The actions of fisetin on glucose metabolism in the rat liver

Cell Biochemistry and Function

Volumn 28, Issue 2, 2010, Pages 149-158

  Constantin, Rodrigo Polimeni ^a   Constantin, Jorgete ^a   Pagadigorria, Clairce Luzia Salgueiro ^a   Ishii Iwamoto, Emy Luiza ^a   Bracht, Adelar ^a   De Kássia Cardoso Ono, Mariana ^a   Yamamoto, Nair Seiko ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Fisetin; Glucagon; Gluconeogenesis; Glycogen; Liver perfusion

Indexed keywords

2,4 DINITROPHENOL; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; FISETIN; FRUCTOSE; GLUCAGON; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE; GLYCOGEN; LACTIC ACID; PYRUVIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CARBOXYLATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; FREEZE THAWING; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGENOLYSIS; GLYCOLYSIS; IC 50; LIVER; LIVER MITOCHONDRION; LIVER PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANACARDIACEAE; ANIMALS; FLAVONOIDS; FRUCTOSE; GLUCAGON; GLUCONEOGENESIS; GLUCOSE; GLUCOSE-6-PHOSPHATASE; GLYCOLYSIS; LACTATES; LIVER; MALE; MITOCHONDRIA, LIVER; NAD; PYRUVATES; RATS; RATS, WISTAR;

COTINUS; RATTUS;

EID: 77249089784     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1635     Document Type: Article

References (44)

1. Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N. Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 2000; 130: 2243-2250.
2. Nijveldt RJ, Nood EV, Hoorn DEC, Boelens PG, Norren KV, Leeuwen PAM. Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 2001; 74: 418-425.
3. Suolinna EM, Buchsbaum DN, Racker E. The effect of flavonoids on aerobic glycolysis and growth of tumor cells. Cancer Res 1975; 35: 1865-1872.
4. Jung UJ, Lee MK, Park YB, Kang MA, Choi MS. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 2006; 38: 1134-1145. DOI: 10.1016/j.biocel.2005.12.002
5. Jung UJ, Lee MK, Jeong KS, Choi MS. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. J Nutr 2004; 134: 2499-2503.
6. Gasparin FR, Salgueiro-Pagadigorria CL, Bracht L, Ishii-Iwamoto EL, Bracht A, Constantin J. Action of quercetin on glycogen catabolism in the rat liver. Xenobiotica 2003; 33: 587-602. DOI: 10.1080/ 0049825031000089100
7. Shetty AK, Rashmi R, Rajan MG, Sambaiah K, Salimath PV. Antidiabetic influence of quercetin in streptozotocin-induced diabetic rats. Nutr Res 2004; 24: 373-381. DOI: 10.1016/j.nutres.2003.11.010
8. Kato A, Nasu N, Takahashi K, et al. Structure-activity relationships of flavonoids as potential inhibitors of glycogen phosphorylase. J Agric Food Chem 2008; 56: 4469-4473. DOI: 10.1021/jf800569s
9. Kyriakidis SM, Sotiroudis TG, Evangelopoulos AE. Interaction of flavonoids with rabbit muscle phosphorylase kinase. Biochim Biophys Acta 1986; 871: 121-129.
10. Kelmer-Bracht AM, Ishii-Iwamoto EL, Andrade PV, Bracht A. Construction of a liver perfusion apparatus for studies on metabolic regulation and mechanisms of drug action. Arq Biol Tecnol 1984; 27: 419-438.
11. Scholz R, Bücher T. Hemoglobin-free perfusion of rat liver. In Control of Energy Metabolism, Chance B, Estabrook RW,Williamson JR (eds). Academic Press: New York, 1965; 393-414.
12. Czok R, Lamprecht W. 1974; Pyruvate, phosphoenolpyruvate and D-glycerate 2-phosphate. In Methods of Enzymatic Analysis, Bergmeyer HU (ed.). Academic Press: New York, 1446-1451.
13. +. In Methods of Enzymatic Analysis, Bergmeyer HU (ed.). Academic Press: New York, 1974; 1464-1468.
14. 2 tension. Trans Am Soc Artif Intern Organs 1956; 2: 41-49.
15. Dubowski KM. An o-toluidine method for body-fluid glucose determination. Clin Chem 1962; 8: 215-235.
16. Jaworek D, GruberW, Bergmeyer U. Adenosine 5'-diphosphate and 5'-monophosphate. In Methods of Enzymatic Analysis, Bergmeyer HU (ed.). Academic Press: New York, 1974; 2127-2131.
17. Lamprecht W, Trautschold I. Adenosine-5'-triphosphate. Determination with hexokinase and glucose-6-phosphate dehydrogenase. In Methods of Enzymatic Analysis, Bergmeyer HU (ed.). Academic Press: New York, 1974; 2101-2110.
18. Lang G, Michal G. D-glucose 6-phosphate and D-fructose 6-phosphate. In Methods of Enzymatic Analysis, Bergmeyer HU (ed.). Academic Press: New York, 1974; 1238-1242.
19. 5 reductase from rabbit liver microsomes with detergents and its properties. J Biochem 1972; 71: 725-735.
20. Lowry OH, Rosebrough NJ, Farr AC, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
21. Mendicino J, Beaudreau C, Hsu LL, Medicus R. Purification and properties of D-fructose 1,6-diphosphatase from swine kidney. J Biol Chem 1968; 243: 2703-2709.
22. Fiske CH, Subbarow Y. The colorimetric determination of phosphorus. J Biol Chem 1925; 66: 375-400.
23. Voss DO, Campello SP, Bacila M. The respiratory chain and the oxidative phosphorylation of rat brain mitochondria. Biochem Biophys Res Commun 1961; 4: 48-51.
24. 2 fixation by glucagon, epinephrine, and cortisol. J Biol Chem 1969; 244: 6444-6450.
25. Henning HV, Stumpf B, Seubert W. The glucogenic capacity and the activities of pyruvate carboxylase and phosphoenolpyruvate-carboxylase of rat kidney and rat liver after cortisol treatment and starvation. The mechanism of gluconeogenesis and its regulation. Biochem Z 1966; 344: 274-288.
26. Hess B, Wieker H. Pyruvate kinase from yeast. In Methods of Enzymatic Analysis, Bergmeyer HU (ed.). Academic Press: New York, 1974; 778-783.
27. Chan T, Galati G, O'brien PJ. Oxygen activation during peroxidase catalysed metabolism of flavones or flavanones. Chem Biol Interact 1999; 122: 15-25. DOI: 10.1016/S0009-2797(99)00103-9
28. Kimmig R, Mauch TJ, Kerzl W, Schwabe U, Scholz R. Actions of glucagon on flux rates in perfused rat liver. 1. Kinetics of the inhibitory effect on glycolysis and the stimulatory effect on glycogenolysis. Eur J Biochem 1983; 136: 609-616. DOI: 10.1111/j.1432-1033. 1983.tb07784.x
29. Williamson DH, Brosnan JT., Concentration of metabolites in animal tissues. In Methods of Enzymatic Analysis, Bergmeyer HU, (ed.). Academic Press: New York, 1974; 2266-2302.
30. Kelmer-Bracht AM, Santos CP, Ishii-Iwamoto EL, Broetto-Biazon AC, Bracht A. Kinetic properties of the glucose 6-phosphatase of the liver from arthritic rats. Biochim Biophys Acta 2003; 1638: 50-56. DOI: 10.1016/S0925-4439(03)00041-3
31. Dunn EE, Morgulis S. Studies on the catalase and peroxidase activity of the liver cell. J Biol Chem 1937; 118: 545-547.
32. Flatmark T. Demonstration of peroxidase activity in the rat kidney and liver: peroxidase effect of cytochrome c. Nature 1962; 196: 894-895. DOI: 10.1038/196894a0
33. Mendes-Mourão J, Halestrap AP, Crisp DM, Pogson CI. The involvement of mitochondrial pyruvate transport in the pathways of gluconeogenesis from serine and alanine in isolated rat and mouse liver cells. FEBS Lett 1975; 53: 29-32.
34. Lima LCN, Buss GD, Ishii-Iwamoto EL, et al. Metabolic effects of pcoumaric acid in the perfused rat liver. J Biochem Mol Toxicol 2006; 20: 18-26. DOI: 10.1002/jbt.20114
35. Groen AK, Van Roermund CWT, Vervoorn RC, Tager JM. Control of gluconeogenesis in rat liver cells. Biochem J 1986; 237: 379-389.
36. Galati G, Sabzevari O, Wilson JX, O'brien PJ. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonois and other polyphenolics. Toxicology 2002; 177: 91-104. DOI: 10.1016/S0300-483X(02)00198-1
37. Jakobs S, Fridrich D, Hofem S, Pahlke G, Eisenbrand G. Natural Flavonoids are potent inhibitors of glycogen phosphorylase. Mol Nutr Food Res 2005; 50: 52-57. DOI: 10.1002/mnfr.200500163
38. Bánhegyi G, Garzó T, Antoni F, Mandl J. Glycogenolysis and not gluconeogenesis is the source of UDP-glucuronic acid for glucuronidation. Biochim Biophys Acta 1988; 967: 429-435.
39. Scholz R, Hansen W, Thurman RG. Interaction of mixed-function oxidation with biosynthetic processes. 1. Inhibition of gluconeogenesis by aminopyrine in perfused rat liver. Eur J Biochem 1973; 38: 64-72. DOI: 10.1111/j.1432-1033. 1973.tb03034.x
40. Fedatto-Junior Z, Ishii-Iwamoto EL, Bersani-Amado C, et al. Gluconeogenesis in the liver of arthritic rats. Cell Biochem Funct 1999; 17: 271-278. DOI: 10.1002/(SICI)1099-0844(199912)17:4〈271::AID.- CBF839〉3.0.CO;2-P
41. Bollen M, Keppens S, Stalmans W. Specific features of glycogen metabolism in the liver. Biochem J 1998; 336: 19-31.
42. Van Dijk TH, Van Der Sluijs FH, Wiegman CH, et al. Acute inhibition of hepatic glucose 6-phosphatase does not affect gluconeogenesis but directs gluconeogenic flux toward glycogen in fasted rats. J Biol Chem 2001; 276: 25727-25735. DOI: 10.1074/jbc.M101223200
43. Guigas B, Naboulsi R, Villanueva GR, et al. The flavonoid silibinin decreases glucose-6-phosphate hydrolysis in perifused rat hepatocytes by an inhibitory effect on glucose-6-phosphatase. Cell Physiol Biochem 2007; 20: 925-934. DOI: 10.1159/000110453
44. Diraison F, Large V, Brunengraber H, Beylot M. Non-invasive tracing of liver intermediary metabolism in normal subjects and in moderately hyperglycaemic NIDDM subjects. Evidence against increased gluconeogenesis and hepatic fatty acid oxidation in NIDDM. Diabetologia 1998; 41: 212-220. DOI: 10.1007/s001250050892