메뉴 건너뛰기




Volumn 8, Issue 7, 2013, Pages

Sulphatation Does Not Appear to Be a Protective Mechanism to Prevent Oxysterol Accumulation in Humans and Mice

Author keywords

[No Author keywords available]

Indexed keywords

24 HYDROXYCHOLESTEROL; 25 HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; CHOLESTEROL DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 7B1; UNCLASSIFIED DRUG;

EID: 84879774903     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068031     Document Type: Article
Times cited : (5)

References (28)
  • 1
    • 66349136255 scopus 로고    scopus 로고
    • Are side-chain oxidized oxysterols regulators also in vivo?
    • Bjorkhem I, (2009) Are side-chain oxidized oxysterols regulators also in vivo? J Lipid Res 50Suppl: S213-218.
    • (2009) J Lipid Res , vol.50
    • Bjorkhem, I.1
  • 2
    • 0036096897 scopus 로고    scopus 로고
    • Oxysterols: friends, foes, or just fellow passengers?
    • Bjorkhem I, Diczfalusy U, (2002) Oxysterols: friends, foes, or just fellow passengers? Arterioscler Thromb Vasc Biol 22: 734-742.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 734-742
    • Bjorkhem, I.1    Diczfalusy, U.2
  • 3
    • 0342316532 scopus 로고    scopus 로고
    • Oxysterols: modulators of cholesterol metabolism and other processes
    • Schroepfer GJ Jr, (2000) Oxysterols: modulators of cholesterol metabolism and other processes. Physiol Rev 80: 361-554.
    • (2000) Physiol Rev , vol.80 , pp. 361-554
    • Schroepfer Jr., G.J.1
  • 4
    • 34548231638 scopus 로고    scopus 로고
    • Oxysterols, cholesterol homeostasis, and Alzheimer disease
    • Vaya J, Schipper HM, (2007) Oxysterols, cholesterol homeostasis, and Alzheimer disease. J Neurochem 102: 1727-1737.
    • (2007) J Neurochem , vol.102 , pp. 1727-1737
    • Vaya, J.1    Schipper, H.M.2
  • 5
    • 0034595445 scopus 로고    scopus 로고
    • Disruption of the oxysterol 7alpha-hydroxylase gene in mice
    • Li-Hawkins J, Lund EG, Turley SD, Russell DW, (2000) Disruption of the oxysterol 7alpha-hydroxylase gene in mice. J Biol Chem 275: 16536-16542.
    • (2000) J Biol Chem , vol.275 , pp. 16536-16542
    • Li-Hawkins, J.1    Lund, E.G.2    Turley, S.D.3    Russell, D.W.4
  • 6
    • 0038265008 scopus 로고    scopus 로고
    • Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
    • Lund EG, Xie C, Kotti T, Turley SD, Dietschy JM, et al. (2003) Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J Biol Chem 278: 22980-22988.
    • (2003) J Biol Chem , vol.278 , pp. 22980-22988
    • Lund, E.G.1    Xie, C.2    Kotti, T.3    Turley, S.D.4    Dietschy, J.M.5
  • 7
    • 0037072799 scopus 로고    scopus 로고
    • Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis
    • Meir K, Kitsberg D, Alkalay I, Szafer F, Rosen H, et al. (2002) Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis. J Biol Chem 277: 34036-34041.
    • (2002) J Biol Chem , vol.277 , pp. 34036-34041
    • Meir, K.1    Kitsberg, D.2    Alkalay, I.3    Szafer, F.4    Rosen, H.5
  • 8
    • 0032511035 scopus 로고    scopus 로고
    • Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene
    • Rosen H, Reshef A, Maeda N, Lippoldt A, Shpizen S, et al. (1998) Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene. J Biol Chem 273: 14805-14812.
    • (1998) J Biol Chem , vol.273 , pp. 14805-14812
    • Rosen, H.1    Reshef, A.2    Maeda, N.3    Lippoldt, A.4    Shpizen, S.5
  • 9
    • 80052965098 scopus 로고    scopus 로고
    • Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo
    • Shafaati M, Olin M, Bavner A, Pettersson H, Rozell B, et al. (2011) Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med 270: 377-387.
    • (2011) J Intern Med , vol.270 , pp. 377-387
    • Shafaati, M.1    Olin, M.2    Bavner, A.3    Pettersson, H.4    Rozell, B.5
  • 10
