sci , vol.27 , pp. 475-482
    • Mukherjee, A.1    Snyder, G.2    McCann, S.M.3
  • 12
    • 0023678687 scopus 로고
    • Immunocytochemical and pharmacological evidence for an intrinsic cholinomimetic system modulating prolactin and growth hormone release in rat pituitary
    • Carmeliet P, Denef C. Immunocytochemical and pharmacological evidence for an intrinsic cholinomimetic system modulating prolactin and growth hormone release in rat pituitary. Endocrinology 1988;123:1128-39
    • (1988) Endocrinology , vol.123 , pp. 1128-1139
    • Carmeliet, P.1    Denef, C.2
  • 13
    • 59649112705 scopus 로고    scopus 로고
    • Estrogen receptor-alpha mediates the epidermal growth factor-stimulated prolactin expression and release in lactotrophs
    • Ben-Jonathan N, Chen S, Dunckley JA, et al. Estrogen receptor-alpha mediates the epidermal growth factor-stimulated prolactin expression and release in lactotrophs. Endocrinology 2009;150:795-802
    • (2009) Endocrinology , vol.150 , pp. 795-802
    • Ben-Jonathan, N.1    Chen, S.2    Dunckley, J.A.3
  • 14
    • 84865984323 scopus 로고    scopus 로고
    • Molecular mechanisms of prolactin and its receptor
    • Brooks CL. Molecular mechanisms of prolactin and its receptor. Endocr Rev 2012;33:504-25
    • (2012) Endocr Rev , vol.33 , pp. 504-525
    • Brooks, C.L.1
  • 15
    • 0022721745 scopus 로고
    • Structural features of prolactins and growth hormones that can be related to their biological properties
    • Nicoll CS, Mayer GL, Russell SM. Structural features of prolactins and growth hormones that can be related to their biological properties. Endocr Rev 1986;7:169-203
    • (1986) Endocr Rev , vol.7 , pp. 169-203
    • Nicoll, C.S.1    Mayer, G.L.2    Russell, S.M.3
  • 16
    • 0032460226 scopus 로고    scopus 로고
    • Prolactin (PRL) and its receptor: Actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice
    • Bole-Feysot C, Goffin V, Edery M, et al. Prolactin (PRL) and its receptor: Actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev 1998;19:225-68
    • (1998) Endocr Rev , vol.19 , pp. 225-268
    • Bole-Feysot, C.1    Goffin, V.2    Edery, M.3
  • 17
    • 3843145143 scopus 로고    scopus 로고
    • Prolactin acts as a potent survival factor for human breast cancer cell lines
    • Perks CM, Keith AJ, Goodhew KL, et al. Prolactin acts as a potent survival factor for human breast cancer cell lines. Br J Cancer 2004;91:305-11
    • (2004) Br J Cancer , vol.91 , pp. 305-311
    • Perks, C.M.1    Keith, A.J.2    Goodhew, K.L.3
  • 19
    • 0037338178 scopus 로고    scopus 로고
    • Antipsychotic-induced hyperprolactinaemia in women: Pathophysiology, severity and consequences. Selective literature review
    • Wieck A, Haddad PM. Antipsychotic-induced hyperprolactinaemia in women: Pathophysiology, severity and consequences. Selective literature review. Br J Psychiatry 2003;182:199-204
    • (2003) Br J Psychiatry , vol.182 , pp. 199-204
    • Wieck, A.1    Haddad, P.M.2
  • 20
    • 0027288417 scopus 로고
    • Curatively resected primary malignant melanoma of the esophagus: Report of a case
    • Haga Y, Iwanaga Y, Matsumura F, et al. Curatively resected primary malignant melanoma of the esophagus: Report of a case. Surg Today 1993;23:820-4
    • (1993) Surg Today , vol.23 , pp. 820-824
    • Haga, Y.1    Iwanaga, Y.2    Matsumura, F.3
  • 21
    • 69949181144 scopus 로고    scopus 로고
    • Schizophrenia and breast cancer incidence: A systematic review of clinical studies
    • Bushe CJ, Bradley AJ, Wildgust HJ, et al. Schizophrenia and breast cancer incidence: A systematic review of clinical studies. Schizophr Res 2009;114:6-16
    • (2009) Schizophr Res , vol.114 , pp. 6-16
    • Bushe, C.J.1    Bradley, A.J.2    Wildgust, H.J.3
  • 22
    • 77955923557 scopus 로고    scopus 로고
    • The risk for breast cancer is not evidently increased in women with hyperprolactinemia
    • Dekkers OM, Romijn JA, de Boer A, et al. The risk for breast cancer is not evidently increased in women with hyperprolactinemia. Pituitary 2010;13:195-8
    • (2010) Pituitary , vol.13 , pp. 195-198
    • Dekkers, O.M.1    Romijn, J.A.2    De Boer, A.3
  • 23
    • 0031904920 scopus 로고    scopus 로고
    • Sexual dysfunction: The unspoken side effect of antipsychotics
    • Peuskens J, Sienaert P, De Hert M. Sexual dysfunction: The unspoken side effect of antipsychotics. Eur Psychiatry 1998(13):23s-30s
    • (1998) Eur Psychiatry , vol.13
    • Peuskens, J.1    Sienaert, P.2    De Hert, M.3
  • 24
    • 3342908588 scopus 로고    scopus 로고
    • Gender differences in the prescribing of antipsychotic drugs
    • Seeman MV. Gender differences in the prescribing of antipsychotic drugs. Am J Psychiatry 2004;161:1324-33
