-
4
-
-
17644441947
-
The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: Efficacy, safety, and pharmacokinetics
-
Corne J, Djukanovic R, Thomas L, et al. The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics. J Clin Invest 1997; 99: 879-87. (Pubitemid 27123624)
-
(1997)
Journal of Clinical Investigation
, vol.99
, Issue.5
, pp. 879-887
-
-
Corne, J.1
Djukanovic, R.2
Thomas, L.3
Warner, J.4
Botta, L.5
Grandordy, B.6
Gygax, D.7
Heusser, C.8
Patalano, F.9
Richardson, W.10
Kilchherr, E.11
Staehelin, T.12
Davis, F.13
Gordon, W.14
Sun, L.15
Liou, R.16
Wang, G.17
Chang, T.-W.18
Holgate, S.19
-
5
-
-
4444232912
-
Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma
-
Djukanovic R, Wilson SJ, Kraft M, et al. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med 2004; 170: 583-93.
-
(2004)
Am J Respir Crit Care Med
, vol.170
, pp. 583-593
-
-
Djukanovic, R.1
Wilson, S.J.2
Kraft, M.3
-
6
-
-
33744477341
-
How corticosteroids control inflammation: Quintiles Prize Lecture 2005
-
DOI 10.1038/sj.bjp.0706736
-
Barnes PJ. How corticosteroids control inflammation. Quintiles Prize Lecture. Br J Pharmacol 2005; 48: 245-54. (Pubitemid 43804814)
-
(2006)
British Journal of Pharmacology
, vol.148
, Issue.3
, pp. 245-254
-
-
Barnes, P.J.1
-
7
-
-
0032914288
-
Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma
-
Hamid QA, Wenzel SE, Hauk PJ, et al. Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 1999; 159: 160-4.
-
(1999)
Am J Respir Crit Care Med
, vol.159
, pp. 160-164
-
-
Hamid, Q.A.1
Wenzel, S.E.2
Hauk, P.J.3
-
8
-
-
0141507943
-
Corticosteroid-insensitive asthma: Molecular mechanisms
-
DOI 10.1677/joe.0.1780347
-
Adcock IM, Lane SJ. Corticosteroid-insensitive asthma: molecular mechanisms. J Endocrinol 2003; 178: 347-55. (Pubitemid 37220162)
-
(2003)
Journal of Endocrinology
, vol.178
, Issue.3
, pp. 347-355
-
-
Adcock, I.M.1
Lane, S.J.2
-
9
-
-
1242276386
-
Oxidants and asthma
-
DOI 10.1136/thorax.2002.002477
-
Caramori G, Papi A. Oxidants and asthma. Thorax 2004; 59: 170-3. (Pubitemid 38228419)
-
(2004)
Thorax
, vol.59
, Issue.2
, pp. 170-173
-
-
Caramori, G.1
Papi, A.2
-
10
-
-
0036231010
-
p38 mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma
-
DOI 10.1067/mai.2002.122465
-
Irusen E, Matthews JG, Takahashi A, Barnes PJ, Chung KF, Adcock IM. p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol 2002; 109: 649-57. (Pubitemid 34327193)
-
(2002)
Journal of Allergy and Clinical Immunology
, vol.109
, Issue.4
, pp. 649-657
-
-
Irusen, E.1
Matthews, J.G.2
Takahashi, A.3
Barnes, P.J.4
Chung, K.F.5
Adcock, I.M.6
-
11
-
-
2342567291
-
Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients
-
DOI 10.1016/j.jaci.2004.03.018, PII S0091674904011509
-
Matthews JG, Ito K, Barnes PJ, Adcock IM. Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol 2004; 113: 1100-8. (Pubitemid 38857992)
-
(2004)
Journal of Allergy and Clinical Immunology
, vol.113
, Issue.6
, pp. 1100-1108
-
-
Matthews, J.G.1
Ito, K.2
Barnes, P.J.3
Adcock, I.M.4
-
12
-
-
0028881859
-
Abnormal glucocorticoid receptor/AP-1 interaction in steroid resistant asthma
-
Adcock IM, Lane SJ, Brown CR, Lee TH, Barnes PJ. Abnormal glucocorticoid receptor/AP-1 interaction in steroid resistant asthma. J Exp Med 1995; 182: 1951-8.
-
(1995)
J Exp Med
, vol.182
, pp. 1951-1958
-
-
Adcock, I.M.1
Lane, S.J.2
Brown, C.R.3
Lee, T.H.4
Barnes, P.J.5
-
13
-
-
77952733788
-
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced anti-body-dependent cell-mediated cytotoxicity function
-
Kolbeck R, Kozhich A, Koike M, et al. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced anti-body-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol 2010; 125: 1344-53.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1344-1353
-
-
Kolbeck, R.1
Kozhich, A.2
Koike, M.3
-
14
-
-
77950801090
-
MEDI-528, an anti-IL-9 humanized antibody for the treatment of asthma
-
Antoniu SA. MEDI-528, an anti-IL-9 humanized antibody for the treatment of asthma. Curr Opin Mol Ther 2010; 12: 233-9.
