메뉴 건너뛰기




Volumn 750, Issue , 2012, Pages 44-55

Naturally occurring antibodies as therapeutics for neurologic disease can human monoclonal IgMs replace the limited resource IVIG?

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; MEMBRANE ANTIGEN; MONOCLONAL ANTIBODY; NATURAL ANTIBODY; UNCLASSIFIED DRUG; AUTOANTIBODY; CALCIUM; IMMUNOGLOBULIN; RECOMBINANT PROTEIN;

EID: 84866782855     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-3461-0_4     Document Type: Article
Times cited : (4)

References (48)
  • 3
    • 33846080463 scopus 로고    scopus 로고
    • Drug Insight: The use of intravenous immunoglobulin in neurology - Therapeutic considerations and practical issues
    • DOI 10.1038/ncpneuro0376, PII NCPNEURO0376
    • Gold R, Stangel M, Dalakas MC. Drug Insight: The use of intravenous immunoglobulin in neurology-therapeutic considerations and practical issues. Nat Clin Pract Neurol 2007; 3:36-44. PMID:17205073 doi:10.1038/ncpneuro0376 (Pubitemid 46056032)
    • (2007) Nature Clinical Practice Neurology , vol.3 , Issue.1 , pp. 36-44
    • Gold, R.1    Stangel, M.2    Dalakas, M.C.3
  • 4
    • 0034727066 scopus 로고    scopus 로고
    • Multiple sclerosis
    • PMID:11006371 doi:10.1056/NEJM200009283431307
    • Noseworthy JH, Lucchinetti C, Rodriguez M et al. Multiple sclerosis. N Engl J Med 2000; 343:938-52. PMID:11006371 doi:10.1056/NEJM200009283431307
    • (2000) N Engl J Med , vol.343 , pp. 938-952
    • Noseworthy, J.H.1    Lucchinetti, C.2    Rodriguez, M.3
  • 5
    • 0031057970 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis
    • DOI 10.1016/S0140-6736(96)09377-4
    • Fazekas F, Deisenhammer F, Strasser-Fuchs S et al. Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis. Austrian Immunoglobulin in Multiple Sclerosis Study Group. Lancet 1997; 349:589-93. PMID:9057729 doi:10.1016/S0140-6736(96)09377-4 (Pubitemid 27101884)
    • (1997) Lancet , vol.349 , Issue.9052 , pp. 589-593
    • Fazekas, F.1    Deisenhammer, F.2    Strasser-Fuchs, S.3    Nahler, G.4    Mamoli, B.5
  • 7
    • 25844440884 scopus 로고    scopus 로고
    • Intravenous immunoglobulins in the treatment of relapsing remitting multiple sclerosis-results of a retrospective multicenter observational study over five years
    • PMID:16193894 doi:10.1191/1352458505ms1224oa
    • Haas J, Maas-Enriquez M, Hartung HP. Intravenous immunoglobulins in the treatment of relapsing remitting multiple sclerosis-results of a retrospective multicenter observational study over five years. Mult Scler 11:562-7. PMID:16193894 doi:10.1191/1352458505ms1224oa
    • Mult Scler , vol.11 , pp. 562-567
    • Haas, J.1    Maas-Enriquez, M.2    Hartung, H.P.3
  • 8
    • 50549098795 scopus 로고    scopus 로고
    • Intravenous immunoglobulin in relapsing-remitting multiple sclerosis: A dose-finding trial
    • PMID:18645164 doi:10.1212/01.wnl.0000318281.98220.6f
    • Fazekas F, Lublin FD, Li D et al. Intravenous immunoglobulin in relapsing-remitting multiple sclerosis: A dose-finding trial. Neurology 2008; 71:265-71. PMID:18645164 doi:10.1212/01.wnl.0000318281.98220.6f
    • (2008) Neurology , vol.71 , pp. 265-271
    • Fazekas, F.1    Lublin, F.D.2    Li, D.3
  • 9
    • 4644250609 scopus 로고    scopus 로고
    • Intravenous immunoglobulin in secondary progressive multiple sclerosis: Randomised placebo-controlled trial
    • 56. PMID:15451222 doi:10.1016/ S0140-6736(04
