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Volumn 436, Issue 3, 2013, Pages 377-381

Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway

Author keywords

Fatty acid oxidation; Peroxisome proliferator activated receptor gamma coactivator 1 (PGC 1 ); Sirtuin 1 (Sirt1); Trans caryophyllene; Type 2 cannabinoid receptor (CB2R)

Indexed keywords

CANNABINOID 2 RECEPTOR; CARYOPHYLLENE DERIVATIVE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SIRTUIN 1;

EID: 84879881379     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.05.108     Document Type: Article
Times cited : (34)

References (25)
  • 1
    • 0035173459 scopus 로고    scopus 로고
    • Diabetes mellitus and coronary heart disease
    • Wilson P.W. Diabetes mellitus and coronary heart disease. Endocrinol. Metab. Clin. North Am. 2001, 30:857-881.
    • (2001) Endocrinol. Metab. Clin. North Am. , vol.30 , pp. 857-881
    • Wilson, P.W.1
  • 2
    • 8844255630 scopus 로고    scopus 로고
    • Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction
    • Boden G., Shulman G.I. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur. J. Clin. Invest. 2002, 32(Suppl 3):14-23.
    • (2002) Eur. J. Clin. Invest. , vol.32 , Issue.SUPPL. 3 , pp. 14-23
    • Boden, G.1    Shulman, G.I.2
  • 3
    • 77954987061 scopus 로고    scopus 로고
    • PPARalpha: energy combustion, hypolipidemia, inflammation and cancer
    • Pyper S.R., Viswakarma N., Yu S., et al. PPARalpha: energy combustion, hypolipidemia, inflammation and cancer. Nucl. Recept. Signal. 2010, 8:e002.
    • (2010) Nucl. Recept. Signal. , vol.8
    • Pyper, S.R.1    Viswakarma, N.2    Yu, S.3
  • 4
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    • Rodgers J.T., Lerin C., Haas W., et al. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005, 434:113-118.
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3
  • 5
    • 84255198350 scopus 로고    scopus 로고
    • The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+)
    • Gerhart-Hines Z., Dominy J.E., Blattler S.M., et al. The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol. Cell 2011, 44:851-863.
    • (2011) Mol. Cell , vol.44 , pp. 851-863
    • Gerhart-Hines, Z.1    Dominy, J.E.2    Blattler, S.M.3
  • 6
    • 0030611978 scopus 로고    scopus 로고
    • Pharmacology of cannabinoid CB1 and CB2 receptors
    • Pertwee R.G. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol. Ther. 1997, 74:129-180.
    • (1997) Pharmacol. Ther. , vol.74 , pp. 129-180
    • Pertwee, R.G.1
  • 7
    • 63049105150 scopus 로고    scopus 로고
    • Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation
    • Cabral G.A., Griffin-Thomas L. Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation. Expert Rev. Mol. Med. 2009, 11:e3.
    • (2009) Expert Rev. Mol. Med. , vol.11
    • Cabral, G.A.1    Griffin-Thomas, L.2
  • 8
    • 0037365941 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis by cannabinoids
    • Blazquez C., Casanova M.L., Planas A., et al. Inhibition of tumor angiogenesis by cannabinoids. FASEB J. 2003, 17:529-531.
    • (2003) FASEB J. , vol.17 , pp. 529-531
    • Blazquez, C.1    Casanova, M.L.2    Planas, A.3
  • 9
    • 26844504226 scopus 로고    scopus 로고
    • Identification and functional characterization of brainstem cannabinoid CB2 receptors
    • Van Sickle M.D., Duncan M., Kingsley P.J., et al. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science 2005, 310:329-332.
    • (2005) Science , vol.310 , pp. 329-332
    • Van Sickle, M.D.1    Duncan, M.2    Kingsley, P.J.3
  • 10
    • 38349113185 scopus 로고    scopus 로고
    • CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration
    • Rajesh M., Mukhopadhyay P., Hasko G., et al. CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration. Br .J. Pharmacol. 2008, 153:347-357.
    • (2008) Br .J. Pharmacol. , vol.153 , pp. 347-357
    • Rajesh, M.1    Mukhopadhyay, P.2    Hasko, G.3
  • 12
    • 84874536805 scopus 로고    scopus 로고
    • Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury
    • Choi I.Y., Ju C., Anthony Jalin A.M., et al. Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury. Am. J. Pathol. 2013, 182:928-939.
    • (2013) Am. J. Pathol. , vol.182 , pp. 928-939
    • Choi, I.Y.1    Ju, C.2    Anthony Jalin, A.M.3
  • 13
    • 34247259630 scopus 로고    scopus 로고
    • Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
    • Gerhart-Hines Z., Rodgers J.T., Bare O., et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 2007, 26:1913-1923.
