메뉴 건너뛰기




Volumn 30, Issue 16, 2010, Pages 3929-3942

Zinc finger protein Gfi1 controls the endotoxin-mediated toll-like receptor inflammatory response by antagonizing NF-κB p65

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; PROTEIN GFI1; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

EID: 77955642223     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00087-10     Document Type: Article
Times cited : (28)

References (57)
  • 1
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499-511.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 2
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira, S., K. Takeda, and T. Kaisho. 2001. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2:675-680.
    • (2001) Nat. Immunol. , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 3
    • 0037317763 scopus 로고    scopus 로고
    • Innate immune sensing and its roots: The story of endotoxin
    • Beutler, B., and E. T. Rietschel. 2003. Innate immune sensing and its roots: the story of endotoxin. Nat. Rev. Immunol. 3:169-176.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 169-176
    • Beutler, B.1    Rietschel, E.T.2
  • 4
    • 1642581653 scopus 로고    scopus 로고
    • Hypoxic gene activation by lipopolysaccharide in macrophages: Implication of hypoxia-inducible factor 1alpha
    • Blouin, C. C., E. L. Page, G. M. Soucy, and D. E. Richard. 2004. Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha. Blood 103:1124-1130.
    • (2004) Blood , vol.103 , pp. 1124-1130
    • Blouin, C.C.1    Page, E.L.2    Soucy, G.M.3    Richard, D.E.4
  • 6
    • 5444254408 scopus 로고    scopus 로고
    • Toll-like receptors in the pathogenesis of human disease
    • Cook, D. N., D. S. Pisetsky, and D. A. Schwartz. 2004. Toll-like receptors in the pathogenesis of human disease. Nat. Immunol. 5:975-979.
    • (2004) Nat. Immunol. , vol.5 , pp. 975-979
    • Cook, D.N.1    Pisetsky, D.S.2    Schwartz, D.A.3
  • 7
    • 0037218547 scopus 로고    scopus 로고
    • Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: Effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components
    • Dobrovolskaia, M. A., A. E. Medvedev, K. E. Thomas, N. Cuesta, V. Toshchakov, T. Ren, M. J. Cody, S. M. Michalek, N. R. Rice, and S. N. Vogel. 2003. Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components. J. Immunol. 170:508-519.
    • (2003) J. Immunol. , vol.170 , pp. 508-519
    • Dobrovolskaia, M.A.1    Medvedev, A.E.2    Thomas, K.E.3    Cuesta, N.4    Toshchakov, V.5    Ren, T.6    Cody, M.J.7    Michalek, S.M.8    Rice, N.R.9    Vogel, S.N.10
  • 8
    • 0142180052 scopus 로고    scopus 로고
    • Gfi-1 oncoproteins in hematopoiesis
    • Duan, Z., and M. Horwitz. 2003. Gfi-1 oncoproteins in hematopoiesis. Hematology 8:339-344.
    • (2003) Hematology , vol.8 , pp. 339-344
    • Duan, Z.1    Horwitz, M.2
  • 9
    • 0242552753 scopus 로고    scopus 로고
    • Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: Roles of the receptor complex
    • Fujihara, M., M. Muroi, K. Tanamoto, T. Suzuki, H. Azuma, and H. Ikeda. 2003. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol. Ther. 100:171-194.
    • (2003) Pharmacol. Ther. , vol.100 , pp. 171-194
    • Fujihara, M.1    Muroi, M.2    Tanamoto, K.3    Suzuki, T.4    Azuma, H.5    Ikeda, H.6
  • 10
    • 54949147176 scopus 로고    scopus 로고
    • New regulators of NF-kappaB in inflammation
    • Ghosh, S., and M. S. Hayden. 2008. New regulators of NF-kappaB in inflammation. Nat. Rev. Immunol. 8:837-848.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 837-848
    • Ghosh, S.1    Hayden, M.S.2
  • 11
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh, S., and M. Karin. 2002. Missing pieces in the NF-kappaB puzzle. Cell 109(Suppl.):S81-S96.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 12
    • 0027462484 scopus 로고
    • Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein
    • Gilks, C. B., S. E. Bear, H. L. Grimes, and P. N. Tsichlis. 1993. Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Mol. Cell. Biol. 13:1759-1768.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1759-1768
    • Gilks, C.B.1    Bear, S.E.2    Grimes, H.L.3    Tsichlis, P.N.4
  • 13
    • 11144224785 scopus 로고    scopus 로고
    • Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling
    • Gingras, S., E. Parganas, A. de Pauw, J. N. Ihle, and P. J. Murray. 2004. Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J. Biol. Chem. 279:54702-54707.