-
(2010)
Curr Opin Mol Ther
, vol.12
, pp. 233-239
-
-
Antoniu, S.A.1
-
15
-
-
76749141384
-
A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma
-
Singh D, Kane B, Molfino NA, Faggioni R, Roskos L, Woodcock A. A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma. BMC Pulm Med 2010; 10: 3.
-
(2010)
BMC Pulm Med
, vol.10
, pp. 3
-
-
Singh, D.1
Kane, B.2
Molfino, N.A.3
Faggioni, R.4
Roskos, L.5
Woodcock, A.6
-
16
-
-
79954583416
-
Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
-
Gauvreau GM, Boulet LP, Cockcroft DW, et al. Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma. Am J Respir Crit Care Med 2011; 183: 1007-14.
-
(2011)
Am J Respir Crit Care Med
, vol.183
, pp. 1007-1014
-
-
Gauvreau, G.M.1
Boulet, L.P.2
Cockcroft, D.W.3
-
17
-
-
80051548418
-
Asthma translational medicine: Report card
-
Mullane K. Asthma translational medicine: report card. Biochem Pharmacol 2011; 82: 567-85.
-
(2011)
Biochem Pharmacol
, vol.82
, pp. 567-585
-
-
Mullane, K.1
-
20
-
-
67650314629
-
Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics
-
Humbert M, de Blay F, Garcia G, et al. Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics. Allergy 2009; 64: 1194-201.
-
(2009)
Allergy
, vol.64
, pp. 1194-1201
-
-
Humbert, M.1
De Blay, F.2
Garcia, G.3
-
21
-
-
77952491177
-
The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma
-
Singh D, Petavy F, Macdonald AJ, Lazaar AL, O'Connor BJ. The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma. Respir Res 2010; 11: 26.
-
(2010)
Respir Res
, vol.11
, pp. 26
-
-
Singh, D.1
Petavy, F.2
Macdonald, A.J.3
Lazaar, A.L.4
O'Connor, B.J.5
-
23
-
-
0037202790
-
Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial
-
DOI 10.1016/S0140-6736(02)11679-5
-
Green RH, Brightling CE, McKenna S, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002; 360: 1715-21. (Pubitemid 35447900)
-
(2002)
Lancet
, vol.360
, Issue.9347
, pp. 1715-1721
-
-
Green, R.H.1
Brightling, C.E.2
McKenna, S.3
Hargadon, B.4
Parker, D.5
Bradding, P.6
Wardlaw, A.J.7
Pavord, I.D.8
-
24
-
-
6644229440
-
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
-
Leckie MJ, ten Brinke A, Khan J, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000; 356: 2144-8.
-
(2000)
Lancet
, vol.356
, pp. 2144-2148
-
-
Leckie, M.J.1
Ten Brinke, A.2
Khan, J.3
-
25
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360: 973-84.
-
(2009)
N Engl J Med
, vol.360
, pp. 973-984
-
-
Haldar, P.1
Brightling, C.E.2
Hargadon, B.3
-
26
-
-
62549084077
-
A randomized, double-blind placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
-
T03 Asthma Investigators
-
Wenzel SE, Barnes PJ, Bleecker ER, et al.; T03 Asthma Investigators. A randomized, double-blind placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med 2009; 179: 549-58.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 549-558
-
-
Wenzel, S.E.1
Barnes, P.J.2
Bleecker, E.R.3
-
27
-
-
77953039047
-
A randomized, controlled, phase 2 study of AMG 317, an IL-4R-alpha antagonist, in patients with asthma
-
Corren J, Busse W, Meltzer EO, et al. A randomized, controlled, phase 2 study of AMG 317, an IL-4R-alpha antagonist, in patients with asthma. Am J Respir Crit Care Med 2010; 181: 788-96.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 788-796
-
-
Corren, J.1
Busse, W.2
Meltzer, E.O.3
-
28
-
-
4844231763
-
Rational design of potent and selective VLA-4 inhibitors and their utility in the treatment of asthma
-
DOI 10.2174/1568026043387520
-
Singh J, Adams S, Carter MB, et al. Rational design of potent and selective VLA-4 inhibitors and their utility in the treatment of asthma. Curr Top Med Chem 2004; 4: 1497-507. (Pubitemid 39317605)
-
(2004)
Current Topics in Medicinal Chemistry
, vol.4
, Issue.14
, pp. 1497-1507
-
-
Singh, J.1
Adams, S.2
Carter, M.B.3
Cuervo, H.4
Lee, W.-C.5
Lobb, R.R.6
Pepinsky, R.B.7
Petter, R.8
Scott, D.9
-
29
-
-
33847106380
-
Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4
-
DOI 10.1016/j.ejphar.2006.11.065, PII S0014299906013951
-
Okigami H, Takeshita K, Tajimi M, et al. Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4. Eur J Pharmacol 2007; 559: 202-9. (Pubitemid 46295402)
-
(2007)
European Journal of Pharmacology
, vol.559
, Issue.2-3
, pp. 202-209
-
-
Okigami, H.1
Takeshita, K.2
Tajimi, M.3
Komura, H.4
Albers, M.5
Lehmann, T.E.6
Rolle, T.7
Bacon, K.B.8
-
30
-
-
33645324424
-
Bimosiamose, an inhaled small-molecule panselectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: A randomized, double-blind, placebo-controlled clinical cross-over-trial
-
Beeh KM, Beier J, Meyer M, Buhl R, Zahlten R, Wolff G. Bimosiamose, an inhaled small-molecule panselectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial. Pulm Pharmacol Ther 2006; 19: 233-41.
