Inhibition of phosphodiesterases relaxes detrusor smooth muscle via activation of the large-conductance voltage- and Ca2+-activated K+ channel

American Journal of Physiology - Cell Physiology

Volumn 302, Issue 9, 2012, Pages

  Xin, Wenkuan ^a   Cheng, Qiuping ^a   Soder, Rupal P ^a   Petkov, Georgi V ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Contractility; Hyperpolarization; Patch clamp; Urinary bladder

Indexed keywords

CARBACHOL; ISOBUTYLMETHYLXANTHINE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; PHOSPHODIESTERASE;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DETRUSOR MUSCLE; ELECTROSTIMULATION; ENZYME INHIBITION; EXPERIMENTAL GUINEA PIG; HYPERPOLARIZATION; MALE; MUSCLE CONTRACTION; MUSCLE FORCE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; MUSCLE TONE; NONHUMAN; OVERACTIVE BLADDER; PATCH CLAMP; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; ENZYME INHIBITORS; GUINEA PIGS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PHOSPHORIC DIESTER HYDROLASES; URINARY BLADDER;

CAVIA;

EID: 84860539089     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00432.2011     Document Type: Article

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