메뉴 건너뛰기




Volumn 41, Issue 5, 2011, Pages 673-687

Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance

Author keywords

Apoptosis; Asthma; Eosinophils

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE 9; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 5; PROTEIN MCL 1; ROSCOVITINE;

EID: 79954497986     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2010.03680.x     Document Type: Article
Times cited : (25)

References (50)
  • 1
    • 0034049677 scopus 로고    scopus 로고
    • Mechanisms of eosinophil-associated inflammation
    • Gleich GJ. Mechanisms of eosinophil-associated inflammation. J Allergy Clin Immunol 2000; 105:651-63.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 651-663
    • Gleich, G.J.1
  • 2
    • 4544304222 scopus 로고    scopus 로고
    • Defining a link with asthma in mice congenitally deficient in eosinophils
    • Lee JJ, Dimina D, Macias MP et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 2004; 305:1773-6.
    • (2004) Science , vol.305 , pp. 1773-1776
    • Lee, J.J.1    Dimina, D.2    Macias, M.P.3
  • 3
    • 4544274172 scopus 로고    scopus 로고
    • A critical role for eosinophils in allergic airways remodeling
    • Humbles AA, Lloyd CM, McMillan SJ et al. A critical role for eosinophils in allergic airways remodeling. Science 2004; 305:1776-9.
    • (2004) Science , vol.305 , pp. 1776-1779
    • Humbles, A.A.1    Lloyd, C.M.2    McMillan, S.J.3
  • 4
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    • Green RH, Brightling CE, McKenna S et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002; 360:1715-21.
    • (2002) Lancet , vol.360 , pp. 1715-1721
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3
  • 5
    • 0031569468 scopus 로고    scopus 로고
    • Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia
    • Simon H-U, Yousefi S, Schranz C, Schapowal A, Bachert C, Blaser K. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 1997; 158:3902-8.
    • (1997) J Immunol , vol.158 , pp. 3902-3908
    • Simon, H.-U.1    Yousefi, S.2    Schranz, C.3    Schapowal, A.4    Bachert, C.5    Blaser, K.6
  • 6
    • 0035891587 scopus 로고    scopus 로고
    • Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatment
    • Uller L, Persson CG, Källström L, Erjefält JS. Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatment. Am J Respir Crit Care Med 2001; 164:1948-56.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1948-1956
    • Uller, L.1    Persson, C.G.2    Källström, L.3    Erjefält, J.S.4
  • 7
  • 9
    • 33845915536 scopus 로고    scopus 로고
    • Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5
    • Goodyear S, Sharma MC. Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5. Exp Mol Pathol 2007; 82:25-32.
    • (2007) Exp Mol Pathol , vol.82 , pp. 25-32
    • Goodyear, S.1    Sharma, M.C.2
  • 10
    • 67849119262 scopus 로고    scopus 로고
    • The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1
    • Duffin R, Leitch AE, Sheldrake TA et al. The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1. FEBS Lett 2009; 583:2540-6.
    • (2009) FEBS Lett , vol.583 , pp. 2540-2546
    • Duffin, R.1    Leitch, A.E.2    Sheldrake, T.A.3
  • 11
    • 33748462267 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
    • Rossi AG, Sawatzky DA, Walker A et al. Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis. Nat Med 2006; 12:1056-64.
    • (2006) Nat Med , vol.12 , pp. 1056-1064
    • Rossi, A.G.1    Sawatzky, D.A.2    Walker, A.3
  • 12
    • 34548768840 scopus 로고    scopus 로고
    • Eotaxin-1/CC chemokine ligand 11: a novel eosinophil survival factor secreted by human pulmonary artery endothelial cells
    • Farahi N, Cowburn AS, Upton PD et al. Eotaxin-1/CC chemokine ligand 11: a novel eosinophil survival factor secreted by human pulmonary artery endothelial cells. J Immunol 2007; 179:1264-73.
    • (2007) J Immunol , vol.179 , pp. 1264-1273
    • Farahi, N.1    Cowburn, A.S.2    Upton, P.D.3
  • 13
    • 69249240524 scopus 로고    scopus 로고
    • Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
    • Uller L, Mathiesen JM, Alenmyr L et al. Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Respir Res 2007; 8:16.
