Design and synthesis of novel 4-(4-oxo-2-arylthiazolidin-3-yl) benzenesulfonamides as selective inhibitors of carbonic anhydrase IX over I and II with potential anticancer activity

European Journal of Medicinal Chemistry

Volumn 66, Issue , 2013, Pages 372-379

  Suthar, Sharad Kumar ^a   Bansal, Sumit ^a   Lohan, Sandeep ^a   Modak, Vikarm ^b   Chaudhary, Anil ^c   Tiwari, Amit ^a  

^a MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

^b MAEER S MAHARASHTRA INSTITUTE OF PHARMACY   (India)

^c Mahakal Institute of Pharmaceutical Studies   (India)

Author keywords

Anticancer; Benzenesulfonamide; Carbonic anhydrase IX; Cell lines; Daltion's lymphoma ascites; Thiazolidin 4 one

Indexed keywords

4 (4 OXO 2 ARYLTHIAZOLIDIN 3 YL)BENZENESULFONAMIDE DERIVATIVE; 4 (4 OXO 2 PHENYLTHIAZOLIDIN 3 YL)BENZENESULFONAMIDE; 4 [2 (2 BROMOPHENYL) 4 OXOTHIAZOLIDIN 3 YL]BENZENESULFONAMIDE; 4 [2 (2 CHLOROPHENYL) 4 OXOTHIAZOLIDIN 3 YL]BENZENESULFONAMIDE; 4 [2 (2 FLUOROPHENYL) 4 OXOTHIAZOLIDIN 3 YL]BENZENESULFONAMIDE; 4 [2 (3 BROMOPHENYL) 4 OXOTHIAZOLIDIN 3 YL]BENZENESULFONAMIDE; 4 [2 (3 CHLOROPHENYL) 4 OXOTHIAZOLIDIN 3 YL]BENZENESULFONAMIDE; 4 [2 (3 FLUOROPHENYL) 4 OXOTHIAZOLIDIN 3 YL]BENZENESULFONAMIDE; 4 [2 (4 BROMOPHENYL) 4 OXOTHIAZOLIDIN 3 YL)BENZENESULFONAMIDE; 4 [2 (4 CHLOROPHENYL) 4 OXOTHIAZOLIDIN 3 YL]BENZENESULFONAMIDE; 4 [2 (4 FLUOROPHENYL) 4 OXOTHIAZOLIDIN 3 YL]BENZENESULFONAMIDE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ACETAZOLAMIDE; ANTINEOPLASTIC AGENT; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CISPLATIN; UNCLASSIFIED DRUG; 4 [ 2 ( 3 CHLOROPHENYL) 4 OXOTHIAZOLIDIN 3 YL]BENZENESULFONAMIDE; ACRIDINE ORANGE; CARBONATE DEHYDRATASE; ETHIDIUM BROMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; TUMOR VOLUME; WEIGHT CHANGE; ADULT; ASCITES; BODY WEIGHT; CANCER CELL LINE; DALTON LYMPHOMA ASCITES; IC50; IN VIVO STUDY; INHIBITION CONSTANT; LYMPHOMA; PHARMACOPHORE; POLYMERIZATION; SINGLE DRUG DOSE; SOLID TUMOR; STAINING; TUMOR XENOGRAFT;

EID: 84879833246     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.06.003     Document Type: Article

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