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Leading references for each metal are: For copper: I.I.F. Boogaerts, G.C. Fortman, M.R.L. Furst, C.S.J. Cazin, and S.P. Nolan Angew. Chem., Int. Ed. 49 2010 8674 8677
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See especially Refs. 10,11
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42
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68349114664
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But it is noteworthy that the reaction requires more forcing conditions than those reported by the same group for the arylation of 3,5- dimethylisoxazole, for which see: Y. Fall, C. Reynaud, H. Doucet, and M. Santelli Eur. J. Org. Chem. 2009 4041 4050
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Pyrazoles have successfully been arylated by exploiting the SEM group to enhance reactivity: R. Goikhman, T.L. Jacques, and D. Sames J. Am. Chem. Soc. 131 2009 3042 3048
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44
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41149168872
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To our knowledge the only other report of arylation of C-H pyrazoles is intramolecular: C. Blaszykowski, E. Aktoudianakis, D. Alberico, C. Bressy, D.G. Hulcoop, F. Jafarpour, A. Joushaghani, B. Laleu, and M. Lautens J. Org. Chem. 73 2008 1888 1897
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Laleu, B.8
Lautens, M.9
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45
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79956207925
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note
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