    • (2004) Am J Psychiatry , Issue.161 , pp. 1324-1333
    • Seeman, M.V.1
  • 25
    • 63749097354 scopus 로고    scopus 로고
    • The effects of hyperprolactinemia on bone and fat
    • Shibli-Rahhal A, Schlechte J. The effects of hyperprolactinemia on bone and fat. Pituitary 2009;12:96-104
    • (2009) Pituitary , vol.12 , pp. 96-104
    • Shibli-Rahhal, A.1    Schlechte, J.2
  • 26
    • 33748441155 scopus 로고    scopus 로고
    • Hypoadiponectinemia in lean lactating women: Prolactin inhibits adiponectin secretion from human adipocytes
    • Asai-Sato M, Okamoto M, Endo M, et al. Hypoadiponectinemia in lean lactating women: Prolactin inhibits adiponectin secretion from human adipocytes. Endocr J 2006;53:555-62
    • (2006) Endocr J , vol.53 , pp. 555-562
    • Asai-Sato, M.1    Okamoto, M.2    Endo, M.3
  • 27
    • 72149086675 scopus 로고    scopus 로고
    • Facteurs prédictifs de la survenue du stress post-traumatique chez des individus ayant vécu deux évenements de vie majeurs (tremblement de terre et terrorisme en Algérie): Réponse corticotrope et prolactinique a une faible dose de dexaméthasone (0.50 mg)
    • Frih H, Sahraoui L, Frih N, et al. Facteurs prédictifs de la survenue du stress post-traumatique chez des individus ayant vécu deux évenements de vie majeurs (tremblement de terre et terrorisme en Algérie): Réponse corticotrope et prolactinique a une faible dose de dexaméthasone (0.50 mg). L'É volution Psychiatrique 2009;74:581-91
    • (2009) L'É volution Psychiatrique , vol.74 , pp. 581-591
    • Frih, H.1    Sahraoui, L.2    Frih, N.3
  • 28
    • 33751330400 scopus 로고    scopus 로고
    • HPA- and HPT-axis alterations in chronic posttraumatic stress disorder
    • Olff M, Guzelcan Y, de Vries GJ, et al. HPA- and HPT-axis alterations in chronic posttraumatic stress disorder. Psychoneuroendocrinology 2006;31:1220-30
    • (2006) Psychoneuroendocrinology , vol.31 , pp. 1220-1230
    • Olff, M.1    Guzelcan, Y.2    De Vries, G.J.3
  • 29
    • 0345688684 scopus 로고    scopus 로고
    • Prolactin, psychological stress and environment in humans: Adaptation and maladaptation
    • Sobrinho LG. Prolactin, psychological stress and environment in humans: Adaptation and maladaptation. Pituitary 2003;6:35-9
    • (2003) Pituitary , vol.6 , pp. 35-39
    • Sobrinho, L.G.1
  • 30
    • 27144486599 scopus 로고    scopus 로고
    • Increased pituitary volume in antipsychotic-free and antipsychotic- treated patients of the AEsop first-onset psychosis study
    • Pariante CM, Dazzan P, Danese A, et al. Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the AEsop first-onset psychosis study. Neuropsychopharmacology 2005;30:1923-31
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1923-1931
    • Pariante, C.M.1    Dazzan, P.2    Danese, A.3
  • 31
    • 1942467897 scopus 로고    scopus 로고
    • From galactorrhea to osteopenia: Rethinking serotonin-prolactin interactions
    • Emiliano AB, Fudge JL. From galactorrhea to osteopenia: Rethinking serotonin-prolactin interactions. Neuropsychopharmacology 2004;29:833-46
    • (2004) Neuropsychopharmacology , vol.29 , pp. 833-846
    • Emiliano, A.B.1    Fudge, J.L.2
  • 32
    • 0024545674 scopus 로고
    • The natural history of untreated hyperprolactinemia: A prospective analysis
    • Schlechte J, Dolan K, Sherman B, et al. The natural history of untreated hyperprolactinemia: A prospective analysis. J Clin Endocrinol Metab 1989;68:412-18
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 412-418
    • Schlechte, J.1    Dolan, K.2    Sherman, B.3
  • 33
    • 84861307668 scopus 로고    scopus 로고
    • Strategies for the treatment of antipsychotic-induced sexual dysfunction and/or hyperprolactinemia among patients of the schizophrenia spectrum: A review
    • Nunes LV, Moreira HC, Razzouk D, et al. Strategies for the treatment of antipsychotic-induced sexual dysfunction and/or hyperprolactinemia among patients of the schizophrenia spectrum: A review. J Sex Marital Ther 2012;38:281-301
    • (2012) J Sex Marital Ther , vol.38 , pp. 281-301
    • Nunes, L.V.1    Moreira, H.C.2    Razzouk, D.3
  • 34
    • 56449093569 scopus 로고    scopus 로고
    • Time course of the changes in antipsychotic-induced hyperprolactinemia following the switch to aripiprazole
    • Lu ML, Shen WW, Chen CH. Time course of the changes in antipsychotic-induced hyperprolactinemia following the switch to aripiprazole. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1978-81
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 1978-1981
    • Lu, M.L.1    Shen, W.W.2    Chen, C.H.3
  • 35
    • 33746514504 scopus 로고    scopus 로고
