Multiwall carbon nano-onions induce DNA damage and apoptosis in human umbilical vein endothelial cells

Environmental Toxicology

Volumn 28, Issue 8, 2013, Pages 442-450

  Xu, Yuying ^a,b   Wang, Shuang Ying ^a,c   Yang, Jie ^a   Gu, Xiaomin ^a   Zhang, Jun ^a   Zheng, Yi Fan ^a   Yang, Jun ^d   Xu, Lihong ^b   Zhu, Xin Qiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Zhejiang Ctr Dis Contr and Prev   (China)

^d HANGZHOU NORMAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle; Reactive oxygen species

Indexed keywords

AFTER-TREATMENT; BIOLOGICAL EFFECTS; CARBON NANO-ONIONS; CELL CYCLE; FLOW CYTOMETRY ANALYSIS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; INHIBITORY EFFECT; REACTIVE OXYGEN SPECIES;

CARBON; DNA; ENDOTHELIAL CELLS; OXYGEN;

CELL DEATH;

DNA; MULTI WALLED NANOTUBE; MULTIWALL CARBON NANO ONION; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; CARBON; CARDIOVASCULAR SYSTEM; CYTOLOGY; DNA; NANOTECHNOLOGY; OXYGEN;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; UMBILICAL VEIN ENDOTHELIAL CELL;

APOPTOSIS; CELL CYCLE; REACTIVE OXYGEN SPECIES;

APOPTOSIS; CELL PROLIFERATION; DNA DAMAGE; FLOW CYTOMETRY; FULLERENES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; REACTIVE OXYGEN SPECIES;

EID: 84880045372     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20736     Document Type: Article

References (48)

