Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer

Oncology Reports

Volumn 28, Issue 4, 2012, Pages 1301-1308

  Wang, Chunxia ^a,b   Xie, Jingping ^b   Guo, Jiasong ^a   Manning, H Charles ^b,c   Gore, John C ^b,c,d   Guo, Ning ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cancer stem cells; Colorectal cancer; Invasion; Markers; Proliferation

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; CD133 ANTIGEN; CELL SURFACE MARKER; EPITHELIAL CELL ADHESION MOLECULE; HERMES ANTIGEN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INVASION; CANCER STEM CELL; CELL ASSAY; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL SUBPOPULATION; COLONY FORMATION; COLORECTAL CANCER; CONTROLLED STUDY; DRUG RESISTANCE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTIGENS, CD; ANTIGENS, CD44; ANTIGENS, NEOPLASM; APOPTOSIS; CAMPTOTHECIN; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; GLYCOPROTEINS; HUMANS; ISOENZYMES; NEOPLASTIC STEM CELLS; PEPTIDES; RETINAL DEHYDROGENASE; TUMOR MARKERS, BIOLOGICAL;

EID: 84866459145     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1951     Document Type: Article

References (33)

1. Kinzler KW and Vogelstein B: Lessons from hereditary colorectal cancer. Cell 87: 159-170, 1996.
2. Bonnet D and Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3: 730-737, 1997.
3. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988, 2003.
4. Li C, Heidt DG, Dalerba P, et al: Identification of pancreatic cancer stem cells. Cancer Res 67: 1030-1037, 2007.
5. O'Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: 106-110, 2007.
6. Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al: Identification and expansion of human colon-cancer-initiating cells. Nature 445: 111-115, 2007.
7. Dalerba P, Dylla SJ, Park IK, et al: Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 104: 10158-10163, 2007.
8. Du L, Wang H, He L, et al: CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 14: 6751-6760, 2008.
9. Takaishi S, Okumura T, Tu S, et al: Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells 27: 1006-1020, 2009.
10. Huang EH, Hynes MJ, Zhang T, et al: Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 69: 3382-3389, 2009.
11. - metastatic colon cancer cells initiate tumors. J Clin Invest 118: 2111-2120, 2008.
12. Bao S, Wu Q, Sathornsumetee S, et al: Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 66: 7843-7848, 2006.
13. + cancer stem cells in childhood malignant melanoma and its correlation with metastasis. Mod Pathol 23: 376-380, 2010.
14. Artells R, Moreno I, Diaz T, et al: Tumour CD133 mRNA expression and clinical outcome in surgically resected colorectal cancer patients. Eur J Cancer 46: 642-649, 2010.
15. + ovarian cancer cells. Oncogene 28: 209-218, 2009.
16. + cancer stem cells displaying high tumorigenicity in vivo. FASEB J 25: 2022-2030, 2011
17. Griguer CE, Oliva CR, Gobin E, et al: CD133 is a marker of bioenergetic stress in human glioma. PLoS ONE 3: e3655, 2008.
18. Bidlingmaier S, Zhu X and Liu B: The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells. J Mol Med 86: 1025-1032, 2008.
19. Futschik M, Jeffs A, Pattison S, et al: Gene expression profiling of metastatic and nonmetastatic colorectal cancer cell lines. Genome Lett 1: 26-34, 2002.
20. + cancer cells express higher levels of the anti-apoptotic protein Bcl-2 in breast tumours. Cancer Immun 9: 4, 2009.
21. Hao JL, Cozzi PJ, Khatri A, Power CA and Li Y: CD147/ EMMPRIN and CD44 are potential therapeutic targets for metastatic prostate cancer. Curr Cancer Drug Targets 10: 287-306, 2010.
22. Huerta S, Harris DM, Jazirehi A, et al: Gene expression profile of metastatic colon cancer cells resistant to cisplatin-induced apoptosis. Int J Oncol 22: 663-670, 2003.
23. Kawamoto H, Yuasa T, Kubota Y, et al: Characteristics of CD133(+) human colon cancer SW620 cells. Cell Transplant 19: 857-864, 2010.
24. Todaro M, Alea MP, Di Stefano AB, et al: Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 1: 389-402, 2007.
25. + population efficiently enriches colon cancer initiating cells. Ann Surgical Oncol 15: 2927-2933, 2008.
26. Miletti-Gonzalez KE, Chen S, Muthukumaran N, et al: The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer. Cancer Res 65: 6660-6667, 2005.
27. Wiranowska M, Ladd S, Smith SR and Gottschall PE: CD44 adhesion molecule and neuro-glial proteoglycan NG2 as invasive markers of glioma. Brain Cell Biol 35: 159-172, 2006.
28. Kojima M, Ishii G, Atsumi N, Fujii S, Saito N and Ochiai A: Immunohistochemical detection of CD133 expression in colorectal cancer: a clinicopathological study. Cancer Sci 99: 1578-1583, 2008.
29. Bendardaf R, Algars A, Elzagheid A, et al: Comparison of CD44 expression in primary tumours and metastases of colorectal cancer. Oncol Rep 16: 741-746, 2006.
30. Huh JW, Kim HR, Kim YJ, et al: Expression of standard CD44 in human colorectal carcinoma: association with prognosis. Pathol Int 59: 241-246, 2009.
31. Liu C, Kelnar K, Liu B, et al: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 17: 211-215, 2011.
32. Gao AC, Lou W, Dong JT and Isaacs JT: CD44 is a metastasis suppressor gene for prostatic cancer located on human chromosome 11p13. Cancer Res 57: 846-849, 1997.
33. Abetamann V, Kern HF and Elsasser HP: Differential expression of the hyaluronan receptors CD44 and RHAMM in human pancreatic cancer cells. Clin Cancer Res 2: 1607-1618, 1996.