    • Hommes OR, Sorensen PS, Fazekas F et al. Intravenous immunoglobulin in secondary progressive multiple sclerosis: randomised placebo-controlled trial. Lancet 2004; 364:1149-56. PMID:15451222 doi:10.1016/ S0140-6736(04)17101-8
    • (2004) Lancet , vol.364 , Issue.1149 , pp. 17101-17108
    • Hommes, O.R.1    Sorensen, P.S.2    Fazekas, F.3
  • 10
    • 0026808845 scopus 로고
    • The ocular manifestations of multiple sclerosis. 1. Abnormalities of the afferent visual system
    • PMID:1402963 doi:10.1136/jnnp.55.9.747
    • McDonald WI, Barnes D. The ocular manifestations of multiple sclerosis. 1. Abnormalities of the afferent visual system. J Neurol Neurosurg Psychiatry 1992; 55:747-52. PMID:1402963 doi:10.1136/jnnp.55.9.747
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 747-752
    • McDonald, W.I.1    Barnes, D.2
  • 12
    • 14644430331 scopus 로고    scopus 로고
    • A double-blind, randomized trial of IV immunoglobulin treatment in acute optic neuritis
    • Roed HG, Langkilde A, Sellebjerg F et al. A double-blind, randomized trial of IV immunoglobulin treatment in acute optic neuritis. Neurology 2005; 64:804-10. PMID:15753413 doi:10.1212/01. WNL.0000152873.82631.B3 (Pubitemid 40316316)
    • (2005) Neurology , vol.64 , Issue.5 , pp. 804-810
    • Roed, H.G.1    Langkilde, A.2    Sellebjerg, F.3    Lauritzen, M.4    Bang, P.5    Morup, A.6    Frederiksen, J.L.7
  • 13
    • 0034711155 scopus 로고    scopus 로고
    • IV immunoglobulin does not reverse established weakness in M.S.
    • PMID:11071491
    • Noseworthy JH, O'Brien PC, Weinshenker BG et al. IV immunoglobulin does not reverse established weakness in MS. Neurology 2000; 55:1135-43. PMID:11071491
    • (2000) Neurology , vol.55 , pp. 1135-1143
    • Noseworthy, J.H.1    O'Brien, P.C.2    Weinshenker, B.G.3
  • 14
    • 53549104740 scopus 로고    scopus 로고
    • Treatment of corticosteroid refractory optic neuritis in multiple sclerosis patients with intravenous immunoglobulin
    • PMID:18727675 doi:10.1111/j.1468-1331.2008.02258.x
    • Tselis A, Perumal J, Caon C et al. Treatment of corticosteroid refractory optic neuritis in multiple sclerosis patients with intravenous immunoglobulin. Eur J Neurol 2008; 15:1163-7. PMID:18727675 doi:10.1111/j.1468-1331.2008.02258.x
    • (2008) Eur J Neurol , vol.15 , pp. 1163-1167
    • Tselis, A.1    Perumal, J.2    Caon, C.3
  • 15
    • 0023494731 scopus 로고
    • Theiler's murine encephalomyelitis: A model of demyelination and persistence of virus
    • PMID:2827957
    • Rodriguez M, Oleszak E, Leibowitz J. Theiler's murine encephalomyelitis: A model of demyelination and persistence of virus. Crit Rev Immunol 1987; 7:325-65. PMID:2827957
    • (1987) Crit Rev Immunol , vol.7 , pp. 325-365
    • Rodriguez, M.1    Oleszak, E.2    Leibowitz, J.3
  • 16
    • 0033975629 scopus 로고    scopus 로고
    • Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis
    • McGavern DB, Murray PD, Rivera-Quinones C et al. Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis. Brain 2000; 123:519-31. PMID:10686175 doi:10.1093/ brain/123.3.519 (Pubitemid 30099537)
    • (2000) Brain , vol.123 , Issue.3 , pp. 519-531
    • McGavern, D.B.1    Murray, P.D.2    Rivera-Quinones, C.3    Schmelzer, J.D.4    Low, P.A.5    Rodriguez, M.6
  • 17
    • 0033571378 scopus 로고    scopus 로고
