-
1
-
-
0344825356
-
P-glycoprotein: from genomics to mechanism
-
Ambudkar SV, Kimchi-Sarfaty C, Sauna ZE, et al (2003). P-glycoprotein: from genomics to mechanism. Oncogene, 22, 7468-85.
-
(2003)
Oncogene
, vol.22
, pp. 7468-7485
-
-
Ambudkar, S.V.1
Kimchi-Sarfaty, C.2
Sauna, Z.E.3
-
2
-
-
84869839802
-
Evaluation of the C3435T polymorphism in the MDR1 gene in patients with hepatocellular carcinoma
-
Baldissera VD, de Mattos AA, Coral GP, et al (2012). Evaluation of the C3435T polymorphism in the MDR1 gene in patients with hepatocellular carcinoma. Ann Hepatol, 11, 899-906.
-
(2012)
Ann Hepatol
, vol.11
, pp. 899-906
-
-
Baldissera, V.D.1
de Mattos, A.A.2
Coral, G.P.3
-
3
-
-
33847644090
-
Genomic Variations and Transcriptional Regulation of the Human Mu-Opioid Receptor Gene
-
Bayerer B, Stamer U, Hoeft A, et al (2007). Genomic Variations and Transcriptional Regulation of the Human Mu-Opioid Receptor Gene. Eur J Pain, 11, 421-7.
-
(2007)
Eur J Pain
, vol.11
, pp. 421-427
-
-
Bayerer, B.1
Stamer, U.2
Hoeft, A.3
-
4
-
-
0035793631
-
A Single Nucleotide Polymorphic Mutation in the Human Mu-Opooid Receptor Severely Impairs Receptor Signaling
-
Befort K, Filliol D, Decaillot FM, et al (2001). A Single Nucleotide Polymorphic Mutation in the Human Mu-Opooid Receptor Severely Impairs Receptor Signaling. J Biol Chem, 276, 3130-7.
-
(2001)
J Biol Chem
, vol.276
, pp. 3130-3137
-
-
Befort, K.1
Filliol, D.2
Decaillot, F.M.3
-
5
-
-
2042527666
-
Effect of the A118G polymorphism on binding affinity, potency and agonistmediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor
-
Beyer A, Koch T, Schröder H, et al (2004). Effect of the A118G polymorphism on binding affinity, potency and agonistmediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor. J Neurochem, 89, 553-60.
-
(2004)
J Neurochem
, vol.89
, pp. 553-560
-
-
Beyer, A.1
Koch, T.2
Schröder, H.3
-
6
-
-
13144261678
-
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction
-
Bond C, LaForge KS, Tian M, et al (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A, 95, 9608-13.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 9608-9613
-
-
Bond, C.1
LaForge, K.S.2
Tian, M.3
-
7
-
-
40949150784
-
Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief
-
Campa D, Gioia A, Tomei A, et al (2008). Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Clin Pharmacol Ther, 83, 559-66.
-
(2008)
Clin Pharmacol Ther
, vol.83
, pp. 559-566
-
-
Campa, D.1
Gioia, A.2
Tomei, A.3
-
8
-
-
0022972654
-
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
-
Chen CJ, Chin JE, Ueda K, et al (1986). Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell, 47, 381-9.
-
(1986)
Cell
, vol.47
, pp. 381-389
-
-
Chen, C.J.1
Chin, J.E.2
Ueda, K.3
-
9
-
-
0033539339
-
The epidemiology of chronic pain in the community
-
Elliott AM, Smith BH, Penny KI, et al (1999). The epidemiology of chronic pain in the community. Lancet, 354, 1248-52.
-
(1999)
Lancet
, vol.354
, pp. 1248-1252
-
-
Elliott, A.M.1
Smith, B.H.2
Penny, K.I.3
-
11
-
-
71349085144
-
Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer
-
Fujita K, Ando Y, Yamamoto W, et al (2010). Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer. Cancer Chemother Pharmacol, 65, 251-8.
-
(2010)
Cancer Chemother Pharmacol
, vol.65
, pp. 251-258
-
-
Fujita, K.1
Ando, Y.2
Yamamoto, W.3
-
12
-
-
84877653005
-
OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis
-
Haerian BS, Haerian MS (2013). OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis. Pharmacogenomics, 14, 813-24.
-
(2013)
Pharmacogenomics
, vol.14
, pp. 813-824
-
-
Haerian, B.S.1
Haerian, M.S.2
-
13
-
-
33846252839
-
P-glycoprotein ATPase activating effect of opioid analgesics and their P-glycoprotein-dependent antinociception in mice
-
Hamabe W, Maeda T, Fukazawa Y, et al (2006). P-glycoprotein ATPase activating effect of opioid analgesics and their P-glycoprotein-dependent antinociception in mice. Pharmacol Biochem Behav, 85, 629-36.