    • Hyperprolactinaemia as an adverse effect in regulatory and clinical toxicology: Role in breast and prostate cancer
    • Harvey PW, Everett DJ, Springall CJ. Hyperprolactinaemia as an adverse effect in regulatory and clinical toxicology: Role in breast and prostate cancer. Hum Exp Toxicol 2006;25:395-404
    • (2006) Hum Exp Toxicol , vol.25 , pp. 395-404
    • Harvey, P.W.1    Everett, D.J.2    Springall, C.J.3
  • 36
    • 33847157949 scopus 로고    scopus 로고
    • Sexual problems in patients on antipsychotic medication
    • Murthy S, Wylie KR. Sexual problems in patients on antipsychotic medication. Sex Relationship Ther 2007;22:97-107
    • (2007) Sex Relationship Ther , vol.22 , pp. 97-107
    • Murthy, S.1    Wylie, K.R.2
  • 37
    • 84859214561 scopus 로고    scopus 로고
    • New insights on the consequences of biotransformation processes on the distribution and pharmacodynamic profiles of some neuropsychotropic drugs
    • Voicu VA, de Leon J, Medvedovici AV, et al. New insights on the consequences of biotransformation processes on the distribution and pharmacodynamic profiles of some neuropsychotropic drugs. Eur Neuropsychopharmacol 2012;22:319-29
    • (2012) Eur Neuropsychopharmacol , vol.22 , pp. 319-329
    • Voicu, V.A.1    De Leon, J.2    Medvedovici, A.V.3
  • 38
    • 62649083604 scopus 로고    scopus 로고
    • An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment
    • Friberg LE, Vermeulen AM, Petersson KJ, et al. An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment. Clin Pharmacol Ther 2009;85:409-17
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 409-417
    • Friberg, L.E.1    Vermeulen, A.M.2    Petersson, K.J.3
  • 39
    • 84870057403 scopus 로고    scopus 로고
    • Pharmacological treatment of schizophrenia: A critical review of the pharmacology and clinical effects of current and future therapeutic agents
    • Miyamoto S, Miyake N, Jarskog LF, et al. Pharmacological treatment of schizophrenia: A critical review of the pharmacology and clinical effects of current and future therapeutic agents. Mol Psychiatry 2012;17:1206-27
    • (2012) Mol Psychiatry , vol.17 , pp. 1206-1227
    • Miyamoto, S.1    Miyake, N.2    Jarskog, L.F.3
  • 40
    • 73949137552 scopus 로고    scopus 로고
    • Schizophrenia port psychopharmacological treatment recommendations and summary statements
    • Buchanan RW, Kreyenbuhl J, Kelly DL, et al. The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements. Schizophr Bull 2010;36:71-93
    • (2009) Schizophr Bull , vol.36 , pp. 71-93
    • Buchanan, R.W.1    Kreyenbuhl, J.2    Kelly, D.L.3
  • 41
    • 79955589132 scopus 로고    scopus 로고
    • Sexual dysfunction in first-episode schizophrenia patients: Results from European First Episode Schizophrenia Trial
    • Malik P, Kemmler G, Hummer M, et al. Sexual dysfunction in first-episode schizophrenia patients: Results from European First Episode Schizophrenia Trial. J Clin Psychopharmacol 2011;31:274-80
    • (2011) J Clin Psychopharmacol , vol.31 , pp. 274-280
    • Malik, P.1    Kemmler, G.2    Hummer, M.3
  • 42
    • 69549086733 scopus 로고    scopus 로고
    • Antipsychotic medication in children and adolescents: A descriptive review of the effects on prolactin level and associated side effects
    • Roke Y, van Harten PN, Boot AM, et al. Antipsychotic medication in children and adolescents: A descriptive review of the effects on prolactin level and associated side effects. J Child Adolesc Psychopharmacol 2009;19:403-14
    • (2009) J Child Adolesc Psychopharmacol , vol.19 , pp. 403-414
    • Roke, Y.1    Van Harten, P.N.2    Boot, A.M.3
  • 43
    • 35048827065 scopus 로고    scopus 로고
    • Adverse effects of atypical antipsychotics: Differential risk and clinical implications
    • Haddad PM, Sharma SG. Adverse effects of atypical antipsychotics: Differential risk and clinical implications. CNS Drugs 2007;21:911-36
    • (2007) CNS Drugs , vol.21 , pp. 911-936
    • Haddad, P.M.1    Sharma, S.G.2
  • 44
    • 33846562907 scopus 로고    scopus 로고
    • Effects of short- and long-term risperidone treatment on prolactin levels in children with autism
    • Anderson GM, Scahill L, McCracken JT, et al. Effects of short- and long-term risperidone treatment on prolactin levels in children with autism. Biol Psychiatry 2007;61:545-50
    • (2007) Biol Psychiatry , vol.61 , pp. 545-550
    • Anderson, G.M.1    Scahill, L.2    McCracken, J.T.3
  • 45
    • 0344119561 scopus 로고    scopus 로고
    • Prolactin levels during long-term risperidone treatment in children and adolescents
    • Findling RL, Kusumakar V, Daneman D, et al. Prolactin levels during long-term risperidone treatment in children and adolescents. J Clin Psychiatry 2003;64:1362-9
