Zinc finger protein ZBTB20 promotes toll-like receptor-triggered innate immune responses by repressing IκBα gene transcription

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 27, 2013, Pages 11097-11102

  Liu, Xingguang ^a   Zhang, Peng ^a   Bao, Yan ^a   Han, Yanmei ^a   Wang, Yan ^a   Zhang, Qian ^b   Zhan, Zhenzhen ^a   Meng, Jun ^c   Li, Yingke ^a   Li, Nan ^a   Zhang, Weiping J ^a   Cao, Xuetao ^a,b,c  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 6; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ZINC FINGER AND BTB DOMAIN CONTAINING 20 PROTEIN; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA SEQUENCE; ESCHERICHIA COLI; GRAM NEGATIVE SEPSIS; HIGH THROUGHPUT SEQUENCING; INFECTION RESISTANCE; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; SEPTIC SHOCK; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; DOWN-REGULATION; ESCHERICHIA COLI INFECTIONS; FEMALE; I-KAPPA B PROTEINS; IMMUNITY, INNATE; MACROPHAGES; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID CELLS; NF-KAPPA B; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SHOCK, SEPTIC; SUPPRESSION, GENETIC; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ESCHERICHIA COLI; MUS;

EID: 84879733488     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1301257110     Document Type: Article

References (41)

1. Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nat Immunol 11(5):373-384.
2. Iwasaki A, Medzhitov R (2010) Regulation of adaptive immunity by the innate immune system. Science 327(5963):291-295.
3. O'Neill LA, Bowie AG (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7(5):353-364. (Pubitemid 46674493)
4. Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140(6):805-820.
5. Marshak-Rothstein A, Rifkin IR (2007) Immunologically active autoantigens: The role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol 25:419-441. (Pubitemid 46697913)
6. Netea MG, Wijmenga C, O'Neill LA (2012) Genetic variation in Toll-like receptors and disease susceptibility. Nat Immunol 13(6):535-542.
7. Liu J, Liu S, Cao X (2012) Highlights of the advances in basic immunology in 2011. Cell Mol Immunol 9(3):197-207.
8. Murray PJ, Smale ST (2012) Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways. Nat Immunol 13(10):916-924.
9. Schneider M, et al. (2012) The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol 13(9):823-831.
10. Kelly KF, Daniel JM (2006) POZ for effect - POZ-ZF transcription factors in cancer and development. Trends Cell Biol 16(11):578-587. (Pubitemid 44636217)
11. Lee SU, Maeda T (2012) POK/ZBTB proteins: An emerging family of proteins that regulate lymphoid development and function. Immunol Rev 247(1):107-119.
12. Mitchelmore C, et al. (2002) Characterization of two novel nuclear BTB/POZ domain zinc finger isoforms. Association with differentiation of hippocampal neurons, cerebellar granule cells, and macroglia. J Biol Chem 277(9):7598-7609. (Pubitemid 34953159)
13. Nielsen JV, Nielsen FH, Ismail R, Noraberg J, Jensen NA (2007) Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice. Development 134(6):1133-1140. (Pubitemid 46630081)
14. Zhang W, et al. (2001) Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6. Biochem Biophys Res Commun 282(4):1067-1073. (Pubitemid 32924604)
15. Xie Z, et al. (2008) Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci USA 105(31):10859-10864.
16. Sutherland AP, et al. (2009) Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis. Mol Cell Biol 29(10):2804-2815.
17. Zhang Y, et al. (2012) The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice. Gastroenterology 142(7):1571-1580.
18. Xie Z, et al. (2010) Zbtb20 is essential for the specification of CA1 field identity in the developing hippocampus. Proc Natl Acad Sci USA 107(14):6510-6515.
19. Clausen BE, Burkhardt C, Reith W, Renkawitz R, Förster I (1999) Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8(4):265-277. (Pubitemid 29523965)
20. Haziot A, Hijiya N, Gangloff SC, Silver J, Goyert SM (2001) Induction of a novel mechanism of accelerated bacterial clearance by lipopolysaccharide in CD14-deficient and Toll-like receptor 4-deficient mice. J Immunol 166(2):1075-1078. (Pubitemid 32060265)
21. Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signaling. Cell 132(3):344-362.
22. Hiscott J (2007) Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response. Cytokine Growth Factor Rev 18(5-6):483-490.
23. Apostolou E, Thanos D (2008) Virus infection induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression. Cell 134(1):85-96. (Pubitemid 351905745)
24. Dev A, Iyer S, Razani B, Cheng G (2011) NF-κB and innate immunity. Curr Top Microbiol Immunol 349(2011):115-143.
25. Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu Rev Immunol 18(2000):621-663. (Pubitemid 30365393)
26. Hoffmann A, Levchenko A, Scott ML, Baltimore D (2002) The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation. Science 298(5596):1241-1245. (Pubitemid 35285493)
27. Egan LJ, Toruner M (2006) NF-kappaB signaling: Pros and cons of altering NF-kappaB as a therapeutic approach. Ann N Y Acad Sci 1072(2006):114-122. (Pubitemid 44448447)
28. Krishna SS, Majumdar I, Grishin NV (2003) Structural classification of zinc fingers: Survey and summary. Nucleic Acids Res 31(2):532-550. (Pubitemid 36175942)
29. Costoya JA (2007) Functional analysis of the role of POK transcriptional repressors. Brief Funct Genomics Proteomics 6(1):8-18.
30. Beaulieu AM, Sant'Angelo DB (2011) The BTB-ZF family of transcription factors: Key regulators of lineage commitment and effector function development in the immune system. J Immunol 187(6):2841-2847.
31. Xu D, et al. (2009) Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity. Immunity 30(6):802-816.
32. Daniel JM, Spring CM, Crawford HC, Reynolds AB, Baig A (2002) The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. Nucleic Acids Res 30(13):2911-2919. (Pubitemid 34778152)
33. Karsunky H, et al. (2002) Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet 30(3):295-300.
34. Sharif-Askari E, et al. (2010) Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65. Mol Cell Biol 30(16):3929-3942.
35. Liang J, et al. (2008) A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. J Biol Chem 283(10):6337-6346.
36. Matsushita K, et al. (2009) Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 458(7242):1185-1190.
37. Chen W, et al. (2013) Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation. Cell 152(3):467-478.
38. Liu X, et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses bymaintaining activation of the kinase Btk. Nat Immunol 12(5):416-424.
39. Xu S, et al. (2012) Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol 13(6):551-559.
40. Hou J, et al. (2011) Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell 19(2):232-243.
41. Wei L, et al. (2010) Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity 32(6):840-851.