AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol

Free Radical Biology and Medicine

Volumn 51, Issue 9, 2011, Pages 1736-1748

  Ge, Wei ^a,b   Guo, Rui ^b   Ren, Jun ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

Author keywords

Akt; ALDH2; AMPK; Autophagy; Autophagy flux; Ethanol; Free radicals; Myocardial dysfunction

Indexed keywords

3 METHYLADENINE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ALCOHOL; ALDA 1; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ALOXISTATIN; BAFILOMYCIN A1; BECLIN 1; CASPASE 3; COMPOUND C; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; PEPSTATIN; RAPAMYCIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

ALCOHOL INTOXICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARDIOTOXICITY; CONTROLLED STUDY; CYTOSOLIC FRACTION; ECHOCARDIOGRAPHY; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART PROTECTION; LYSOSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TREATMENT OUTCOME; WESTERN BLOTTING;

ALDEHYDE DEHYDROGENASE; ANIMALS; AUTOPHAGY; BENZAMIDES; BENZODIOXOLES; CELL LINE; ECHOCARDIOGRAPHY; ETHANOL; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHOTRANSFERASES (PHOSPHATE GROUP ACCEPTOR);

MURINAE; MUS MUSCULUS;

EID: 80053616724     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.08.002     Document Type: Article

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