Leukocytes of exceptionally old persons display ultra-short telomeres

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 293, Issue 6, 2007, Pages

  Kimura, M ^a   Barbieri, M ^b   Gardner, J P ^a   Skurnick, J ^a   Cao, X ^a   Van Riel, N ^c   Rizzo, M R ^b   Paoliso, G ^c   Aviv, A ^a  

^a University of Medicine and Dentistry of New Jersey Medical School   (United States)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

Aging; Centenarians; Lifespan; Mortality; Replication; Senescence

Indexed keywords

ARTICLE; GERIATRIC CARE; HUMAN; LEUKOCYTE; LIFESPAN; PRIORITY JOURNAL; TELOMERE; X CHROMOSOME; Y CHROMOSOME;

ADULT; AGED; AGED, 80 AND OVER; AGING; CELLS, CULTURED; FEMALE; HUMANS; LEUKOCYTES; LONGEVITY; MALE; MIDDLE AGED; TELOMERE;

EID: 36849013147     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00615.2007     Document Type: Article

References (46)

1. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15: 539-553, 1998.
2. Andersen-Ranberg K, Schroll M, Jeune B. Healthy centenarians do not exist, but autonomous centenarians do: a population-based study of morbidity among Danish centenarians. J Am Geriatr Soc 49: 900-908, 2001.
3. Andrew T, Aviv A, Falchi M, Surdulescu GL, Gardner JP, Lu X, Kimura M, Kato BS, Valdes AM, Spector TD. Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected, female sibling pairs. Am J Hum Genet 78: 480-486, 2006.
4. Atzmon G, Schechter C, Greiner W, Davidson D, Rennert G, Barzilai N. Clinical phenotype of families with longevity. J Am Geriatr Soc 52: 274-277, 2004.
5. Aviv A. Telomeres and human aging: facts and fibs. Sci Aging Knowledge Environ 51: 43, 2004.
6. Aviv A, Valdes AM, Spector TD. Human telomere biology: pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol 35: 1424-1429, 2006.
7. Baird DM, Britt-Compton B, Rowson J, Amso NN, Gregory L, Kipling D. Telomere instability in the male germline. Hum Mol Genet 15: 45-51, 2006.
8. Baird DM, Rowson J, Wynford-Thomas D, Kipling D. Extensive allelic variation and ultra-short telomeres in senescent human cells. Nature Genet 33: 203-207, 2003.
9. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev 78: 547-581, 1998.
10. Bekaert S, De Meyer T, Rietzschel ER, De Buyzere ML, De Bacquer D, Langlois M, Segers P, Cooman L, Van Damme P, Cassiman P, Van Criekinge W, Verdonck P, De Backer GG, Gillebert TC, Van Oostveldt P; on behalf of the Asklepios Investigators. Telomere length and cardiovascular risk factors in middle-aged population free of overt cardiovascular disease. Aging Cell 6: 639-647, 2007.
11. Benetos A, Okuda K, Lajemi M, Kimura M, Thomas F, Skurnick J, Labat C, Bean K, Aviv A. Telomere length as an indicator of biological aging: The gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 37: 381-385, 2001.
12. Berzlanovich AM, Keil W, Waldhoer T, Sim E, Fasching P, Fazeny-Dorner B. Do centenarians die healthy? An autopsy study. J Gerontol A Biol Sci Med Sci 60: 862-865, 2005.
13. Bischoff C, Petersen HC, Graakjaer J, Andersen-Ranberg K, Vaupel JW, Bohr VA, Kolvraa S, Christensen K. No association between telomere length and survival among the elderly and oldest old. Epidemiology 17: 190-194. 2006.
14. Canela A, Vera E, Klatt P, Blasco MA. High-throughput telomere length quantification by FISH and it application to human population studies. Proc Natl Acad Sci USA 104: 5300-5305, 2007.
15. Carnes BA, Olshansky SJ, Grahn D. Biological evidence for limits to the duration of life. Biogerontology 4: 31-45, 2003.
16. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361: 393-395, 2003.
17. Cherkas LF, Aviv A, Valdes AM, Hunkin JL, Gardner JP, Surdulescu GL, Kimura M, Spector TD. The Effects of Social Status on Biological Ageing as measured by white cell telomere length. Aging Cell 5: 361-365, 2006.
18. Demissie S, Levy D, Benjamin EJ, Cupples LA, Gardner JP, Herbert A, Kimura M, Larson MG, Meigs JB, Keaney JF, Aviv A. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell 5: 325-330, 2006.
19. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA 101: 17312-17315, 2004.
20. Finch CE, Crimmins EM. Inflammatory exposure and historical changes in human life-spans. Science 305: 1736-1739, 2004.
