The challenges of axon survival: Introduction to the special issue on axonal degeneration

Experimental Neurology

Volumn 246, Issue , 2013, Pages 1-5

  Coleman, Michael P ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; HUNTINGTIN; MITOFUSIN 2; MYELIN; PARKIN; TAU PROTEIN; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 2;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BRAIN ISCHEMIA; CELL DEATH; CELL SURVIVAL; DEGENERATIVE DISEASE; DEMYELINATION; EDITORIAL; GENE MUTATION; GLAUCOMA; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; HUNTINGTON CHOREA; MOLECULAR GENETICS; NERVE FIBER DEGENERATION; NERVE FIBER REGENERATION; NERVE FIBER TRANSPORT; NONHUMAN; PARKINSON DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REINNERVATION; RISK FACTOR; TRAUMATIC BRAIN INJURY; WALLERIAN DEGENERATION;

ANIMALS; AXONS; CELL SURVIVAL; HUMANS; NERVE DEGENERATION; NERVE FIBERS, MYELINATED; NERVE REGENERATION; WALLERIAN DEGENERATION;

EID: 84879795235     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.06.007     Document Type: Editorial

References (66)

1. Adalbert R., Coleman M.P. Axon pathology in age-related neurodegenerative disorders. Neuropathol. Appl. Neurobiol. 2012, (in press). 10.1111/j.1365-2990.2012.01308.x.
2. Adalbert R., Nogradi A., Babetto E., Janeckova L., Walker S.A., Kerschensteiner M., Misgeld T., Coleman M.P. Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies. Brain 2009, 132:402-416.
3. Amiri M., Hollenbeck P.J. Mitochondrial biogenesis in the axons of vertebrate peripheral neurons. Dev. Neurobiol. 2008, 68:1348-1361.
4. Babetto E., Beirowski B., Russler E.V., Milbrandt J., Diantonio A. The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction. Cell Rep. 2013, 1-8.
5. Barisic N., Claeys K.G., Sirotković-Skerlev M., Löfgren A., Nelis E., De Jonghe P., Timmerman V. Charcot-Marie-Tooth disease: a clinico-genetic confrontation. Ann. Hum. Genet. 2008, 72:416-441.
6. Bjartmar C., Yin X., Trapp B.D. Axonal pathology in myelin disorders. J. Neurocytol. 1999, 28:383-395.
7. Büki A., Povlishock J.T. All roads lead to disconnection?-traumatic axonal injury revisited. Acta Neurochir. (Wien) 2006, 148:181-193. (discussion 193-4).
8. Cai Q., Zakaria H.M., Simone A., Sheng Z.-H. Spatial Parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons. Curr. Biol. 2012, 22:545-552.
9. Coleman M. Axon degeneration mechanisms: commonality amid diversity. Nat. Rev. Neurosci. 2005, 6:889-898.
10. Collins C.A., Wairkar Y.P., Johnson S.L., Diantonio A. Highwire restrains synaptic growth by attenuating a MAP kinase signal. Neuron 2006, 51:57-69.
11. Costa V., Giacomello M., Hudec R., Lopreiato R., Ermak G., Lim D., Malorni W., Davies K.J.A., Carafoli E., Scorrano L. Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol. Med. 2010, 2:490-503.
12. Cuesta A., Pedrola L., Sevilla T., García-Planells J., Chumillas M.J., Mayordomo F., LeGuern E., Marín I., Vílchez J.J., Palau F. The gene encoding ganglioside-induced differentiation-associated protein 1 is mutated in axonal Charcot-Marie-Tooth type 4A disease. Nat. Genet. 2002, 30:22-25.
13. Ferguson B., Matyszak M.K., Esiri M.M., Perry V.H. Axonal damage in acute multiple sclerosis lesions. Brain 1997, 120(Pt 3):393-399.
14. Fischer L.R., Culver D.G., Tennant P., Davis A.A., Wang M., Castellano-Sanchez A., Khan J., Polak M.A., Glass J.D. Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp. Neurol. 2004, 185:232-240.
