An ultra-high throughput cell-based screen for wee1 degradation inhibitors

Journal of Biomolecular Screening

Volumn 15, Issue 8, 2010, Pages 907-917

  Madoux, Franck ^a   Simanski, Scott ^b   Chase, Peter ^a   Mishra, Jitendra K ^b   Roush, William R ^b   Ayad, Nagi G ^b   Hodder, Peter ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Department of Cancer Biology ^*  (United States)

Author keywords

cryopreserved cells; degradation; ML118; MLPCN; proteasome; reporter assay; stabilizer; transient transfection; ubiquitin; Wee1

Indexed keywords

HYBRID PROTEIN; LUCIFERASE; PROTEIN TYROSINE KINASE; TYROSINE KINASE WEE1; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CELL CYCLE PROGRESSION; CELL VIABILITY; CONTROLLED STUDY; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOLECULAR LIBRARY; PRIORITY JOURNAL; PROTEIN DEGRADATION; SCREENING;

CALIBRATION; CELL CULTURE TECHNIQUES; CELL CYCLE PROTEINS; CELLS, CULTURED; GENES, REPORTER; HELA CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LUCIFERASES; MINIATURIZATION; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-TYROSINE KINASES; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 78449285209     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110375848     Document Type: Article

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