21. Fitzpatrick AL, Kronmal RA, Gardner JP, Psaty BM, Jenny NS, Tracy RP, Walston J, Kimura M, Aviv A. Leukocyte telomere length and cardiovascular disease in the Cardiovascular Health Study. Am J Epidemiol 165: 14-21, 2007.
22. Fries JF. Aging, natural death, and the compression of morbidity. N Engl J Med 303: 130-135, 1980.
23. Gardner JP, Li S, Srinivasan SR, Chen W, Kimura M, Lu X, Berenson GS, Aviv A. Rise in insulin resistance is associated with escalated telomere attrition. Circulation 111: 2171-2177, 2005.
24. Guan JZ, Maeda T, Sugano M, Oyama J, Higuchi Y, Makino N. Change in the telomere length distribution with age in the Japanese population. Mol Cell Biochem 304: 353-360, 2007.
25. Gudmundsson H, Gudbjartsson DF, Frigge M, Gulcher JR, Stefansson K. Inheritance of human longevity in Iceland. Eur J Hum Genet 8: 743-749, 2000.
26. Harris SE, Deary I, MacIntyre A, Lamb KJ, Radhakrishnan K, Starr JM, Whalley LJ, Shiels PG. The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people. Neurosci Lett 406: 260-264, 2006.
27. Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107: 67-77, 2001.
28. Hitt R, Young-Xu Y, Silver M, Perls T. Centenarians: the older you get, the healthier you have been. Lancet 354: 652, 1999.
29. Honig LS, Schupf N, Lee JH, Tang MX, Mayeux R. Shorter telomeres are associated with mortality in those with APOE ε4 and dementia. Ann Neurol 60: 181-187, 2006.
30. Ivanova R, Henon N, Lepage V, Charron D, Vicaunt E, Schachter F. HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity. Hum Mol Genet 7: 187-194, 1998.
31. Jeanclos E, Schork NJ, Kyvik KO, Kimura M, Skurnick JH, Aviv A. Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension 6: 195-200, 2000.
32. Mannucci PM, Mari D, Merati G, Peyvandi F, Tagliabue L, Sacchi E, Taioli E, Sansoni P, Bertolini S, Franceschi C. Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians. Arterioscler Thromb Vasc Biol 17: 755-759, 1997.
33. Martens UM, Chavez EA, Poon SS, Schmoor C, Lansdorp PM. Accumulation of short telomeres in human fibroblasts prior to replicative senescence. Exp Cell Res 256: 291-299, 2000.
34. Martin-Ruiz CM, Gussekloo J, van Heemst D, von Zglinicki T, Westendorp RJ. Telomere length in white blood cells is not associated with morbidity and mortality in the oldest old: a population-based study. Aging Cell 4: 287-290, 2005.
35. Nawrot TS, Staessen JA, Gardner JP, Aviv A. Telomere length and possible link to X chromosome. Lancet 363: 507-510, 2004.
36. Oeppen J, Vaupel Demography JW. Broken limits to life expectancy. Science 296: 1029-1031, 2002.
37. op den Buijs, J., van den Bosch P.PJ, Musters MW, van Riel NA. Mathematical modeling confirms the length-dependency of telomere shortening. Mec Aging Dev 125: 437-444, 2004.
38. Perls TT, Bubrick E, Wager CG, Vijg J, Kruglyak L. Siblings of centenarians live longer. Lancet 351: 1560, 1998.
39. Perls TT, Wilmoth J, Levenson R, Drinkwater M, Cohen M, Bogan H, Joyce E, Brewster S, Kunkel L, Puca A. Life-long sustained mortality advantage of siblings of centenarians. Proc Natl Acad Sci USA 99: 8442-8447, 2002.
40. Puca AA, Daly MJ, Brewster SJ, Matise TC, Barrett J, Shea-Drinkwater M, Kang S, Joyce E, Nicoli J, Benson E, Kunkel LM, Perls T. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci USA 98: 10505-10508, 2001.
41. Schachter F, Faure-Delanef L, Guenot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet 6: 29-32, 1994.
42. Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 55: 876-882, 1994.
43. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, Aviv A, Spector TD. Obesity, cigarette smoking, and telomere length in women. Lancet 365: 662-664, 2005.
44. Vasa-Nicotera M, Brouilette S, Mangino M, Thompson JR, Braund P, Clemitson JR, Mason A, Bodycote CL, Raleigh SM, Louis E, Samani NJ. Mapping of a major locus that determines telomere length in humans. Am J Hum Genet 76: 147-151, 2005. [Erratum. Am J Hum Genet 76: 373, 2005.]
45. Vaziri H, Schachter F, Uchida I, Wei L, Zhu X, Effros R, Cohen D, Harley CB. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 52: 661-667, 1993.
46. Zou Y, Sfeir A, Gryaznor SM, Shay JW, Wright WE. Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell 15: 3709-3718, 2004.