    • (2007) Respir Res , vol.8 , pp. 16
    • Uller, L.1    Mathiesen, J.M.2    Alenmyr, L.3
  • 14
    • 33645025863 scopus 로고    scopus 로고
    • Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation
    • Uller L, Lloyd CM, Rydell-Törmänen K, Persson CG, Erjefält JS. Effects of steroid treatment on lung CC chemokines, apoptosis and transepithelial cell clearance during development and resolution of allergic airway inflammation. Clin Exp Allergy 2006; 36:111-21.
    • (2006) Clin Exp Allergy , vol.36 , pp. 111-121
    • Uller, L.1    Lloyd, C.M.2    Rydell-Törmänen, K.3    Persson, C.G.4    Erjefält, J.S.5
  • 15
    • 0034891987 scopus 로고    scopus 로고
    • A novel method for isolation of neutrophils from murine blood using negative immunomagnetic separation
    • Cotter MJ, Norman KE, Hellewell PG, Ridger VC. A novel method for isolation of neutrophils from murine blood using negative immunomagnetic separation. Am J Pathol 2001; 159:473-81.
    • (2001) Am J Pathol , vol.159 , pp. 473-481
    • Cotter, M.J.1    Norman, K.E.2    Hellewell, P.G.3    Ridger, V.C.4
  • 16
    • 33646950429 scopus 로고    scopus 로고
    • Isolation of neutrophils from mouse liver: a novel method to study effector leukocytes during inflammation
    • Cotter MJ, Muruve DA. Isolation of neutrophils from mouse liver: a novel method to study effector leukocytes during inflammation. J Immunol Methods 2006; 312:68-78.
    • (2006) J Immunol Methods , vol.312 , pp. 68-78
    • Cotter, M.J.1    Muruve, D.A.2
  • 17
    • 76749098219 scopus 로고    scopus 로고
    • Pulmonary vascular remodeling correlates with lung eggs and cytokines
    • Crosby A, Jones FM, Southwood M et al. Pulmonary vascular remodeling correlates with lung eggs and cytokines. Am J Respir Crit Care Med 2010; 181:279-88.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 279-288
    • Crosby, A.1    Jones, F.M.2    Southwood, M.3
  • 18
    • 33646037367 scopus 로고    scopus 로고
    • RhoG regulates the neutrophil NADPH oxidase
    • Condliffe AM, Webb LM, Ferguson GJ et al. RhoG regulates the neutrophil NADPH oxidase. J Immunol 2006; 176:5314-20.
    • (2006) J Immunol , vol.176 , pp. 5314-5320
    • Condliffe, A.M.1    Webb, L.M.2    Ferguson, G.J.3
  • 20
    • 77951177406 scopus 로고    scopus 로고
    • Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis
    • Gavet O, Pines J. Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis. J Cell Biol 2010; 189:247-59.
    • (2010) J Cell Biol , vol.189 , pp. 247-259
    • Gavet, O.1    Pines, J.2
  • 21
    • 0037387215 scopus 로고    scopus 로고
    • Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential
    • Lahusen T, De Siervi A, Kunick C et al. Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Mol Carcinogen 2003; 36:183-94.
    • (2003) Mol Carcinogen , vol.36 , pp. 183-194
    • Lahusen, T.1    De Siervi, A.2    Kunick, C.3
  • 22
    • 79954574841 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 regulates granule exocytosis but not superoxide release in human peripheral blood eosinophils
    • Odemuyiwa SO, Logan MR, Davoine F, Adamko DJ, Moqbel R. Cyclin-dependent kinase 5 regulates granule exocytosis but not superoxide release in human peripheral blood eosinophils. FASEB J 2005; 19:A43.
    • (2005) FASEB J , vol.19
    • Odemuyiwa, S.O.1    Logan, M.R.2    Davoine, F.3    Adamko, D.J.4    Moqbel, R.5
  • 23
    • 0041403441 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic cells by human macrophages: analysis by multiparameter flow cytometry
    • Jersmann HP, Ross KA, Vivers S, Brown SB, Haslett C, Dransfield I. Phagocytosis of apoptotic cells by human macrophages: analysis by multiparameter flow cytometry. Cytometry A 2003; 51:7-15.
