Rational design of angiotensin-I-converting enzyme inhibitory peptides by integrating insilico modeling and an invitro assay

ChemMedChem

Volumn 8, Issue 7, 2013, Pages 1057-1066

  Jing, Tao ^a   Feng, Jian ^b   Li, De ^c   Liu, Jianping ^a   He, Guoxiang ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b SOUTHWEST MEDICAL UNIVERSITY   (China)

^c CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

Angiotensin I converting enzyme; Hypertension; Inhibitors; Molecular dynamics; Molecular modeling; Peptides

Indexed keywords

ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; SILICON;

ARTICLE; CHEMICAL MODIFICATION; COMPUTER MODEL; DRUG DESIGN; DRUG DETERMINATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYPERTENSION; IN VITRO STUDY; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; DRUG DESIGN; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PEPTIDES; PEPTIDYL-DIPEPTIDASE A; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879781689     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300132     Document Type: Article

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