    • Quantitation of spinal cord demyelination, remyelination, atrophy, and axonal loss in a model of progressive neurologic injury
    • DOI 10.1002/(SICI)1097-4547(19991115)58:4<492::AID-JNR3>3.0.CO;2-P
    • McGavern DB, Murray PD, Rodriguez M. Quantitation of spinal cord demyelination, remyelination, atrophy, and axonal loss in a model of progressive neurologic injury. J Neurosci Res 1999; 58:492-504. PMID:10533042 doi:10.1002/(SICI)1097-4547(19991115)58:4<492::AID-JNR3>3.0.CO;2-P (Pubitemid 29530433)
    • (1999) Journal of Neuroscience Research , vol.58 , Issue.4 , pp. 492-504
    • McGavern, D.B.1    Murray, P.D.2    Rodriguez, M.3
  • 18
    • 0032868603 scopus 로고    scopus 로고
    • Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination
    • DOI 10.1006/exnr.1999.7082
    • McGavern DB, Zoecklein L, Drescher KM et al. Quantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination. Exp Neurol 1999; 158:171-81. PMID:10448429 doi:10.1006/exnr.1999.7082 (Pubitemid 29344329)
    • (1999) Experimental Neurology , vol.158 , Issue.1 , pp. 171-181
    • McGavern, D.B.1    Zoecklein, L.2    Drescher, K.M.3    Rodriguez, M.4
  • 20
    • 0025099773 scopus 로고
    • Immunoglobulins promote remyelination in the central nervous system
    • DOI 10.1002/ana.410270104
    • Rodriguez M, Lennon VA. Immunoglobulins promote remyelination in the central nervous system. Ann Neurol 1990; 27:12-7. PMID:2301922 doi:10.1002/ana.410270104 (Pubitemid 20031353)
    • (1990) Annals of Neurology , vol.27 , Issue.1 , pp. 12-17
    • Rodriguez, M.1    Lennon, V.A.2
  • 21
    • 0033231307 scopus 로고    scopus 로고
    • A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord
    • 47. PMID:10595515 doi:10.1016/ S0896-6273(00
    • Huang DW, McKerracher L, Braun PE et al. A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord. Neuron 1999; 24:639-47. PMID:10595515 doi:10.1016/ S0896-6273(00)81118-6
    • (1999) Neuron , vol.24 , Issue.639 , pp. 81118-81126
    • Huang, D.W.1    McKerracher, L.2    Braun, P.E.3
  • 22
    • 0037328021 scopus 로고    scopus 로고
    • Vaccination stimulates retinal ganglion cell regeneration in the adult optic nerve
    • DOI 10.1016/S0969-9961(02)00013-X
    • Ellezam B, Bertrand J, Dergham P et al. Vaccination stimulates retinal ganglion cell regeneration in the adult optic nerve. Neurobiol Dis 2003; 12:1-10. PMID:12609484 doi:10.1016/S0969-9961(02)00013-X (Pubitemid 36262034)
    • (2003) Neurobiology of Disease , vol.12 , Issue.1 , pp. 1-10
    • Ellezam, B.1    Bertrand, J.2    Dergham, P.3    McKerracher, L.4
  • 23
    • 0028071114 scopus 로고
    • Monoclonal autoantibodies promote central nervous system repair in an animal model of multiple sclerosis
    • Miller DJ, Sanborn KS, Katzmann JA et al. Monoclonal autoantibodies promote central nervous system repair in an animal model of multiple sclerosis. J Neurosci 1994; 14:6230-8. PMID:7931575 (Pubitemid 24307813)
    • (1994) Journal of Neuroscience , vol.14 , Issue.10 , pp. 6230-6238
    • Miller, D.J.1    Sanborn, K.S.2    Katzmann, J.A.3    Rodriguez, M.4
  • 24
    • 0030024834 scopus 로고    scopus 로고
    • Monoclonal autoantibody SCH94.03, which promotes central nervous system remyelination, recognizes an antigen on the surface of oligodendrocytes
    • DOI 10.1002/(SICI)1097-4547(19960201)43:3<273::AID-JNR2>3.0.CO;2-G