    • (2004) J. Biol. Chem. , vol.279 , pp. 54702-54707
    • Gingras, S.1    Parganas, E.2    De Pauw, A.3    Ihle, J.N.4    Murray, P.J.5
  • 15
    • 0029806268 scopus 로고    scopus 로고
    • The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal
    • Grimes, H. L., T. O. Chan, P. A. Zweidler-McKay, B. Tong, and P. N. Tsichlis. 1996. The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal. Mol. Cell. Biol. 16:6263-6272.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 6263-6272
    • Grimes, H.L.1    Chan, T.O.2    Zweidler-McKay, P.A.3    Tong, B.4    Tsichlis, P.N.5
  • 16
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKK-related kinases
    • Hacker, H., and M. Karin. 2006. Regulation and function of IKK and IKK-related kinases. Sci. STKE 2006:re13.
    • (2006) Sci. STKE , vol.2006
    • Hacker, H.1    Karin, M.2
  • 17
    • 0035212589 scopus 로고    scopus 로고
    • The ups and downs of MEK kinase interactions
    • Hagemann, C., and J. L. Blank. 2001. The ups and downs of MEK kinase interactions. Cell. Signal. 13:863-875.
    • (2001) Cell. Signal. , vol.13 , pp. 863-875
    • Hagemann, C.1    Blank, J.L.2
  • 18
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • Hayden, M. S., and S. Ghosh. 2008. Shared principles in NF-kappaB signaling. Cell 132:344-362.
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 19
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden, M. S., and S. Ghosh. 2004. Signaling to NF-kappaB. Genes Dev. 18:2195-2224.
    • (2004) Genes Dev. , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 20
    • 33750435582 scopus 로고    scopus 로고
    • NF-kappaB and the immune response
    • Hayden, M. S., A. P. West, and S. Ghosh. 2006. NF-kappaB and the immune response. Oncogene 25:6758-6780.
    • (2006) Oncogene , vol.25 , pp. 6758-6780
    • Hayden, M.S.1    West, A.P.2    Ghosh, S.3
  • 21
    • 7244231429 scopus 로고    scopus 로고
    • Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
    • DOI 10.1038/nature02994
    • Hock, H., M. J. Hamblen, H. M. Rooke, J. W. Schindler, S. Saleque, Y. Fujiwara, and S. H. Orkin. 2004. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature 431:1002-1007. (Pubitemid 39434423)
    • (2004) Nature , vol.431 , Issue.7011 , pp. 1002-1007
    • Hock, H.1    Hamblen, M.J.2    Rooke, H.M.3    Schindler, J.W.4    Saleque, S.5    Fujiwara, Y.6    Orkin, S.H.7
  • 22
    • 0037244284 scopus 로고    scopus 로고
    • Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation
    • DOI 10.1016/S1074-7613(02)00501-0
    • Hock, H., M. J. Hamblen, H. M. Rooke, D. Traver, R. T. Bronson, S. Cameron, and S. H. Orkin. 2003. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity 18:109-120. (Pubitemid 36120692)
    • (2003) Immunity , vol.18 , Issue.1 , pp. 109-120
    • Hock, H.1    Hamblen, M.J.2    Rooke, H.M.3    Traver, D.4    Bronson, R.T.5    Cameron, S.6    Orkin, S.H.7
  • 23
    • 33644843788 scopus 로고    scopus 로고
    • Zinc-finger transcription factor Gfi-1: Versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells
    • Hock, H., and S. H. Orkin. 2006. Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Curr. Opin. Hematol. 13:1-6.
    • (2006) Curr. Opin. Hematol. , vol.13 , pp. 1-6
    • Hock, H.1    Orkin, S.H.2
  • 24
    • 0347146027 scopus 로고    scopus 로고
    • Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
    • Hoebe, K., E. M. Janssen, S. O. Kim, L. Alexopoulou, R. A. Flavell, J. Han, and B. Beutler. 2003. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat. Immunol. 4:1223-1229.