15. Frei R., Mötzing S., Kinkelin I., Schachner M., Koltzenburg M., Martini R. Loss of distal axons and sensory Merkel cells and features indicative of muscle denervation in hindlimbs of P0-deficient mice. J. Neurosci. 1999, 19:6058-6067.
16. Fünfschilling U., Supplie L.M., Mahad D., Boretius S., Saab A.S., Edgar J., Brinkmann B.G., Kassmann C.M., Tzvetanova I.D., Möbius W., Diaz F., Meijer D., Suter U., Hamprecht B., Sereda M.W., Moraes C.T., Frahm J., Goebbels S., Nave K.-A. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 2012, 1-12.
17. Garbern J.Y., Yool D.A., Moore G.J., Wilds I.B., Faulk M.W., Klugmann M., Nave K.-A., Sistermans E.A., van der Knaap M.S., Bird T.D., Shy M.E., Kamholz J.A., Griffiths I.R. Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation. Brain 2002, 125:551-561.
18. Gauthier L.R., Charrin B.C., Borrell-Pagès M., Dompierre J.P., Rangone H., Cordelières F.P., De Mey J., MacDonald M.E., Lessmann V., Humbert S., Saudou F. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 2004, 118:127-138.
19. Gelbard H.A. Synapses and Sisyphus: life without paraplegin. J. Clin. Invest. 2004, 113:185-187.
20. Gilley J., Seereeram A., Ando K., Mosely S., Andrews S., Kerschensteiner M., Misgeld T., Brion J.P., Anderton B., Hanger D.P., Coleman M.P. Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse. Neurobiol. Aging 2011, 1-15.
21. Goshima Y., Usui H., Shiozawa T., Hida T., Kuraoka S., Takeshita S., Yamashita N., Ichikawa Y., Kamiya Y., Gotoh T., Gotoh T. Computational analysis of the effects of antineoplastic agents on axonal transport. J. Pharmacol. Sci. 2010, 114:168-179.
22. Griffiths I., Klugmann M., Anderson T., Yool D., Thomson C., Schwab M.H., Schneider A., Zimmermann F., McCulloch M., Nadon N., Nave K.A. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 1998, 280:1610-1613.
23. Gupta R., Nassiri N., Hazel A., Bathen M., Mozaffar T. Chronic nerve compression alters Schwann cell myelin architecture in a murine model. Muscle Nerve 2012, 45:231-241.
24. Hoopfer E.D., McLaughlin T., Watts R.J., Schuldiner O., O'Leary D.D.M., Luo L. Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron 2006, 50:883-895.
25. Horste G.M.Z., Miesbach T.A., Muller J.I., Fledrich R., Stassart R.M., Kieseier B.C., Coleman M.P., Sereda M.W. The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration. Neurobiol. Dis. 2010, 42:1-8.
26. Kang J.-S., Tian J.-H., Pan P.-Y., Zald P., Li C., Deng C., Sheng Z.-H. Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell 2008, 132:137-148.
27. Kassmann C.M., Lappe-Siefke C., Baes M., Brügger B., Mildner A., Werner H.B., Natt O., Michaelis T., Prinz M., Frahm J., Nave K.-A. Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes. Nat. Genet. 2007, 39:969-976.
28. Kim-Han J.S., Antenor-Dorsey J.A., O'malley K.L. The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons. J. Neurosci. 2011, 31:7212-7221.
29. Lappe-Siefke C., Goebbels S., Gravel M., Nicksch E., Lee J., Braun P.E., Griffiths I.R., Nave K.-A. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat. Genet. 2003, 33:366-374.
30. Lee Y., Morrison B.M., Li Y., Lengacher S., Farah M.H., Hoffman P.N., Liu Y., Tsingalia A., Jin L., Zhang P.-W., Pellerin L., Magistretti P.J., Rothstein J.D. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature 2012, 487:443-448.