    • (2003) J Clin Psychiatry , vol.64 , pp. 1362-1369
    • Findling, R.L.1    Kusumakar, V.2    Daneman, D.3
  • 46
    • 0036036523 scopus 로고    scopus 로고
    • Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levels
    • Schlosser R, Grunder G, Anghelescu I, et al. Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levels. Neuropsychobiology 2002;46:33-40
    • (2002) Neuropsychobiology , vol.46 , pp. 33-40
    • Schlosser, R.1    Grunder, G.2    Anghelescu, I.3
  • 47
    • 51149108773 scopus 로고    scopus 로고
    • Prolactin and dopamine: What is the connection? A review article
    • Fitzgerald P, Dinan TG. Prolactin and dopamine: What is the connection? A review article. J Psychopharmacol 2008;22:12-19
    • (2008) J Psychopharmacol , vol.22 , pp. 12-19
    • Fitzgerald, P.1    Dinan, T.G.2
  • 48
    • 79960416887 scopus 로고    scopus 로고
    • A novel approach on pharmacokinetic/pharmacodynamic correlations of risperidone: Understanding its safety and efficacy profiles
    • Voicu VA, Medvedovici AV, Miron DS, et al. A novel approach on pharmacokinetic/pharmacodynamic correlations of risperidone: Understanding its safety and efficacy profiles. Acta Endocrinologica (Buc)2010;6:265-85
    • (2010) Acta Endocrinologica (Buc , vol.6 , pp. 265-285
    • Voicu, V.A.1    Medvedovici, A.V.2    Miron, D.S.3
  • 49
    • 33747344749 scopus 로고    scopus 로고
    • Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: Comparing aripiprazole to other antipsychotics in animal models
    • Natesan S, Reckless GE, Nobrega JN, et al. Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: Comparing aripiprazole to other antipsychotics in animal models. Neuropsychopharmacology 2006;31:1854-63
    • (2006) Neuropsychopharmacology , vol.31 , pp. 1854-1863
    • Natesan, S.1    Reckless, G.E.2    Nobrega, J.N.3
  • 50
    • 0035953319 scopus 로고    scopus 로고
    • Property-based design: Optimization of drug absorption and pharmacokinetics
    • van de Waterbeemd H, Smith DA, Beaumont K, et al. Property-based design: Optimization of drug absorption and pharmacokinetics. J Med Chem 2001;44:1313-33
    • (2001) J Med Chem , vol.44 , pp. 1313-1333
    • Van De Waterbeemd, H.1    Smith, D.A.2    Beaumont, K.3
  • 52
    • 40949155240 scopus 로고    scopus 로고
    • Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia
    • Arakawa R, Ito H, Takano A, et al. Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia. Psychopharmacology (Berl)2008;197:229-35
    • (2008) Psychopharmacology (Berl , vol.197 , pp. 229-235
    • Arakawa, R.1    Ito, H.2    Takano, A.3
  • 53
    • 41249090837 scopus 로고    scopus 로고
    • Using pharmacokineticpharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics
    • Olsen CK, Brennum LT, Kreilgaard M. Using pharmacokineticpharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics. Eur J Pharmacol 2008;584:318-27
    • (2008) Eur J Pharmacol , vol.584 , pp. 318-327
    • Olsen, C.K.1    Brennum, L.T.2    Kreilgaard, M.3
  • 54
    • 46749152924 scopus 로고    scopus 로고
    • QSAR modeling of the blood-brain barrier permeability for diverse organic compounds
    • Zhang L, Zhu H, Oprea TI, et al. QSAR modeling of the blood-brain barrier permeability for diverse organic compounds. Pharm Res 2008;25:1902-14
    • (2008) Pharm Res , vol.25 , pp. 1902-1914
    • Zhang, L.1    Zhu, H.2    Oprea, T.I.3
  • 55
    • 0032714220 scopus 로고    scopus 로고
    • Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs
    • Kelder J, Grootenhuis PJ, Bayada D, et al. Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs. Pharm Res 1999;16:1514-19
    • (1999) Pharm Res , vol.16 , pp. 1514-1519
    • Kelder, J.1    Grootenhuis, P.J.2    Bayada, D.3
  • 56
    • 0023159769 scopus 로고
    • Blood to brain distribution of neuroleptics
    • Sunderland T, Cohen BM. Blood to brain distribution of neuroleptics. Psychiatry Res 1987;20:299-305
    • (1987) Psychiatry Res , vol.20 , pp. 299-305
    • Sunderland, T.1    Cohen, B.M.2
  • 57
    • 0022523340 scopus 로고
    • Domperidone, a new dopamine antagonist
    • Champion MC, Hartnett M, Yen M. Domperidone, a new dopamine antagonist. CMAJ 1986;135:457-61
    • (1986) CMAJ , vol.135 , pp. 457-461
    • Champion, M.C.1    Hartnett, M.2    Yen, M.3
  • 58
    • 0020669706 scopus 로고
    • The GI drug column. Subcommittee on FDA related matters, American College of Gastroenterology
    • Friedman G. The GI drug column. Subcommittee on FDA related matters, American College of Gastroenterology. Am J Gastroenterol 1983;78:47-8
    • (1983) Am J Gastroenterol , vol.78 , pp. 47-48
    • Friedman, G.1
  • 59
