메뉴 건너뛰기




Volumn 57, Issue 2, 1999, Pages 149-156

Hypermethylation of the p16 gene in sporadic T3NOMO stage colorectal cancers: Association with DNA replication error and shorter survival

Author keywords

CDKN2A; Colorectal cancers; Mehtylation specific PCR; Methylation; MTS1; p16; p16INK4a

Indexed keywords

MICROSATELLITE DNA; PRIMER DNA; PROTEIN P16;

EID: 0032820505     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000012023     Document Type: Article
Times cited : (78)

References (43)
  • 1
    • 0344301900 scopus 로고    scopus 로고
    • Role of the p16 tumor suppressor gene in cancer
    • Liggett WH, Sidransky D: Role of the p16 tumor suppressor gene in cancer. J Clin Oncol 1998;16:1197-1206.
    • (1998) J Clin Oncol , vol.16 , pp. 1197-1206
    • Liggett, W.H.1    Sidransky, D.2
  • 3
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366:704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 4
    • 0027336491 scopus 로고
    • Mammalian G1 cyclins
    • Sherr CJ: Mammalian G1 cyclins. Cell 1993; 73:1059-1065.
    • (1993) Cell , vol.73 , pp. 1059-1065
    • Sherr, C.J.1
  • 5
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori T, Miura K, Wu DJ, Lois A, Takahashi K, Carson DA: Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994;368:753-756.
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takahashi, K.5    Carson, D.A.6
  • 10
    • 0028338514 scopus 로고
    • Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/ cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma
    • Mori T, Miura K, Aoki T, Nishihira T, Mori S, Nakamura Y: Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/ cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res 1994;54:3396-3397.
    • (1994) Cancer Res , vol.54 , pp. 3396-3397
    • Mori, T.1    Miura, K.2    Aoki, T.3    Nishihira, T.4    Mori, S.5    Nakamura, Y.6
  • 15
    • 0028839835 scopus 로고
    • Alterations in DNA methylation may play a variety of roles in carcinogenesis
    • Counts JL, Coodman JI: Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell 1995;83:13-15.
    • (1995) Cell , vol.83 , pp. 13-15
    • Counts, J.L.1    Coodman, J.I.2
  • 16
    • 0026653420 scopus 로고
    • The essentials of DNA methylation
    • Bird AP: The essentials of DNA methylation. Cell 1992;70:5-8.
    • (1992) Cell , vol.70 , pp. 5-8
    • Bird, A.P.1
  • 17
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D: 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995;7:686-692.
    • (1995) Nat Med , vol.7 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 18
    • 0028875205 scopus 로고
    • Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM, Johnes PA: Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 1995;55:4531-4535.
    • (1995) Cancer Res , vol.55 , pp. 4531-4535
    • Gonzalez-Zulueta, M.1    Bender, C.M.2    Yang, A.S.3    Nguyen, T.4    Beart, R.W.5    Van Tornout, J.M.6    Johnes, P.A.7
  • 19
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant dna methylation in all common human cancers
    • Herman JG, Merlo A, Mao L, Lapidus RG, Issa JPJ, Davidson NE, Sidranksy D, Baylin SB: Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995;55:4525-4530.
    • (1995) Cancer Res , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.P.J.5    Davidson, N.E.6    Sidranksy, D.7    Baylin, S.B.8
  • 20
    • 0030046322 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B1
    • Herman JG, Jen J, Merlo A: Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B1. Cancer Res 1996;56:722-727.
    • (1996) Cancer Res , vol.56 , pp. 722-727
    • Herman, J.G.1    Jen, J.2    Merlo, A.3
  • 22
    • 0032962147 scopus 로고    scopus 로고
    • Reappraisal of K-ras and p53 gene mutations in the recurrence of Dukes' B2 rectal cancer after curative resection
    • in press
    • Liang JT, Cheng YM, Chang KJ, Chien CT, Hsu HC: Reappraisal of K-ras and p53 gene mutations in the recurrence of Dukes' B2 rectal cancer after curative resection. Hepatogastroenterology, in press.
    • Hepatogastroenterology
    • Liang, J.T.1    Cheng, Y.M.2    Chang, K.J.3    Chien, C.T.4    Hsu, H.C.5
