The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin

Journal of Biological Chemistry

Volumn 288, Issue 26, 2013, Pages 19154-19165

  Williamson, Danielle M ^a   Elferich, Johannes ^a   Ramakrishnan, Parvathy ^a,c   Thomas, Gary ^b   Shinde, Ujwal ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c DR REDDY'S LABORATORIES LTD   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOCATALYTIC; CLEAVAGE SITES; COMPUTATIONAL APPROACH; PH REGULATION; PROPROTEIN CONVERTASE FURIN; SECRETORY PATHWAYS; STRUCTURAL MODELING; TRANS-GOLGI NETWORK;

COMPLEX NETWORKS; COMPUTER SIMULATION; ENZYME ACTIVITY; PH SENSORS; PROTONATION;

PH;

FURIN; FURIN PROPEPTIDE; HISTIDINE; LEUCINE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; BIOPHYSICS; CELL PH; CIRCULAR DICHROISM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME BINDING; ENZYME REGULATION; ENZYME STABILITY; ENZYME STRUCTURE; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; STRUCTURE ANALYSIS; THERMODYNAMICS; WILD TYPE;

CONVERTASES; FURIN; INTRAMOLECULAR CHAPERONE; PH SENSOR; PROPEPTIDE; PROTEASE ACTIVATION PRECISION; PROTEIN FOLDING; PROTEIN SECRETION; SERINE PROTEASE; SUBCELLULAR ORGANELLES;

CIRCULAR DICHROISM; ENZYME ACTIVATION; FURIN; GLYCEROL; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR CHAPERONES; MOLECULAR DYNAMICS SIMULATION; PEPTIDES; PROTEIN FOLDING; PROTONS; THERMODYNAMICS; TIME FACTORS; UREA;

EID: 84879600328     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.442681     Document Type: Article

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