    • 34548139349 scopus 로고    scopus 로고
    • Domperidone: Review of pharmacology and clinical applications in gastroenterology
    • Reddymasu SC, Soykan I, McCallum RW. Domperidone: Review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol 2007;102:2036-45
    • (2007) Am J Gastroenterol , vol.102 , pp. 2036-2045
    • Reddymasu, S.C.1    Soykan, I.2    McCallum, R.W.3
  • 60
    • 34547633657 scopus 로고    scopus 로고
    • Brain drug development and brain drug targeting
    • Pardridge WM. Brain drug development and brain drug targeting. Pharm Res 2007;24:1729-32
    • (2007) Pharm Res , vol.24 , pp. 1729-1732
    • Pardridge, W.M.1
  • 61
    • 26444441486 scopus 로고    scopus 로고
    • An update of fast-off dopamine D2 atypical antipsychotics
    • Seeman P. An update of fast-off dopamine D2 atypical antipsychotics. Am J Psychiatry 2005;162:1984-5
    • (2005) Am J Psychiatry , vol.162 , pp. 1984-1985
    • Seeman, P.1
  • 62
    • 0028580136 scopus 로고
    • Acute antagonism of dopamine D2-like receptors by amisulpride: Effects on hormone secretion in healthy volunteers
    • Wetzel H, Wiesner J, Hiemke C, et al. Acute antagonism of dopamine D2-like receptors by amisulpride: Effects on hormone secretion in healthy volunteers. J Psychiatr Res 1994;28:461-73
    • (1994) J Psychiatr Res , vol.28 , pp. 461-473
    • Wetzel, H.1    Wiesner, J.2    Hiemke, C.3
  • 63
    • 38349155532 scopus 로고    scopus 로고
    • Relationship between prolactin secretion, and plasma risperidone and 9-hydroxyrisperidone concentrations in adolescents with schizophreniform disorder
    • Duval F, Guillon MS, Mokrani MC, et al. Relationship between prolactin secretion, and plasma risperidone and 9-hydroxyrisperidone concentrations in adolescents with schizophreniform disorder. Psychoneuroendocrinology 2008;33:255-9
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 255-259
    • Duval, F.1    Guillon, M.S.2    Mokrani, M.C.3
  • 64
    • 33846316741 scopus 로고    scopus 로고
    • Amisulpride-induced hyperprolactinaemia is not reversed by addition of aripiprazole
    • Paulzen M, Grunder G. Amisulpride-induced hyperprolactinaemia is not reversed by addition of aripiprazole. Int J Neuropsychopharmacol 2007;10:149-51
    • (2007) Int J Neuropsychopharmacol , vol.10 , pp. 149-151
    • Paulzen, M.1    Grunder, G.2
  • 65
    • 39149124458 scopus 로고    scopus 로고
    • Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in mice
    • Kirschbaum KM, Henken S, Hiemke C, et al. Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in mice. Behav Brain Res 2008;188:298-303
    • (2008) Behav Brain Res , vol.188 , pp. 298-303
    • Kirschbaum, K.M.1    Henken, S.2    Hiemke, C.3
  • 66
    • 4344701123 scopus 로고    scopus 로고
    • Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds - implications for pharmacokinetics of selected substrates
    • El Ela AA, Hartter S, Schmitt U, et al. Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds - implications for pharmacokinetics of selected substrates. J Pharm Pharmacol 2004;56:967-75
    • (2004) J Pharm Pharmacol , vol.56 , pp. 967-975
    • El Ela, A.A.1    Hartter, S.2    Schmitt, U.3
  • 67
    • 84861674275 scopus 로고    scopus 로고
    • In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes
    • Schmitt U, Kirschbaum KM, Poller B, et al. In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes. Pharmacol Biochem Behav 2012;102:312-20
    • (2012) Pharmacol Biochem Behav , vol.102 , pp. 312-320
    • Schmitt, U.1    Kirschbaum, K.M.2    Poller, B.3
  • 68
    • 19944425121 scopus 로고    scopus 로고
    • The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model
    • Doran A, Obach RS, Smith BJ, et al. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 2005;33:165-74
    • (2005) Drug Metab Dispos , vol.33 , pp. 165-174
    • Doran, A.1    Obach, R.S.2    Smith, B.J.3
  • 69
    • 77956896838 scopus 로고    scopus 로고
    • Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice
    • Kirschbaum KM, Uhr M, Holthoewer D, et al. Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice. Neuropharmacology 2010;59:474-9
    • (2010) Neuropharmacology , vol.59 , pp. 474-479
    • Kirschbaum, K.M.1    Uhr, M.2    Holthoewer, D.3
  • 70
    • 33745491975 scopus 로고    scopus 로고
    • Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp)
    • Schmitt U, Abou El-Ela A, Guo LJ, et al. Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp). J Neural Transm 2006;113:787-801
    • (2006) J Neural Transm , vol.113 , pp. 787-801
    • Schmitt, U.1    Abou El-Ela, A.2    Guo, L.J.3
  • 71
    • 72149090641 scopus 로고    scopus 로고
    • Metabolic side effects of antipsychotic drug treatment-pharmacological mechanisms