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
    • Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ, (1996) An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383: 728-731.
    • (1996) Nature , vol.383 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 11
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    • Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, et al. (1998) Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93: 693-704.
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.M.5
  • 12
    • 0029835410 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
    • Lutjohann D, Breuer O, Ahlborg G, Nennesmo I, Siden A, et al. (1996) Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci U S A 93: 9799-9804.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 9799-9804
    • Lutjohann, D.1    Breuer, O.2    Ahlborg, G.3    Nennesmo, I.4    Siden, A.5
  • 13
    • 77950599782 scopus 로고    scopus 로고
    • Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis
    • Schule R, Siddique T, Deng HX, Yang Y, Donkervoort S, et al. (2010) Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. J Lipid Res 51: 819-823.
    • (2010) J Lipid Res , vol.51 , pp. 819-823
    • Schule, R.1    Siddique, T.2    Deng, H.X.3    Yang, Y.4    Donkervoort, S.5
  • 14
    • 0036788262 scopus 로고    scopus 로고
    • Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles
    • Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Weiglein AH, et al. (2002) Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles. Gastroenterology 123: 1238-1251.
    • (2002) Gastroenterology , vol.123 , pp. 1238-1251
    • Fickert, P.1    Zollner, G.2    Fuchsbichler, A.3    Stumptner, C.4    Weiglein, A.H.5
  • 15
    • 0028816863 scopus 로고
    • Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry
    • Dzeletovic S, Breuer O, Lund E, Diczfalusy U, (1995) Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal Biochem 225: 73-80.
    • (1995) Anal Biochem , vol.225 , pp. 73-80
    • Dzeletovic, S.1    Breuer, O.2    Lund, E.3    Diczfalusy, U.4
  • 16
    • 0034991507 scopus 로고    scopus 로고
    • Cholesterol and hydroxycholesterol sulfotransferases: identification, distinction from dehydroepiandrosterone sulfotransferase, and differential tissue expression
    • Javitt NB, Lee YC, Shimizu C, Fuda H, Strott CA, (2001) Cholesterol and hydroxycholesterol sulfotransferases: identification, distinction from dehydroepiandrosterone sulfotransferase, and differential tissue expression. Endocrinology 142: 2978-2984.
    • (2001) Endocrinology , vol.142 , pp. 2978-2984
    • Javitt, N.B.1    Lee, Y.C.2    Shimizu, C.3    Fuda, H.4    Strott, C.A.5
  • 17
    • 34447566893 scopus 로고    scopus 로고
    • Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes
    • Ren S, Li X, Rodriguez-Agudo D, Gil G, Hylemon P, et al. (2007) Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes. Biochem Biophys Res Commun 360: 802-808.
    • (2007) Biochem Biophys Res Commun , vol.360 , pp. 802-808
    • Ren, S.1    Li, X.2    Rodriguez-Agudo, D.3    Gil, G.4    Hylemon, P.5
  • 18
    • 84859847698 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols
    • Fakheri RJ, Javitt NB, (2012) 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols. Steroids 77: 575-577.
    • (2012) Steroids , vol.77 , pp. 575-577
    • Fakheri, R.J.1    Javitt, N.B.2
  • 19
    • 0001400992 scopus 로고
    • Hydrolysis of ketosteroid hydrogen sulfates by solvolysis procedures
    • Burstein S, Lieberman S, (1958) Hydrolysis of ketosteroid hydrogen sulfates by solvolysis procedures. J Biol Chem 233: 331-335.
    • (1958) J Biol Chem , vol.233 , pp. 331-335
    • Burstein, S.1    Lieberman, S.2
  • 20
    • 33947485274 scopus 로고