    • (2003) Nat. Immunol. , vol.4 , pp. 1223-1229
    • Hoebe, K.1    Janssen, E.M.2    Kim, S.O.3    Alexopoulou, L.4    Flavell, R.A.5    Han, J.6    Beutler, B.7
  • 25
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki, A., and R. Medzhitov. 2004. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5:987-995.
    • (2004) Nat. Immunol. , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 26
    • 4744356736 scopus 로고    scopus 로고
    • Gfi/Pag-3/senseless zinc finger proteins: A unifying theme?
    • Jafar-Nejad, H., and H. J. Bellen. 2004. Gfi/Pag-3/senseless zinc finger proteins: a unifying theme? Mol. Cell. Biol. 24:8803-8812.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 8803-8812
    • Jafar-Nejad, H.1    Bellen, H.J.2
  • 27
    • 2642520591 scopus 로고    scopus 로고
    • PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit
    • Jang, H. D., K. Yoon, Y. J. Shin, J. Kim, and S. Y. Lee. 2004. PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit. J. Biol. Chem. 279:24873-24880.
    • (2004) J. Biol. Chem. , vol.279 , pp. 24873-24880
    • Jang, H.D.1    Yoon, K.2    Shin, Y.J.3    Kim, J.4    Lee, S.Y.5
  • 28
    • 0037292275 scopus 로고    scopus 로고
    • Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members
    • DOI 10.1016/S1097-2765(03)00053-4
    • Janssens, S., and R. Beyaert. 2003. Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol. Cell 11:293-302. (Pubitemid 36293825)
    • (2003) Molecular Cell , vol.11 , Issue.2 , pp. 293-302
    • Janssens, S.1    Beyaert, R.2
  • 29
    • 0042236366 scopus 로고    scopus 로고
    • S, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression
    • DOI 10.1016/S0014-5793(03)00747-6
    • Janssens, S., K. Burns, E. Vercammen, J. Tschopp, and R. Beyaert. 2003. MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression. FEBS Lett. 548:103-107. (Pubitemid 37281258)
    • (2003) FEBS Letters , vol.548 , Issue.1-3 , pp. 103-107
    • Janssens, S.1    Burns, K.2    Vercammen, E.3    Tschopp, J.4    Beyaert, R.5
  • 30
    • 32944482517 scopus 로고    scopus 로고
    • The zinc finger protein Gfi1 acts upstream of TNF to attenuate endotoxin-mediated inflammatory responses in the lung
    • Jin, J., H. Zeng, K. W. Schmid, M. Toetsch, S. Uhlig, and T. Moroy. 2006. The zinc finger protein Gfi1 acts upstream of TNF to attenuate endotoxin-mediated inflammatory responses in the lung. Eur. J. Immunol. 36:421-430.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 421-430
    • Jin, J.1    Zeng, H.2    Schmid, K.W.3    Toetsch, M.4    Uhlig, S.5    Moroy, T.6
  • 31
    • 85047697279 scopus 로고    scopus 로고
    • High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells
    • DOI 10.1038/sj/onc/1205216
    • Karsunky, H., I. Mende, T. Schmidt, and T. Moroy. 2002. High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells. Oncogene 21:1571-1579. (Pubitemid 34226145)
    • (2002) Oncogene , vol.21 , Issue.10 , pp. 1571-1579
    • Karsunky, H.1    Mende, I.2    Schmidt, T.3    Moroy, T.4
  • 32
  • 33
    • 33746195568 scopus 로고    scopus 로고
    • The growth factor independence-1 transcription factor: New functions and new insights
    • Kazanjian, A., E. A. Gross, and H. L. Grimes. 2006. The growth factor independence-1 transcription factor: new functions and new insights. Crit. Rev. Oncol. Hematol. 59:85-97.
