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Volumn 9, Issue 16, 1998, Pages 2791-2794

Efficient asymmetric synthesis of ABT-594; a potent, orally effective analgesic

Author keywords

[No Author keywords available]

Indexed keywords

5 (2 AZETIDINYLMETHOXY) 2 CHLOROPYRIDINE; ANALGESIC AGENT; EPIBATIDINE;

EID: 0032555560     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(98)00291-2     Document Type: Article
Times cited : (42)

References (22)
  • 18
    • 0344280678 scopus 로고    scopus 로고
    • Alternatively, removal of the benzyl group of 8 by hydrogenation (Pd/C, 4 atm hydrogen, THF) followed by LAH reduction produced 4 in 45-55% yield. Although lower yielding, this process eliminated the need for separation of benzyl alcohol by flash silica gel chromatography
    • Alternatively, removal of the benzyl group of 8 by hydrogenation (Pd/C, 4 atm hydrogen, THF) followed by LAH reduction produced 4 in 45-55% yield. Although lower yielding, this process eliminated the need for separation of benzyl alcohol by flash silica gel chromatography.
  • 19
    • 0345574622 scopus 로고    scopus 로고
    • Chiralpak AD column, 90:10 hexane:EtOAc (1.0 mL/min) at 210 nm. Michael Fitzgerald and Michael Rasmussen (D45L) are gratefully acknowledged for developing the method and running the analyses
    • Chiralpak AD column, 90:10 hexane:EtOAc (1.0 mL/min) at 210 nm. Michael Fitzgerald and Michael Rasmussen (D45L) are gratefully acknowledged for developing the method and running the analyses.
  • 22
    • 0345574620 scopus 로고    scopus 로고
    • Dr. Devalina Law of Abbott Laboratories (Pharmaceutics, D4P3) is gratefully acknowledged for evaluation of the physical properties of the different salts of ABT-594
    • Dr. Devalina Law of Abbott Laboratories (Pharmaceutics, D4P3) is gratefully acknowledged for evaluation of the physical properties of the different salts of ABT-594.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.