-
(2006)
Pulm Pharmacol Ther
, vol.19
, pp. 233-241
-
-
Beeh, K.M.1
Beier, J.2
Meyer, M.3
Buhl, R.4
Zahlten, R.5
Wolff, G.6
-
31
-
-
78649603174
-
Interleukin-5 inhibits glucocorticoid-mediated apoptosis in human eosinophils
-
Brode S, Farahi N, Cowburn AS, Juss JK, Condliffe AM, Chilvers ER. Interleukin-5 inhibits glucocorticoid-mediated apoptosis in human eosinophils. Thorax 2010; 65: 1116-7.
-
(2010)
Thorax
, vol.65
, pp. 1116-1117
-
-
Brode, S.1
Farahi, N.2
Cowburn, A.S.3
Juss, J.K.4
Condliffe, A.M.5
Chilvers, E.R.6
-
32
-
-
34547652003
-
Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease
-
DOI 10.1152/ajplung.00108.2007
-
Salter M, Biggadike K, Matthews JL, et al. Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease. Am J Physiol Lung Cell Mol Physiol 2007; 293: L660-7. (Pubitemid 47358828)
-
(2007)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.293
, Issue.3
-
-
Salter, M.1
Biggadike, K.2
Matthews, J.L.3
West, M.R.4
Haase, M.V.5
Farrow, S.N.6
Uings, I.J.7
Gray, D.W.8
-
33
-
-
78349264228
-
Prolonged protection of the new inhaled corticosteroid fluticasone furoate against AMP hyperresponsiveness in patients with asthma
-
Van den Berge M, Luijk B, Bareille P, Dallow N, Postma DS, Lammers JW. Prolonged protection of the new inhaled corticosteroid fluticasone furoate against AMP hyperresponsiveness in patients with asthma. Allergy 2010; 65: 1531-5.
-
(2010)
Allergy
, vol.65
, pp. 1531-1535
-
-
Van Den Berge, M.1
Luijk, B.2
Bareille, P.3
Dallow, N.4
Postma, D.S.5
Lammers, J.W.6
-
35
-
-
0347719371
-
Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects
-
DOI 10.1073/pnas.0300372101
-
Schaecke H, Schottelius A, Döcke WD, et al. Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects. Proc Natl Acad Sci USA 2004; 101: 227-32. (Pubitemid 38084232)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.1
, pp. 227-232
-
-
Schacke, H.1
Schottelius, A.2
Docke, W.-D.3
Strehlke, P.4
Jaroch, S.5
Schmees, N.6
Rehwinkel, H.7
Hennekes, H.8
Asadullah, K.9
-
36
-
-
77952950546
-
Selective glucocorticoid receptor modulators
-
De Bosscher K. Selective glucocorticoid receptor modulators. J Steroid Biochem. Mol Biol 2010; 120: 96-104.
-
(2010)
J Steroid Biochem. Mol Biol
, vol.120
, pp. 96-104
-
-
De Bosscher, K.1
-
37
-
-
24744435115
-
Blockade of PI3K-gamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
-
DOI 10.1038/nm1284
-
Camps M, Ruckle T, Ji H, et al. Blockade of PI3K-gamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 2005; 11: 936-43. (Pubitemid 41294438)
-
(2005)
Nature Medicine
, vol.11
, Issue.9
, pp. 936-943
-
-
Camps, M.1
Ruckle, T.2
Ji, H.3
Ardissone, V.4
Rintelen, F.5
Shaw, J.6
Ferrandi, C.7
Chabert, C.8
Gillieron, C.9
Francon, B.10
Martin, T.11
Gretener, D.12
Perrin, D.13
Leroy, D.14
Vitte, P.-A.15
Hirsch, E.16
Wymann, M.P.17
Cirillo, R.18
Schwarz, M.K.19
Rommel, C.20
more..