    • Asakura K, Miller DJ, Murray K et al. Monoclonal autoantibody SCH94.03, which promotes central nervous system remyelination, recognizes an antigen on the surface of oligodendrocytes. J Neurosci Res 1996; 43:273-81. PMID:8714516 doi:10.1002/(SICI)1097-4547(19960201)43:3<273::AID-JNR2>3.0.CO;2-G (Pubitemid 26057424)
    • (1996) Journal of Neuroscience Research , vol.43 , Issue.3 , pp. 273-281
    • Asakura, K.1    Miller, D.J.2    Murray, K.3    Bansal, R.4    Pfeiffer, S.E.5    Rodriguez, M.6
  • 25
    • 0026658286 scopus 로고
    • Proliferation and differentiation of O4+ oligodendrocytes in postnatal rat cerebellum: Analysis in unfixed tissue slices using anti-glycolipid antibodies
    • PMID:1453495 doi:10.1002/jnr.490330218
    • Warrington AE, Pfeiffer SE. Proliferation and differentiation of O4+ oligodendrocytes in postnatal rat cerebellum: Analysis in unfixed tissue slices using anti-glycolipid antibodies. J Neurosci Res 1992; 33:338-53. PMID:1453495 doi:10.1002/jnr.490330218
    • (1992) J Neurosci Res , vol.33 , pp. 338-353
    • Warrington, A.E.1    Pfeiffer, S.E.2
  • 26
    • 0032173451 scopus 로고    scopus 로고
    • Targeting of IgMκ antibodies to oligodendrocytes promotes CNS remyelination
    • Asakura K, Miller DJ, Pease LR et al. Targeting of IgMkappa antibodies to oligodendrocytes promotes CNS remyelination. J Neurosci 1998; 18:7700-8. PMID:9742140 (Pubitemid 28441011)
    • (1998) Journal of Neuroscience , vol.18 , Issue.19 , pp. 7700-7708
    • Asakura, K.1    Miller, D.J.2    Pease, L.R.3    Rodriguez, M.4
  • 27
    • 0029562053 scopus 로고
    • Oligodendrocyte-reactive O1, O4, and HNK-1 monoclonal antibodies are encoded by germline immunoglobulin genes
    • DOI 10.1016/0169-328X(95)00190-4
    • Asakura K, Miller DJ, Pogulis RJ et al. Oligodendrocyte-reactive O1, O4, and HNK-1 monoclonal antibodies are encoded by germline immunoglobulin genes. Brain Res Mol Brain Res 1995; 34:283-93. PMID:8750831 doi:10.1016/0169-328X(95) 00190-4 (Pubitemid 26007084)
    • (1995) Molecular Brain Research , vol.34 , Issue.2 , pp. 283-293
    • Asakura, K.1    Miller, D.J.2    Pogulis, R.J.3    Pease, L.R.4    Rodriguez, M.5
  • 28
    • 35448937286 scopus 로고    scopus 로고
    • Naturally occurring B-cell autoreactivity: A critical overview
    • DOI 10.1016/j.jaut.2007.07.010, PII S0896841107000959, Pathophysiology of Autoimmune Desease
    • Avrameas S, Ternynck T, Tsonis IA et al. Naturally occurring B-cell autoreactivity: A critical overview. J Autoimmun 2007; 29:213-8. PMID:17888629 doi:10.1016/j.jaut.2007.07.010 (Pubitemid 47633147)
    • (2007) Journal of Autoimmunity , vol.29 , Issue.4 , pp. 213-218
    • Avrameas, S.1    Ternynck, T.2    Tsonis, I.A.3    Lymberi, P.4
  • 30
    • 0020059795 scopus 로고
    • Immunoglobulin expression by human B lymphocytes clonally transformed by Epstein Barr virus
    • Brown NA, Miller G. Immunoglobulin expression by human B lymphocytes clonally transformed by Epstein Barr virus. J Immunol 1982; 128:24-9. PMID:6274955 (Pubitemid 12207414)
    • (1982) Journal of Immunology , vol.128 , Issue.1 , pp. 24-29
    • Brown, N.A.1    Miller, G.2
  • 31
    • 0036674424 scopus 로고    scopus 로고
    • Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic-progressive demyelinating disease
    • PMID:12154009
