Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 305, Issue 2, 2013, Pages

  Morgan, Richard G ^a,b,c   Ives, Stephen J ^a,b   Lesniewski, Lisa A ^a,b,c   Cawthon, Richard M ^c   Andtbacka, Robert H I ^c   Dirk Noyes, R ^c   Richardson, Russell S ^a,b,c   Donato, Anthony J ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Arteries; Inflammation; Senescence; Telomeres

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HISTONE H2A; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P21; PROTEIN P53; TELOMERIC REPEAT BINDING FACTOR 2;

ADULT; AGED; ARTICLE; BLOOD VESSEL BIOPSY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL AGING; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GENE EXPRESSION; GROUPS BY AGE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MUSCLE BLOOD VESSEL; PERIPHERAL VASCULAR DISEASE; PRESCRIPTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; SENESCENCE; SKELETAL MUSCLE; TELOMERE; TELOMERE HOMEOSTASIS; TELOMERE SHORTENING; TELOMERE UNCAPPING; VASCULITIS;

AGING; ARTERIES; INFLAMMATION; SENESCENCE; TELOMERES;

ADULT; AGE FACTORS; AGED; AGING; ANALYSIS OF VARIANCE; ARTERIES; ARTERITIS; BINDING SITES; CELL AGING; CHEMOKINE CCL2; CHI-SQUARE DISTRIBUTION; CHROMATIN IMMUNOPRECIPITATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; HISTONES; HUMANS; INTERLEUKIN-8; MALE; MIDDLE AGED; MUSCLE, SKELETAL; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PRESCRIPTION DRUGS; PROMOTER REGIONS, GENETIC; RISK FACTORS; RNA, MESSENGER; TELOMERE; TELOMERE SHORTENING; TELOMERIC REPEAT BINDING PROTEIN 2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84880158654     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00197.2013     Document Type: Article

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