메뉴 건너뛰기




Volumn 6, Issue 3, 2013, Pages 120-128

The CpG island methylator phenotype (CIMP) in colorectal cancer

Author keywords

CIMP; Clinical implication; Colorectal Cancer

Indexed keywords

B RAF KINASE; BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 2A; FLUOROURACIL; K RAS PROTEIN;

EID: 84880002767     PISSN: 20082258     EISSN: 20084234     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (152)

References (66)
  • 1
    • 84866235428 scopus 로고    scopus 로고
    • Genetic and epigenetic events generate multiple pathways in colorectal cancer progression
    • Pancione M, Remo A, Colantuoni V. Genetic and epigenetic events generate multiple pathways in colorectal cancer progression. Patholog Res Int 2012;1-11.
    • (2012) Patholog Res Int , pp. 1-11
    • Pancione, M.1    Remo, A.2    Colantuoni, V.3
  • 2
    • 78049332872 scopus 로고    scopus 로고
    • Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors
    • Haggar FA, Boushey RP. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg 2009;22:191-97.
    • (2009) Clin Colon Rectal Surg , vol.22 , pp. 191-197
    • Haggar, F.A.1    Boushey, R.P.2
  • 3
    • 33845691410 scopus 로고    scopus 로고
    • Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer
    • Slattery ML, Curtin K, Sweeney C, Levin TR, Potter J, Wolff RK, et al. Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer. Int J Cancer 2007 ;120:656-63.
    • (2007) Int J Cancer , vol.120 , pp. 656-663
    • Slattery, M.L.1    Curtin, K.2    Sweeney, C.3    Levin, T.R.4    Potter, J.5    Wolff, R.K.6
  • 4
    • 77951630296 scopus 로고    scopus 로고
    • Primary prevention of colorectal cancer
    • Chan AT, Giovannucci EL. Primary prevention of colorectal cancer. Gastroenterology 2010 ;138:2029-43.
    • (2010) Gastroenterology , vol.138 , pp. 2029-2043
    • Chan, A.T.1    Giovannucci, E.L.2
  • 5
    • 79958173795 scopus 로고    scopus 로고
    • Colorectal cancer: molecular features and clinical opportunities
    • Worthley DL, Leggett BA. Colorectal cancer: molecular features and clinical opportunities. Clin Biochem Rev 2010; 31:31-38.
    • (2010) Clin Biochem Rev , vol.31 , pp. 31-38
    • Worthley, D.L.1    Leggett, B.A.2
  • 6
    • 77449130761 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer
    • Boland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology 2010; 138:2073-87.
    • (2010) Gastroenterology , vol.138 , pp. 2073-2087
    • Boland, C.R.1    Goel, A.2
  • 7
    • 84876495060 scopus 로고    scopus 로고
    • CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer
    • Wu C, Bekaii-Saab T. CpG Island Methylation, Microsatellite Instability, and BRAF Mutations and Their Clinical Application in the Treatment of Colon Cancer. Chemother Res Pract 2012; 2012:359041.
    • (2012) Chemother Res Pract , vol.2012 , pp. 359041
    • Wu, C.1    Bekaii-Saab, T.2
  • 9
    • 79958261864 scopus 로고    scopus 로고
    • Microsatellite instability in the management of colorectal cancer
    • Pino MS, Chung DC. Microsatellite instability in the management of colorectal cancer. Expert Rev Gastroenterol Hepatol 2011; 5:385-99.
    • (2011) Expert Rev Gastroenterol Hepatol , vol.5 , pp. 385-399
    • Pino, M.S.1    Chung, D.C.2
  • 10
    • 77951627056 scopus 로고    scopus 로고
    • The chromosomal instability pathway in colon cancer
    • Pino MS, Chung DC. The chromosomal instability pathway in colon cancer. Gastroenterology 2010; 138:2059-72.
    • (2010) Gastroenterology , vol.138 , pp. 2059-2072
    • Pino, M.S.1    Chung, D.C.2
  • 11
    • 1242292420 scopus 로고    scopus 로고
    • Genomic instability and colon cancer
    • Grady WM. Genomic instability and colon cancer. Cancer Metastasis Rev 2004; 23:11-27.
