Pharmacological inhibition of HSP90 activity negatively modulates myogenic differentiation and cell survival in C2C12 cells

Molecular and Cellular Biochemistry

Volumn 358, Issue 1-2, 2011, Pages 265-280

  Wagatsuma, Akira ^a   Shiozuka, Masataka ^a   Kotake, Naoki ^b   Takayuki, Kawachi ^a   Yusuke, Honda ^a   Mabuchi, Kunihiko ^a   Matsuda, Ryoichi ^a   Yamada, Shigeru ^c  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL FISHERIES UNIVERSITY   (Japan)

^c JISSEN WOMEN'S UNIVERSITY   (Japan)

Author keywords

Apoptosis; HSP90; JNK; Myogenic differentiation; Survival

Indexed keywords

17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN; BENZOQUINONE DERIVATIVE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MACROCYCLIC LACTAM; MITOGEN ACTIVATED PROTEIN KINASE P38; MYOD PROTEIN; MYOGENIN; MYOSIN HEAVY CHAIN; PROTEIN BAX; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TANESPIMYCIN;

ANIMAL; APOPTOSIS; ARTICLE; C57BL MOUSE; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; MALE; METABOLISM; MOUSE; MUSCLE DEVELOPMENT; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TRANSPORT; REGENERATION; SKELETAL MUSCLE; UPREGULATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZOQUINONES; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; HSP90 HEAT-SHOCK PROTEINS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LACTAMS, MACROCYCLIC; MALE; MICE; MICE, INBRED C57BL; MUSCLE DEVELOPMENT; MUSCLE FIBERS, SKELETAL; MYOD PROTEIN; MYOGENIN; MYOSIN HEAVY CHAINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; REGENERATION; UP-REGULATION;

EID: 84857163488     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0977-0     Document Type: Article

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