31. Liblau R.S., Gonzalez-Dunia D., Wiendl H., Zipp F. Neurons as targets for T cells in the nervous system. Trends Neurosci. 2013, 36:315-324.
32. Lunn E.R., Perry V.H., Brown M.C., Rosen H., Gordon S. Absence of Wallerian degeneration does not hinder regeneration in peripheral nerve. Eur. J. Neurosci. 1989, 1:27-33.
33. MacDonald J.M., Beach M.G., Porpiglia E., Sheehan A.E., Watts R.J., Freeman M.R. The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons. Neuron 2006, 50:869-881.
34. Mack T.G., Reiner M., Beirowski B., Mi W., Emanuelli M., Wagner D., Thomson D., Gillingwater T., Court F., Conforti L., Fernando F.S., Tarlton A., Andressen C., Addicks K., Magni G., Ribchester R.R., Perry V.H., Coleman M.P. Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat. Neurosci. 2001, 4:1199-1206.
35. Maday S., Wallace K.E., Holzbaur E.L.F. Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. J. Cell Biol. 2012, 1-15.
36. Marinkovic P., Reuter M.S., Brill M.S., Godinho L., Kerschensteiner M., Misgeld T. Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. 2012, 109:4296-4301.
37. Martin N., Jaubert J., Gounon P., Salido E., Haase G., Szatanik M., Guénet J.-L. A missense mutation in Tbce causes progressive motor neuronopathy in mice. Nat. Genet. 2002, 32:443-447.
38. Martin K.R.G., Quigley H.A., Valenta D., Kielczewski J., Pease M.E. Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma. Exp. Eye Res. 2006, 83:255-262.
39. Matsuda W., Furuta T., Nakamura K.C., Hioki H., Fujiyama F., Arai R., Kaneko T. Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum. J. Neurosci. 2009, 29:444-453.
40. Matsuda N., Sato S., Shiba K., Okatsu K., Saisho K., Gautier C.A., Sou Y.-S., Saiki S., Kawajiri S., Sato F., Kimura M., Komatsu M., Hattori N., Tanaka K. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J. Cell Biol. 2010, 189:211-221.
41. Medana I., Martinic M.A., Wekerle H., Neumann H. Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes. Am. J. Pathol. 2001, 159:809-815.
42. Misgeld T., Kerschensteiner M., Bareyre F.M., Burgess R.W., Lichtman J.W. Imaging axonal transport of mitochondria in vivo. Nat. Methods 2007, 4:559-561.
43. Narendra D.P., Jin S.M., Tanaka A., Suen D.-F., Gautier C.A., Shen J., Cookson M.R., Youle R.J. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol. 2010, 8:e1000298.
44. Nave K.-A. Myelination and the trophic support of long axons. Nat. Rev. Neurosci. 2010, 11:275-283.
45. Nikić I., Merkler D., Sorbara C., Brinkoetter M., Kreutzfeldt M., Bareyre F.M., Brück W., Bishop D., Misgeld T., Kerschensteiner M. A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat. Med. 2011, 17:495-499.
46. Osterloh J.M., Yang J., Rooney T.M., Fox A.N., Adalbert R., Powell E.H., Sheehan A.E., Avery M.A., Hackett R., Logan M.A., MacDonald J.M., Ziegenfuss J.S., Milde S., Hou Y.-J., Nathan C., Ding A., Brown R.H., Conforti L., Coleman M., Tessier-Lavigne M., Züchner S., Freeman M.R. dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science 2012, 337:481-484.
47. Perry R.B.-T., Doron-Mandel E., Iavnilovitch E., Rishal I., Dagan S.Y., Tsoory M., Coppola G., McDonald M.K., Gomes C., Geschwind D.H., Twiss J.L., Yaron A., Fainzilber M. Subcellular knockout of importin β1 perturbs axonal retrograde signaling. Neuron 2012, 75:294-305.
48. Reid E., Kloos M., Ashley-Koch A., Hughes L., Bevan S., Svenson I.K., Graham F.L., Gaskell P.C., Dearlove A., Pericak-Vance M.A., Rubinsztein D.C., Marchuk D.A. A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am. J. Hum. Genet. 2002, 71:1189-1194.
