Hydroxynaphthoic acids identified in a high throughput screening potently ameliorate endoplasmic reticulum stress as novel chemical chaperones

Chemical and Pharmaceutical Bulletin

Volumn 61, Issue 7, 2013, Pages 740-746

  Jeong, Kwi Wan ^a   Ku, Jin Mo ^a   Park, Myung Whan ^a   Park, Sun Mi ^a   Yang, Jung Eun ^a   Nam, Tae Gyu ^b  

^a Gyeonggi Institute of Science and Technology Promotion   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Chemical chaperone; Endoplasmic reticulum stress; Hydroxynaphthoic acid; Unfolded protein response

Indexed keywords

1 HYDROXY 2 NAPHTHOIC ACID; 2 NAPHTHOIC ACID DERIVATIVE; 3 HYDROXY 2 NAPHTHOIC ACID; 6 HYDROXY 2 NAPHTHOIC ACID; CCAAT ENHANCER BINDING PROTEIN; GLUCOSE REGULATED PROTEIN 78; MESSENGER RNA; PROTEIN IRE1; PROTEIN IRE1 ALPHA; PROTEIN KINASE R; RENILLA LUCIFERIN 2 MONOOXYGENASE; SALICYLIC ACID; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; 1-HYDROXY-2-NAPHTHOIC ACID; DNA BINDING PROTEIN; ERN1 PROTEIN, HUMAN; NAPHTHOL DERIVATIVE; PROTEIN SERINE THREONINE KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTORS; RIBONUCLEASE; SALICYLIC ACID DERIVATIVE; TRANSCRIPTION FACTOR;

ARTICLE; CELL ASSAY; CELL STRAIN HEPG2; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENTIATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SIGNALING; RNA SPLICING; UNFOLDED PROTEIN RESPONSE; CHEMISTRY; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENETICS; HEK293 CELL LINE; HEPG2 CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION;

DNA-BINDING PROTEINS; DOWN-REGULATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HEK293 CELLS; HEP G2 CELLS; HUMANS; NAPHTHOLS; PROTEIN-SERINE-THREONINE KINASES; SALICYLATES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 84880014131     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c13-00251     Document Type: Article

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