A new and direct route to 3-fluoromethyl substituted pyrazol-4-acrylates via Pd-catalyzed C-H activation

Tetrahedron

Volumn 69, Issue 34, 2013, Pages 6993-7000

  Wang, Xiaoguang ^a   Fang, Xiang ^a   Xiao, Hongyuan ^a   Gong, Dongming ^a   Yang, Xueyan ^a   Wu, Fanhong ^b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF TECHNOLOGY   (China)

Author keywords

3 Fluoromethyl pyrazoles; Benzoquinone; C4 H activation; Concerted metalation deprotonation (CMD); Pd catalyzed

Indexed keywords

3 [5 (4 FLUOROPHENYL) 1 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]ACRYLONITRILE; ACRYLIC ACID; BENZOQUINONE; BUTYL 3 [1 (4 METHOXYPHENYL) 5 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL)ACRYLATE; BUTYL 3 [1 METHYL 5 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL)ACRYLATE; BUTYL 3 [5 (4 FLUOROPHENYL) 1 (4 METHOXYPHENYL) 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]ACRYLATE; BUTYL 3 [5 (4 FLUOROPHENYL) 1 (4 NITROPHENYL) 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]ACRYLATE; BUTYL 3 [5 (4 FLUOROPHENYL) 1 METHYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]ACRYLATE; BUTYL 3 [5 (4 FLUOROPHENYL) 1 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]ACRYLATE; BUTYL 3 [5 (4 METHOXYPHENYL) 1 (4 NITROPHENYL) 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]ACRYLATE; CARBON; ETHYL 3 [5 (4 FLUOROPHENYL) 1 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]ACRYLATE; ETHYL 3 [5 (4 METHOXYPHENYL) 1 METHYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]ACRYLATE; HYDROGEN; PALLADIUM; PYRAZOLE DERIVATIVE; TERT BUTYL 3 [5 (4 FLUOROPHENYL) 1 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]ACRYLATE; TERT BUTYL 3 [5 (4 METHOXYPHENYL) 1 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]ACRYLATE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; OLEFINATION; OXIDATIVE COUPLING; PRIORITY JOURNAL;

EID: 84880131707     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2013.06.058     Document Type: Article

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