    • (2004) Cancer Metastasis Rev , vol.23 , pp. 11-27
    • Grady, W.M.1
  • 12
    • 9244263076 scopus 로고    scopus 로고
    • Aneuploidy and cancer
    • Rajagopalan H, Lengauer C. Aneuploidy and cancer. Nature 2004; 432:338-41.
    • (2004) Nature , vol.432 , pp. 338-341
    • Rajagopalan, H.1    Lengauer, C.2
  • 19
    • 0036145156 scopus 로고    scopus 로고
    • Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
    • Esteller M, Herman JG. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol 2002; 196: 1-7.
    • (2002) J Pathol , vol.196 , pp. 1-7
    • Esteller, M.1    Herman, J.G.2
  • 20
    • 78650215860 scopus 로고    scopus 로고
    • Two groups of DNA methylation markers to classify colorectal cancer into three epigenotypes
    • Kaneda A, Yagi K. Two groups of DNA methylation markers to classify colorectal cancer into three epigenotypes. Cancer Sci 2011; 102:18-24.
    • (2011) Cancer Sci , vol.102 , pp. 18-24
    • Kaneda, A.1    Yagi, K.2
  • 21
    • 0032739329 scopus 로고    scopus 로고
    • CpG island methylator phenotypes in aging and cancer
    • Toyota M, Issa JP. CpG island methylator phenotypes in aging and cancer. Semin Cancer Biol 1999; 9:349-57.
    • (1999) Semin Cancer Biol , vol.9 , pp. 349-357
    • Toyota, M.1    Issa, J.P.2
  • 22
    • 5444255150 scopus 로고    scopus 로고
    • The epigenetics of cancer etiology
    • Feinberg AP. The epigenetics of cancer etiology. Semin Cancer Biol 2004; 14:427-32.
    • (2004) Semin Cancer Biol , vol.14 , pp. 427-432
    • Feinberg, A.P.1
  • 23
    • 72749115699 scopus 로고    scopus 로고
    • Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG islandhypermethylation in colorectal cancer
    • de Vogel S, Wouters KA, Gottschalk RW, van Schooten FJ, de Goeij AF, de Bruïne AP, et al. Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG islandhypermethylation in colorectal cancer. Cancer Epidemiol Biomarkers Prev 2009 ;18:3086-96.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 3086-3096
    • de Vogel, S.1    Wouters, K.A.2    Gottschalk, R.W.3    van Schooten, F.J.4    de Goeij, A.F.5    de Bruïne, A.P.6
  • 24
    • 0036895068 scopus 로고    scopus 로고
    • Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands
    • van Rijnsoever M, Grieu F, Elsaleh H, Joseph D, Iacopetta B. Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut 2002; 51:797-802.
    • (2002) Gut , vol.51 , pp. 797-802
    • van Rijnsoever, M.1    Grieu, F.2    Elsaleh, H.3    Joseph, D.4    Iacopetta, B.5
  • 25
    • 0033913645 scopus 로고    scopus 로고
    • Aging, methylation and cancer
    • Ahuja N, Issa JP. Aging, methylation and cancer. Histol Histopathol 2000; 15:835-842.
    • (2000) Histol Histopathol , vol.15 , pp. 835-842
    • Ahuja, N.1    Issa, J.P.2
  • 26
    • 33749598345 scopus 로고    scopus 로고
    • Epigenetic activation of tumor suppressor microRNAs in human cancer cells
    • Saito Y, Jones PA. Epigenetic activation of tumor suppressor microRNAs in human cancer cells. Cell Cycle 2006; 5:2220-22.
    • (2006) Cell Cycle , vol.5 , pp. 2220-2222
    • Saito, Y.1    Jones, P.A.2
  • 27
    • 70649095120 scopus 로고    scopus 로고
    • Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
    • Doi A, Park IH, Wen B, Murakami P, Aryee MJ, Irizarry R, et al. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet 2009; 41:1350-53.
    • (2009) Nat Genet , vol.41 , pp. 1350-1353
    • Doi, A.1    Park, I.H.2    Wen, B.3    Murakami, P.4    Aryee, M.J.5    Irizarry, R.6
  • 28
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 2009 ;41:178-86.
