Selective hypoperfusion of anterior cingulate gyrus in depressed AD patients: A brain SPECT finding by statistical parametric mapping

Dementia and Geriatric Cognitive Disorders

Volumn 16, Issue 4, 2003, Pages 238-244

  Liao, Yi Chu ^a   Liu, Ren Shyan ^a   Lee, Yi Chung ^a   Sun, Chen Ming ^a   Liu, Chia Yih ^b   Wang, Po Shan ^a   Wang, Pei Ning ^a   Liu, Hsiu Chih ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Alzheimer's disease; Depression; Single photon emission computed tomography; Statistical parametric mapping

Indexed keywords

HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN MAPPING; BRAIN PERFUSION; BRAIN REGION; CINGULATE GYRUS; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; DISEASE SEVERITY; FEMALE; HAMILTON SCALE; HUMAN; HYPOTHESIS; INTERVIEW; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC EXAMINATION; NEUROPSYCHOLOGY; PARAMETRIC TEST; PATHOGENESIS; PRIORITY JOURNAL; REDUCTION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

AGED; ALZHEIMER DISEASE; BRAIN MAPPING; DEPRESSIVE DISORDER; FEMALE; GYRUS CINGULI; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M EXAMETAZIME; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0141505031     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000072808     Document Type: Article

References (39)