    • Mitsunaga Y, Ciric B, Van Keulen V et al. Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic-progressive demyelinating disease. FASEB J 2002; 16:1325-7. PMID:12154009
    • (2002) FASEB J , vol.16 , pp. 1325-1327
    • Mitsunaga, Y.1    Ciric, B.2    Van Keulen, V.3
  • 32
    • 0036509862 scopus 로고    scopus 로고
    • Human antibodies accelerate the rate of remyelination following lysolecithin-induced demyelination in mice
    • PMID:11857682 doi:10.1002/glia.10033
    • Bieber AJ, Warrington A, Asakura K et al. Human antibodies accelerate the rate of remyelination following lysolecithin-induced demyelination in mice. Glia 2002; 37:241-9. PMID:11857682 doi:10.1002/glia.10033
    • (2002) Glia , vol.37 , pp. 241-249
    • Bieber, A.J.1    Warrington, A.2    Asakura, K.3
  • 34
    • 9444237918 scopus 로고    scopus 로고
    • A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS
    • DOI 10.1096/fj.04-2026fje
    • Pirko I, Ciric B, Gamez J et al. A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS. FASEB J 2004; 18:1577-9. PMID:15319372 (Pubitemid 39561638)
    • (2004) FASEB Journal , vol.18 , Issue.13 , pp. 1577-1579
    • Pirko, I.1    Ciric, B.2    Gamez, J.3    Bieber, A.J.4    Warrington, A.E.5    Johnson, A.J.6    Hanson, D.P.7    Pease, L.R.8    MacUra, S.I.9    Rodriguez, M.10
  • 35
    • 0030752967 scopus 로고    scopus 로고
    • Monoclonal remyelination-promoting natural autoantibody SCH 94.03: Pharmacokinetics and in vivo targets within demyelinated spinal cord in a mouse model of multiple sclerosis
    • DOI 10.1016/S0022-510X(97)00080-4, PII S0022510X97000804
    • Hunter SF, Miller DJ, Rodriguez M. Monoclonal remyelination-promoting natural autoantibody SCH.03: Pharmacokinetics and in vivo targets within demyelinated spinal cord in a mouse model of multiple sclerosis. J Neurol Sci 1997; 150:103-13. PMID:9268236 doi:10.1016/S0022-510X(97)00080-4 (Pubitemid 27317687)
    • (1997) Journal of the Neurological Sciences , vol.150 , Issue.2 , pp. 103-113
    • Hunter, S.F.1    Miller, D.J.2    Rodriguez, M.3
  • 36
    • 34447622675 scopus 로고    scopus 로고
    • Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: An age-related selective uptake with reversal of learning impairment
    • DOI 10.1016/j.expneurol.2007.05.005, PII S0014488607001987
    • Banks WA, Farr SA, Morley JE et al. Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: An age-related selective uptake with reversal of learning impairment. Exp Neurol 2007; 206:248-56. PMID:17582399 doi:10.1016/j.expneurol.2007.05.005 (Pubitemid 47094769)
    • (2007) Experimental Neurology , vol.206 , Issue.2 , pp. 248-256
    • Banks, W.A.1    Farr, S.A.2    Morley, J.E.3    Wolf, K.M.4    Geylis, V.5    Steinitz, M.6
  • 37
    • 0037285507 scopus 로고    scopus 로고
    • Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: Relationship to the mechanism of myelin repair
    • DOI 10.1016/S1044-7431(02)00018-0
    • Paz Soldán MM, Warrington AE, Bieber AJ et al. Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair. Mol Cell Neurosci 2003; 22:14-24. PMID:12595235 doi:10.1016/S1044-7431(02) 00018-0 (Pubitemid 36269112)
    • (2003) Molecular and Cellular Neuroscience , vol.22 , Issue.1 , pp. 14-24
    • Soldan, M.M.P.1    Warrington, A.E.2    Bieber, A.J.3    Ciric, B.4    Van Keulen, V.5    Pease, L.R.6    Rodriguez, M.7
  • 38
    • 78649338732 scopus 로고    scopus 로고
