Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. part II

Journal of Medicinal Chemistry

Volumn 56, Issue 13, 2013, Pages 5495-5504

  Zhang, Han Kun ^a   Yu, Li Fang ^a   Eaton, J Brek ^b   Whiteaker, Paul ^b   Onajole, Oluseye K ^a   Hanania, Taleen ^c   Brunner, Daniela ^c,d   Lukas, Ronald J ^b   Kozikowski, Alan P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b BARROW NEUROLOGICAL INSTITUTE   (United States)

^c PSYCHOGENICS INC   (United States)

^d NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [( 3 AZABICYCLO[3.1.0]HEXAN 2 YL)METHOXY] 5 [(2 (2 METHOXYETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [(1 ETHYL 2 PYRROLIDINYL)METHOXY] 5 [2 (2 METHOXYETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [(1 METHYL 2 PYRROLIDINYL)METHOXY] 5 [2 (2 METHOXYETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [(2 AZETIDINYL)METHOXY] 5 [2 (2 (MORPHOLIN 4 YL)ETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [(2 AZETIDINYL)METHOXY] 5 [2 (2 (PIPERAZIN 1 YL)ETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [(2 AZETIDINYL)METHOXY] 5 [2 (2 (PIPERIDIN 1 YL)ETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [(2 AZETIDINYL)METHOXY] 5 [2 (3 HYDROXYPROPYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [(2 AZETIDINYL)METHOXY] 5 [2 (HYDROXYMETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [(2 PIPERIDINYL)METHOXY] 5 [2 (2 METHOXYETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [(3 PYRROLIDINYL)METHOXY] 5 [2 (2 METHOXYETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [(3 PYRROLIDINYL)OXY] 5 [2 (2 METHOXYETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [2 (AZETIDINYL)METHOXY] 5 [2 (2 TRIFLUOROMETHOXYETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [2 (ISOPROPYLAMINO)ETHOXY] 5 [2 (2 METHOXYETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [2 (PYRROLIDINYL)METHOXY] 5 [2 (2 METHOXYETHYL)CYCLOPROPYL]PYRIDINE TRIFLUOROACETATE; 3 [2 [5 [(AZETIDIN 2 YL)METHOXY]PYRIDIN 3 YL]CYCLOPROPYL]PROPANOIC ACID TRIFLUOROACETATE; ANTIDEPRESSANT AGENT; AZETIDINE; CYCLOPROPANE DERIVATIVE; ETHYL [2 [2 [5 [(AZETIDIN 2 YL)METHOXY]PYRIDIN 3 YL]CYCLOPROPYL]ETHYL]CARBAMATE TRIFLUOROACETATE; ISOPROPYL [2 [2 [5 [(AZETIDIN 2 YL)METHOXY]PYRIDIN 3 YL]CYCLOPROPYL]ETHYL]CARBAMATE TRIFLUOROACETATE; NICOTINIC AGENT; NICOTINIC RECEPTOR ALPHA4BETA2; UNCLASSIFIED DRUG;

ANTIDEPRESSANT ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STABILITY; FORCED SWIMMING TEST; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; BINDING, COMPETITIVE; CACO-2 CELLS; CELL LINE; CELL LINE, TUMOR; CYCLOPROPANES; CYTOCHROME P-450 ENZYME SYSTEM; DRUG STABILITY; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICROSOMES, LIVER; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MOTOR ACTIVITY; NICOTINIC AGONISTS; RADIOLIGAND ASSAY; RATS; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SWIMMING;

EID: 84880153461     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400510u     Document Type: Article

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