    • Reynolds GP, Kirk SL. Metabolic side effects of antipsychotic drug treatment-pharmacological mechanisms. Pharmacol Ther 2010;125(1):169-79
    • (2010) Pharmacol Ther , vol.125 , Issue.1 , pp. 169-179
    • Reynolds, G.P.1    Kirk, S.L.2
  • 72
    • 84874758413 scopus 로고    scopus 로고
    • Available From: Pdsp.med.unc.eduindexR.html [Last Accessed 4 January 2013]
    • Psychoactive Drug Screening Program. Available from: Pdsp.med.unc.edu/ indexR.html [Last accessed 4 January 2013]
    • Psychoactive Drug Screening Program
  • 73
    • 45749088608 scopus 로고    scopus 로고
    • Prolactin-related and metabolic adverse effects of atypical antipsychotic agents
    • Henderson DC, Doraiswamy PM. Prolactin-related and metabolic adverse effects of atypical antipsychotic agents. J Clin Psychiatry 2008;69:32-44
    • (2008) J Clin Psychiatry , vol.69 , pp. 32-44
    • Henderson, D.C.1    Doraiswamy, P.M.2
  • 74
    • 0031953450 scopus 로고    scopus 로고
    • Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors
    • Seeman P, Tallerico T. Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Mol Psychiatry 1998;3:123-34
    • (1998) Mol Psychiatry , vol.3 , pp. 123-134
    • Seeman, P.1    Tallerico, T.2
  • 75
    • 0036127024 scopus 로고    scopus 로고
    • Prolactin elevation with antipsychotic medications: Mechanisms of action and clinical consequences
    • Maguire GA. Prolactin elevation with antipsychotic medications: Mechanisms of action and clinical consequences. J Clin Psychiatry 2002;63:56-62
    • (2002) J Clin Psychiatry , vol.63 , pp. 56-62
    • Maguire, G.A.1
  • 76
    • 33746320121 scopus 로고    scopus 로고
    • Tardive dyskinesia in schizophrenia is associated with prolactin-related sexual disturbances
    • Tenback DE, van Harten PN, Slooff CJ, et al. Tardive dyskinesia in schizophrenia is associated with prolactin-related sexual disturbances. Neuropsychopharmacology 2006;31:1832-7
    • (2006) Neuropsychopharmacology , vol.31 , pp. 1832-1837
    • Tenback, D.E.1    Van Harten, P.N.2    Slooff, C.J.3
  • 77
    • 0029112299 scopus 로고
    • Coherent view of non-Hodgkin's lymphoma
    • Aisenberg AC. Coherent view of non-Hodgkin's lymphoma. J Clin Oncol 1995;13:2656-75
    • (1995) J Clin Oncol , vol.13 , pp. 2656-2675
    • Aisenberg, A.C.1
  • 80
    • 34347370652 scopus 로고    scopus 로고
    • Reducing the burden of side effects during long-term antipsychotic therapy: The role of switching medications
    • Weiden PJ, Buckley PF. Reducing the burden of side effects during long-term antipsychotic therapy: The role of "switching" medications. J Clin Psychiatry 2007;68:14-23
    • (2007) J Clin Psychiatry , vol.68 , pp. 14-23
    • Weiden, P.J.1    Buckley, P.F.2
  • 81
    • 68149160037 scopus 로고    scopus 로고
    • Oral antipsychotics for the treatment of schizophrenia: Heterogeneity in efficacy and tolerability should drive decision-making
    • Volavka J, Citrome L. Oral antipsychotics for the treatment of schizophrenia: Heterogeneity in efficacy and tolerability should drive decision-making. Expert Opin Pharmacother 2009;10:1917-28
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 1917-1928
    • Volavka, J.1    Citrome, L.2
  • 82
    • 84874607585 scopus 로고    scopus 로고
    • Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: A randomized, 6-week, open-label study
    • McEvoy JP, Citrome L, Hernandez D, et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: A randomized, 6-week, open-label study. J Clin Psychiatry 2013;74(2):170-9
    • (2013) J Clin Psychiatry , vol.74 , Issue.2 , pp. 170-179
    • McEvoy, J.P.1    Citrome, L.2    Hernandez, D.3
  • 83
    • 34648833682 scopus 로고    scopus 로고
    • Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic-induced hyperprolactinemia: A placebo-controlled trial
    • Shim JC, Shin JG, Kelly DL, et al. Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic-induced hyperprolactinemia: A placebo-controlled trial. Am J Psychiatry 2007;164:1404-10
    • (2007) Am J Psychiatry , vol.164 , pp. 1404-1410
    • Shim, J.C.1    Shin, J.G.2    Kelly, D.L.3
  • 84
    • 36448964190 scopus 로고    scopus 로고
    • Pharmacological causes of hyperprolactinemia
    • Torre DL, Falorni A. Pharmacological causes of hyperprolactinemia. Ther Clin Risk Manag 2007;3:929-51
    • (2007) Ther Clin Risk Manag , vol.3 , pp. 929-951
    • Torre, D.L.1    Falorni, A.2
  • 85
    • 23344432626 scopus 로고    scopus 로고
    • Reversal of symptomatic hyperprolactinemia by aripiprazole
    • Wahl R, Ostroff R. Reversal of symptomatic hyperprolactinemia by aripiprazole. Am J Psychiatry 2005;162:1542-3