1. Liu CY, Fuh JL, Teng EL, Wang SJ, Wang PN, Yang YY, Liu HC: Depressive disorders in Chinese patients with Alzheimer's disease. Acta Psychiatr Scand 1999;100:451-455.
2. Espiritu DA, Rashid H, Mast BT, Fitzgerald J, Steinberg J, Lichtenberg PA: Depression, cognitive impairment and function in Alzheimer's disease. Int J Geriatr Psychiatry 2001;16:1098-1103.
3. Alexopoulos GS, Abrams RC: Depression in Alzheimer disease. Psychiatr Clin North Am 1991;14:327-340.
4. Kral VA: The relationship between senile dementia (Alzheimer's type) and depression. Can J Psychiatry 1983;28:304-306.
5. Zubenko GS, Moossy J: Major depression in primary dementia: Clinical and neuropathologic correlates. Arch Neurol 1988;45:1182-1186.
6. Zweig RM, Ross CA, Hedreen JC, Steele C, Cardillo JE, Whitehouse PJ, Folstein MF, Price DL: The neuropathology of aminergic nuclei in Alzheimer's disease. Ann Neurol 1988;24:233-242.
7. Zubenko GS, Moossy J, Kopp U: Neurochemical correlates of major depression in primary dementia. Arch Neurol 1990;47:209-214.
8. Nitrini R, Buchpiguel CA, Caramelli P, Bahia VS, Mathias SC, Nascimento CMR, Degenszajn J, Caixeta L: SPECT in Alzheimer's disease: Features associated with bilateral parieto-temporal hypoperfusion. Acta Neurol Scand 2000;101:172-176.
9. Matsuda H: Cerebral blood flow and metabolic abnormalities in Alzheimer's disease. Ann Nucl Med 2001;15:85-92.
10. Sabbagh MN, Lynn P, Jhingran S, Massman P, Villanueva-Meyer J, Olup J, Doody RS: Correlations between SPECT regional cerebral blood flow and psychometric testing in patients with Alzheimer's disease. J Neuropsychiatry Clin Neurosci 1997;9:68-74.
11. Galynker II, Dutta E, Vilkas N, Ongseng F, Finestone H, Gallagher R, Serseni D, Rosenthal RN: Hypofrontality and negative symptoms in patients with dementia of Alzheimer type. Neuropsychiatry Neuropsychol Behav Neurol 2000;13:53-59.
12. Mega MS, Lee L, Dinov ID, Mishkin F, Toga AW, Cummings JL: Cerebral correlates of psychotic symptoms in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2000;69:167-171.
13. Hirono N, Mori E, Ishii K, Ikejiri Y, Imamura T, Shimomura T, Hashimoto M, Yamashita H, Sasaki M: Frontal lobe hypometabolism and depression in Alzheimer's disease. Neurology 1998;50:380-383.
14. Sultzer DL, Mahler ME, Mandelkern MA, Cummings JL, Van Gorp WG, Hinkin CH, Berisford MA: The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer's disease. J Neuropsychiatry Clin Neurosci 1995;7:476-484.
15. Vercelletto M, Martinez F, Lanier S, Magne C, Jaulin P, Bourin M: Negative symptoms, depression and Alzheimer's disease. Int J Geriatr Psychiatry 2002;17:383-387.
16. Benoit M, Dygai I, Migneco O, Robert PH, Bertogliati C, Darcourt J, Benoliel J, Aubin-Brunet V, Pringuey D: Behavioral and psychological symptoms in Alzheimer's disease: Relation between apathy and regional cerebral perfusion. Dement Geriatr Cogn Disord 1999;10:511-517.
17. Benoit M, Koulibaly PM, Migneco O, Darcourt J, Pringuey DJ, Robert PH: Brain perfusion in Alzheimer's disease with and without apathy: A SPECT study with statistical parametric mapping analysis. Psychiatry Res 2002;114:103-111.
18. Craig AH, Cummings JL, Fairbanks L, Itti L, Miller BL, Li J, Mena I: Cerebral blood flow correlates of apathy in Alzheimer disease. Arch Neurol 1996;53:1116-1120.
19. Starkstein SE, Vazquez S, Petracca G, Sabe L, Migliorelli R, Teson A, Leiguarda R: A SPECT study of delusions in Alzheimer disease. Neurology 1994;44:2055-2059.
20. Staff RT, Venneri A, Gemmell HG, Shanks MF, Pestell SJ, Murray AD: HMPAO SPECT imaging of Alzheimer's disease patients with similar content-specific autobiographic delusion: Comparison using statistical parametric mapping. J Nucl Med 2000;41:1451-1455.
21. Friston KJ, Holmes AP, Worsley KJ, Poline JP, Frith CD, Frackowiak RSJ: Statistical parametric maps in functional imaging: A general linear approach. Hum Brain Mapp 1995;2:189-210.
22. Lee YC, Liu RS, Liao YC, Sun CM, Wang PS, Wang PN, Liu HC: Statistical parametric mapping of brain SPECT perfusion abnormalities in patients with Alzheimer's disease. Eur Neurol 2003;49:142-145.
23. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939-944.
24. Lin KN, Wang PN, Liu CY, Chen WT, Lee YC, Liu HC: Cutoff scores of cognitive abilities screening instrument, Chinese version (CASIC-2.0) in screening of dementia. Dement Geriatr Cogn Disord 2002;14:176-182.
25. Folstein MF, Folstein SE, McHugh PR: 'Minimental state': A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
26. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL: A new clinical scale for the staging of dementia. Br J Psychiatry 1982;140:566-572.
27. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 3, revised (DSM-III-R). Washington, American Psychiatric Association, 1987.
28. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62.
29. Talairach J, Tournoux P: Co-Planar Stereotactic Atlas of the Human Brain 3-Dimentional Proportional System: An Approach to Cerebral Imaging. New York, Thieme Medical, 1988.
30. Friston KJ, Ashburner J, Firth CD, Poline JB, Heather JD, Frackowiak RSJ: Spatial registration and normalization of images. Hum Brain Mapp 1995;2:165-189.
31. Salmom E, Collette F, Degueldre C, Lemaire C, Franck G: Voxel-based analysis of confounding effects of age and dementia severity on cerebral metabolism in Alzheimer's disease. Hum Brain Mapp 2000;10:39-48.
32. Bench CJ, Friston KJ, Brown RG, Scott LC, Frackowiak RS, Dolan RJ: The anatomy of melancholia: Focal abnormalities of cerebral blood flow in major depression. Psychol Med 1992;22:607-615.
33. George MS, Ketter TA, Post RM: SPECT and PET imaging in mood disorders. J Clin Psychiatry 1993;54:6-13.
34. Drevets WC: Functional neuroimaging studies of depression: The anatomy of melancholia. Annu Rev Med 1998;49:341-361.
35. Mayberg HS, Starkstein SE, Sadzot B, Preziosi T, Andrezejewski PL, Dannals RF, Wagner HN Jr, Robinson RG: Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson's disease. Ann Neurol 1990;28:57-64.
36. Mayberg HS, Starkstein SE, Peyser CE, Brandt J, Dannals RF, Folstein SE: Paralimbic frontal lobe hypometabolism in depression associated with Huntington's disease. Neurology 1992;42:1791-1797.
37. Mega MS, Cummings JL: Frontal-subcortical circuits and neuropsychiatric disorders. J Neuropsychiatry Clin Neurosci 1994;6:358-370.
38. Cummings JL: Frontal-subcortical circuits and human behavior. Arch Neurol 1993;50:873-880.
39. Devinsky O, Morrell MJ, Vogt BA: Contributions of anterior cingulate cortex to behaviour. Brain 1995;118:279-306.