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Alternatively, removal of the benzyl group of 8 by hydrogenation (Pd/C, 4 atm hydrogen, THF) followed by LAH reduction produced 4 in 45-55% yield. Although lower yielding, this process eliminated the need for separation of benzyl alcohol by flash silica gel chromatography
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Alternatively, removal of the benzyl group of 8 by hydrogenation (Pd/C, 4 atm hydrogen, THF) followed by LAH reduction produced 4 in 45-55% yield. Although lower yielding, this process eliminated the need for separation of benzyl alcohol by flash silica gel chromatography.
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0345574622
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Chiralpak AD column, 90:10 hexane:EtOAc (1.0 mL/min) at 210 nm. Michael Fitzgerald and Michael Rasmussen (D45L) are gratefully acknowledged for developing the method and running the analyses
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Chiralpak AD column, 90:10 hexane:EtOAc (1.0 mL/min) at 210 nm. Michael Fitzgerald and Michael Rasmussen (D45L) are gratefully acknowledged for developing the method and running the analyses.
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0345574620
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Dr. Devalina Law of Abbott Laboratories (Pharmaceutics, D4P3) is gratefully acknowledged for evaluation of the physical properties of the different salts of ABT-594
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Dr. Devalina Law of Abbott Laboratories (Pharmaceutics, D4P3) is gratefully acknowledged for evaluation of the physical properties of the different salts of ABT-594.
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