23-Residue C-terminal α-helix governs kinetic cooperativity in monomeric human glucokinase

Biochemistry

Volumn 48, Issue 26, 2009, Pages 6157-6165

  Larion, Mioara ^a   Miller, Brian G ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC REGULATION; ALLOSTERY; C-TERMINUS; CATALYTIC ACTIVITY; COOPERATIVITY; CRYSTALLOGRAPHIC DATA; ENZYME CONFORMATIONS; EQUILIBRIUM BINDING AFFINITY; FULL-LENGTH ENZYMES; GENETIC SELECTION; GLUCOKINASE; GLUCOSE CONCENTRATION; HILL COEFFICIENT; INTERCONVERSION; MICHAELIS-MENTEN KINETIC; MONOMERIC ENZYMES; POLYALANINE; PRIMARY AMINO ACID; PRIMARY SEQUENCES; STEADY-STATE KINETICS; STRUCTURAL REARRANGEMENT; WILD-TYPE ENZYMES;

AMINES; AMINO ACIDS; BINDING ENERGY; DYES; ENZYME ACTIVITY; ENZYMES; ORGANIC ACIDS;

GLUCOSE;

ENZYME VARIANT; GLUCOKINASE; GLUCOSE; SYNTHETIC PEPTIDE;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME KINETICS; GENETIC SELECTION; MICHAELIS CONSTANT; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; STEADY STATE; THERMODYNAMICS; WILD TYPE;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; BIOCATALYSIS; GENE DELETION; GLUCOKINASE; GLUCOSE; HUMANS; KINETICS; MUTAGENESIS, INSERTIONAL; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE;

BACTERIA (MICROORGANISMS);

EID: 67650088881     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9007534     Document Type: Article

References (35)

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