-
(2006)
Pharmacol Biochem Behav
, vol.85
, pp. 629-636
-
-
Hamabe, W.1
Maeda, T.2
Fukazawa, Y.3
-
14
-
-
0344950514
-
Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy
-
Hirota T, Ieiri I, Takane H, et al (2003). Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy. Drug Metab Dispos, 31, 677-80
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 677-680
-
-
Hirota, T.1
Ieiri, I.2
Takane, H.3
-
15
-
-
0034703870
-
Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence
-
Hoehe MR, Köpke K, Wendel B, et al (2000). Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence. Hum Mol Genet, 9, 2895-908.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2895-2908
-
-
Hoehe, M.R.1
Köpke, K.2
Wendel, B.3
-
16
-
-
0034724324
-
Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
-
Hoffmeyer S, Burk O, von Richter O, et al (2000). Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A, 97, 3473-8.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 3473-3478
-
-
Hoffmeyer, S.1
Burk, O.2
von Richter, O.3
-
17
-
-
84055223534
-
A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability
-
Huang P, Chen C, Mague SD, et al (2012). A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability. Biochem J, 441, 379-86.
-
(2012)
Biochem J
, vol.441
, pp. 379-386
-
-
Huang, P.1
Chen, C.2
Mague, S.D.3
-
18
-
-
42149157159
-
Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs
-
Hung CC, Chen CC, Lin CJ, et al (2008). Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics, 18, 390-402.
-
(2008)
Pharmacogenet Genomics
, vol.18
, pp. 390-402
-
-
Hung, C.C.1
Chen, C.C.2
Lin, C.J.3
-
19
-
-
19544376335
-
How individual sensitivity to opiates can be predicted by gene analyses
-
Ikeda K, Ide S, Han W, et al (2005). How individual sensitivity to opiates can be predicted by gene analyses. Trends Pharmacol Sci, 26, 311-7.
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 311-317
-
-
Ikeda, K.1
Ide, S.2
Han, W.3
-
20
-
-
45849109198
-
Candidate gene polymorphisms predicting individual sensitivity to opioids
-
Kasai S, Hayashida M, Sora I, et al (2008). Candidate gene polymorphisms predicting individual sensitivity to opioids. Naunyn Schmiedebergs Arch Pharmacol, 377, 269-81.
-
(2008)
Naunyn Schmiedebergs Arch Pharmacol
, vol.377
, pp. 269-281
-
-
Kasai, S.1
Hayashida, M.2
Sora, I.3
-
21
-
-
80052956397
-
Pharmacogenomics of the human μ-opioid receptor
-
Kasai S, Ikeda K (2011). Pharmacogenomics of the human μ-opioid receptor. Pharmacogenomics, 12, 1305-20.
-
(2011)
Pharmacogenomics
, vol.12
, pp. 1305-1320
-
-
Kasai, S.1
Ikeda, K.2
-
22
-
-
33846504706
-
A "silent" polymorphism in the MDR1 gene changes substrate specificity
-
Kimchi-Sarfaty C, Oh JM, Kim IW, et al (2007). A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science, 315, 525-8.
-
(2007)
Science
, vol.315
, pp. 525-528
-
-
Kimchi-Sarfaty, C.1
Oh, J.M.2
Kim, I.W.3
-
23
-
-
79954583889
-
Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients
-
Klepstad P, Fladvad T, Skorpen F, et al (2011). Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients. Pain, 152, 1139-45.
-
(2011)
Pain
, vol.152
, pp. 1139-1145
-
-
Klepstad, P.1
Fladvad, T.2
Skorpen, F.3
-
25
-
-
51549101026
-
Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women
-
Landau R, Kern C, Columb MO, et al (2008). Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women. Pain, 139, 5-14.
-
(2008)
Pain
, vol.139
, pp. 5-14
-
-
Landau, R.1
Kern, C.2
Columb, M.O.3
-
26
-
-
33744501248
-
Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance
-
Leschziner G, Zabaneh D, Pirmohamed M, et al (2006). Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance. Pharmacogenet Genomics, 16, 439-50.
-
(2006)
Pharmacogenet Genomics
, vol.16
, pp. 439-450
-
-
Leschziner, G.1
Zabaneh, D.2
Pirmohamed, M.3
-
27
-
-
33846845118
-
Genetic polymorphisms in MDR1 and CYP3A5 and MDR1 haplotype in mainland Chinese Han, Uygur and Kazakh ethnic groups
-
Li D, Zhang GL, Lou YQ, et al (2007). Genetic polymorphisms in MDR1 and CYP3A5 and MDR1 haplotype in mainland Chinese Han, Uygur and Kazakh ethnic groups. J Clin Pharm Ther, 32, 89-95.