    • (2006) Crit. Rev. Oncol. Hematol. , vol.59 , pp. 85-97
    • Kazanjian, A.1    Gross, E.A.2    Grimes, H.L.3
  • 35
    • 0037178785 scopus 로고    scopus 로고
    • IRAK-M is a negative regulator of Toll-like receptor signaling
    • DOI 10.1016/S0092-8674(02)00827-9
    • Kobayashi, K., L. D. Hernandez, J. E. Galan, C. A. Janeway, Jr., R. Medzhitov, and R. A. Flavell. 2002. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110:191-202. (Pubitemid 34876547)
    • (2002) Cell , vol.110 , Issue.2 , pp. 191-202
    • Kobayashi, K.1    Hernandez, L.D.2    Galan, J.E.3    Janeway Jr., C.A.4    Medzhitov, R.5    Flavell, R.A.6
  • 36
  • 37
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated immune responses
    • Liew, F. Y., D. Xu, E. K. Brint, and L. A. O'Neill. 2005. Negative regulation of toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5:446-458.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3    O'Neill, L.A.4
  • 38
    • 43649109029 scopus 로고    scopus 로고
    • Inflammation and cancer: Role of nuclear factor-kappaB activation
    • DOI 10.1111/j.1349-7006.2008.00763.x
    • Maeda, S., and M. Omata. 2008. Inflammation and cancer: role of nuclear factor-kappaB activation. Cancer Sci. 99:836-842. (Pubitemid 352002583)
    • (2008) Cancer Science , vol.99 , Issue.5 , pp. 836-842
    • Maeda, S.1    Omata, M.2
  • 39
    • 57649115445 scopus 로고    scopus 로고
    • Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor
    • Montoya-Durango, D. E., C. S. Velu, A. Kazanjian, M. E. Rojas, C. M. Jay, G. D. Longmore, and H. L. Grimes. 2008. Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor. J. Biol. Chem. 283:32056-32065.
    • (2008) J. Biol. Chem. , vol.283 , pp. 32056-32065
    • Montoya-Durango, D.E.1    Velu, C.S.2    Kazanjian, A.3    Rojas, M.E.4    Jay, C.M.5    Longmore, G.D.6    Grimes, H.L.7
  • 40
    • 11144322855 scopus 로고    scopus 로고
    • The zinc finger transcription factor Growth factor independence 1 (Gfi1)
    • Moroy, T. 2005. The zinc finger transcription factor Growth factor independence 1 (Gfi1). Int. J. Biochem. Cell Biol. 37:541-546.
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 541-546
    • Moroy, T.1
  • 41
    • 41649106096 scopus 로고    scopus 로고
    • The zinc finger protein and transcriptional repressor Gfi1 as a regulator of the innate immune response
    • Moroy, T., H. Zeng, J. Jin, K. W. Schmid, A. Carpinteiro, and E. Gulbins. 2008. The zinc finger protein and transcriptional repressor Gfi1 as a regulator of the innate immune response. Immunobiology 213:341-352.
    • (2008) Immunobiology , vol.213 , pp. 341-352
    • Moroy, T.1    Zeng, H.2    Jin, J.3    Schmid, K.W.4    Carpinteiro, A.5    Gulbins, E.6
  • 43
    • 46749136412 scopus 로고    scopus 로고
    • When signaling pathways collide: Positive and negative regulation of toll-like receptor signal transduction
    • O'Neill, L. A. 2008. When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction. Immunity 29:12-20.
    • (2008) Immunity , vol.29 , pp. 12-20
    • O'Neill, L.A.1
  • 44
    • 20344389060 scopus 로고    scopus 로고
    • Toll-like receptors: Linking innate and adaptive immunity
    • Pasare, C., and R. Medzhitov. 2005. Toll-like receptors: linking innate and adaptive immunity. Adv. Exp. Med. Biol. 560:11-18.
    • (2005) Adv. Exp. Med. Biol. , vol.560 , pp. 11-18
    • Pasare, C.1    Medzhitov, R.2
  • 45
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl, M. W. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e45.
    • (2001) Nucleic Acids Res. , vol.29
    • Pfaffl, M.W.1
  • 47
    • 1542390447 scopus 로고    scopus 로고
    • Control of the expression of inflammatory response genes
    • Saklatvala, J., J. Dean, and A. Clark. 2003. Control of the expression of inflammatory response genes. Biochem. Soc. Symp. 70:95-106.