-
38
-
-
79957841139
-
Steroids and extracellular signal-regulated kinase 1/2 activity suppress activating transcription factor 3 expression in patients with severe asthma
-
Sadhu C, Masinovsky B, Dick K, et al. Steroids and extracellular signal-regulated kinase 1/2 activity suppress activating transcription factor 3 expression in patients with severe asthma. J Allergy Clin Immunol 2011; 127: 1632-4.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 1632-1634
-
-
Sadhu, C.1
Masinovsky, B.2
Dick, K.3
-
39
-
-
77955918109
-
Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor
-
Hasan AM, Mourtada-Maarabouni M, Hameed MS, Williams GT, Dent G. Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. Int Immunopharmacol 2010; 10: 1017-21.
-
(2010)
Int Immunopharmacol
, vol.10
, pp. 1017-1021
-
-
Hasan, A.M.1
Mourtada-Maarabouni, M.2
Hameed, M.S.3
Williams, G.T.4
Dent, G.5
-
40
-
-
70350132390
-
Small molecule inhibitors of phosphoinositide 3-kinase (PI3K) delta and gamma
-
Ameriks MK, Venable JD. Small molecule inhibitors of phosphoinositide 3-kinase (PI3K) delta and gamma. Curr Top Med Chem 2009; 9: 738-53.
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 738-753
-
-
Ameriks, M.K.1
Venable, J.D.2
-
41
-
-
77958173826
-
Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease
-
To Y, Ito K, Kizawa Y, et al. Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010; 182: 897-904.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 897-904
-
-
To, Y.1
Ito, K.2
Kizawa, Y.3
-
42
-
-
78349304262
-
Phosphoinositide 3-kinase delta inhibitor suppresses interleukin-17 expression in a murine asthma model
-
Park SJ, Lee KS, Kim SR, et al. Phosphoinositide 3-kinase delta inhibitor suppresses interleukin-17 expression in a murine asthma model. Eur Respir J 2010; 36: 1448-59.
-
(2010)
Eur Respir J
, vol.36
, pp. 1448-1459
-
-
Park, S.J.1
Lee, K.S.2
Kim, S.R.3
-
44
-
-
42749088759
-
Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation
-
Hallett JM, Leitch AE, Riley NA, Duffin R, Haslett C, Rossi AG. Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation. Trends Pharmacol Sci 2008; 29: 250-7.
-
(2008)
Trends Pharmacol Sci
, vol.29
, pp. 250-257
-
-
Hallett, J.M.1
Leitch, A.E.2
Riley, N.A.3
Duffin, R.4
Haslett, C.5
Rossi, A.G.6
-
45
-
-
67849119262
-
The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by downregulation of Mcl-1
-
Duffin R, Leitch AE, Sheldrake TA, et al. The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by downregulation of Mcl-1. FEBS Lett 2009; 583: 2540-6.
-
(2009)
FEBS Lett
, vol.583
, pp. 2540-2546
-
-
Duffin, R.1
Leitch, A.E.2
Sheldrake, T.A.3
-
46
-
-
79954497986
-
Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance
-
Farahi N, Uller L, Juss JK, et al. Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance. Clin Exp Allergy 2011; 41: 673-87.
-
(2011)
Clin Exp Allergy
, vol.41
, pp. 673-687
-
-
Farahi, N.1
Uller, L.2
Juss, J.K.3
-
47
-
-
67650073265
-
Cell cycle kinases as therapeutic targets for cancer
-
Lapenna S, Giordano A. Cell cycle kinases as therapeutic targets for cancer. Nature Reviews Drug Discovery 2009; 8: 547-66.
-
(2009)
Nature Reviews Drug Discovery
, vol.8
, pp. 547-566
-
-
Lapenna, S.1
Giordano, A.2
-
48
-
-
53349122333
-
Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation
-
Gilchrist M, Henderson WR Jr, Clark AE, et al. Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation. J Exp Med 2008; 205: 2349-57.
-
(2008)
J Exp Med
, vol.205
, pp. 2349-2357
-
-
Gilchrist, M.1
Henderson Jr., W.R.2
Clark, A.E.3
-
49
-
-
79959228157
-
The emerging role of microRNAs in asthma
-
Jiang X. The emerging role of microRNAs in asthma. Mol Cell Biochem 2011; 353: 35-40.
-
(2011)
Mol Cell Biochem
, vol.353
, pp. 35-40
-
-
Jiang, X.1
-
50
-
-
79959828991
-
Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment
-
Collison A, Mattes J, Plank M, Foster PS. Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment. J Allergy Clin Immunol 2011; 128: 160-7.
-
(2011)
J Allergy Clin Immunol
, vol.128
, pp. 160-167
-
-
Collison, A.1
Mattes, J.2
Plank, M.3
Foster, P.S.4
|