    • Studies on Steroid Conjugates. Iv. Demonstration and Identification of Solvolyzable Corticosteroids in Human Urine and Plasma
    • Kornel L, (1965) Studies on Steroid Conjugates. Iv. Demonstration and Identification of Solvolyzable Corticosteroids in Human Urine and Plasma. Biochemistry 4: 444-452.
    • (1965) Biochemistry , vol.4 , pp. 444-452
    • Kornel, L.1
  • 21
    • 37249016419 scopus 로고    scopus 로고
    • Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes
    • Li X, Pandak WM, Erickson SK, Ma Y, Yin L, et al. (2007) Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes. J Lipid Res 48: 2587-2596.
    • (2007) J Lipid Res , vol.48 , pp. 2587-2596
    • Li, X.1    Pandak, W.M.2    Erickson, S.K.3    Ma, Y.4    Yin, L.5
  • 22
    • 0030203363 scopus 로고    scopus 로고
    • The identification of novel steroid N-acetylglucosaminides in the urine of pregnant women
    • Meng LJ, Griffiths WJ, Sjovall J, (1996) The identification of novel steroid N-acetylglucosaminides in the urine of pregnant women. J Steroid Biochem Mol Biol 58: 585-598.
    • (1996) J Steroid Biochem Mol Biol , vol.58 , pp. 585-598
    • Meng, L.J.1    Griffiths, W.J.2    Sjovall, J.3
  • 23
    • 70449328152 scopus 로고
    • The acid-catalyzed solvolysis of dehydroepiandrosterone sulfate and its significance in the examination of urinary 17-ketosteroids
    • Segal L, Segal B, Nes WR, (1960) The acid-catalyzed solvolysis of dehydroepiandrosterone sulfate and its significance in the examination of urinary 17-ketosteroids. J Biol Chem 235: 3108-3111.
    • (1960) J Biol Chem , vol.235 , pp. 3108-3111
    • Segal, L.1    Segal, B.2    Nes, W.R.3
  • 24
    • 0030906963 scopus 로고    scopus 로고
    • High levels of (24S)-24-hydroxycholesterol 3-sulfate, 24-glucuronide in the serum and urine of children with severe cholestatic liver disease
    • Meng LJ, Griffiths WJ, Nazer H, Yang Y, Sjovall J, (1997) High levels of (24S)-24-hydroxycholesterol 3-sulfate, 24-glucuronide in the serum and urine of children with severe cholestatic liver disease. J Lipid Res 38: 926-934.
    • (1997) J Lipid Res , vol.38 , pp. 926-934
    • Meng, L.J.1    Griffiths, W.J.2    Nazer, H.3    Yang, Y.4    Sjovall, J.5
  • 25
    • 0031848338 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
    • Bjorkhem I, Lutjohann D, Diczfalusy U, Stahle L, Ahlborg G, et al. (1998) Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J Lipid Res 39: 1594-1600.
    • (1998) J Lipid Res , vol.39 , pp. 1594-1600
    • Bjorkhem, I.1    Lutjohann, D.2    Diczfalusy, U.3    Stahle, L.4    Ahlborg, G.5
  • 26
    • 0035060475 scopus 로고    scopus 로고
    • Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol
    • Bjorkhem I, Starck L, Andersson U, Lutjohann D, von Bahr S, et al. (2001) Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. J Lipid Res 42: 366-371.
    • (2001) J Lipid Res , vol.42 , pp. 366-371
    • Bjorkhem, I.1    Starck, L.2    Andersson, U.3    Lutjohann, D.4    von Bahr, S.5
  • 27
    • 0343729334 scopus 로고    scopus 로고
    • Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface
    • Bretillon L, Lutjohann D, Stahle L, Widhe T, Bindl L, et al. (2000) Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. J Lipid Res 41: 840-845.
    • (2000) J Lipid Res , vol.41 , pp. 840-845
    • Bretillon, L.1    Lutjohann, D.2    Stahle, L.3    Widhe, T.4    Bindl, L.5
  • 28
    • 0032211865 scopus 로고    scopus 로고
    • Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease
    • Setchell KD, Schwarz M, O'Connell NC, Lund EG, Davis DL, et al. (1998) Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease. J Clin Invest 102: 1690-1703.
    • (1998) J Clin Invest , vol.102 , pp. 1690-1703
    • Setchell, K.D.1    Schwarz, M.2    O'Connell, N.C.3    Lund, E.G.4    Davis, D.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.