β-lapachone significantly increases the effect of ionizing radiation to cause mitochondrial apoptosis via JNK activation in cancer cells

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Park, Moon Taek ^a   Song, Min Jeong ^a   Lee, Hyemi ^a   Oh, Eun Taex ^a   Choi, Bo Hwa ^a   Jeong, Seong Yun ^b   Choi, Eun Kyung ^b   Park, Heon Joo ^a  

^a Inha University School of Medicine   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; BETA LAPACHONE; CASPASE 3; CASPASE 8; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; AIFM1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; BETA-LAPACHONE; NAPHTHOQUINONE; NQO1 PROTEIN, HUMAN; RADIOSENSITIZING AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL NUCLEUS MEMBRANE; CELL TRANSPORT; CLONOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REGULATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MITOCHONDRIAL MEMBRANE POTENTIAL; POSITIVE FEEDBACK; PROTEIN CLEAVAGE; RADIOSENSITIZATION; SIGNAL TRANSDUCTION; ACTIVE TRANSPORT; BREAST TUMOR; CELL NUCLEUS; CHEMORADIOTHERAPY; FEEDBACK SYSTEM; FEMALE; METABOLISM; MITOCHONDRION; MOLECULARLY TARGETED THERAPY; PATHOLOGY; RADIATION EXPOSURE; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL NUCLEUS; CHEMORADIOTHERAPY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, PHYSIOLOGICAL; FEMALE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MOLECULAR TARGETED THERAPY; NAD(P)H DEHYDROGENASE (QUINONE); NAPHTHOQUINONES; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES;

EID: 80053590637     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025976     Document Type: Article

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