Suppressive Oligodeoxynucleotides Promote the Development of Th17 Cells

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Bode, Christian ^a   Yang, Xiang Ping ^b   Kiu, Hiu ^a   Klinman, Dennis M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGODEOXYNUCLEOTIDE DERIVATIVE; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDIASIS; CD4+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; DRUG EFFICACY; EFFECTOR CELL; FEMALE; GENE ACTIVATION; GENE EXPRESSION REGULATION; HOST RESISTANCE; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; MOUSE; NONHUMAN; TH17 CELL;

ANIMALS; BASE SEQUENCE; CANDIDA ALBICANS; CANDIDIASIS; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HOST-PATHOGEN INTERACTIONS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-GAMMA; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; OLIGODEOXYRIBONUCLEOTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TH17 CELLS;

CANDIDA ALBICANS; MUS;

EID: 84879747914     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067991     Document Type: Article

References (47)

1. Gursel I, Gursel M, Yamada H, Ishii KJ, Takeshita F, et al. (2003) Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J Immunol 171: 1393-1400.
2. Dong l, Ito S, Ishii K, Klinman DM, (2004) Suppressive oligodeoxy-nucleotides Delay the Onset of Glomerulonephritis and Prolong the Survival of Lupus-prone NZB/W Mice. Arthritis Rheum 52: 651-658.
3. Dong L, Ito S, Ishii KJ, Klinman DM, (2004) Suppressive oligonucleotides protect against collagen-induced arthritis in mice. Arthritis Rheum 50: 1686-1689.
4. Fujimoto C, Klinman DM, Shi G, Yin H, Vistica BP, et al. (2009) A suppressive oligodeoxynucleotide inhibits ocular inflammation Clin Exp Immunol. 156: 528-534.
5. Cheng X, Chen Y, Xie JJ, Yao R, Yu X, et al. (2008) Suppressive oligodeoxynucleotides inhibit atherosclerosis in ApoE(-/-) mice through modulation of Th1/Th2 balance. J Mol Cell Cardiol 45: 168-175.
6. Ikeuchi H, Kinjo T, Klinman DM, (2011) Effect of suppressive oligodeoxynucleotides on the development of inflammation-induced papillomas. Cancer Prev Res (Phila) 4: 752-757.
7. Sato T, Shimosato T, Alvord WG, Klinman DM, (2008) Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation. J Immunol 180: 7648-7654.
8. Shirota H, Gursel M, Klinman DM, (2004) Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-gamma- and IL-12-mediated signaling. J Immunol 173: 5002-5007.
9. Shirota H, Gursel I, Gursel M, Klinman DM, (2005) Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock. J Immunol 174: 4579-4583.
10. Maddur MS, Miossec P, Kaveri SV, Bayry J, (2012) Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. Am J Pathol 181: 8-18.
11. McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, et al. (2007) TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 8: 1390-1397.
12. Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, et al. (2010) Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling. Nature 467: 967-971.
13. Codarri L, Gyulveszi G, Tosevski V, Hesske L, Fontana A, et al. (2011) RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 12: 560-567.
14. El-Behi M, Ciric B, Dai H, Yan Y, Cullimore M, et al. (2011) The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol 12: 568-575.
15. Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, et al. (2003) Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198: 1951-1957.
16. Zhang Z, Kyttaris VC, Tsokos GC, (2009) The role of IL-23/IL-17 axis in lupus nephritis. J Immunol 183: 3160-3169.
17. Hernandez-Santos N, Gaffen SL, (2012) Th17 cells in immunity to Candida albicans. Cell Host Microbe 11: 425-435.
18. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
19. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B, (2006) TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24: 179-189.
20. Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, et al. (2007) STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 282: 9358-9363.
21. Chen Z, Laurence A, Kanno Y, Pacher-Zavisin M, Zhu BM, et al. (2006) Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A 103: 8137-8142.
22. Qin H, Wang L, Feng T, Elson CO, Niyongere SA, et al. (2009) TGF-beta promotes Th17 cell development through inhibition of SOCS3. J Immunol 183: 97-105.
23. Croker BA, Krebs DL, Zhang JG, Wormald S, Willson TA, et al. (2003) SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 4: 540-545.
24. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6: 1123-1132.
25. Jacob N, Yang H, Pricop L, Liu Y, Gao X, et al. (2009) Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway. J Immunol 182: 2532-2541.
26. Kang HK, Liu M, Datta SK, (2007) Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells. J Immunol 178: 7849-7858.
27. Huang W, Na L, Fidel PL, Schwarzenberger P, (2004) Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 190: 624-631.
28. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, et al. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133.
29. LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, et al. (2007) Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 8: 630-638.
30. Hirota K, Duarte JH, Veldhoen M, Hornsby E, Li Y, et al. (2011) Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 12: 255-263.
31. Odds FC, Van NL, Gow NA, (2000) Survival in experimental Candida albicans infections depends on inoculum growth conditions as well as animal host. Microbiology 146 (Pt 8): 1881-1889.
32. Spellberg B, Ibrahim AS, Edwards JE Jr, Filler SG, (2005) Mice with disseminated candidiasis die of progressive sepsis. J Infect Dis 192: 336-343.
33. MacCallum DM, Odds FC, (2005) Temporal events in the intravenous challenge model for experimental Candida albicans infections in female mice. Mycoses 48: 151-161.
34. Peters A, Lee Y, Kuchroo VK, (2011) The many faces of Th17 cells. Curr Opin Immunol 23: 702-706.
35. Ghoreschi K, Laurence A, Yang XP, Hirahara K, O'Shea JJ, (2011) T helper 17 cell heterogeneity and pathogenicity in autoimmune disease. Trends Immunol 32: 395-401.
36. Mathur AN, Chang HC, Zisoulis DG, Stritesky GL, Yu Q, et al. (2007) Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol 178: 4901-4907.
37. Kimura A, Naka T, Kishimoto T, (2007) IL-6-dependent and-independent pathways in the development of interleukin 17-producing T helper cells. Proc Natl Acad Sci U S A 104: 12099-12104.
38. Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, et al. (2006) Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 7: 937-945.
39. Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, et al. (2007) Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26: 371-381.
40. Korn T, Bettelli E, Oukka M, Kuchroo VK, (2009) IL-17 and Th17 Cells. Annu Rev Immunol 27: 485-517.41.
41. Peck A, Mellins ED, (2010) Precarious balance: Th17 cells in host defense. Infect Immun 78: 32-38.
42. Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, et al. (2010) Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 32: 681-691.
43. Cua DJ, Tato CM, (2010) Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 10: 479-489.
44. Dejima T, Shibata K, Yamada H, Hara H, Iwakura Y, et al. (2011) Protective role of naturally occurring interleukin-17A-producing gammadelta T cells in the lung at the early stage of systemic candidiasis in mice. Infect Immun 79: 4503-4510.
45. Gladiator A, Wangler N, Trautwein-Weidner K, LeibundGut-Landmann S, (2013) Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection. J Immunol 190: 521-525.
46. Huber S, Gagliani N, Esplugues E, O'Connor W, Huber FJ, et al. (2011) Th17 cells express interleukin-10 receptor and are controlled by Foxp3(-) and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 34: 554-565.
47. Ghoreschi K, Jesson MI, Li X, Lee JL, Ghosh S, et al. (2011) Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol 186: 4234-4243.