A suppressive oligodeoxynucleotide inhibits ocular inflammation

Clinical and Experimental Immunology

Volumn 156, Issue 3, 2009, Pages 528-534

  Fujimoto, C ^a   Klinman, D M ^b   Shi, G ^a   Yin, H ^a   Vistica, B P ^a   Lovaas, J D ^a   Wawrousek, E F ^a   Igarashi, T ^a   Chan, C C ^a   Gery, I ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

EAU; Immunopathogenic process; Immunosuppression; ODN

Indexed keywords

A 151; CYTOKINE; HEN EGG LYSOZYME; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 22; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; LYSOZYME; OLIGODEOXYNUCLEOTIDE; RETINA S ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG MECHANISM; EYE INFLAMMATION; FEMALE; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; STATISTICAL ANALYSIS; TH1 CELL; TRANSGENIC MOUSE; UVEITIS;

ADOPTIVE TRANSFER; ANIMALS; AUTOIMMUNE DISEASES; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; EYE PROTEINS; FEMALE; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION MEDIATORS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; MURAMIDASE; OLIGODEOXYRIBONUCLEOTIDES; RETINOL-BINDING PROTEINS; TH1 CELLS; UVEITIS;

EID: 66149124876     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2009.03918.x     Document Type: Article

References (40)

1. Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci USA 1996 93 : 2879 83. (Pubitemid 26116242)
2. Klinman DM, Currie D, Gursel I, Verthelyi D. Use of CpG oligodeoxynucleotides as immune adjuvants. Immunol Rev 2004 199 : 201 16. (Pubitemid 38736773)
3. Roman M, Martin-Orozco E, Goodman JS et al. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med 1997 3 : 849 54. (Pubitemid 27353443)
4. Krieg AM. The role of CpG motifs in innate immunity. Curr Opin Immunol 2000 12 : 35 43. (Pubitemid 30093448)
5. Zakian VA. Telomeres: beginning to understand the end. Science 1995 270 : 1601 7. (Pubitemid 26002435)
6. Rudolph KL, Chang S, Lee HW et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1996 96 : 701 12.
7. Blasco MA, Lee HW, Hande MP et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997 91 : 25 34. (Pubitemid 27431310)
8. Gursel I, Gursel M, Yamada H, Ishii KJ, Takeshita F, Klinman DM. Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J Immunol 2003 171 : 1393 400. (Pubitemid 36900072)
9. Shirota H, Gursel M, Klinman DM. Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-gamma- and IL-12-mediated signaling. J Immunol 2004 173 : 5002 7. (Pubitemid 39402951)
10. Dong L, Ito S, Ishii KJ, Klinman DM. Suppressive oligonucleotides protect against collagen-induced arthritis in mice. Arthritis Rheum 2004 50 : 1686 9. (Pubitemid 38608092)
11. Shirota H, Gursel I, Gursel M, Klinman DM. Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock. J Immunol 2005 174 : 4579 83. (Pubitemid 40504537)
12. Dong L, Ito S, Ishii KJ, Klinman DM. Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice. Arthritis Rheum 2005 52 : 651 8. (Pubitemid 40216332)
13. Ho PG, Fontoura P, Platten M et al. A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease. J Immunol 2005 175 : 6226 34. (Pubitemid 41508112)
14. Rothova A, Suttorp-van Schulten MS, Frits Treffers W., Kijlstra A. Causes and frequency of blindness in patients with intraocular inflammatory disease. Br J Ophthalmol 1996 80 : 332 6. (Pubitemid 26113585)
15. Nussenblatt RB. Treating intraocular inflammatory disease in the 21st century. Arch Ophthalmol 2005 123 : 1000 1.
16. Durrani OM, Tehrani NN, Marr JE, Moradi P, Stavrou P, Murray PI. Degree, duration, and causes of visual loss in uveitis. Br J Ophthalmol 2004 88 : 1159 62. (Pubitemid 39141376)
17. Nussenblatt RB. Bench to bedside: new approaches to the immunotherapy of uveitic disease. Int Rev Immunol 2002 21 : 273 89.
18. Whitcup SM, Nussenblatt RB. Treatment of autoimmune uveitis. Ann NY Acad Sci 1993 696 : 307 18. (Pubitemid 24062802)
19. Forrester JV, Liversidge J, Dua HS, Dick A, Harper F, McMenamin PG. Experimental autoimmune uveoretinitis: a model system for immunointervention: a review. Curr Eye Res 1992 11 (Suppl. 33 40.
20. Caspi RR. Immune mechanisms in uveitis. Springer Semin Immunopathol 1999 21 : 113 24. (Pubitemid 29353999)
21. Wacker WB, Donoso LA, Kalsow CM, Yankeelov JA Jr., Organisciak DT. Experimental allergic uveitis. Isolation, characterization, and localization of a soluble uveitopathogenic antigen from bovine retina. J Immunol 1977 119 : 1949 58. (Pubitemid 8232088)
22. Nussenblatt RB, Kuwabara T, de Monasterio FM, Wacker WB. S-antigen uveitis in primates. A new model for human disease. Arch Ophthalmol 1981 99 : 1090 2. (Pubitemid 11070436)
23. Gery I, Wiggert B, Redmond TM et al. Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein. Invest Ophthalmol Vis Sci 1986 27 : 1296 300. (Pubitemid 16033866)
24. Hirose S, Kuwabara T, Nussenblatt RB, Wiggert B, Redmond TM, Gery I. Uveitis induced in primates by interphotoreceptor retinoid-binding protein. Arch Ophthalmol 1986 104 : 1698 702. (Pubitemid 17174542)
25. Caspi RR, Roberge FG, Chan CC et al. A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J Immunol 1988 140 : 1490 5. (Pubitemid 18103572)
26. Foxman EF, Zhang M, Hurst SD et al. Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Th1- versus Th2-mediated ocular inflammation. J Immunol 2002 168 : 2483 92. (Pubitemid 34171854)
27. Kim SJ, Zhang M, Vistica BP et al. Induction of ocular inflammation by T-helper lymphocytes type 2. Invest Ophthalmol Vis Sci 2002 43 : 758 65. (Pubitemid 34184494)
28. Lai JC, Fukushima A, Wawrousek EF et al. Immunotolerance against a foreign antigen transgenically expressed in the lens. Invest Ophthalmol Vis Sci 1998 39 : 2049 57. (Pubitemid 28455074)
29. Ho WY, Cooke MP, Goodnow CC, Davis MM. Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells. J Exp Med 1994 179 : 1539 49. (Pubitemid 24129571)
30. Pepperberg DR, Okajima TL, Ripps H, Chader GJ, Wiggert B. Functional properties of interphotoreceptor retinoid-binding protein. Photochem Photobiol 1991 54 : 1057 60.
31. Caspi RR, Chan CC, Leake WC, Higuchi M, Wiggert B, Chader GJ. Experimental autoimmune uveoretinitis in mice. Induction by a single eliciting event and dependence on quantitative parameters of immunization. J Autoimmun 1990 3 : 237 46. (Pubitemid 20337654)
32. Chan CC, Caspi RR, Ni M et al. Pathology of experimental autoimmune uveoretinitis in mice. J Autoimmun 1990 3 : 247 55. (Pubitemid 20337655)
33. Stockinger B, Veldhoen M. Differentiation and function of Th17 T cells. Curr Opin Immunol 2007 19 : 281 6. (Pubitemid 46687011)
34. McGeachy MJ, Dua DJ. Th17 cell differentiation: the long and winding road. Immunity 2008 28 : 445 53.
35. Amadi-Obi A, Yu C-R, Liu X et al. Th17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med 2007 13 : 711 18. (Pubitemid 46889754)
36. Luger D, Silver PB, Tang J et al. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med 2008 205 : 799 810.
37. Caspi RR. Regulation, counter-regulation, and immunotherapy of autoimmune responses to immunologically privileged retinal antigens. Immunol Res 2003 27 : 149 60. (Pubitemid 36995002)
38. Chen J, Vistica BP, Takase H et al. A unique pattern of up- and down-regulation of chemokine receptor CXCR3 on inflammation-inducing Th1 cells. Eur J Immunol 2004 34 : 2885 94. (Pubitemid 39430164)
39. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T-cells in immunological tolerance to self and non-self. Nat Immunol 2005 6 : 345 52. (Pubitemid 41716771)
40. Chen X, Winkler-Pickett RT, Carbonetti NH, Ortaldo JR, Oppenheim JJ, Howard OM. Pertussis toxin as an adjuvant suppresses the number and function of CD+CD25+ T regulatory cells. Eur J Immunol 2006 36 : 671 80.