    • (2005) Am J Psychiatry , vol.162 , pp. 1542-1543
    • Wahl, R.1    Ostroff, R.2
  • 86
    • 84872007897 scopus 로고    scopus 로고
    • Aripiprazole reverses Paliperidone induced hyperprolactinemia
    • Basterreche N, Zumarraga M, Arrue A, et al. Aripiprazole reverses Paliperidone induced hyperprolactinemia. Actas Esp Psiquiatr 2012;40:290-2
    • (2012) Actas Esp Psiquiatr , vol.40 , pp. 290-292
    • Basterreche, N.1    Zumarraga, M.2    Arrue, A.3
  • 87
    • 45349099523 scopus 로고    scopus 로고
    • Change in sexual dysfunction with aripiprazole: A switching or add-on study
    • Mir A, Shivakumar K, Williamson RJ, et al. Change in sexual dysfunction with aripiprazole: A switching or add-on study. J Psychopharmacol 2008;22:244-53
    • (2008) J Psychopharmacol , vol.22 , pp. 244-253
    • Mir, A.1    Shivakumar, K.2    Williamson, R.J.3
  • 88
    • 4444350507 scopus 로고    scopus 로고
    • Management of hyperprolactinemia in patients receiving antipsychotics
    • Miller KK. Management of hyperprolactinemia in patients receiving antipsychotics. CNS Spectr 2004;9:28-32
    • (2004) CNS Spectr , vol.9 , pp. 28-32
    • Miller, K.K.1
  • 89
    • 69249142661 scopus 로고    scopus 로고
    • Evidence for the partial dopamine-receptor agonist aripiprazole as a first-line treatment of psychosis in patients with iatrogenic or tumorigenic hyperprolactinemia
    • Hoffer ZS, Roth RL, Mathews M. Evidence for the partial dopamine-receptor agonist aripiprazole as a first-line treatment of psychosis in patients with iatrogenic or tumorigenic hyperprolactinemia. Psychosomatics 2009;50:317-24
    • (2009) Psychosomatics , vol.50 , pp. 317-324
    • Hoffer, Z.S.1    Roth, R.L.2    Mathews, M.3
  • 90
    • 80053895923 scopus 로고    scopus 로고
    • Cabergoline versus bromocriptine in the treatment of hyperprolactinemia: A systematic review of randomized controlled trials and meta-analysis
    • dos Santos Nunes V, El Dib R, Boguszewski CL, et al. Cabergoline versus bromocriptine in the treatment of hyperprolactinemia: A systematic review of randomized controlled trials and meta-analysis. Pituitary 2011;14:259-65
    • (2011) Pituitary , vol.14 , pp. 259-265
    • Dos Santos Nunes, V.1    El Dib, R.2    Boguszewski, C.L.3
  • 91
    • 84875772322 scopus 로고    scopus 로고
    • Treatment of hyperprolactinemia: A systematic review and meta-analysis
    • Published Online 24 July 2012 doi:10.1186/2046-4053-1-33
    • Wang AT, Mullan RJ, Lane MA, et al. Treatment of hyperprolactinemia: A systematic review and meta-analysis. Syst Rev 2012; published online 24 July 2012; doi:10.1186/2046-4053-1-33
    • (2012) Syst Rev
    • Wang, A.T.1    Mullan, R.J.2    Lane, M.A.3
  • 92
    • 80053138418 scopus 로고    scopus 로고
    • Physical illness in patients with severe mental disorders. II. Barriers to care, monitoring and treatment guidelines, plus recommendations at the system and individual level
    • De Hert M, Cohen D, Bobes J, et al. Physical illness in patients with severe mental disorders. II. Barriers to care, monitoring and treatment guidelines, plus recommendations at the system and individual level. World Psychiatry 2011;10:138-51
    • (2011) World Psychiatry , vol.10 , pp. 138-151
    • De Hert, M.1    Cohen, D.2    Bobes, J.3
  • 93
    • 79952395209 scopus 로고    scopus 로고
    • Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care
    • De Hert M, Correll CU, Bobes J, et al. Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care. World Psychiatry 2011;10:52-77
    • (2011) World Psychiatry , vol.10 , pp. 52-77
    • De Hert, M.1    Correll, C.U.2    Bobes, J.3
  • 94
    • 75749112923 scopus 로고    scopus 로고
    • A pilot study to determine a prolactin threshold that identifies improved sexual functioning when switching from a prolactin-elevating to a prolactin-neutral antipsychotic
    • Byerly M, Nakonezny P. A pilot study to determine a prolactin threshold that identifies improved sexual functioning when switching from a prolactin-elevating to a prolactin-neutral antipsychotic. Clin Schizophrenia Related Psychoses 2010;3:209-16
    • (2010) Clin Schizophrenia Related Psychoses , vol.3 , pp. 209-216
    • Byerly, M.1    Nakonezny, P.2
  • 95
    • 33745301687 scopus 로고    scopus 로고
    • Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents
    • Correll CU, Carlson HE. Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents. J Am Acad Child Adolesc Psychiatry 2006;45:771-91
    • (2006) J Am Acad Child Adolesc Psychiatry , vol.45 , pp. 771-791
    • Correll, C.U.1    Carlson, H.E.2
  • 97
    • 1442332132 scopus 로고    scopus 로고
    • Worsened agitation with aripiprazole adverse effect of dopamine partial agonism?
