Hydroxycamptothecin induces apoptosis of human tenon's capsule fibroblasts by activating the perk signaling pathway

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 7, 2013, Pages 4749-4758

  Yin, Xue ^a   Sun, Hong ^a   Yu, Dongyi ^a   Liang, Ya ^a   Yuan, Zhilan ^a   Ge, Yingbin ^b  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Endoplasmic reticulum stress; Human tenon's capsule fibroblasts; Hydroxycamptothecin; Mitochondrial apoptotic pathway; PRKR like ER kinase

Indexed keywords

10 HYDROXYCAMPTOTHECIN; ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE 3; CASPASE 9; CHOLECYSTOKININ OCTAPEPTIDE; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LIPOCORTIN 5; PHOSPHATIDYLINOSITOL KINASE; PHOSPHO STRESS ACTIVATED PROTEIN KINASE; PRKR LIKE ENDOPLASMIC RETICULUM KINASE; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL VIABILITY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; FIBROBLAST; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SURVIVAL RATE; TENON CAPSULE; WESTERN BLOTTING;

ENDOPLASMIC RETICULUM STRESS; HUMAN TENON'S CAPSULE FIBROBLASTS; HYDROXYCAMPTOTHECIN; MITOCHONDRIAL APOPTOTIC PATHWAY; PRKR-LIKE ER KINASE;

APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CAMPTOTHECIN; CASPASES; CELL CYCLE; CELL SURVIVAL; CELLS, CULTURED; CICATRIX; CYTOCHROMES C; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; FIBROBLASTS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TENON CAPSULE;

EID: 84880263721     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-11447     Document Type: Article

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