A pilot study to determine a prolactin threshold that identifies improved sexual functioning when switching from a prolactin-elevating to a prolactin-neutral antipsychotic

Clinical Schizophrenia and Related Psychoses

Volumn 3, Issue 4, 2010, Pages 209-216

  Byerly, Matthew J ^a   Nakonezny, Paul A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Antipsychotic; Endocrine; Neuroendocrine; Side Effect

Indexed keywords

ANTIDEPRESSANT AGENT; PROLACTIN; QUETIAPINE; RISPERIDONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SUBSTITUTION; DRUG WITHDRAWAL; HUMAN; MALE; OPEN STUDY; OUTPATIENT; PILOT STUDY; PROLACTIN BLOOD LEVEL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SEXUAL DYSFUNCTION; SEXUALITY; SIDE EFFECT;

EID: 75749112923     PISSN: 19351232     EISSN: None     Source Type: Journal    
DOI: 10.3371/CSRP.3.4.3     Document Type: Article

References (19)

1. Kelly DL, Conley RR. Sexuality and schizophrenia: a review. Schizophr Bull 2004;30(4): 767-779.
2. Cutler AJ. Sexual dysfunction and antipsychotic treatment. Psychoneuroendocrinology 2003;28(Suppl 1):69-82.
3. Ghadirian AM, Chouinard G, Annable L. Sexual dysfunction and plasma prolactin levels in neuroleptic-treated schizophrenic outpatients. J Nerv Ment Dis 1982;170(8):463-467.
4. Nakonezny PA, Byerly MJ, Rush AJ. The relationship between serum prolactin level and sexual functioning among male outpatients with schizophrenia or schizoaffective disorder: a randomized double-blind trial of risperidone vs. quetiapine. J Sex Marital Ther 2007;33(3):203-216.
5. Knegtering H, Van Der Moolen AE, Castelein S, Kluiter H, Van Den Bosch RJ. What are the effects of antipsychotics on sexual dysfunctions and endocrine functioning? Psychoneuroendocrinology 2003;28(Suppl 2):109-123.
6. Knegtering R, Castelein S, Bous H, Van Der Linde J, Bruggeman R, Kluiter H, et al.. A randomized open-label study of the impact of quetiapine versus risperidone on sexual functioning. J Clin Psychopharmacol 2004;24(1):56-61.
7. Dickson RA, Glazer WM. Hyperprolactinemia and male sexual dysfunction. J Clin Psychiatry 1999;60(2):125.
8. Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, et al..; Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005;353(12):1209-1223.
9. Hamner MB, Arvanitis LA, Miller BG, Link CG, Hong WW. Plasma prolactin in schizophrenia subjects treated with Seroquel (ICI 204,636). Psychopharmacol Bull 1996;32(1):107-110.
10. Casey DE, Carson WH, Saha AR, Liebeskind A, Ali MW, Jody D, et al.. Switching patients to aripiprazole from other antipsychotic agents: a multicenter randomized study. Psychopharmacology (Berl) 2003;166(4):391-399.
11. McGahuey CA, Gelenberg AJ, Laukes CA, Moreno FA, Delgado PL, McKnight KM, et al.. The Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther 2000;26(1):25-40.
12. Soykan A. The reliability and validity of Arizona sexual experiences scale in Turkish ESRD patients undergoing hemodialysis. Int J Impot Res 2004;16(6):531-534.
13. Byerly MJ, Lescouflair E, Weber MT, Bugno RM, Fisher R, Carmody T, et al.. An open-label trial of quetiapine for antipsychotic-induced sexual dysfunction. J Sex Marital Ther 2004;30(5):325-332.
14. Byerly MJ, Nakonezny PA, Rush AJ. Sexual functioning associated with quetiapine switch vs. risperidone continuation in outpatients with schizophrenia or schizoaffective disorder: a randomized double-blind pilot trial. Psychiatry Res 2008;159(1-2):115-120.
15. Byerly MJ, Nakonezny PA, Fisher R, Magouirk B, Rush AJ. An empirical evaluation of the Arizona sexual experience scale and a simple one-item screening test for assessing antipsychotic-related sexual dysfunction in outpatients with schizophrenia and schizoaffective disorder. Schizophr Res 2006;81(2-3):311-316.
16. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13(2):261-276.
17. Farah A. Atypicality of atypical antipsychotics. Prim Care Companion J Clin Psychiatry 2005;7(6):268-274.
18. Kinon BJ, Ahl J, Liu-Seifert H, Maguire GA. Improvement in hyperprolactinemia and reproductive comorbidities in patients with schizophrenia switched from conventional antipsychotics or risperidone to olanzapine. Psychoneuroendocrinology 2006;31(5):577-588.
19. Gitlin MJ. Psychotropic medications and their effects on sexual function: diagnosis, biology, and treatment approaches. J Clin Psychiatry 1994;55(9):406-413.