-
(2007)
J Clin Pharm Ther
, vol.32
, pp. 89-95
-
-
Li, D.1
Zhang, G.L.2
Lou, Y.Q.3
-
28
-
-
80052314519
-
Pilot study examining the frequency of several gene polymorphisms involved in morphine pharmacodynamics and pharmacokinetics in a morbidly obese population
-
Lloret Linares C, Hajj A, Poitou C, et al (2011). Pilot study examining the frequency of several gene polymorphisms involved in morphine pharmacodynamics and pharmacokinetics in a morbidly obese population. Obes Surg, 21, 1257-64.
-
(2011)
Obes Surg
, vol.21
, pp. 1257-1264
-
-
Lloret Linares, C.1
Hajj, A.2
Poitou, C.3
-
29
-
-
33744749555
-
Relevance of frequent muopioid receptor polymorphisms for opioid activity in healthy volunteers
-
Lötsch J, Geisslinger G (2006). Relevance of frequent muopioid receptor polymorphisms for opioid activity in healthy volunteers. Pharmacogenomics J, 6, 200-10.
-
(2006)
Pharmacogenomics J
, vol.6
, pp. 200-210
-
-
Lötsch, J.1
Geisslinger, G.2
-
30
-
-
30344473318
-
Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action
-
Lötsch J, Skarke C, Wieting J, et al (2006). Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action. Clin Pharmacol Ther, 79, 72-89.
-
(2006)
Clin Pharmacol Ther
, vol.79
, pp. 72-89
-
-
Lötsch, J.1
Skarke, C.2
Wieting, J.3
-
31
-
-
55249113858
-
Canine ABCB1 and macrocyclic lactones: heartworm prevention and pharmacogenetics
-
Mealey KL (2008). Canine ABCB1 and macrocyclic lactones: heartworm prevention and pharmacogenetics. Vet Parasitol, 158, 215-22.
-
(2008)
Vet Parasitol
, vol.158
, pp. 215-222
-
-
Mealey, K.L.1
-
32
-
-
33747126106
-
The mu-opioid receptor gene polymorphism 118A>G depletes alfentanilinduced analgesia and protects against respiratory depression in homozygous carriers
-
Oertel BG, Schmidt R, Schneider A, et al (2006). The mu-opioid receptor gene polymorphism 118A>G depletes alfentanilinduced analgesia and protects against respiratory depression in homozygous carriers. Pharmacogenet Genomics, 16, 625-36.
-
(2006)
Pharmacogenet Genomics
, vol.16
, pp. 625-636
-
-
Oertel, B.G.1
Schmidt, R.2
Schneider, A.3
-
33
-
-
34249794271
-
Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene
-
Reyes-Gibby CC, Shete S, Rakvåg T, et al (2007). Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain, 130, 25-30.
-
(2007)
Pain
, vol.130
, pp. 25-30
-
-
Reyes-Gibby, C.C.1
Shete, S.2
Rakvåg, T.3
-
34
-
-
33749989048
-
MDR1 haplotypes significantly minimize intracellular uptake and transcellular P-gp substrate transport in recombinant LLC-PK1 cells
-
Salama NN, Yang Z, Bui T, et al (2006). MDR1 haplotypes significantly minimize intracellular uptake and transcellular P-gp substrate transport in recombinant LLC-PK1 cells. J Pharm Sci, 95, 2293-308.
-
(2006)
J Pharm Sci
, vol.95
, pp. 2293-2308
-
-
Salama, N.N.1
Yang, Z.2
Bui, T.3
-
35
-
-
61849086376
-
Expansion of the human mu-opioid receptor gene architecture: novel functional variants
-
Shabalina SA, Zaykin DV, Gris P, et al (2009). Expansion of the human mu-opioid receptor gene architecture: novel functional variants. Hum Mol Genet, 18, 1037-51.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 1037-1051
-
-
Shabalina, S.A.1
Zaykin, D.V.2
Gris, P.3
-
36
-
-
52649103910
-
A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia
-
Sia AT, Lim Y, Lim EC, et al (2008). A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia. Anesthesiology, 109, 520-6.