49. Samsam M., Mi W., Wessig C., Zielasek J., Toyka K.V., Coleman M.P., Martini R. The Wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy. J. Neurosci. 2003, 23:2833-2839.
50. Schaefer A.M., Sanes J.R., Lichtman J.W. A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis. J. Comp. Neurol. 2005, 490:209-219.
51. Schellingerhout D., LeRoux L.G., Hobbs B.P., Bredow S. Impairment of retrograde neuronal transport in oxaliplatin-induced neuropathy demonstrated by molecular imaging. PLoS One 2012, 7:e45776.
52. Siffrin V., Brandt A.U., Radbruch H., Herz J., Boldakowa N., Leuenberger T., Werr J., Hahner A., Schulze-Topphoff U., Nitsch R., Zipp F. Differential immune cell dynamics in the CNS cause CD4+ T cell compartmentalization. Brain 2009, 132:1247-1258.
53. Stamer K., Vogel R., Thies E., Mandelkow E., Mandelkow E. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J. Cell Biol. 2002, 156:1051.
54. Stokin G.B., Lillo C., Falzone T.L., Brusch R.G., Rockenstein E., Mount S.L., Raman R., Davies P., Masliah E., Williams D.S., Goldstein L.S.B. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 2005, 307:1282-1288.
55. Stone J.R., Okonkwo D.O., Dialo A.O., Rubin D.G., Mutlu L.K., Povlishock J.T., Helm G.A. Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injury. Exp. Neurol. 2004, 190:59-69.
56. Tang-Schomer M.D., Patel A.R., Baas P.W., Smith D.H. Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration. FASEB J. 2010, 24:1401-1410.
57. Viader A., Golden J.P., Baloh R.H., Schmidt R.E., Hunter D.A., Milbrandt J. Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. J. Neurosci. 2011, 31:10128-10140.
58. Vossel K.A., Zhang K., Brodbeck J., Daub A.C., Sharma P., Finkbeiner S., Cui B., Mucke L. Tau reduction prevents Abeta-induced defects in axonal transport. Science 2010, 330:198.
59. Wang X., Schwarz T.L. The mechanism of Ca2+-dependent regulation of kinesin-mediated mitochondrial motility. Cell 2009, 136:163-174.
60. Wang X., Su B., Lee H.-G., Li X., Perry G., Smith M.A., Zhu X. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J. Neurosci. 2009, 29:9090-9103.
61. Warshawsky I., Rudick R.A., Staugaitis S.M., Natowicz M.R. Primary progressive multiple sclerosis as a phenotype of a PLP1 gene mutation. Ann. Neurol. 2005, 58:470-473.
62. Williamson T., Cleveland D. Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat. Neurosci. 1999, 2:50-56.
63. Xiong X., Hao Y., Sun K., Li J., Li X., Mishra B., Soppina P., Wu C., Hume R.I., Collins C.A. The highwire ubiquitin ligase promotes axonal degeneration by tuning levels of nmnat protein. PLoS Biol. 2012, 10:e1001440.
64. Yang Y., Coleman M., Zhang L., Zheng X., Yue Z. Autophagy in axonal and dendritic degeneration. Trends Neurosci. 2013, (in press). 10.1016/j.tins.2013.04.001.
65. Zhu Y.-B., Sheng Z.-H. Increased axonal mitochondrial mobility does not slow ALS-like disease in mutant SOD1 mice. J. Biol. Chem. 2011, 286:23432-23440.
66. Züchner S., Mersiyanova I.V., Muglia M., Bissar-Tadmouri N., Rochelle J., Dadali E.L., Zappia M., Nelis E., Patitucci A., Senderek J., Parman Y., Evgrafov O., De Jonghe P., Takahashi Y., Tsuji S., Pericak-Vance M.A., Quattrone A., Battaloglu E., Polyakov A.V., Timmerman V., Schröder J.M., Vance J.M., Battologlu E. Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat. Genet. 2004, 36:449-451.