  • 23
    • 0024312892 scopus 로고
    • Rapid detection of ras oncogenes in human tumors: Application to colon, esophageal, and gastric cancer
    • Jiang W, Kahn SM, Guillem JG, Lu SH, Weinstein IB: Rapid detection of ras oncogenes in human tumors: Application to colon, esophageal, and gastric cancer. Oncogene 1989;4:923-928.
    • (1989) Oncogene , vol.4 , pp. 923-928
    • Jiang, W.1    Kahn, S.M.2    Guillem, J.G.3    Lu, S.H.4    Weinstein, I.B.5
  • 24
    • 0027483964 scopus 로고
    • Expression of p53 gene in 184 unifocal hepatocellular carcinomas: Association with tumor growth and invasiveness
    • Hsu HC, Tseng HW, Lai PL, Lee PH, Peng SY: Expression of p53 gene in 184 unifocal hepatocellular carcinomas: Association with tumor growth and invasiveness. Cancer Res 1993;53: 4691-4694.
    • (1993) Cancer Res , vol.53 , pp. 4691-4694
    • Hsu, H.C.1    Tseng, H.W.2    Lai, P.L.3    Lee, P.H.4    Peng, S.Y.5
  • 27
    • 0025945632 scopus 로고
    • DNA methylation and gene expression
    • Razin A, Cedar H: DNA methylation and gene expression. Microbiol Rev 1991;55:451-458.
    • (1991) Microbiol Rev , vol.55 , pp. 451-458
    • Razin, A.1    Cedar, H.2
  • 28
    • 0027400888 scopus 로고
    • Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal
    • Stoger R, Kubicka P, Liu CG, Kafri T, Razin A, Cedar H, Barlow DP: Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell 1993;73:61-71.
    • (1993) Cell , vol.73 , pp. 61-71
    • Stoger, R.1    Kubicka, P.2    Liu, C.G.3    Kafri, T.4    Razin, A.5    Cedar, H.6    Barlow, D.P.7
  • 29
    • 0025031568 scopus 로고
    • Use of Hpa II-polymerase chain reaction assay to study DNA methylation of the PgK-1 CpG island of mouse embryo at the time of X-chromosome inactivation
    • Singer-Sam J, Grant M, LeBon JM, Okuyama K, Chapman V, Monk M, Riggs AD: Use of Hpa II-polymerase chain reaction assay to study DNA methylation of the PgK-1 CpG island of mouse embryo at the time of X-chromosome inactivation. Mol Cell Biol 1990;10: 4987-4989.
    • (1990) Mol Cell Biol , vol.10 , pp. 4987-4989
    • Singer-Sam, J.1    Grant, M.2    LeBon, J.M.3    Okuyama, K.4    Chapman, V.5    Monk, M.6    Riggs, A.D.7
  • 30
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 1990;61:759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 32
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • Ionov Y, Reinado MA, Malkhosyan S, Shibata D, Perucho M: Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993;363:558-561.
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Reinado, Ma.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 33
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau SN, Bren G, Schaid D: Microsatellite instability in cancer of the proximal colon. Science 1993;260:816-819.
    • (1993) Science , vol.260 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 34
    • 0028276666 scopus 로고
    • Clinical and pathological charactristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
    • Kim H, Jen J, Vogelstein B, Hamilton SR: Clinical and pathological charactristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994;145:148-156.
    • (1994) Am J Pathol , vol.145 , pp. 148-156
    • Kim, H.1    Jen, J.2    Vogelstein, B.3    Hamilton, S.R.4
  • 36
    • 0030983076 scopus 로고    scopus 로고
    • DNA methylation and genetic instability in colorectal cancer cells
    • Lengaur C, Kinzler KW, Vogelstein B: DNA methylation and genetic instability in colorectal cancer cells. Proc Natl Acad Sci USA 1997; 94:2545-2550.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2545-2550
    • Lengaur, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 37
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane MF, Loda M, Gaida GM, Lipman J, Mishra R, Goldman H, Jessup JM, Kolodner R: Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997; 57:808-811.
    • (1997) Cancer Res , vol.57 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3    Lipman, J.4    Mishra, R.5    Goldman, H.6    Jessup, J.M.7    Kolodner, R.8
  • 41


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.