    • (2003) Cytometry A , vol.51 , pp. 7-15
    • Jersmann, H.P.1    Ross, K.A.2    Vivers, S.3    Brown, S.B.4    Haslett, C.5    Dransfield, I.6
  • 24
    • 0029992571 scopus 로고    scopus 로고
    • Eosinophil viability during immunoglobulin-induced degranulation
    • Weiler CR, Kita H, Hukee M, Gleich GJ. Eosinophil viability during immunoglobulin-induced degranulation. J Leukoc Biol 1996; 60:493-501.
    • (1996) J Leukoc Biol , vol.60 , pp. 493-501
    • Weiler, C.R.1    Kita, H.2    Hukee, M.3    Gleich, G.J.4
  • 25
    • 0032772074 scopus 로고    scopus 로고
    • Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airways
    • Erjefält JS, Greiff L, Andersson M et al. Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airways. Am J Respir Crit Care Med 1999; 160:304-12.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 304-312
    • Erjefält, J.S.1    Greiff, L.2    Andersson, M.3
  • 27
    • 0029972142 scopus 로고    scopus 로고
    • Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes
    • Meagher LC, Cousin JM, Seckl JR, Haslett C. Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J Immunol 1996; 156:4422-8.
    • (1996) J Immunol , vol.156 , pp. 4422-4428
    • Meagher, L.C.1    Cousin, J.M.2    Seckl, J.R.3    Haslett, C.4
  • 28
    • 0032433670 scopus 로고    scopus 로고
    • IL-4-induced apoptosis in peripheral blood eosinophils
    • Wedi B, Raap U, Lewrick H, Kapp A. IL-4-induced apoptosis in peripheral blood eosinophils. J Allergy Clin Immunol 1998; 102:1013-20.
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 1013-1020
    • Wedi, B.1    Raap, U.2    Lewrick, H.3    Kapp, A.4
  • 29
    • 0028040125 scopus 로고
    • Transforming growth factor beta abrogates the effects of hematopoietins on eosinophils and induces their apoptosis
    • Alam R, Forsythe P, Stafford S, Fukuda Y. Transforming growth factor beta abrogates the effects of hematopoietins on eosinophils and induces their apoptosis. J Exp Med 1994; 179:1041-5.
    • (1994) J Exp Med , vol.179 , pp. 1041-1045
    • Alam, R.1    Forsythe, P.2    Stafford, S.3    Fukuda, Y.4
  • 30
    • 0029148643 scopus 로고
    • Induction of apoptosis in human eosinophils by anti-Fas antibody treatment in vitro
    • Matsumoto K, Schleimer RP, Saito H, Iikura Y, Bochner BS. Induction of apoptosis in human eosinophils by anti-Fas antibody treatment in vitro. Blood 1995; 86:1437-43.
    • (1995) Blood , vol.86 , pp. 1437-1443
    • Matsumoto, K.1    Schleimer, R.P.2    Saito, H.3    Iikura, Y.4    Bochner, B.S.5
  • 31
    • 0029990357 scopus 로고    scopus 로고
    • Ligation of CD69 induces apoptosis and cell death in human eosinophils cultured with granulocyte-macrophage colony-stimulating factor
    • Walsh GM, Williamson ML, Symon FA, Willars GB, Wardlaw AJ. Ligation of CD69 induces apoptosis and cell death in human eosinophils cultured with granulocyte-macrophage colony-stimulating factor. Blood 1996; 87:2815-21.
    • (1996) Blood , vol.87 , pp. 2815-2821
    • Walsh, G.M.1    Williamson, M.L.2    Symon, F.A.3    Willars, G.B.4    Wardlaw, A.J.5
  • 32
    • 0842321788 scopus 로고    scopus 로고
    • Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro
    • Matsumoto K, Terakawa M, Miura K, Fukuda S, Nakajima T, Saito H. Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro. J Immunol 2004; 172:2186-93.
    • (2004) J Immunol , vol.172 , pp. 2186-2193
    • Matsumoto, K.1    Terakawa, M.2    Miura, K.3    Fukuda, S.4    Nakajima, T.5    Saito, H.6
  • 33
    • 1542287347 scopus 로고    scopus 로고
    • Neutrophil extracellular traps kill bacteria
    • Brinkmann V, Reichard U, Goosmann C et al. Neutrophil extracellular traps kill bacteria. Science 2004; 303:1532-5.