    • (2009) Nat Genet , vol.41 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3    Wu, Z.4    Montano, C.5    Onyango, P.6
  • 29
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • Issa JP. CpG island methylator phenotype in cancer. Nat Rev Cancer 2004; 4:988-93.
    • (2004) Nat Rev Cancer , vol.4 , pp. 988-993
    • Issa, J.P.1
  • 30
    • 77952449085 scopus 로고    scopus 로고
    • Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features
    • Ang PW, Loh M, Liem N, Lim PL, Grieu F, Vaithilingam A, et al. Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features. BMC Cancer 2010; 10:227.
    • (2010) BMC Cancer , vol.10 , pp. 227
    • Ang, P.W.1    Loh, M.2    Liem, N.3    Lim, P.L.4    Grieu, F.5    Vaithilingam, A.6
  • 31
    • 36749025213 scopus 로고    scopus 로고
    • Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
    • Shen L, Toyota M, Kondo Y, Lin E, Zhang L, Guo Y, et al. Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci U S A 2007; 104:18654-59.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18654-18659
    • Shen, L.1    Toyota, M.2    Kondo, Y.3    Lin, E.4    Zhang, L.5    Guo, Y.6
  • 32
    • 33745541234 scopus 로고    scopus 로고
    • CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    • Weisenberger DJ, Siegmund KD, Campan M, Young J, Long TI, Faasse MA, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006; 38:787-93.
    • (2006) Nat Genet , vol.38 , pp. 787-793
    • Weisenberger, D.J.1    Siegmund, K.D.2    Campan, M.3    Young, J.4    Long, T.I.5    Faasse, M.A.6
  • 33
    • 0030812206 scopus 로고    scopus 로고
    • Association between CpG island methylation and microsatellite instability in colorectal cancer
    • Ahuja N, Mohan AL, Li Q, Stolker JM, Herman JG, Hamilton SR, Baylin SB, et al. Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res 1997; 57:3370-74.
    • (1997) Cancer Res , vol.57 , pp. 3370-3374
    • Ahuja, N.1    Mohan, A.L.2    Li, Q.3    Stolker, J.M.4    Herman, J.G.5    Hamilton, S.R.6    Baylin, S.B.7
  • 34
    • 0036242782 scopus 로고    scopus 로고
    • CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability
    • Hawkins N, Norrie M, Cheong K, Mokany E, Ku SL, Meagher A, et al. CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology 2002; 122: 1376-87.
    • (2002) Gastroenterology , vol.122 , pp. 1376-1387
    • Hawkins, N.1    Norrie, M.2    Cheong, K.3    Mokany, E.4    Ku, S.L.5    Meagher, A.6
  • 35
    • 0142087630 scopus 로고    scopus 로고
    • Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability
    • Ward RL, Cheong K, Ku SL, Meagher A, O'Connor T, Hawkins NJ. Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability. J Clin Oncol 2003; 21: 3729-36.
    • (2003) J Clin Oncol , vol.21 , pp. 3729-3736
    • Ward, R.L.1    Cheong, K.2    Ku, S.L.3    Meagher, A.4    O'Connor, T.5    Hawkins, N.J.6
  • 36
    • 35948981194 scopus 로고    scopus 로고
    • Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy
    • Shen L, Catalano PJ, Benson AB, 3rd, O'Dwyer P, Hamilton SR, Issa JP. Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy. Clin Cancer Res 2007; 13:6093-98.
    • (2007) Clin Cancer Res , vol.13 , pp. 6093-6098
    • Shen, L.1    Catalano, P.J.2    Benson, A.B.3    O'Dwyer, P.4    Hamilton, S.R.5    Issa, J.P.6
  • 37
    • 54249165951 scopus 로고    scopus 로고
    • Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases
    • Barault L, Charon-Barra C, Jooste V, de la Vega MF, Martin L, Roignot P, et al. Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases. Cancer Res 2008; 68:8541-46.
    • (2008) Cancer Res , vol.68 , pp. 8541-8546
    • Barault, L.1    Charon-Barra, C.2    Jooste, V.3    de la Vega, M.F.4    Martin, L.5    Roignot, P.6
  • 38
    • 33749069927 scopus 로고    scopus 로고
    • CpG island methylatorphenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations
    • Ogino S, Kawasaki T, Kirkner GJ, Loda M, Fuchs CS. CpG island methylatorphenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. J Mol Diagn 2006; 8:582-88.