    • (2007) EMBO J. , vol.26 , pp. 1913-1923
    • Gerhart-Hines, Z.1    Rodgers, J.T.2    Bare, O.3
  • 14
    • 29144501185 scopus 로고    scopus 로고
    • Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1
    • Napper A.D., Hixon J., McDonagh T., et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J. Med. Chem. 2005, 48:8045-8054.
    • (2005) J. Med. Chem. , vol.48 , pp. 8045-8054
    • Napper, A.D.1    Hixon, J.2    McDonagh, T.3
  • 15
    • 84255198350 scopus 로고    scopus 로고
    • The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+)
    • Gerhart-Hines Z., Dominy J.E., Blättler S.M., et al. The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol. Cell 2011, 44:851-863.
    • (2011) Mol. Cell , vol.44 , pp. 851-863
    • Gerhart-Hines, Z.1    Dominy, J.E.2    Blättler, S.M.3
  • 16
    • 84855687153 scopus 로고    scopus 로고
    • Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease
    • Sheng B., Wang X., Su B., et al. Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. J. Neurochem. 2012, 120:419-429.
    • (2012) J. Neurochem. , vol.120 , pp. 419-429
    • Sheng, B.1    Wang, X.2    Su, B.3
  • 17
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging
    • Wenz T., Rossi S.G., Rotundo R.L., et al. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc. Natl. Acad. Sci. USA 2009, 106:20405-20410.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 20405-20410
    • Wenz, T.1    Rossi, S.G.2    Rotundo, R.L.3
  • 18
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • Bostrom P., Wu J., Jedrychowski M.P., et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012, 481:463-468.
    • (2012) Nature , vol.481 , pp. 463-468
    • Bostrom, P.1    Wu, J.2    Jedrychowski, M.P.3
  • 19
    • 34247189205 scopus 로고    scopus 로고
    • Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells
    • Meeson A.P., Shi X., Alexander M.S., et al. Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells. EMBO J. 2007, 26:1902-1912.
    • (2007) EMBO J. , vol.26 , pp. 1902-1912
    • Meeson, A.P.1    Shi, X.2    Alexander, M.S.3
  • 20
    • 0043244921 scopus 로고    scopus 로고
    • Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
    • Fulco M., Schiltz R.L., Iezzi S., et al. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell 2003, 12:51-62.
    • (2003) Mol. Cell , vol.12 , pp. 51-62
    • Fulco, M.1    Schiltz, R.L.2    Iezzi, S.3
  • 21
    • 18844400058 scopus 로고    scopus 로고
    • Cannabinoid-based drugs as anti-inflammatory therapeutics
    • Klein T.W. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat. Rev. Immunol. 2005, 5:400-411.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 400-411
    • Klein, T.W.1
  • 22
    • 34247579754 scopus 로고    scopus 로고
    • Endocannabinoid receptor CB2 in nonalcoholic fatty liver disease
    • Mendez-Sanchez N., Zamora-Valdes D., Pichardo-Bahena R., et al. Endocannabinoid receptor CB2 in nonalcoholic fatty liver disease. Liver Int. 2007, 27:215-219.
    • (2007) Liver Int. , vol.27 , pp. 215-219
    • Mendez-Sanchez, N.1    Zamora-Valdes, D.2    Pichardo-Bahena, R.3
  • 23
    • 33748056090 scopus 로고    scopus 로고
    • The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection
    • Mestre L., Correa F., Docagne F., et al. The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection. Biochem. Pharmacol. 2006, 72:869-880.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 869-880
    • Mestre, L.1    Correa, F.2    Docagne, F.3
  • 24
    • 77449118145 scopus 로고    scopus 로고
    • Regulation of MAP kinase-directed mitogenic and protein kinase B-mediated signaling by cannabinoid receptor type 1 in skeletal muscle cells
    • Lipina C., Stretton C., Hastings S., et al. Regulation of MAP kinase-directed mitogenic and protein kinase B-mediated signaling by cannabinoid receptor type 1 in skeletal muscle cells. Diabetes 2010, 59:375-385.
    • (2010) Diabetes , vol.59 , pp. 375-385
    • Lipina, C.1    Stretton, C.2    Hastings, S.3
  • 25
    • 63349100859 scopus 로고    scopus 로고
    • CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion
    • Montecucco F., Lenglet S., Braunersreuther V., et al. CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion. J. Mol. Cell. Cardiol. 2009, 46:612-620.
    • (2009) J. Mol. Cell. Cardiol. , vol.46 , pp. 612-620
    • Montecucco, F.1    Lenglet, S.2    Braunersreuther, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.