    • (2004) Science , vol.303 , pp. 1532-1535
    • Brinkmann, V.1    Reichard, U.2    Goosmann, C.3
  • 34
    • 51349135381 scopus 로고    scopus 로고
    • Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense
    • Yousefi S, Gold JA, Andina N et al. Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat Med 2008; 14:949-53.
    • (2008) Nat Med , vol.14 , pp. 949-953
    • Yousefi, S.1    Gold, J.A.2    Andina, N.3
  • 35
    • 0029892010 scopus 로고    scopus 로고
    • Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis
    • Takei H, Araki A, Watanabe H, Ichinose A, Sendo F. Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis. J Leukoc Biol 1996; 59:229-40.
    • (1996) J Leukoc Biol , vol.59 , pp. 229-240
    • Takei, H.1    Araki, A.2    Watanabe, H.3    Ichinose, A.4    Sendo, F.5
  • 36
    • 26244464292 scopus 로고    scopus 로고
    • Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation
    • Uller L, Rydell-Törmänen K, Persson CG, Erjefält JS. Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation. Respir Res 2005; 6:90.
    • (2005) Respir Res , vol.6 , pp. 90
    • Uller, L.1    Rydell-Törmänen, K.2    Persson, C.G.3    Erjefält, J.S.4
  • 37
    • 33947381835 scopus 로고    scopus 로고
    • Neutrophil cannibalism-a back up when the macrophage clearance system is insufficient
    • Rydell-Törmänen K, Uller L, Erjefält JS. Neutrophil cannibalism-a back up when the macrophage clearance system is insufficient. Respir Res 2006; 7:143.
    • (2006) Respir Res , vol.7 , pp. 143
    • Rydell-Törmänen, K.1    Uller, L.2    Erjefält, J.S.3
  • 38
    • 0035208625 scopus 로고    scopus 로고
    • Critical role for caspases 3 and 8 in neutrophil but not eosinophil apoptosis
    • Daigle I, Simon H-U. Critical role for caspases 3 and 8 in neutrophil but not eosinophil apoptosis. Int Arch Allergy Immunol 2001; 126:147-56.
    • (2001) Int Arch Allergy Immunol , vol.126 , pp. 147-156
    • Daigle, I.1    Simon, H.-U.2
  • 39
    • 34447629367 scopus 로고    scopus 로고
    • The differential effect of dexamethasone on granulocyte apoptosis involves stabilization of Mcl-1L in neutrophils but not in eosinophils
    • Sivertson KL, Seeds MC, Long DL, Peachman KK, Bass DA. The differential effect of dexamethasone on granulocyte apoptosis involves stabilization of Mcl-1L in neutrophils but not in eosinophils. Cell Immunol 2007; 246:34-45.
    • (2007) Cell Immunol , vol.246 , pp. 34-45
    • Sivertson, K.L.1    Seeds, M.C.2    Long, D.L.3    Peachman, K.K.4    Bass, D.A.5
  • 40
    • 1642494839 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway
    • Whittaker SR, Walton MI, Garrett MD, Workman P. The cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. Cancer Res 2004; 64:262-72.
    • (2004) Cancer Res , vol.64 , pp. 262-272
    • Whittaker, S.R.1    Walton, M.I.2    Garrett, M.D.3    Workman, P.4
  • 41
    • 8444230802 scopus 로고    scopus 로고
    • Eosinophil adhesion to cholinergic IMR-32 cells protects against induced neuronal apoptosis
    • Morgan RK, Kingham PJ, Walsh MT. Eosinophil adhesion to cholinergic IMR-32 cells protects against induced neuronal apoptosis. J Immunol 2004; 173:5963-70.
    • (2004) J Immunol , vol.173 , pp. 5963-5970
    • Morgan, R.K.1    Kingham, P.J.2    Walsh, M.T.3
  • 42
    • 0035496902 scopus 로고    scopus 로고
    • Transduction of a dominant-negative H-Ras into human eosinophils attenuates extracellular signal-regulated kinase activation and interleukin-5-mediated cell viability
    • Hall DJ, Cui J, Bates ME et al. Transduction of a dominant-negative H-Ras into human eosinophils attenuates extracellular signal-regulated kinase activation and interleukin-5-mediated cell viability. Blood 2001; 98:2014-21.