    • (2006) J Mol Diagn , vol.8 , pp. 582-588
    • Ogino, S.1    Kawasaki, T.2    Kirkner, G.J.3    Loda, M.4    Fuchs, C.S.5
  • 39
    • 33745500432 scopus 로고    scopus 로고
    • CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies
    • Ogino S, Cantor M, Kawasaki T, Brahmandam M, Kirkner GJ, Weisenberger DJ, et al. CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut 2006; 55:1000-1006.
    • (2006) Gut , vol.55 , pp. 1000-1006
    • Ogino, S.1    Cantor, M.2    Kawasaki, T.3    Brahmandam, M.4    Kirkner, G.J.5    Weisenberger, D.J.6
  • 40
    • 34247638013 scopus 로고    scopus 로고
    • CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma
    • Ogino S, Meyerhardt JA, Kawasaki T, Clark JW, Ryan DP, Kulke MH, et al. CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. Virchows Arch 2007; 450:529-37.
    • (2007) Virchows Arch , vol.450 , pp. 529-537
    • Ogino, S.1    Meyerhardt, J.A.2    Kawasaki, T.3    Clark, J.W.4    Ryan, D.P.5    Kulke, M.H.6
  • 41
    • 34247570795 scopus 로고    scopus 로고
    • Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample
    • Ogino S, Kawasaki T, Kirkner GJ, Kraft P, Loda M, Fuchs CS. Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. J Mol Diagn 2007; 9:305- 14.
    • (2007) J Mol Diagn , vol.9 , pp. 305-314
    • Ogino, S.1    Kawasaki, T.2    Kirkner, G.J.3    Kraft, P.4    Loda, M.5    Fuchs, C.S.6
  • 42
    • 54449092791 scopus 로고    scopus 로고
    • CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels
    • Lee S, Cho NY, Yoo EJ, Kim JH, Kang GH. CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels. Arch Pathol Lab Med 2008; 132:1657-65.
    • (2008) Arch Pathol Lab Med , vol.132 , pp. 1657-1665
    • Lee, S.1    Cho, N.Y.2    Yoo, E.J.3    Kim, J.H.4    Kang, G.H.5
  • 44
    • 44449146998 scopus 로고    scopus 로고
    • Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics
    • Deng G, Kakar S, Tanaka H, Matsuzaki K, Miura S, Sleisenger MH, et al. Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics. Eur J Cancer 2008; 44:1290-301.
    • (2008) Eur J Cancer , vol.44 , pp. 1290-1301
    • Deng, G.1    Kakar, S.2    Tanaka, H.3    Matsuzaki, K.4    Miura, S.5    Sleisenger, M.H.6
  • 45
    • 84859055066 scopus 로고    scopus 로고
    • Novel molecular screening approaches in colorectal cancer
    • Miller S, Steele S. Novel molecular screening approaches in colorectal cancer. J Surg Oncol 2012; 105:459-67.
    • (2012) J Surg Oncol , vol.105 , pp. 459-467
    • Miller, S.1    Steele, S.2
  • 46
    • 78650733422 scopus 로고    scopus 로고
    • Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review
    • Shima K, Nosho K, Baba Y, Cantor M, Meyerhardt JA, Giovannucci EL, et al. Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. Int J Cancer 2011; 128:1080-94.
    • (2011) Int J Cancer , vol.128 , pp. 1080-1094
    • Shima, K.1    Nosho, K.2    Baba, Y.3    Cantor, M.4    Meyerhardt, J.A.5    Giovannucci, E.L.6
  • 47
    • 0032820505 scopus 로고    scopus 로고
    • Hypermethylation of the p16 gene in sporadic T3N0M0 stage colorectal cancers: association with DNA replication error and shorter survival
    • Liang JT, Chang KJ, Chen JC, Lee CC, Cheng YM, Hsu HC, et al. Hypermethylation of the p16 gene in sporadic T3N0M0 stage colorectal cancers: association with DNA replication error and shorter survival. Oncology 1999; 57:149-56.
