Measured haplotype analysis of the aldosterone synthase gene and heart size (European Journal of Human Genetics (2003) vol. 11 (395-401) 10.1038/sj.ejhg.5200967;Measured haplotype analysis of the aldosterone synthase gene and heart size

European Journal of Human Genetics

Volumn 11, Issue 5, 2003, Pages 395-401

  Mayosi, Bongani M ^a,b   Keavney, Bernard ^c   Watkins, Hugh ^a   Farrall, Martin ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c INSTITUTE OF HUMAN GENETICS   (United Kingdom)

Author keywords

Aldosterone; Association; Echocardiography; Haplotypes; Heart; Hypertrophy; Polymorphisms

Indexed keywords

ALDOSTERONE SYNTHASE;

ADULT; AGED; ALLELE; ARTICLE; CAUCASIAN; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FEMALE; GENE CONVERSION; GENE LINKAGE DISEQUILIBRIUM; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HEART SIZE; HEART VENTRICLE HYPERTROPHY; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STATISTICAL ANALYSIS; UNITED KINGDOM;

EID: 0038282483     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5201427     Document Type: Erratum

References (30)

1. Garner C, Lecomte E, Visvikis S, Abergel E, Lathrop M, Soubrier F: Genetic and environmental influences on left ventricular mass: a family study. Hypertension 2000; 36: 740-746.
2. Busjahn A, Li GH, Faulhaber HD et al: Beta-2 adrenergic receptor gene variations, blood pressure, and heart size in normal twins. Hypertension 2000; 35: 555-560.
3. Kotchen TA, Kotchen JM, Grim CE et al: Genetic determinants of hypertension: identification of candidate phenotypes. Hypertension 2000; 36: 7-13.
4. Weber KT, Brilla CG: Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 1991; 83: 1849-1865.
5. Pojoga L, Gautier S, Blanc H et al: Genetic determination of plasma aldosterone levels in essential hypertension. Am J Hypertens 1998; 11: 856-860.
6. Schunkert H, Hense HW, Muscholl M et al: Associations between circulating components of the renin-angiotensin-aldosterone system and left ventricular mass. Heart 1997; 77: 24-31.
7. Lombes M, Alfaidy N, Eugene E, Lessana A, Farman N, Bonvalet JP: Prerequisite for cardiac aldosterone action. Mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase in the human heart. Circulation 1995; 92: 175-182.
8. Kupari M, Hautanen A, Lankinen L et al: Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function. Circulation 1998; 97: 569-575.
9. Schunkert H, Hengstenberg C, Holmer SR et al: Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure. Circulation 1999; 99: 2255-2260.
10. Hengstenberg C, Holmer SR, Mayer B et al: Evaluation of the aldosterone synthase (CYP11B2) gene polymorphism in patients with myocardial infarction. Hypertension 2000; 35: 704-709.
11. Delles C, Erdmann J, Jacobi J et al: Aldosterone synthase (CYP11B2) -344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension. J Am Coll Cardiol 2001; 37: 878-884.
12. Keavney B, McKenzie C, Parish S et al: Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators. Lancet 2000; 355: 434-442.
13. Farrall M, Keavney B, McKenzie C, Delepine M, Matsuda F, Lathrop GM: Fine-mapping of an ancestral recombination breakpoint in DCP1. Nat Genet 1999; 23: 270-271.
14. Keavney B, McKenzie CA, Connell JM et al: Measured haplotype analysis of the angiotensin-I converting enzyme gene. Hum Mol Genet 1998; 7: 1745-1751.
15. Mayosi BM, Vickers MV, Green FR et al: Evidence of a quantitative trait locus for plasma fibrinogen from a family-based association study. GeneScreen 2001; 1: 151-155.
16. Vickers MV, Green FR, Terry C et al: Genotype at a promoter polymorphism of the interleukin-6 gene is associated with plasma c-reactive protein. Cardiovasc Res 2002; 53: 1029-1034.
17. Mayosi BM, Keavney B, Kardos A et al: Electrocardiographic measures of left ventricular hypertrophy show greater heritability than echocardiographic left ventricular mass: a family study. Eur Heart J 2002; 23: 74-82.
18. Davies E, Holloway CD, Ingram MC et al: Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2. Hypertension 1999; 33: 703-707.
19. White PC, Slutsker L: Haplotype analysis of CYP11B2. Endocr Res 1995; 21: 437-442.
20. Fardella CE, Rodriguez H, Montero J et al: Genetic variation in P450c11AS in Chilean patients with low renin hypertension. J Clin Endocrinol Metab 1996; 81: 4347-4351.
21. Halushka MK, Fan JB, Bentley K et al: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet 1999; 22: 239-247.
22. O'Connell JR, Weeks DE: PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998; 63: 259-266.
23. Soubrier F, Martin S, Alonso A et al: High-resolution genetic mapping of the ACE-linked QTL influencing circulating ACE activity. Eur J Hum Genet 2002; 10: 553-561.
24. Lathrop GM, Lalouel JM, Julier C, Ott J: Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. Am J Hum Genet 1985; 37: 482-498.
25. Cox R, Bouzekri N, Martin S et al: Angiotensin-1 converting enzyme (ACE) plasma concentration is influenced by multiple ACE-linked quantitative trait nucleotides. Hum Mol Genet 2002; 11: 2969-2977.
26. Devereux RB, Pickering TG, Alderman MH, Chien S, Borer JS, Laragh JH: Left ventricular hypertrophy in hypertension. Prevalence and relationship to pathophysiologic variables. Hypertension 1987; 9: II-53-60.
27. Brand E, Chatelain N, Mulatero P et al: Structural analysis and evaluation of the aldosterone synthase gene in hypertension. Hypertension 1998; 32: 198-204.
28. Hautanena A, Lankinen L, Kupari M et al: Associations between aldosterone synthase gene polymorphism and the adrenocortical function in males. J Intern Med 1998; 244: 11-18.
29. Lander ES, Schork NJ: Genetic dissection of complex traits. Science 1994; 265: 2037-2048.
30. Abecasis GR, Cardon LR, Cookson WO: A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000; 66: 279-292.