    • (2001) Blood , vol.98 , pp. 2014-2021
    • Hall, D.J.1    Cui, J.2    Bates, M.E.3
  • 43
    • 11144228303 scopus 로고    scopus 로고
    • GTP-dependent secretion from neutrophils is regulated by Cdk5
    • Rosales JL, Ernst JD, Hallows J, Lee KY. GTP-dependent secretion from neutrophils is regulated by Cdk5. J Biol Chem 2004; 24:53932-6.
    • (2004) J Biol Chem , vol.24 , pp. 53932-53936
    • Rosales, J.L.1    Ernst, J.D.2    Hallows, J.3    Lee, K.Y.4
  • 44
    • 0032014925 scopus 로고    scopus 로고
    • Human eosinophils express bcl-2 family proteins: modulation of Mcl-1 expression by IFN-gamma
    • Druilhe A, Arock M, Le Goff L, Pretolani M. Human eosinophils express bcl-2 family proteins: modulation of Mcl-1 expression by IFN-gamma. Am J Respir Cell Mol Biol 1998; 18:315-22.
    • (1998) Am J Respir Cell Mol Biol , vol.18 , pp. 315-322
    • Druilhe, A.1    Arock, M.2    Le Goff, L.3    Pretolani, M.4
  • 45
    • 35549012854 scopus 로고    scopus 로고
    • Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection
    • Hallaert DY, Spijker R, Jak M et al. Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection. Cell Death Differ 2007; 11:1958-67.
    • (2007) Cell Death Differ , vol.11 , pp. 1958-1967
    • Hallaert, D.Y.1    Spijker, R.2    Jak, M.3
  • 46
    • 27144441483 scopus 로고    scopus 로고
    • Cdk5-dependent regulation of glucose-stimulated insulin secretion
    • Wei FY, Nagashima K, Ohshima T et al. Cdk5-dependent regulation of glucose-stimulated insulin secretion. Nat Med 2005; 11:1104-8.
    • (2005) Nat Med , vol.11 , pp. 1104-1108
    • Wei, F.Y.1    Nagashima, K.2    Ohshima, T.3
  • 47
    • 33750014263 scopus 로고    scopus 로고
    • Extraneuronal roles of cyclin-dependent kinase 5
    • Rosales JL, Lee KY. Extraneuronal roles of cyclin-dependent kinase 5. Bioessays 2006; 28:1023-34.
    • (2006) Bioessays , vol.28 , pp. 1023-1034
    • Rosales, J.L.1    Lee, K.Y.2
  • 48
    • 0030781307 scopus 로고    scopus 로고
    • Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist
    • Pippin JW, Qu Q, Meijer L, Shankland SJ. Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist. J Clin Invest 1997; 100:2512-20.
    • (1997) J Clin Invest , vol.100 , pp. 2512-2520
    • Pippin, J.W.1    Qu, Q.2    Meijer, L.3    Shankland, S.J.4
  • 49
    • 0037099316 scopus 로고    scopus 로고
    • The effects of intranasal budesonide on allergen-induced production of interleukin-5 and eotaxin, airways, blood, and bone marrow eosinophilia, and eosinophil progenitor expansion in sensitized mice
    • Shen H, O'Byrne PM, Ellis R, Wattie J, Tang C, Inman MD. The effects of intranasal budesonide on allergen-induced production of interleukin-5 and eotaxin, airways, blood, and bone marrow eosinophilia, and eosinophil progenitor expansion in sensitized mice. Am J Respir Crit Care Med 2002; 166:146-53.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 146-153
    • Shen, H.1    O'Byrne, P.M.2    Ellis, R.3    Wattie, J.4    Tang, C.5    Inman, M.D.6
  • 50
    • 46949106881 scopus 로고    scopus 로고
    • Differential rates of apoptosis and recruitment limit eosinophil accumulation in the lungs of asthma-resistant CBA/Ca mice
    • Tumes DJ, Wong AC, Sewell WA, McColl SR, Connolly A, Dent LA. Differential rates of apoptosis and recruitment limit eosinophil accumulation in the lungs of asthma-resistant CBA/Ca mice. Mol Immunol 2008; 45:3609-17.
    • (2008) Mol Immunol , vol.45 , pp. 3609-3617
    • Tumes, D.J.1    Wong, A.C.2    Sewell, W.A.3    McColl, S.R.4    Connolly, A.5    Dent, L.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.