    • (1999) Oncology , vol.57 , pp. 149-156
    • Liang, J.T.1    Chang, K.J.2    Chen, J.C.3    Lee, C.C.4    Cheng, Y.M.5    Hsu, H.C.6
  • 48
    • 38149135181 scopus 로고    scopus 로고
    • Clinicopathological features of CpG island methylator phenotype-positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation
    • Lee S, Cho NY, Choi M, Yoo EJ, Kim JH, Kang GH. Clinicopathological features of CpG island methylator phenotype-positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation. Pathol Int 2008; 58:104-13.
    • (2008) Pathol Int , vol.58 , pp. 104-113
    • Lee, S.1    Cho, N.Y.2    Choi, M.3    Yoo, E.J.4    Kim, J.H.5    Kang, G.H.6
  • 49
    • 73449118889 scopus 로고    scopus 로고
    • Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers
    • Kim JH, Shin SH, Kwon HJ, Cho NY, Kang GH. Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers. Virchows Arch 2009; 455: 485-94.
    • (2009) Virchows Arch , vol.455 , pp. 485-494
    • Kim, J.H.1    Shin, S.H.2    Kwon, H.J.3    Cho, N.Y.4    Kang, G.H.5
  • 50
    • 70350111184 scopus 로고    scopus 로고
    • Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer
    • Sanchez JA, Krumroy L, Plummer S, Aung P, Merkulova A, Skacel M, et al. Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer. Br J Surg 2009; 96: 1196-204.
    • (2009) Br J Surg , vol.96 , pp. 1196-1204
    • Sanchez, J.A.1    Krumroy, L.2    Plummer, S.3    Aung, P.4    Merkulova, A.5    Skacel, M.6
  • 51
    • 45549090492 scopus 로고    scopus 로고
    • Clinicopathologic characteristics, CpG island methylator phenotype, and BRAF mutations in microsatellite-stable colorectal cancers without chromosomal instability
    • Kakar S, Deng G, Sahai V, Matsuzaki K, Tanaka H, Miura S, et al. Clinicopathologic characteristics, CpG island methylator phenotype, and BRAF mutations in microsatellite-stable colorectal cancers without chromosomal instability. Arch Pathol Lab Med 2008; 132: 958-64.
    • (2008) Arch Pathol Lab Med , vol.132 , pp. 958-964
    • Kakar, S.1    Deng, G.2    Sahai, V.3    Matsuzaki, K.4    Tanaka, H.5    Miura, S.6
  • 52
    • 33749037187 scopus 로고    scopus 로고
    • Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers
    • Rodriguez J, Frigola J, Vendrell E, Risques RA, Fraga MF, Morales C, et al. Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res 2006; 66: 8462-68.
    • (2006) Cancer Res , vol.66 , pp. 8462-868
    • Rodriguez, J.1    Frigola, J.2    Vendrell, E.3    Risques, R.A.4    Fraga, M.F.5    Morales, C.6
  • 53
    • 24144449572 scopus 로고    scopus 로고
    • Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer
    • Samowitz WS, Albertsen H, Herrick J, Levin TR, Sweeney C, Murtaugh MA, et al. Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology 2005; 129: 837-45.
    • (2005) Gastroenterology , vol.129 , pp. 837-845
    • Samowitz, W.S.1    Albertsen, H.2    Herrick, J.3    Levin, T.R.4    Sweeney, C.5    Murtaugh, M.A.6
  • 54
    • 41649093940 scopus 로고    scopus 로고
    • The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile
    • Ferracin M, Gafà R, Miotto E, Veronese A, Pultrone C, Sabbioni S, et al. The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile. J Pathol 2008; 214: 594- 602.
    • (2008) J Pathol , vol.214 , pp. 594-602
    • Ferracin, M.1    Gafà, R.2    Miotto, E.3    Veronese, A.4    Pultrone, C.5    Sabbioni, S.6
  • 56
  • 57
    • 0035328527 scopus 로고    scopus 로고
    • Accelerated age-related CpG island methylation in ulcerative colitis
    • Issa JP, Ahuja N, Toyota M, Bronner MP, Brentnall TA. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res 2001; 61: 3573-77.