    • DeQuardo Jr. Worsened agitation with aripiprazole: Adverse effect of dopamine partial agonism? J Clin Psychiatry 2004;65:132-3
    • (2004) J Clin Psychiatry , vol.65 , pp. 132-133
    • DeQuardo, J.R.1
  • 99
    • 36348931627 scopus 로고    scopus 로고
    • Worsened agitation and confusion in schizophrenia subsequent to high-dose aripiprazole
    • Thone J. Worsened agitation and confusion in schizophrenia subsequent to high-dose aripiprazole. J Neuropsychiatry Clin Neurosci 2007;19:481-2
    • (2007) J Neuropsychiatry Clin Neurosci , vol.19 , pp. 481-482
    • Thone, J.1
  • 100
    • 77953545947 scopus 로고    scopus 로고
    • Aripiprazole-induced behavioural disturbance related to impulse control in a clinical setting
    • Kodama M, Hamamura T. Aripiprazole-induced behavioural disturbance related to impulse control in a clinical setting. Int J Neuropsychopharmacol 2010;13:549-51
    • (2010) Int J Neuropsychopharmacol , vol.13 , pp. 549-551
    • Kodama, M.1    Hamamura, T.2
  • 101
    • 62249199785 scopus 로고    scopus 로고
    • Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors
    • Tadori Y, Forbes RA, McQuade RD, et al. Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors. Eur J Pharmacol 2009;607:35-40
    • (2009) Eur J Pharmacol , vol.607 , pp. 35-40
    • Tadori, Y.1    Forbes, R.A.2    McQuade, R.D.3
  • 102
    • 0025371994 scopus 로고
    • Neuroleptic-induced supersensitivity psychosis in patients with bipolar affective disorder
    • Steiner W, Laporta M, Chouinard G. Neuroleptic-induced supersensitivity psychosis in patients with bipolar affective disorder. Acta Psychiatr Scand 1990;81:437-40
    • (1990) Acta Psychiatr Scand , vol.81 , pp. 437-440
    • Steiner, W.1    Laporta, M.2    Chouinard, G.3
  • 103
    • 17144366945 scopus 로고    scopus 로고
    • Partial agonists in schizophrenia
    • Cousins DA, Young AH. Partial agonists in schizophrenia. Br J Psychiatry 2005;186:354
    • (2005) Br J Psychiatry , vol.186 , pp. 354
    • Cousins, D.A.1    Young, A.H.2
  • 104
    • 0036721406 scopus 로고    scopus 로고
    • The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood-brain disposition: A pharmacological analysis in rats
    • Kapur S, Langlois X, Vinken P, et al. The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood-brain disposition: A pharmacological analysis in rats. J Pharmacol Exp Ther 2002;302:1129-34
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 1129-1134
    • Kapur, S.1    Langlois, X.2    Vinken, P.3
  • 105
    • 23244440715 scopus 로고    scopus 로고
    • Medication-induced hyperprolactinemia
    • Molitch ME. Medication-induced hyperprolactinemia. Mayo Clin Proc 2005;80:1050-7
    • (2005) Mayo Clin Proc , vol.80 , pp. 1050-1057
    • Molitch, M.E.1
  • 106
    • 43049178224 scopus 로고    scopus 로고
    • Drugs and prolactin
    • Molitch ME. Drugs and prolactin. Pituitary 2008;11:209-18
    • (2008) Pituitary , vol.11 , pp. 209-218
    • Molitch, M.E.1
  • 107
  • 108
    • 34447272429 scopus 로고    scopus 로고
    • Estrous cycle-dependent histology and review of sex steroid receptor expression in dog reproductive tissues and mammary gland and associated hormone levels
    • Rehm S, Stanislaus DJ, Williams AM. Estrous cycle-dependent histology and review of sex steroid receptor expression in dog reproductive tissues and mammary gland and associated hormone levels. Birth Defects Res B Dev Reprod Toxicol 2007;80:233-45
    • (2007) Birth Defects Res B Dev Reprod Toxicol , vol.80 , pp. 233-245
    • Rehm, S.1    Stanislaus, D.J.2    Williams, A.M.3


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