    • Human remyelination promoting antibody inhibits apoptotic signaling and differentiation through Lyn kinase in primary rat oligodendrocytes
    • PMID:20645409 doi:10.1002/glia.21048
    • Watzlawik J, Holicky E, Edberg DD et al. Human remyelination promoting antibody inhibits apoptotic signaling and differentiation through Lyn kinase in primary rat oligodendrocytes. Glia 2010; 58:1782-93. PMID:20645409 doi:10.1002/glia.21048
    • (2010) Glia , vol.58 , pp. 1782-1793
    • Watzlawik, J.1    Holicky, E.2    Edberg, D.D.3
  • 40
    • 76749113309 scopus 로고    scopus 로고
    • Structure and function of immunoglobulins
    • PMID:20176268 doi:10.1016/j.jaci.2009.09.046
    • Schroeder HW Jr., Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol 2010; 125(Suppl 2):S41-52. PMID:20176268 doi:10.1016/j.jaci.2009.09.046
    • (2010) J Allergy Clin Immunol , vol.125 , Issue.SUPPL. 2
    • Schroeder Jr., H.W.1    Cavacini, L.2
  • 41
    • 1642578925 scopus 로고    scopus 로고
    • Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody
    • DOI 10.1016/j.nbd.2003.09.002
    • Howe CL, Bieber AJ, Warrington AE et al. Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody. Neurobiol Dis 2004; 15:120-31. PMID:14751777 doi:10.1016/j.nbd.2003.09.002 (Pubitemid 38134387)
    • (2004) Neurobiology of Disease , vol.15 , Issue.1 , pp. 120-131
    • Howe, C.L.1    Bieber, A.J.2    Warrington, A.E.3    Pease, L.R.4    Rodriguez, M.5
  • 44
    • 13644249899 scopus 로고    scopus 로고
    • Human monoclonal antibodies against amyloid-beta from healthy adults
    • DOI 10.1016/j.neurobiolaging.2004.06.008
    • Geylis V, Kourilov V, Meiner Z et al. Human monoclonal antibodies against amyloid-beta from healthy adults. Neurobiol Aging 2005; 26:597-606. PMID:15708434 doi:10.1016/j.neurobiolaging.2004.06.008 (Pubitemid 40228751)
    • (2005) Neurobiology of Aging , vol.26 , Issue.5 , pp. 597-606
    • Geylis, V.1    Kourilov, V.2    Meiner, Z.3    Nennesmo, I.4    Bogdanovic, N.5    Steinitz, M.6
  • 45
    • 51749103554 scopus 로고    scopus 로고
    • Natural human antibodies to amyloid beta peptide
    • PMID:18558354 doi:10.1016/j.autrev.2008.03.007
    • Szabo P, Relkin N, Weksler ME. Natural human antibodies to amyloid beta peptide. Autoimmun Rev 2008; 7:415-20. PMID:18558354 doi:10.1016/j.autrev.2008. 03.007
    • (2008) Autoimmun Rev , vol.7 , pp. 415-420
    • Szabo, P.1    Relkin, N.2    Weksler, M.E.3
  • 47
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • PMID:10932230 doi:10.1038/78682
    • Bard F, Cannon C, Barbour R et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6:916-9. PMID:10932230 doi:10.1038/78682
    • Nat Med , vol.6 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3
  • 48
    • 78649754766 scopus 로고    scopus 로고
    • Amyloid-beta oligomer specificity mediated by the IgM isotype-implications for a specific protective mechanism exerted by endogenous auto-antibodies
    • PMID:21085663 doi:10.1371/journal.pone.0013928
    • Lindhagen-Persson M, Brannstrom K, Vestling M et al. Amyloid-beta oligomer specificity mediated by the IgM isotype-implications for a specific protective mechanism exerted by endogenous auto-antibodies. PLoS ONE 2010; 5:e13928. PMID:21085663 doi:10.1371/journal.pone.0013928
    • (2010) PLoS ONE , vol.5
    • Lindhagen-Persson, M.1    Brannstrom, K.2    Vestling, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.