    • (2001) Cancer Res , vol.61 , pp. 3573-377
    • Issa, J.P.1    Ahuja, N.2    Toyota, M.3    Bronner, M.P.4    Brentnall, T.A.5
  • 59
    • 84858700966 scopus 로고    scopus 로고
    • Unique patterns of CpG island methylation in inflammatory bowel disease-associated colorectal cancers
    • Laru AV, Cheng Y, Agarwal R, Yang J, David S, Abraham JM, et al. Unique patterns of CpG island methylation in inflammatory bowel disease-associated colorectal cancers. Inflamm Bowel Dis 2012; 18: 641-48.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 641-648
    • Laru, A.V.1    Cheng, Y.2    Agarwal, R.3    Yang, J.4    David, S.5    Abraham, J.M.6
  • 60
    • 80755173982 scopus 로고    scopus 로고
    • Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer
    • Sanchez JA, Dejulius KL, Bronner M, Church JM, Kalady MF. Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer. Inflamm Bowel Dis 2011; 17: 1966-70.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1966-1970
    • Sanchez, J.A.1    Dejulius, K.L.2    Bronner, M.3    Church, J.M.4    Kalady, M.F.5
  • 61
    • 77955053997 scopus 로고    scopus 로고
    • Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation
    • Bouzourene H, Hutter P, Losi L, Martin P, Benhattar J. Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation. Fam Cancer 2010; 9: 167-72.
    • (2010) Fam Cancer , vol.9 , pp. 167-172
    • Bouzourene, H.1    Hutter, P.2    Losi, L.3    Martin, P.4    Benhattar, J.5
  • 62
    • 84863591414 scopus 로고    scopus 로고
    • Genome-wide screening for methylation-silenced genes in colorectal cancer
    • Khamas A, Ishikawa T, Mogushi K, Iida S, Ishiguro M, Tanaka H, et al. Genome-wide screening for methylation-silenced genes in colorectal cancer. Int J Oncol 2012; 41: 490-96.
    • (2012) Int J Oncol , vol.41 , pp. 490-496
    • Khamas, A.1    Ishikawa, T.2    Mogushi, K.3    Iida, S.4    Ishiguro, M.5    Tanaka, H.6
  • 63
    • 79953217628 scopus 로고    scopus 로고
    • 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer
    • Jover R, Nguyen TP, Pérez-Carbonell L, Zapater P, Payá A, Alenda C, et al. 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer. Gastroenterology 2011; 140: 1174-81.
    • (2011) Gastroenterology , vol.140 , pp. 1174-1181
    • Jover, R.1    Nguyen, T.P.2    Pérez-Carbonell, L.3    Zapater, P.4    Payá, A.5    Alenda, C.6
  • 64
    • 79955397102 scopus 로고    scopus 로고
    • DNA methylation predicts recurrence from resected stage III proximal colon cancer
    • Ahn JB, Chung WB, Maeda O, Shin SJ, Kim HS, Chung HC, et al. DNA methylation predicts recurrence from resected stage III proximal colon cancer. Cancer 2011; 117: 1847-54.
    • (2011) Cancer , vol.117 , pp. 1847-1854
    • Ahn, J.B.1    Chung, W.B.2    Maeda, O.3    Shin, S.J.4    Kim, H.S.5    Chung, H.C.6
  • 65
    • 0041524111 scopus 로고    scopus 로고
    • CpG island methylator phenotype is an independent predictor of survival benefit from 5- fluorouracil in stage III colorectal cancer
    • Van Rijnsoever M, Elsaleh H, Joseph D, McCaul K, Iacopetta B. CpG island methylator phenotype is an independent predictor of survival benefit from 5- fluorouracil in stage III colorectal cancer. Clin Cancer Res 2003; 9: 2898-903.
    • (2003) Clin Cancer Res , vol.9 , pp. 2898-2903
    • Van Rijnsoever, M.1    Elsaleh, H.2    Joseph, D.3    McCaul, K.4    Iacopetta, B.5
  • 66
    • 58249089525 scopus 로고    scopus 로고
    • CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
    • Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Meyerhardt JA, Loda M, et al. CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut 2009; 58: 90-96.
    • (2009) Gut , vol.58 , pp. 90-96
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3    Kawasaki, T.4    Meyerhardt, J.A.5    Loda, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.