1. Ali SS, Hardt JI, Quick KL, Kim-Han JS, Erlanger BF, Huang TT, Epstein CJ, Dugan LL.2004.A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties.Free Radic Biol Med37:1191-1202.
2. Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE.2008.Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress.Circ Res102:589-596.
3. Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everitt JI.2004.Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles.Toxicol Sci77:347-357.
4. Block ML, Wu X, Pei Z, Li G, Wang T, Qin L, Wilson B, Yang J, Hong JS, Veronesi B.2004.Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: The role of microglia, phagocytosis, and NADPH oxidase.FASEB J18:1618-1620.
5. Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC.2005.In vitro cytotoxicity of nanoparticles in mammalian germline stem cells.Toxicol Sci88:412-419.
6. Brito JM, Belotti L, Toledo AC, Antonangelo L, Silva FS, Alvim DS, Andre PA, Saldiva PH, Rivero DH.2010.Acute cardiovascular and inflammatory toxicity induced by inhalation of diesel and biodiesel exhaust particles.Toxicol Sci116:67-78.
7. Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K.2001.Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines.Toxicol Appl Pharmacol175:191-199.
8. Chen K, Keaney J.2004.Reactive oxygen species-mediated signal transduction in the endothelium.Endothelium11:109-121.
9. Daniel R, Ramcharan J, Rogakou E, Taganov KD, Greger JG, Bonner W, Nussenzweig A, Katz RA, Skalka AM.2004.Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair.J Biol Chem279:45810-45814.
10. Ding L, Stilwell J, Zhang T, Elboudwarej O, Jiang H, Selegue JP, Cooke PA, Gray JW, Chen FF.2005.Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast.Nano Lett5:2448-2464.
11. Dresselhaus MS, Dresselhaus G, Eklund PC.1996.Science of Fullerenes and Carbon Nanotubes: Their Properties and Applications.New York, NY: Academic Press.
12. Freestone B, Krishnamoorthy S, Lip GY.2010.Assessment of endothelial dysfunction.Expert Rev Cardiovasc Ther8:557-571.
13. Gao J, Wang HL, Shreve A, Iyer R.2010.Fullerene derivatives induce premature senescence: A new toxicity paradigm or novel biomedical applications.Toxicol Appl Pharmacol244:130-143.
14. Guo J, Zhang X, Li Q, Li W.2007.Biodistribution of functionalized multiwall carbon nanotubes in mice.Nucl Med Biol34:579-583.
15. Guo YY, Zhang J, Zheng YF, Yang J, Zhu XQ.2011.Cytotoxic and genotoxic effects of multi-wall carbon nanotubes on human umbilical vein endothelial cells in vitro.Mutat Res721:184-191.
16. Gurr JR, Wang AS, Chen CH, Jan KY.2005.Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells.Toxicology213:66-73.
17. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ.2005.In vitro toxicity of nanoparticles in BRL 3A rat liver cells.Toxicol In Vitro19:975-983.
18. Jacobsen NR, Pojana G, White P, Moller P, Cohn CA, Korsholm KS, Vogel U, Marcomini A, Loft S, Wallin H.2008.Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C(60) fullerenes in the FE1-Mutatrade markMouse lung epithelial cells.Environ Mol Mutagen49:476-487.
19. Jiang W, Kim BY, Rutka JT, Chan WC.2007.Advances and challenges of nanotechnology-based drug delivery systems.Expert Opin Drug Deliv4:621-633.
20. Kadish KM, Ruoff RS.2000.Fullerenes: Chemistry, Physics, and Technology.New York, NY:Wiley-Interscience.
21. Knaapen AM, Borm PJ, Albrecht C, Schins RP.2004.Inhaled particles and lung cancer. Part A: Mechanisms.Int J Cancer109:799-809.
22. Koike E, Takano H, Inoue KI, Yanagisawa R, Sakurai M, Aoyagi H, Shinohara R, Kobayashi T.2008.Pulmonary exposure to carbon black nanoparticles increases the number of antigen-presenting cells in murine lung.Int J Immunopathol Pharmacol21:35-42.
23. Lam CW, James JT, McCluskey R, Arepalli S, Hunter RL.2006.A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks.Crit Rev Toxicol36:189-217.
24. Li N, Hao M, Phalen RF, Hinds WC, Nel AE.2003.Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects.Clin Immunol109:250-265.
25. Luszczyn J, Plonska-Brzezinska ME, Palkar A, Dubis AT, Simionescu A, Simionescu DT, Kalska-Szostko B, Winkler K, Echegoyen L.2010.Small noncytotoxic carbon nano-onions: First covalent functionalization with biomolecules.Chemistry16:4870-4880.
26. Maynard AD, Baron PA, Foley M, Shvedova AA, Kisin ER, Castranova V.2004.Exposure to carbon nanotube material: Aerosol release during the handling of unrefined single-walled carbon nanotube material.J Toxicol Environ Health A67:87-107.
27. Ng CT, Li JJ, Bay BH, Yung LY.2010.Current studies into the genotoxic effects of nanomaterials.J Nucleic Acids. doi:10.4061/2010/947859.
28. Oberdorster E.2004.Manufactured nanomaterials (fullerenes. C60) induce oxidative stress in the brain of juvenile largemouth bass.Environ Health Perspect112:1058-1062.
29. Patlolla A, Patlolla B, Tchounwou P.2010.Evaluation of cell viability. DNA damage, and cell death in normal human dermal fibroblast cells induced by functionalized multiwalled carbon nanotube.Mol Cell Biochem338:225-232.
30. Rakesh L, Howell BA, Chai M, Mueller A, Kujawski M, Fan D, Ravi S, Slominski C.2008.Computer-aided applications of nanoscale smart materials for biomedical applications.Nanomedicine (Lond)3:719-739.
31. Rancan F, Rosan S, Boehm F, Cantrell A, Brellreich M, Schoenberger H, Hirsch A, Moussa F.2002.Cytotoxicity and photocytotoxicity of a dendritic C(60) mono-adduct and a malonic acid C(60) tris-adduct on Jurkat cells.J Photochem Photobiol B67:157-162.
32. Roco MC.2003.Nanotechnology: Convergence with modern biology and medicine.Curr Opin Biotechnol14:337-346.
33. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM.1998.DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.J Biol Chem273:5858-5868.
34. Sayes CM, Reed KL, Warheit DB.2007.Assessing toxicity of fine and nanoparticles: Comparing in vitro measurements to in vivo pulmonary toxicity profiles.Toxicol Sci97:163-180.
35. Schulz H, Harder V, Ibald-Mulli A, Khandoga A, Koenig W, Krombach F, Radykewicz R, Stampfl A, Thorand B, Peters A.2005.Cardiovascular effects of fine and ultrafine particles.J Aerosol Med18:1-22.
36. Shiba K.2006.Functionalization of carbon nanomaterials by evolutionary molecular engineering: Potential application in drug delivery systems.J Drug Target14:512-518.
37. Shvedova AA, Castranova V, Kisin ER, Schwegler-Berry D, Murray AR, Gandelsman VZ, Maynard A, Baron P.2003.Exposure to carbon nanotube material: Assessment of nanotube cytotoxicity using human keratinocyte cells.J Toxicol Environ Health A66:1909-1926.
38. Srivastava RK, Pant AB, Kashyap MP, Kumar V, Lohani M, Jonas L, Rahman Q.2010.Multi-walled carbon nanotubes induce oxidative stress and apoptosis in human lung cancer cell line-A549.Nanotoxicology. doi: 10.3109/17435390.2010.503944
39. Taneja N, Davis M, Choy JS, Beckett MA, Singh R, Kron SJ, Weichselbaum RR.2004.Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy.J Biol Chem279:2273-2280.
40. Touyz RM, Briones AM.2011.Reactive oxygen species and vascular biology: Implications in human hypertension.Hypertens Res34:5-14.
41. Tsukahara T, Haniu H.2011.Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells.Mol Cell Biochem. DOI 10.1007/s11010-011-0739-z.
42. Upadhyay S, Ganguly K, Stoeger T, Semmler-Bhenke M, Takenaka S, Kreyling WG, Pitz M, Reitmeir P, Peters A, Eickelberg O, Wichmann HE, Schulz H.2010.Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs).Part Fibre Toxicol7:27.
43. Vesterdal LK, Folkmann JK, Jacobsen NR, Sheykhzade M, Wallin H, Loft S, Moller P.2010.Pulmonary exposure to carbon black nanoparticles and vascular effects.Part Fibre Toxicol7:33.
44. Wang H, Joseph JA.1999.Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader.Free Radic Biol Med27:612-616.
45. Wielgus AR, Zhao B, Chignell CF, Hu DN, Roberts JE.2010.Phototoxicity and cytotoxicity of fullerol in human retinal pigment epithelial cells.Toxicol Appl Pharmacol242:79-90.
46. Yan L, Zhao F, Li S, Hu Z, Zhao Y.2011.Low-toxic and safe nanomaterials by surface-chemical design, carbon nanotubes, fullerenes, metallofullerenes, and graphenes.Nanoscale3:362-382.
47. Yu Y, Zhu W, Diao H, Zhou C, Chen FF, Yang J.2006.A comparative study of using comet assay and gammaH2AX foci formation in the detection of N-methyl-N′-nitro-N-nitrosoguanidine-induced DNA damage.Toxicol In Vitro20:959-965.
48. Zhou C, Li Z, Diao H, Yu Y, Zhu W, Dai Y, Chen FF, Yang J.2006.DNA damage evaluated by gammaH2AX foci formation by a selective group of chemical/physical stressors.Mutat Res604:8-18.