Small-molecule allosteric activation of human glucokinase in the absence of glucose

ACS Medicinal Chemistry Letters

Volumn 4, Issue 7, 2013, Pages 580-584

  Bowler, Joseph M ^a   Hervert, Katherine L ^b   Kearley, Mark L ^a   Miller, Brian G ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

^b OHIO WESLEYAN UNIVERSITY   (United States)

Author keywords

glucokinase activators; hysteretic enzyme; kinetic cooperativity; Maturity onset diabetes of the young type II

Indexed keywords

GKA 22; GLUCOKINASE; GLUCOSE; PHOSPHOTRANSFERASE INHIBITOR; RO 281675; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SOLUBILITY; DRUG SYNTHESIS; ENTHALPY; ENTROPY; ENZYME KINETICS; ENZYME RELEASE; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DOCKING; MOLECULE; PRIORITY JOURNAL; STEADY STATE; VISCOSITY;

EID: 84880145278     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400061x     Document Type: Article

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