    • (2003) Biochem. Soc. Symp. , vol.70 , pp. 95-106
    • Saklatvala, J.1    Dean, J.2    Clark, A.3
  • 48
    • 34547785073 scopus 로고    scopus 로고
    • Epigenetic Regulation of Hematopoietic Differentiation by Gfi-1 and Gfi-1b Is Mediated by the Cofactors CoREST and LSD1
    • DOI 10.1016/j.molcel.2007.06.039, PII S1097276507004832
    • Saleque, S., J. Kim, H. M. Rooke, and S. H. Orkin. 2007. Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol. Cell 27:562-572. (Pubitemid 47238633)
    • (2007) Molecular Cell , vol.27 , Issue.4 , pp. 562-572
    • Saleque, S.1    Kim, J.2    Rooke, H.M.3    Orkin, S.H.4
  • 49
    • 26944474424 scopus 로고    scopus 로고
    • Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation
    • Shroyer, N. F., D. Wallis, K. J. Venken, H. J. Bellen, and H. Y. Zoghbi. 2005. Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev. 19:2412-2417.
    • (2005) Genes Dev. , vol.19 , pp. 2412-2417
    • Shroyer, N.F.1    Wallis, D.2    Venken, K.J.3    Bellen, H.J.4    Zoghbi, H.Y.5
  • 50
    • 4143102310 scopus 로고    scopus 로고
    • LPS-induced upregulation of SHIP is essential for endotoxin tolerance
    • Sly, L. M., M. J. Rauh, J. Kalesnikoff, C. H. Song, and G. Krystal. 2004. LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity 21:227-239.
    • (2004) Immunity , vol.21 , pp. 227-239
    • Sly, L.M.1    Rauh, M.J.2    Kalesnikoff, J.3    Song, C.H.4    Krystal, G.5
  • 51
    • 0036775463 scopus 로고    scopus 로고
    • IRAK-4 as the central TIR signaling mediator in innate immunity
    • DOI 10.1016/S1471-4906(02)02298-6, PII S1471490602022986
    • Suzuki, N., S. Suzuki, and W. C. Yeh. 2002. IRAK-4 as the central TIR signaling mediator in innate immunity. Trends Immunol. 23:503-506. (Pubitemid 35248046)
    • (2002) Trends in Immunology , vol.23 , Issue.10 , pp. 503-506
    • Suzuki, N.1    Suzuki, S.2    Yeh, W.-C.3
  • 52
    • 14244258985 scopus 로고    scopus 로고
    • Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b
    • DOI 10.1093/nar/gki243
    • Vassen, L., K. Fiolka, S. Mahlmann, and T. Moroy. 2005. Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b. Nucleic Acids Res. 33:987-998. (Pubitemid 41430519)
    • (2005) Nucleic Acids Research , vol.33 , Issue.3 , pp. 987-998
    • Vassen, L.1    Fiolka, K.2    Mahlmann, S.3    Moroy, T.4
  • 54
    • 17644443312 scopus 로고    scopus 로고
    • The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus
    • Yucel, R., H. Karsunky, L. Klein-Hitpass, and T. Moroy. 2003. The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J. Exp. Med. 197:831-844.
    • (2003) J. Exp. Med. , vol.197 , pp. 831-844
    • Yucel, R.1    Karsunky, H.2    Klein-Hitpass, L.3    Moroy, T.4
  • 55
    • 8144220648 scopus 로고    scopus 로고
    • Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells
    • DOI 10.1038/sj.emboj.7600419
    • Zeng, H., R. Yucel, C. Kosan, L. Klein-Hitpass, and T. Moroy. 2004. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 23:4116-4125. (Pubitemid 39472432)
    • (2004) EMBO Journal , vol.23 , Issue.20 , pp. 4116-4125
    • Zeng, H.1    Yucel, R.2    Kosan, C.3    Klein-Hitpass, L.4    Moroy, T.5
  • 56
    • 0034450123 scopus 로고    scopus 로고
    • Molecular mechanisms of NF-κB activation induced by bacterial lipopolysaccharide through Toll-like receptors
    • DOI 10.1179/096805100101532414
    • Zhang, G., and S. Ghosh. 2000. Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors. J. Endotoxin Res. 6:453-457. (Pubitemid 32409432)
    • (2000) Journal of Endotoxin Research , vol.6 , Issue.6 , pp. 453-457
    • Zhang, G.1    Ghosh, S.2
  • 57
    • 0029897536 scopus 로고    scopus 로고
    • Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor
    • Zweidler-Mckay, P. A., H. L. Grimes, M. M. Flubacher, and P. N. Tsichlis. 1996. Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor. Mol. Cell. Biol. 16:4024-4034.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4024-4034
    • Zweidler-Mckay, P.A.1    Grimes, H.L.2    Flubacher, M.M.3    Tsichlis, P.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.