-
(2008)
Anesthesiology
, vol.109
, pp. 520-526
-
-
Sia, A.T.1
Lim, Y.2
Lim, E.C.3
-
37
-
-
77954218059
-
The influence of ATPbinding cassette sub-family B member -1 (ABCB1) genetic polymorphisms on acute and chronic pain after intrathecal morphine for caesarean section: a prospective cohort study
-
Sia AT, Sng BL, Lim EC, et al (2010). The influence of ATPbinding cassette sub-family B member -1 (ABCB1) genetic polymorphisms on acute and chronic pain after intrathecal morphine for caesarean section: a prospective cohort study. Int J Obstet Anesth, 19, 254-60.
-
(2010)
Int J Obstet Anesth
, vol.19
, pp. 254-260
-
-
Sia, A.T.1
Sng, B.L.2
Lim, E.C.3
-
38
-
-
84880348616
-
Low absolute bioavailability of oral naloxone in healthy subjects
-
Smith K, Hopp M, Mundin G, et al (2012). Low absolute bioavailability of oral naloxone in healthy subjects. J Clin Oncol, 19, 2542-54.
-
(2012)
J Clin Oncol
, vol.19
, pp. 2542-2554
-
-
Smith, K.1
Hopp, M.2
Mundin, G.3
-
39
-
-
67651009389
-
Ethnicity and OPRM variant independently predict pain perception and patientcontrolled analgesia usage for post-operative pain
-
Tan EC, Lim EC, Teo YY, et al (2009). Ethnicity and OPRM variant independently predict pain perception and patientcontrolled analgesia usage for post-operative pain. Mol Pain, 5, 32.
-
(2009)
Mol Pain
, vol.5
, pp. 32
-
-
Tan, E.C.1
Lim, E.C.2
Teo, Y.Y.3
-
40
-
-
0038637894
-
Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations
-
Tan EC, Tan CH, Karupathivan U, et al (2003). Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations. Neuroreport, 14, 569-72.
-
(2003)
Neuroreport
, vol.14
, pp. 569-572
-
-
Tan, E.C.1
Tan, C.H.2
Karupathivan, U.3
-
41
-
-
1942421704
-
Genomic evidence for recent positive selection at the human MDR1 gene locus
-
Tang K, Wong LP, Lee EJ, et al (2004). Genomic evidence for recent positive selection at the human MDR1 gene locus. Hum Mol Genet, 13, 783-97.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 783-797
-
-
Tang, K.1
Wong, L.P.2
Lee, E.J.3
-
42
-
-
0033529255
-
The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses
-
Uhl GR, Sora I, Wang Z (1999). The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses. Proc Natl Acad Sci U S A, 96, 7752-55.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 7752-7755
-
-
Uhl, G.R.1
Sora, I.2
Wang, Z.3
-
43
-
-
25144433260
-
Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability
-
Wang D, Johnson AD, Papp AC, et al (2005). Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenet Genomics, 15, 693-704.
-
(2005)
Pharmacogenet Genomics
, vol.15
, pp. 693-704
-
-
Wang, D.1
Johnson, A.D.2
Papp, A.C.3
-
44
-
-
0035860745
-
Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding
-
Wang D, Quillan JM, Winans K, et al (2001). Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding. J Biol Chem, 276, 34624-30.
-
(2001)
J Biol Chem
, vol.276
, pp. 34624-34630
-
-
Wang, D.1
Quillan, J.M.2
Winans, K.3
-
45
-
-
0028089275
-
Human mu opiate receptor: cDNA and genomic clones, pharmacologic characterization and chromosomal assignment
-
Wang JB, Johnson PS, Persico AM, et al (1994). Human mu opiate receptor: cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. FEBS Lett, 338, 217-22.
-
(1994)
FEBS Lett
, vol.338
, pp. 217-222
-
-
Wang, J.B.1
Johnson, P.S.2
Persico, A.M.3
-
46
-
-
84863354703
-
Liver cancer: effects, safety, and cost-effectiveness of controlled-release oxycodone for pain control after TACE
-
Zhou B, Wang J, Yan Z, et al (2012). Liver cancer: effects, safety, and cost-effectiveness of controlled-release oxycodone for pain control after TACE. Radiology, 262, 1014-21.
-
(2012)
Radiology
, vol.262
, pp. 1014-1021
-
-
Zhou, B.1
Wang, J.2
Yan, Z.3
-
47
-
-
34547733497
-
Identification of drugs that interact with herbs in drug development
-
Zhou SF, Zhou ZW, Li CG, et al (2007). Identification of drugs that interact with herbs in drug development. Drug Discov Today, 12, 664-73.
-
(2007)
Drug Discov Today
, vol.12
, pp. 664-673
-
-
Zhou, S.F.1
Zhou, Z.W.2
Li, C.G.3
|