2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/ε

Amino Acids

Volumn 43, Issue 4, 2012, Pages 1577-1591

  Bischof, Joachim ^a   Leban, Johann ^a,b   Zaja, Mirko ^b   Grothey, Arnhild ^a,c   Radunsky, Barbara ^a   Othersen, Olaf ^b   Strobl, Stefan ^b   Vitt, Daniel ^b   Knippschild, Uwe ^a  

^a UNIVERSITY OF ULM   (Germany)

^b 4SC AG   (Germany)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

CK1 ; CK1 ; Crystal structure; FACS; MTT; Phosphorylation; Small molecule inhibitor

Indexed keywords

2 BENZAMIDO N (1H BENZO[D]IMIDAZOL 2 YL)THIAZOLE 4 CARBOXAMIDE DERIVATIVE; 2 [2 [TRIFLUOROMETHOXY]BENZAMIDO]THIAZOLE 4 CARBOXYLIC ACID; 2 [2[TRIFLUOROMETHOXY]BENZAMIDO] N [6 [TRIFLUOROMETHYL] 1H BENZO[D]IMIDAZOL 2 YL]THIAZOLE 4 CARBOXAMIDE; 2 [FURAN 2 CARBOXAMIDO] N [6 [TRIFLUOROMETHYL] 1H BENZO[D]IMIDAZOL 2 YL]THIAZOLE 4 CARBOXAMIDE; 2 [ISONICOTINAMIDO] N [6 [TRIFLUOROMETHYL] 1H BENZO[D]IMIDAZOL 2 YL]THIAZOLE 4 CARBOXAMIDE; AMIDE; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; HETEROCYCLIC COMPOUND; METHYL 2 [2 [2 [TRIFLUOROMETHOXY]BENZAMIDO] THIAZOLE 4 CARBAXAMIDO] 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; N [1 METHYL 1H BENZO[D]IMIDAZOL 2 YL] 2 [2 [TRIFLUOROMETHOXY]BENZ AMIDO]THIAZOLE 4 CARBOXAMIDE; N [1H BENZO[D]IMIDAZOL 2 YL] 2 [2 [TRIFLUOROMETHOXY]BENZAMIDO]THIAZOLE 4 CARBOXAMIDE; N [5 CHLORO 6 FLUORO 1H BENZO[D]IMIDAZOL 2 YL] 2 [2 [TRIFLUOROMETHOXY]BENZAMIDO]THIAZOLE 4 CARBOXAMIDE; N [5 [METHYLSULFONYL] 1H BENZO[D]IMIDAZOL 2 YL] 2 [2 [TRIFLUOROMETHOXY]BENZAMIDO]THIAZOLE 4 CARBOXAMIDE; N [BENZO[D]OXAZOL 2YL] 2 [2 [TRIFLUOROMETHOXY]BENZAMIDO]THIAZOLE 4 CARBOXAMIDE; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL LINE; X RAY ANALYSIS;

EID: 84867577528     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1234-x     Document Type: Article

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